The aging immune system: primer and prospectus

Miller, Richard A.·1996·Science
DOI 10.1126/science.273.5271.70

Cited by (1,000)

Items 101–200 of 1,000

  1. Elderly Humans Show Prolonged In Vivo Inflammatory Activity during Pneumococcal Infections
    Bruunsgaard, Helle, Skinhøj, Peter, Qvist, Jesper, Pedersen, Bente Klarlund · 1999 · The Journal of Infectious Diseases
  2. Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis.
    Birgit Simell, A. Vuorela, N. Ekström, A. Palmu, A. Reunanen, S. Meri, H. Käyhty, M. Väkeväinen · 2011 · Vaccine
  3. Physical Activity and Cancer Prevention: Pathways and Targets for Intervention
    Rogers, Connie J, Colbert, Lisa H, Greiner, John W, Perkins, Susan N, Hursting, Stephen D · 2008 · Sports Medicine
  4. Fatal Inhalational Anthrax in a 94-Year-Old Connecticut Woman
    Lydia Barakat · 2002 · JAMA
  5. Age-related changes in Type 1 and Type 2 cytokine production in humans
    Elizabeth M. Gardner, Donna Marie Murasko · 2002 · Biogerontology
  6. Caloric restriction: From soup to nuts
    Stephen R. Spindler · 2009 · Ageing Research Reviews
  7. Nonhuman Primate Models of Human Immunology
    Ilhem Messaoudi, Ryan D. Estep, Bridget A. Robinson, Scott W. Wong · 2010 · Antioxidants and Redox Signaling
  8. Key role of T cell defects in age-related vulnerability to West Nile virus
    Brien, James D., Uhrlaub, Jennifer L., Hirsch, Alec, Wiley, Clayton A., Nikolich-Žugich, Janko · 2009 · Journal of Experimental Medicine
  9. Physical exercise and immune system function in cancer survivors
    Adrian Fairey, Kerry S. Courneya, Catherine J. Field, John Robert Mackey · 2002 · Cancer
  10. Age‐Related Immune Dysfunction in Health and in Human Immunodeficiency Virus (HIV) Disease: Association of Age and HIV Infection with Naive CD8+Cell Depletion, Reduced Expression of CD28 on CD8+Cells, and Reduced Thymic Volumes
    Robert C. Kalayjian, ALAN L. LANDAY, Richard B. Pollard, Dennis Daniel Taub, Barry H. Gross, Isaac R. Francis, Anne D. Sevin, Minya Pu, John Spritzler, Miriam Chernoff et al. · 2003 · The Journal of Infectious Diseases
  11. Impaired production of proinflammatory cytokines in response to lipopolysaccharide (LPS) stimulation in elderly humans
    Helle Brüünsgaard, Bente Klarlund Pedersen, Marianne Schroll, Peter Skinhøj, Bente Klarlund Pedersen · 1999 · Clinical & Experimental Immunology
  12. How a well-adapted immune system is organized
    Andreas Mayer, Vijay Balasubramanian, Thierry Mora, Aleksandra M. Walczak · 2015 · Proceedings of the National Academy of Sciences
