Compartmentalization of GABAergic inhibition by dendritic spines
Open accessAbstract
Dendritic Precision Strikes: The effects of excitatory synaptic inputs are considered to be highly compartmentalized because of the biophysical properties of dendritic spines. Individual inhibitory synapses, however, are thought to affect dendritic integration in a more extended spatial region. Combining optogenetic stimulation of dendrite-targeting γ-aminobutyric acid—mediated interneurons with two-photon calcium imaging in postsynaptic pyramidal cell dendrites, Chiu et al. (p. 759 ) challenge this latter view. The findings suggest that the effect of an inhibitory synapse can be as compartmentalized as that of an excitatory synapse, provided that the synapses are localized on spine heads.
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Martinotti cells are Sst-expressing interneurons with an axonal plexus in L1 that targets tuft dendrites of pyramidal cells, including synapses on spines.
“we broadly define Martinotti cells as Sst expressing INs with a plexus of axon in L1, where it is known to target the tuft dendrites of pyramidal cells, including making synapses on spines”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Chiu et al., 2013
The paper’s text under the Abstract heading says somatostatin-expressing interneurons target pyramidal-cell dendrites and reports their terminals apposed to apical dendritic spines. It does not identify those interneurons as Martinotti cells or describe a layer 1 axonal plexus targeting tuft dendrites. No page number is available in our copy. (LLM, conf=0.85)
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- Authors
- Chiu, C. Q., Lur, G., Morse, T. M., Carnevale, N. T., Ellis-Davies, G. C. R., & Higley, M. J.
- Affiliations
- Yale University (US)
- Department of Neurobiology, Yale School of Medicine, New Haven, CT 06510, USA.
- Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA.
- Corresponding author
- Chiu, Chiayu Q.
- Higley, Michael J.
- Venue
- Science
- Published
- 2013-05-10
- Volume
- 340
- Issue
- 6133
- Pages
- 759-762
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3752161
- OpenAlex
- W1971977136
- Cited by
- 307
- References
- 42
- Citations by year
- 2026: 12 · 2025: 21 · 2024: 23 · 2023: 23 · 2022: 22 · 2021: 12 · 2020: 28 · 2019: 26 · 2018: 24 · 2017: 27 · 2016: 31 · 2015: 19 · 2014: 30 · 2013: 9
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Institute of Mental Health (K01MH097961, MH099045, R01MH099045)
- National Institute on Deafness and Other Communication Disorders (R01DC009977, DC009977)
- National Institute of General Medical Sciences (GM053395, R01GM053395)
- National Institute of Neurological Disorders and Stroke (NS011613, R01NS069720, NS069720, R01NS011613)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- GABAergic inhibition, dendritic spines, somatostatin interneurons, neocortex, dendritic calcium signaling, pyramidal neurons
- MeSH terms
- Channelrhodopsins, Animals, Calcium, Computer Simulation, Female, gamma-Aminobutyric Acid, Male, Mice, Inbred C57BL, Models, Neurological, Neural Inhibition, Photic Stimulation, Synapses, Pyramidal Cells, Glutamic Acid, Neocortex, Dendritic Spines, Mice
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