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Cellular backpacks for macrophage immunotherapy
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Backpacks enable a new strategy to control cellular phenotypes in vivo by attaching to macrophages and guiding their phenotypes.
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2 retracted
The role of nitric oxide in inflammatory reactions: Nitric oxide: control of immune response
Tripathi, P., Tripathi, P., Kashyap, L., & Singh, V. (2007) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2007.00329.x · Cited by 511
RetractedLiu, Y., Liang, X., Yin, X., Lv, J., Tang, K., Ma, J., Ji, T., Zhang, H., Dong, W., Jin, X., et al. (2017) · Nature Communications · doi:10.1038/ncomms15207 · Cited by 212
RetractedThe M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · cited 1×
“This plasticity allows them to assume many roles like defending against foreign pathogens, aiding in wound healing, and regulating tissue homeostasis (5).”
BackgroundInterferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
Macrophage Cytokines: Involvement in Immunity and Infectious Diseases
Arango Duque, G., & Descoteaux, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00491 · Cited by 2,708 · cited 1×
“Increased expression of IL-6 has been correlated with tumor metastasis (50); however, IL-6 is also secreted by macrophages with anti-inflammatory phenotypes (51).”
BackgroundRole of target geometry in phagocytosis
Champion, J. A., & Mitragotri, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600997103 · Cited by 2,074
Self-citationZanganeh, S., Hutter, G., Spitler, R., Lenkov, O., Mahmoudi, M., Shaw, A., Pajarinen, J. S., Nejadnik, H., Goodman, S., Moseley, M., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.168 · Cited by 1,647
The Isolation and Characterization of Murine Macrophages
Zhang, X., Goncalves, R., & Mosser, D. M. (2008) · Current Protocols in Immunology · doi:10.1002/0471142735.im1401s83 · Cited by 1,536
A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells
Carreno, B. M., Magrini, V., Becker-Hapak, M., Kaabinejadian, S., Hundal, J., Petti, A. A., Ly, A., Lie, W.-R., Hildebrand, W. H., Mardis, E. R., et al. (2015) · Science · doi:10.1126/science.aaa3828 · Cited by 1,285
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy
Khalil, D. N., Smith, E. L., Brentjens, R. J., & Wolchok, J. D. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.25 · Cited by 929
Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA
Steimle, V., Siegrist, C.-A., Mottet, A., Lisowska-Grospierre, B., & Mach, B. (1994) · Science · doi:10.1126/science.8016643 · Cited by 898
Song, M., Liu, T., Shi, C., Zhang, X., & Chen, X. (2016) · ACS Nano · doi:10.1021/acsnano.5b06779 · Cited by 662
Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery
Tang, L., Zheng, Y., Melo, M. B., Mabardi, L., Castaño, A. P., Xie, Y.-Q., Li, N., Kudchodkar, S. B., Wong, H. C., Jeng, E. K., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4181 · Cited by 660
Doedens, A. L., Stockmann, C., Rubinstein, M. P., Liao, D., Zhang, N., DeNardo, D. G., Coussens, L. M., Karin, M., Goldrath, A. W., & Johnson, R. S. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1439 · Cited by 652
ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR FUNCTION
Durante, W., Johnson, F. K., & Johnson, R. A. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04638.x · Cited by 577 · cited 1×
“Arg-1 affects NO synthase and downregulates NO production (32).”