  13. Is ageing associated with a shift in the balance between Type 1 and Type 2 cytokines in humans?
    Marie Sandmand, Helle Brüünsgaard, K. Kemp, Karen Andersen‐Ranberg, Bente Klarlund Pedersen, Peter Skinhøj · 2002 · Clinical & Experimental Immunology
  14. Human Metapneumovirus in Adults
    Lenneke E. M. Haas, Steven F. T. Thijsen, Leontine J. R. van Elden, Karen A. Heemstra · 2013 · Viruses
  15. Modeling Influenza Virus Infection: A Roadmap for Influenza Research
    Alessandro Boianelli, Vān Kính Nguyễn, Thomas Ebensen, Kai Schulze, Esther Wilk, Niharika Sharma, Sabine Stegemann‐Koniszewski, Dunja Bruder, Franklin R. Toapanta, Carlos A. Guzmán et al. · 2015 · Viruses
  16. Senescence in a short‐lived migratory bird: age‐dependent morphology, migration, reproduction and parasitism
    Anders Pape Møller, Florentino de Lope · 1999 · Journal of Animal Ecology
  17. Aging and Cancer: Issues of Basic and Clinical Science
    William B. Ershler, Dan L. Longo · 1997 · JNCI Journal of the National Cancer Institute
  18. Sepsis in Old Age: Review of Human and Animal Studies
    Marlene E. Starr · 2014 · Aging and Disease
  19. Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice
    Liang Zhao, Liguang Sun, Hongjun Wang, Haixia Ma, Guangwei Liu, Yong Xiang Zhao · 2007 · Journal of Leukocyte Biology
  20. Nutrition and immunity in the elderly
    Bruno Lesourd, Lynda Mazari · 1999 · Proceedings of The Nutrition Society
  21. Postthymic Development of CD28−CD8+ T Cell Subset: Age-Associated Expansion and Shift from Memory to Naive Phenotype
    Marcelo Nociari, William G. Telford, Carlo Russo · 1999 · The Journal of Immunology
  22. Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages
    R. Lakshman Chelvarajan, Yu‐Shu Liu, Diana Popa, Marilyn L. Getchell, Thomas V. Getchell, Arnold J. Stromberg, Subbarao Bondada · 2006 · Journal of Leukocyte Biology
  23. Impaired Dendritic Cell Function in Aging Leads to Defective Antitumor Immunity
    Annabelle Grolleau‐Julius, Erin K. Harning, Lisa Abernathy Close, Raymond L. Yung · 2008 · Cancer Research
  24. Low zinc status: a new risk factor for pneumonia in the elderly?
    Barnett, Junaidah B, Hamer, Davidson H, Meydani, Simin N · 2010 · Nutrition Reviews
  25. Stress responses and innate immunity: aging as a contributory factor
    Stephen K. Butcher, Janet M. Lord · 2004 · Aging Cell
  26. Immunologic diagnosis of tuberculosis: a review
    Edward D. Chan, Leonid B. Heifets, Michael D. Iseman · 2000 · Tubercle and Lung Disease
  27. Phenotypic and Immunohistological Analyses of the Human Adult Thymus: Evidence for an Active Thymus during Adult Life
    Jean‐Marc Bertho, Christelle Demarquay, Nathalie Moulian, Anne Van der Meeren, Sonia Berrih‐Aknin, P. Gourmelon · 1997 · Cellular Immunology
  28. Bone Marrow Microenvironmental Changes Underlie Reduced RAG-mediated Recombination and B Cell Generation in Aged Mice
    Labrie, Joseph E., Sah, Alex P., Allman, David M., Cancro, Michael P., Gerstein, Rachel M. · 2004 · The Journal of Experimental Medicine
  29. Relationships and sexual expression in later life: a biopsychosocial perspective
    J. Delamater, Erica R Koepsel · 2015 · Sexual & Relationship Therapy
  30. Loss of Naive T Cells and Repertoire Constriction Predict Poor Response to Vaccination in Old Primates
    Luka Čičin‐Šain, Sue Smyk-Pearson, Noreen Currier, Laura Byrd, Caroline W. Koudelka, Tammie Robinson, Gwendolyn M. Swarbrick, Shane Tackitt, Alfred W. Legasse, Miranda B. Fischer et al. · 2010 · The Journal of Immunology
  31. Myeloid-derived suppressor cells have a central role in attenuated Listeria monocytogenes-based immunotherapy against metastatic breast cancer in young and old mice
    Dinesh Chandra, Arthee Jahangir, Wilber Quispe‐Tintaya, Mark H. Einstein, Claudia Gravekamp · 2013 · British Journal of Cancer
  32. Stress and the aging immune system
    Louise C. Hawkley, John T. Cacioppo · 2003 · Brain Behavior and Immunity
  33. Aging and its impact on innate immunity and inflammation: Implications for periodontitis
    George Hajishengallis · 2013 · Journal of Oral Biosciences
  34. Vitamin E-Enhanced IL-2 Production in Old Mice: Naive But Not Memory T Cells Show Increased Cell Division Cycling and IL-2-Producing Capacity
    Oskar Adolfsson, Brigitte T. Huber, Simin Nikbin Meydani · 2001 · The Journal of Immunology
  35. . Persistent viral infections and immune aging.
