The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
How Cells Handle Cholesterol
Abstract
Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Recent advances suggest that cholesterol exerts many of its actions mainly by maintaining sphingolipid rafts in a functional state. How rafts contribute to cholesterol metabolism and transport in the cell is still an open issue. It has long been known that cellular cholesterol levels are precisely controlled by biosynthesis, efflux from cells, and influx of lipoprotein cholesterol into cells. The regulation of cholesterol homeostasis is now receiving a new focus, and this changed perspective may throw light on diseases caused by cholesterol excess, the prime example being atherosclerosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Self-citationStrittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
Brooks-Wilson, A., Marcil, M., Clee, S. M., Zhang, L.-H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O. F., et al. (1999) · Nature Genetics · doi:10.1038/11905 · Cited by 1,687
Molecular physiology of reverse cholesterol transport.
Fielding, C. J., & Fielding, P. E. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39898-9 · Cited by 1,448
Structure and lipid transport mechanism of a StAR-related domain
Tsujishita (2000) · Nature Structural Biology · doi:10.1038/75192 · Cited by 535
Cited by
CNS synaptogenesis promoted by glia-derived cholesterol
Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711
The human ATP-binding cassette (ABC) transporter superfamily
Dean, M., Hamon, Y., & Chimini, G. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31588-1 · Cited by 1,302
LXR signaling couples sterol metabolism to proliferation in the acquired immune response
Bensinger, S. J., Bradley, M. N., Joseph, S. B., Zelcer, N., Janssen, E. M., Hausner, M. A., Shih, R., Parks, J. S., Edwards, P. A., Jamieson, B. D., et al. (2008) · Cell · doi:10.1016/j.cell.2008.04.052 · Cited by 711
The pharmacology of sigma-1 receptors.
Maurice, T., & Su, T.-P. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.07.001 · Cited by 654
Kwon, H. J., Abi-Mosleh, L., Wang, M. L., Deisenhofer, J., Goldstein, J. L., Brown, M. S., & Infante, R. E. (2009) · Cell · doi:10.1016/j.cell.2009.03.049 · Cited by 636
Duan, Y., Gong, K., Xu, S., Zhang, F., Meng, X., & Han, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01125-5 · Cited by 538
Integrins Regulate Rac Targeting by Internalization of Membrane Domains
del Pozo, M. A., Alderson, N. B., Kiosses, W. B., Chiang, H.-H., Anderson, R. G. W., & Schwartz, M. A. (2004) · Science · doi:10.1126/science.1092571 · Cited by 475
Lipoprotein receptors in the nervous system
Herz, J., & Bock, H. H. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135342 · Cited by 457
Cholesterol homeostasis and function in neurons of the central nervous system
Pfrieger, F. W. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3018-7 · Cited by 453
Statins: a repurposed drug to fight cancer
Jiang, W., Hu, J.-W., He, X.-R., Jin, W.-L., & He, X.-Y. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02041-2 · Cited by 417
Lipid rafts, cholesterol, and the brain
Korade, Z., & Kenworthy, A. K. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.02.019 · Cited by 342
Outsourcing in the brain: Do neurons depend on cholesterol delivery by astrocytes?