BackgroundClass IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages
Guerriero, J. L., Sotayo, A., Ponichtera, H. E., Castrillon, J. A., Pourzia, A. L., Schad, S., Johnson, S. F., Carrasco, R. D., Lazo, S., Bronson, R. T., et al. (2017) · Nature · doi:10.1038/nature21409 · Cited by 558
CAR T-cell Therapy: A New Era in Cancer Immunotherapy
Miliotou, A. N., & Papadopoulou, L. C. (2018) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201019666180418095526 · Cited by 480
Choo, Y. W., Kang, M., Kim, H. Y., Han, J., Kang, S., Lee, J.-R., Jeong, G.-J., Kwon, S. P., Song, S. Y., Go, S., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b02446 · Cited by 465
Edin, S., Wikberg, M. L., Dahlin, A. M., Rutegård, J., Öberg, Å., Oldenborg, P.-A., & Palmqvist, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047045 · Cited by 454
Tumor-associated macrophages: unwitting accomplices in breast cancer malignancy
Williams, C. B., Yeh, E. S., & Soloff, A. C. (2016) · npj Breast Cancer · doi:10.1038/npjbcancer.2015.25 · Cited by 444
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors
Wang, T., Wang, D., Yu, H., Feng, B., Zhou, F., Zhang, H., Zhou, L., Jiao, S., & Li, Y. (2018) · Nature Communications · doi:10.1038/s41467-018-03915-4 · Cited by 391
Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells
Cheung, A. S., Zhang, D. K. Y., Koshy, S. T., & Mooney, D. J. (2018) · Nature Biotechnology · doi:10.1038/nbt.4047 · Cited by 372
A Breakthrough: Macrophage-Directed Cancer Immunotherapy
Mills, C. D., Lenz, L. L., & Harris, R. A. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1737 · Cited by 356
Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression
Yuan, A., Hsiao, Y.-J., Chen, H.-Y., Chen, H.-W., Ho, C.-C., Chen, Y.-Y., Liu, Y.-C., Hong, T.-H., Yu, S.-L., Chen, J. J. W., et al. (2015) · Scientific Reports · doi:10.1038/srep14273 · Cited by 352
Cancer immunoediting by the innate immune system in the absence of adaptive immunity
O’Sullivan, T., Saddawi-Konefka, R., Vermi, W., Koebel, C. M., Arthur, C., White, J. M., Uppaluri, R., Andrews, D. M., Ngiow, S. F., Teng, M. W. L., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112738 · Cited by 348
The Promise of Targeting Macrophages in Cancer Therapy
Brown, J. M., Recht, L., & Strober, S. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-3122 · Cited by 321
Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells
Huang, B., Abraham, W. D., Zheng, Y., Bustamante López, S. C., Luo, S. S., & Irvine, D. J. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa5447 · Cited by 312
Miller, C. H. T., Maher, S. G., & Young, H. A. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05069.x · Cited by 303
Wang, Y., Lin, Y.-X., Qiao, S.-L., An, H.-W., Ma, Y., Qiao, Z.-Y., Rajapaksha, R. P. Y. J., & Wang, H. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.034 · Cited by 266
Parayath, N. N., Parikh, A., & Amiji, M. M. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b00689 · Cited by 262
Li, C., Zhang, Y., Dong, X., Zhang, L., Liu, M., Li, B., Zhang, M., Feng, J., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201807211 · Cited by 201
Macrophage-based cell therapies: The long and winding road
Lee, S., Kivimäe, S., Dolor, A., & Szoka, F. C. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.018 · Cited by 198
Andreesen, R., Scheibenbogen, C., Brugger, W., Krause, S. W., Meerpohl, H. G., Leser, H.-G., Engler, H., & Löhr, G. W. (1990) · PubMed · Cited by 195
Shields, C. W., Wang, L. L., Evans, M. A., & Mitragotri, S. (2020) · Advanced Materials · doi:10.1002/adma.201901633 · Cited by 193
Self-citationCell‐Based Drug Delivery Devices Using Phagocytosis‐Resistant Backpacks
Doshi, N., Swiston, A. J., Gilbert, J. B., Alcaraz, M. L., Cohen, R. E., Rubner, M. F., & Mitragotri, S. (2011) · Advanced Materials · doi:10.1002/adma.201004074 · Cited by 191
Self-citationRamesh, A., Kumar, S., Nandi, D., & Kulkarni, A. (2019) · Advanced Materials · doi:10.1002/adma.201904364 · Cited by 187
Precision Targeting of Tumor Macrophages with a CD206 Binding Peptide
Scodeller, P., Simón-Gracia, L., Kopanchuk, S., Tobi, A., Kilk, K., Säälik, P., Kurm, K., Squadrito, M. L., Kotamraju, V. R., Rinken, A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14709-x · Cited by 179
Macrophages with cellular backpacks for targeted drug delivery to the brain