    Brunner, Stefan, Herndler-Brandstetter, Dietmar, Weinberger, Birgit, Grubeck-Loebenstein, Beatrix · 2011 · Ageing Research Reviews
  36. A Study of Serum Immunoglobulin Levels in Elderly Persons That Provides New Insights into B Cell Immunosenescence
    Florinda Listı̀, Giuseppina Candore, Maria Assunta Modica, Mariangela Russo, Gabriele Di Lorenzo, Maria Esposito-Pellitteri, Giuseppina Colonna‐Romano, Alessandra Aquino, Matteo Bulati, Domenico Lio et al. · 2006 · Annals of the New York Academy of Sciences
  37. GENETIC DETERMINANTS INFLUENCING THE RESPONSE TO INJURY, INFLAMMATION, AND SEPSIS
    Antonio De Maio, Manuel B. Torres, Roger H. Reeves · 2004 · Shock
  38. Too old to fight? Aging and its toll on innate immunity
    George Hajishengallis · 2010 · Molecular Oral Microbiology
  39. Allogeneic stem cell transplantation for older advanced MDS patients: improved survival with young unrelated donor in comparison with HLA-identical siblings
    Nicolaus Martin Kröger, Tatjana Zabelina, Liesbeth C. de Wreede, J. Berger, Haefaa Alchalby, Anja van Biezen, Noel Jean Milpied, Liisa Volin, Mohamad Mohty, Véronique Leblond et al. · 2012 · Leukemia
  40. Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primates
    Čičin-Šain, Luka, Messaoudi, Ilhem, Park, Byung, Currier, Noreen, Planer, Shannon, Fischer, Miranda, Tackitt, Shane, Nikolich-Žugich, Dragana, Legasse, Alfred, Axthelm, Michael K. et al. · 2007 · Proceedings of the National Academy of Sciences
  41. A meta-analysis of genome-wide association studies of epigenetic age acceleration
    Jude Gibson, Tom C. Russ, Toni‐Kim Clarke, David M. Howard, Robert Francis Hillary, Kathryn Louise Evans, Rosie May Walker, Mairead L. Bermingham, Stewart W. Morris, Archie Campbell et al. · 2019 · PLoS Genetics
  42. Age-Dependent Alterations in the Assembly of Signal Transduction Complexes at the Site of T Cell/APC Interaction
    Ami Tamir, Michael D. Eisenbraun, Gonzalo G. Garcia, Richard A. Miller · 2000 · The Journal of Immunology
  43. Impact of aging on antigen presentation cell function of dendritic cells
    Christine K. Wong, Daniel R. Goldstein · 2013 · Current Opinion in Immunology
  44. Yogurt: role in healthy and active aging
    Naglaa El-Abbadi, Maria Carlota Dao, Simin Nikbin Meydani · 2014 · American Journal of Clinical Nutrition
  45. Factors that may impact on immunosenescence: an appraisal
    Ongrádi, Joseph, Kövesdi, Valéria · 2010 · Immunity & Ageing
  46. Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: a systematic review
    Weltevrede, Marlies, Eilers, Renske, de Melker, Hester E., van Baarle, Debbie · 2016 · Experimental Gerontology
  47. Aging and developmental transitions in the B cell lineage
    Johnson, K. M. · 2002 · International Immunology
  48. Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system
    Vitlic, Ana, Lord, Janet M., Phillips, Anna C. · 2014 · AGE
  49. Tumour necrosis factor-α-induced migration of human Langerhans cells: the influence of ageing: TNF-Α and LANGERHANS CELLS
    Bhushan, M., Cumberbatch, M., Dearman, R.J., Andrew, S.M., Kimber, I., Griffiths, C.E.M. · 2002 · British Journal of Dermatology
  50. Poor oral health, a potential new geriatric syndrome
    Gert‐Jan van der Putten, Cees De Baat, Luc De Visschere, Jos M. G. A. Schols · 2014 · Gerodontology
  51. Influence of Aging and Environment on Presentation of Infection in Older Adults
    Nadim G. El Chakhtoura, Robert A. Bonomo, Robin Jump · 2017 · Infectious Disease Clinics of North America
