Bats Are Natural Reservoirs of SARS-Like Coronaviruses

Li, Wendong, Shi, Zhengli, Yu, Meng, Ren, Wuze, Smith, Craig, Epstein, Jonathan H., Wang, Hanzhong, Crameri, Gary, Hu, Zhihong, Zhang, Huajun, Zhang, Jianhong, McEachern, Jennifer, Field, Hume, Daszak, Peter, Eaton, Bryan T., Zhang, Shuyi, Wang, Lin-Fa·2005·Science

DOI 10.1126/science.1118391

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Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak. These viruses, termed SARS-like coronaviruses (SL-CoVs), display greater genetic variation than SARS-CoV isolated from humans or from civets. The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group.

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Authors: Li, W., Shi, Z., Yu, M., Ren, W., Smith, C., Epstein, J. H., Wang, H., Crameri, G., Hu, Z., Zhang, H., Zhang, J., McEachern, J., Field, H., Daszak, P., Eaton, B. T., Zhang, S., & Wang, L.-F.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2005-10-28
Volume: 310
Issue: 5748
Pages: 676-679
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1118391
OpenAlex: W2103503670
Cited by: 2,560
References: 0
FWCI: 52.02
Type: journal article
Language: en
Open access: closed

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Bats Are Natural Reservoirs of SARS-Like Coronaviruses

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