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T H 17 Cell Differentiation Is Regulated by the Circadian Clock
Open accessAbstract
Lighting Up Immunity: T H 17 cells are CD4 + T helper cells that produce the proinflammatory cytokine interleukin-17. In the intestines, T H 17 cells protect the host from fungal and bacterial infections, and their proinflammatory function is linked with autoimmune diseases including inflammatory bowel disease. Yu et al. (p. 727 ) show that the molecular circadian clock directly regulates the differentiation of T H 17 cells in the intestine, which suggest that both nutrition and light are important environmental factors that directly regulate the immune response.
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Metadata
- Authors
- Yu, X., Rollins, D., Ruhn, K. A., Stubblefield, J. J., Green, C. B., Kashiwada, M., Rothman, P. B., Takahashi, J. S., & Hooper, L. V.
- Venue
- Science
- Published
- 2013-11-08
- Volume
- 342
- Issue
- 6159
- Pages
- 727-730
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980682199
- Cited by
- 441
- References
- 9
- FWCI
- 15.26
- Type
- journal article
- Language
- en
- Open access
- green
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