  52. Lymphoid infiltration as a prognostic variable for early-onset breast carcinomas.
    Sylvie Ménard, Gorana Tomasic, Patrizia Casalini, Andrea Balsari, Silvana Pilotti, N. Cascinelli, Bruno Salvadori, MARIA INES COLNAGHI, Franco O. Rilke · 1997 · PubMed
  53. Melatonin counteracts the inhibitory effect of PGE 2 on IL‐2 production in human lymphocytes via its mt1 membrane receptor
    Antonio Carrillo‐Vico, Sofía García‐Mauriño, Juan Ramón Calvo, Juan Miguel Guerrero · 2003 · The FASEB Journal
  54. Clonal Expansions and Loss of Receptor Diversity in the Naive CD8 T Cell Repertoire of Aged Mice
    Mushtaq Ahmed, Kathleen G. Lanzer, Eric J. Yager, Pamela Scott Adams, Lawrence L. Johnson, Marcia A. Blackman · 2009 · The Journal of Immunology
  55. Single-Cell Analyses Reveal Two Defects in Peptide-Specific Activation of Naive T Cells from Aged Mice
    Gonzalo G. Garcia, Richard A. Miller · 2001 · The Journal of Immunology
  56. Nutritional strategies to boost immunity and prevent infection in elderly individuals
    High, Kevin P. · 2001 · Clinical Infectious Diseases
  57. Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study
    van den Biggelaar, Anita H.J., Huizinga, Tom W.J., de Craen, Anton J.M., Gussekloo, Jacobijn, Heijmans, Bastiaan T., Frölich, Marijke, Westendorp, Rudi G.J. · 2004 · Experimental Gerontology
  58. Aging Promotes Neutrophil-Induced Mortality by Augmenting IL-17 Production during Viral Infection
    Heather W. Stout-Delgado, Wei Du, Anushree C. Shirali, Carmen Jane Booth, Daniel R. Goldstein · 2009 · Cell Host & Microbe
  59. Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase
    Motoi Okada, Ha Won Kim, Kaoru Matsu-ura, Yi-Gang Wang, Meifeng Xu, Muhammad Ashraf · 2015 · Stem Cells
  60. T-cell clonality in immune responses
    Mala K. Maini, Giulia Casorati, Paolo Dellabona, Andreas Wack, Peter C. L. Beverley · 1999 · Immunology Today
  61. Age and Neuroinflammation: A Lifetime of Psychoneuroimmune Consequences
    Jonathan P. Godbout, Rodney W. Johnson · 2006 · Neurologic Clinics
  62. IMMUNE DYSFUNCTION FOLLOWING TRAUMA-HAEMORRHAGE: INFLUENCE OF GENDER AND AGE
    Volker Kahlke, Martin Kurt Angele, Alfred Ayala, Martin G. Schwacha, William G. Cioffi, Kirby I. Bland, Irshad H. Chaudry · 2000 · Cytokine
  63. Inflammatory processes in the aging mouse brain: Participation of dendritic cells and T-cells
    Stichel, C.C., Luebbert, H. · 2007 · Neurobiology of Aging
  64. Attenuation of Cadmium-Induced Liver Injury in Senescent Male Fischer 344 Rats: Role of Kupffer Cells and Inflammatory Cytokines
    Tetsuo Yamano, Lacinda A. DeCicco, Lora E. Rikans · 2000 · Toxicology and Applied Pharmacology
  65. The effect of age on the cognate function of CD4<sup>+</sup> T cells
    Haynes, Laura, Eaton, Sheri M. · 2005 · Immunological Reviews
  66. Untitled work
    2002 · 10.1002/1521-4141(200206)32:6
  67. Immune effects of hormone replacement therapy in post-menopausal women
    Verna R. Porter, Gail A. Greendale, Miriam Schocken, Xiaoming Zhu, Rita B. Effros · 2001 · Experimental Gerontology
  68. Improvement of nutritional status and incidence of infection in hospitalised, enterally fed elderly by feeding of fermented milk containing probioticLactobacillus johnsoniiLa1 (NCC533)
