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Cited by 1,142

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Nutritional Control of Reproductive Status in Honeybees via DNA Methylation

Kucharski, R., Maleszka, J., Foret, S., Maleszka, R.·2008·Science
DOI 10.1126/science.1153069
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Abstract

Fertile queens and sterile workers are alternative forms of the adult female honeybee that develop from genetically identical larvae following differential feeding with royal jelly. We show that silencing the expression of DNA methyltransferase Dnmt3, a key driver of epigenetic global reprogramming, in newly hatched larvae led to a royal jelly–like effect on the larval developmental trajectory; the majority of Dnmt3 small interfering RNA–treated individuals emerged as queens with fully developed ovaries. Our results suggest that DNA methylation in Apis is used for storing epigenetic information, that the use of that information can be differentially altered by nutritional input, and that the flexibility of epigenetic modifications underpins, profound shifts in developmental fates, with massive implications for reproductive and behavioral status.

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Crossref · 10.1126/science.1153069

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Metadata

Authors
Kucharski, R., Maleszka, J., Foret, S., & Maleszka, R.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2008-03-28
Volume
319
Issue
5871
Pages
1827-1830
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1153069
OpenAlex
W2072003932
Cited by
1,142
References
6
FWCI
33.05
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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