Klyachko, N. L., Polak, R., Haney, M. J., Zhao, Y., Gomes Neto, R. J., Hill, M. C., Kabanov, A. V., Cohen, R. E., Rubner, M. F., & Batrakova, E. V. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.06.017 · Cited by 176
Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice
Raimondo, T. M., & Mooney, D. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806908115 · Cited by 166
Anselmo, A. C., Gilbert, J. B., Kumar, S., Gupta, V., Cohen, R. E., Rubner, M. F., & Mitragotri, S. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.11.027 · Cited by 159
Self-citationWu, C., Xue, Y., Wang, P., Lin, L., Liu, Q., Li, N., Xu, J., & Cao, X. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302379 · Cited by 156
Angiogenesis and the Tumor Microenvironment: Vascular Endothelial Growth Factor and Beyond
Mittal, K., Ebos, J. M. L., & Rini, B. I. (2014) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.02.007 · Cited by 153
Zhang, Y., Cheng, S., Zhang, M., Zhen, L., Pang, D., Zhang, Q., & Li, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076147 · Cited by 146
Macrophage activation in human diseases
Schultze, J. L., Schmieder, A., & Goerdt, S. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.07.003 · Cited by 135
Evans, M. A., Huang, P.-J., Iwamoto, Y., Ibsen, K. N., Chan, E. M., Hitomi, Y., Ford, P. C., & Mitragotri, S. (2018) · Chemical Science · doi:10.1039/c8sc00015h · Cited by 108
Self-citationPerrotta, C., Cervia, D., Renzo, I. D., Moscheni, C., Bassi, M. T., Campana, L., Martelli, C., Catalani, E., Giovarelli, M., Zecchini, S., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01186 · Cited by 100
Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42
Razidlo, G. L., Burton, K. M., & McNiven, M. A. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003276 · Cited by 100
Hucks, G., & Rheingold, S. R. (2019) · Blood Cancer Journal · doi:10.1038/s41408-018-0164-6 · Cited by 87
Bioactive Polyelectrolyte Multilayers: Hyaluronic Acid Mediated B Lymphocyte Adhesion
Vasconcellos, F. C., Swiston, A. J., Beppu, M. M., Cohen, R. E., & Rubner, M. F. (2010) · Biomacromolecules · doi:10.1021/bm100570r · Cited by 73
Evaluation of Hydrogels Based on Oxidized Hyaluronic Acid for Bioprinting
Weis, M., Shan, J., Kuhlmann, M., Jüngst, T., Teßmar, J., & Gröll, J. (2018) · Gels · doi:10.3390/gels4040082 · Cited by 60
Tong, H.-I., Kang, W., Davy, P. M. C., Shi, Y., Sun, S., Allsopp, R., & Lu, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154022 · Cited by 59
Shahbazi, M., Sedighi, M., Bauleth‐Ramos, T., Kant, K., Correia, A., Poursina, N., Sarmento, B. F. C. C., Hirvonen, J. J., & Santos, H. A. (2018) · ACS Omega · doi:10.1021/acsomega.8b03182 · Cited by 59
Deng, R., Wang, S.-M., Yin, T., Ye, T., Shen, G., Li, L., Zhao, J., Sang, Y., Duan, X.-G., & Wei, Y. (2012) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504013x13715991125684 · Cited by 49
Labrousse, A. M. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00051 · Cited by 47
Zhang, P., & Guan, J. (2011) · Small · doi:10.1002/smll.201101238 · Cited by 44
Pusuluri, A., Krishnan, V., Wu, D., Shields, C. W., Wang, L., & Mitragotri, S. (2019) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10129 · Cited by 36
Self-citationClinical evaluation of macrophages in cancer: role in treatment, modulation and challenges
Tremble, L. F., Forde, P. F., & Soden, D. M. (2017) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-017-2065-0 · Cited by 22
Mularski, A., Marie‐Anaïs, F., Mazzolini, J., & Niedergang, F. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7837-3_16 · Cited by 13
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Vargason, A. M., Anselmo, A. C., & Mitragotri, S. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00698-w · Cited by 1,361
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Mu, W., Chu, Q., Liu, Y., & Zhang, N. (2020) · Nano-Micro Letters · doi:10.1007/s40820-020-00482-6 · Cited by 328
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Metadata
- Authors
- Shields, C. W., Evans, M. A., Wang, L. L.-W., Baugh, N., Iyer, S., Wu, D., Zhao, Z., Pusuluri, A., Ukidve, A., Pan, D. C., & Mitragotri, S.
- Venue
- Science Advances
- Published
- 2020-05
- Volume
- 6
- Issue
- 18
- Pages
- eaaz6579-eaaz6579
- ISSN
- 2375-2548 (ISSN-L)
- OpenAlex
- W3021413923
- Cited by
- 414
- References
- 59
- FWCI
- 16.91
- Type
- journal article
- Language
- en
- Open access
- gold
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