    Yoichi Fukushima, Shingo Miyaguchi, Toshihiko Yamano, Tomoko Kaburagi, Hisakazu Iino, Kazunari Ushida, Kazuto Sato · 2007 · British Journal Of Nutrition
  69. Age-Associated Decline in Effective Immune Synapse Formation of CD4+ T Cells Is Reversed by Vitamin E Supplementation
    Melissa G. Marko, Tanvir Ahmed, Stephen C. Bunnell, Dayong Wu, Heekyung Chung, Brigitte T. Huber, Simin Nikbin Meydani · 2007 · The Journal of Immunology
  70. Cytokine production after influenza vaccination in a healthy elderly population
    Erica D. Bernstein · 1998 · Vaccine
  71. Mice and flies and monkeys too: Caloric restriction rejuvenates the aging immune system of non-human primates
    Janko Nikolich‐Žugich, Ilhem Messaoudi · 2005 · Experimental Gerontology
  72. Biology of Dendritic Cells in Aging
    Anshu Agrawal, Sudhanshu Agrawal, Jia Tay, Sudhir Gupta · 2007 · Journal of Clinical Immunology
  73. Theories of Aging and the Prevalence of Alzheimer’s Disease
    Kaynara Trevisan, Renata Cristina-Pereira, Danyelle Silva-Amaral, Tales Alexandre Aversi‐Ferreira · 2019 · BioMed Research International
  74. Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure
    Christian R. Gómez, Stefanie A. Hirano, Brent T. Cutro, Shirin Z. Birjandi, Horea Baila, Vanessa Nomellini, Elizabeth J. Kovacs · 2006 · Critical Care Medicine
  75. Immune response gene expression increases in the aging murine hippocampus
    Akira Terao, Anjali D. Apte-Deshpande, Linda Dousman, Stephen R. Morairty, Barrett P. Eynon, Thomas S. Kilduff, Yvonne R. Freund · 2002 · Journal of Neuroimmunology
  76. Reversing age-associated immunosenescence via exercise
    Marian L. Kohut, David S. Senchina · 2026 · PubMed
  77. Age-related deregulation of naive T cell homeostasis in elderly humans
    Sara Ferrando‐Martínez, Ezequiel Ruíz-Mateos, Ana Hernández, Encarnación Gutiérrez, María Mar Rodríguez-Méndez, Antonio Ordóñez, Manuel Leal · 2010 · AGE
  78. The process of aging changes the interplay of the immune, endocrine and nervous systems
    Straub, Rainer H, Cutolo, Maurizio, Zietz, Bettina, Schölmerich, Jürgen · 2001 · Mechanisms of Ageing and Development
  79. Effects of Ageing and Gender on Naturally Acquired Antibodies to Pneumococcal Capsular Polysaccharides and Virulence-Associated Proteins
    Birgit Simell, Mika Lahdenkari, Antti Reunanen, Helena M. Käyhty, Merja Väkeväinen · 2008 · Clinical and Vaccine Immunology
  80. Age‐related changes in antibody repertoire: contribution from T cells
    Haifeng Song, Paul W. Price, Jan Černý · 1997 · Immunological Reviews
  81. Ceramide-induced and Age-associated Increase in Macrophage COX-2 Expression Is Mediated through Up-regulation of NF-κB Activity
    Dayong Wu, Melissa G. Marko, Kate Claycombe, K. Eric Paulson, Simin Nikbin Meydani · 2003 · Journal of Biological Chemistry
  82. Cytokines and hormones as possible links between endocrinosenescence and immunosenescence
    Rainer Hans Straub · 2000 · Journal of Neuroimmunology
  83. Interplay between telomere length and telomerase in human leukocyte differentiation and aging
    Nan‐ping Weng · 2001 · Journal of Leukocyte Biology
