Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism
Open accessAbstract
Rates of obesity have been steadily increasing, along with disorders commonly associated with obesity, such as cardiovascular disease and type II diabetes. Simultaneously, average sleep times have progressively decreased. Recently, evidence from both laboratory and epidemiologic studies has suggested that insufficient sleep may stimulate overeating and thus play a role in the current epidemic of obesity and diabetes. In the human sleep laboratory it is now possible to carefully control sleep behavior and study the link between sleep duration and alterations in circulating hormones involved in feeding behavior, glucose metabolism, hunger, and appetite. This article focuses on the methodologies used in experimental protocols that have examined modifications produced by sleep restriction (or extension) compared with normal sleep. The findings provide evidence that sleep restriction does indeed impair glucose metabolism and alters the cross-talk between the periphery and the brain, favoring excessive food intake. A better understanding of the adverse effects of sleep restriction on the CNS control of hunger and appetite may have important implications for public health.
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Sleep deprivation alters appetite-regulating hormones and increases caloric intake.
“Moreover, sleep deprivation alters appetite-regulating hormones and increases caloric intake2,3.”
From The impact of sleep deprivation on food desire in the human brain (2013) · cites this paper as [2]
Prior work has described peripheral body changes in appetite and metabolic regulating hormones following sleep loss that can lead to weight-gain.
“elegant prior work has describe peripheral body changes in appetite and metabolic regulating hormones following sleep loss that can lead to weight-gain2,26,28.”
From The impact of sleep deprivation on food desire in the human brain (2013) · cites this paper as [2]
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- Authors
- Hanlon, E. C., & Van Cauter, E.
- Affiliations
- University of Chicago (US)
- Sleep, Metabolism, and Health Center, Department of Medicine, University of Chicago, Chicago, IL 60637
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-08-18
- Volume
- 108
- Issue
- supplement_3
- Pages
- 15609-15616
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3176603
- OpenAlex
- W2059701926
- Cited by
- 110
- References
- 72
- Citations by year
- 2025: 7 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 12 · 2015: 9 · 2014: 14 · 2013: 13 · 2012: 11
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense
- National Institutes of Health
- Centers for Disease Control and Prevention (PR064727)
- National Institute on Aging (P01-AG11412., P01AG011412)
- National Heart, Lung, and Blood Institute (R01HL075079)
- National Institute of Diabetes and Digestive and Kidney Diseases (P60DK20595, P60DK020595)
- National Center for Research Resources (UL1RR024999, RR-024999)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD057796)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep restriction, sleep extension, sleep duration, obesity, type 2 diabetes, glucose metabolism, appetite, hunger, dietary intake, peripheral metabolism, feeding behavior, circulating hormones
- MeSH terms
- Brain, Diabetes Mellitus, Humans, Obesity, Sleep, Sleep Deprivation, Sleep Wake Disorders
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