  84. Influence of age and physical activity on the primary in vivo antibody and T cell-mediated responses in men
    Taro P. Smith, Sarah L. Kennedy, Monika Fleshner · 2004 · Journal of Applied Physiology
  85. T‐cell Immunoglobulin and ITIM Domain Contributes to CD 8+ T‐cell Immunosenescence
    Yangzi Song, Beibei Wang, Rui Song, Hao Yu, Di Wang, Yuxin Li, Yu Yong Jiang, Ling Xu, Yaluan Ma, Hong Zheng et al. · 2018 · Aging Cell
  86. T cell subsets and mortality in older community-dwelling women
    Richard D. Semba, Joseph B. Margolick, Sean Xiao Leng, Jeremy D Walston, Michelle O. Ricks, Linda P. Fried · 2004 · Experimental Gerontology
  87. Hematopoietic stem cell aging and self-renewal
    Brad J. Dykstra, Gerald de Haan · 2007 · Cell and Tissue Research
  88. Evidence For Early Aging in the Mucosal Immune System
    Toshiya Koga, Jerry R. McGhee, Hirotomo Kato, Rie Kato, Hiroshi Kiyono, Kohtaro Fujihashi · 2000 · The Journal of Immunology
  89. HEMATOPOIESIS AND CYTOKINES
    Carole A. Baraldi-Junkins, Anna Catherine Beck, Gerald Rothstein · 2000 · Hematology/Oncology Clinics of North America
  90. Effects of Insulin-Like Growth Factor Administration and Bone Marrow Transplantation on Thymopoiesis in Aged Mice 1
    Encarnacion Montecino‐Rodriguez, ROSS G. CLARK, Kenneth A Dorshkind · 1998 · Endocrinology
  91. Telomeres shorten more slowly in slow-aging wild animals than in fast-aging ones
    Ben Dantzer, Quinn E. Fletcher · 2015 · Experimental Gerontology
  92. T cell aging
    Janko Nikolich‐Žugich · 2005 · The Journal of Experimental Medicine
  93. Granulocyte and natural killer activity in the elderly
    Gabriele Di Lorenzo, Carmela Rita Balistreri, Giuseppina Candore, Diego Cigna, Alfredo Colombo, Giuseppina Colonna Romano, Antonio Tobia Colucci, Francesco Gervasi, Florinda Listı̀, Marcella Potestio et al. · 1999 · Mechanisms of Ageing and Development
  94. Surgery in the elderly
    Michael E. Zenilman · 1998 · Current Problems in Surgery
  95. Geriatric Physiology and the Frailty Syndrome
    Kashif Khan, Kaveh Hemati, Anne L. Donovan · 2019 · Anesthesiology Clinics
  96. Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen
    Laura Haynes, Sheri M. Eaton, Eve M. Burns, Troy D. Randall, Susan L. Swain · 2005 · The Journal of Experimental Medicine
  97. Antioxidants, Cytokines, and Influenza Infection in Aged Mice and Elderly Humans
    Sung Nim Han, Simin Nikbin Meydani · 2000 · The Journal of Infectious Diseases
  98. Older Age Increases Short-term Surgical Complications After Primary Knee Arthroplasty
    Molly Crimmins Easterlin, Douglas G. Chang, Mark A. Talamini, David C. Chang · 2013 · Clinical Orthopaedics and Related Research
  99. Oral candidiasis and nutritional deficiencies in elderly hospitalised patients
    Éléna Paillaud, Isabelle Merlier, Catherine Dupeyron, Elisabeth Scherman, Joël Poupon, Phuong-Nhi Bories · 2004 · British Journal Of Nutrition
  100. Impaired antigen-induced CD8+ T cell clonal expansion in aging is due to defects in antigen presenting cell function
    Plowden, Julie, Renshaw-Hoelscher, Mary, Gangappa, Shivaprakash, Engleman, Carrie, Katz, Jacqueline M., Sambhara, Suryaprakash · 2004 · Cellular Immunology