Pfrieger, F. W. (2003) · BioEssays · doi:10.1002/bies.10195 · Cited by 308
Microbial impact on cholesterol and bile acid metabolism: current status and future prospects
Kriaa, A., Bourgin, M., Potiron, A., Mkaouar, H., Jablaoui, A., Gérard, P., Maguin, E., & Rhimi, M. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r088989 · Cited by 264
Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts
Riddell, D. R., Christie, G., Hussain, I., & Dingwall, C. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00394-3 · Cited by 253
A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport
Gatta, A. T., Wong, L. H., Sere, Y. Y., Calderón-Noreña, D. M., Cockcroft, S., Menon, A. K., & Levine, T. P. (2015) · eLife · doi:10.7554/elife.07253 · Cited by 251
Oxysterols: A world to explore
Otaegui-Arrazola, A., Menéndez-Carreño, M., Ansorena, D., & Astiasarán, I. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.09.023 · Cited by 228
Mechanisms for cellular cholesterol transport: Defects and human disease
Ikonen, E. (2006) · Physiological Reviews · doi:10.1152/physrev.00022.2005 · Cited by 229
Self-citationMultiple Functions of Sterols in Yeast Endocytosis
Heese-Peck, A., Pichler, H., Zanolari, B., Watanabe, R., Daum, G., & Riezman, H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-04-0186 · Cited by 190
Mason, R. P., Walter, M. F., & Jacob, R. F. (2004) · Circulation · doi:10.1161/01.cir.0000129503.62747.03 · Cited by 175
Role for Human Immunodeficiency Virus Type 1 Membrane Cholesterol in Viral Internalization
Guyader, M., Kiyokawa, E., Abrami, L., Turelli, P., & Trono, D. (2002) · Journal of Virology · doi:10.1128/jvi.76.20.10356-10364.2002 · Cited by 170
Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes
Endapally, S., Frias, D., Grzemska, M., Gay, A., Tomchick, D. R., & Radhakrishnan, A. (2019) · Cell · doi:10.1016/j.cell.2018.12.042 · Cited by 168
Xie, C., Lund, E. G., Turley, S. D., Russell, D. W., & Dietschy, J. M. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300164-jlr200 · Cited by 159
Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging
Larbi, A., Dupuis, G., Khalil, A., Douziech, N., Fortin, C., & Fülöp, T. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.08.016 · Cited by 126
Modulation of Cellular Cholesterol Transport and Homeostasis by Rab11
Hölttä-Vuori, M., Tanhuanpää, K., Möbius, W., Somerharju, P., & Ikonen, E. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-01-0025 · Cited by 120
Self-citationRidsdale, A., Denis, M., Gougeon, P.-Y., Ngsee, J. K., Presley, J. F., & Zha, X. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-02-0100 · Cited by 113
Sensitivity to Lysosome-Dependent Cell Death Is Directly Regulated by Lysosomal Cholesterol Content
Appelqvist, H., Sandin, L., Björnström, K., Saftig, P., Garner, B., Öllinger, K., & Kågedal, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050262 · Cited by 108
“Normally, cholesterol is released from endocytosed low density lipoprotein (LDL) particles by the action of lysosomal acid lipase and is then transported, via the lysosomal NPC proteins, to the ER where it serves as a sensor for cellular cholesterol homeostasis and may be esterified [6].”
BackgroundHypercholesterolemia Induces Angiogenesis and Accelerates Growth of Breast Tumors In Vivo
Pelton, K., Coticchia, C. M., Curatolo, A. S., Schaffner, C. P., Zurakowski, D., Solomon, K. R., & Moses, M. A. (2014) · The American Journal of Pathology · doi:10.1016/j.ajpath.2014.03.006 · Cited by 109
Nonvesicular Lipid Transfer from the Endoplasmic Reticulum
Lev, S. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a013300 · Cited by 103
Glycosphingolipid Accumulation Inhibits Cholesterol Efflux via the ABCA1/Apolipoprotein A-I Pathway
Glaros, E. N., Kim, W. S., Quinn, C. M., Wong, J., Gelissen, I., Jessup, W., & Garner, B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413862200 · Cited by 75
Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer’s disease
Reiss, A. B., Siller, K. A., Rahman, M. M., Chan, E. S. L., Ghiso, J., & de Leon, M. J. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.009 · Cited by 73
MENTHO, a MLN64 homologue devoid of the START domain
Alpy, F., Wendling, C., Rio, M.-C., & Tomasetto, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208290200 · Cited by 58
Igbavboa, U., Eckert, G. P., Malo, T. M., Studniski, A. E., Johnson, L. N. A., Yamamoto, N., Kobayashi, M., Fujita, S. C., Appel, T. R., Müller, W. E., et al. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.11.037 · Cited by 41
Johnson, K. A., Endapally, S., Vazquez, D. C., Infante, R. E., & Radhakrishnan, A. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010393 · Cited by 39
Zhao, Z., Dong, Q., Liu, X., Wei, L., Liu, L., Li, Y., & Wang, X. (2020) · Genomics · doi:10.1016/j.ygeno.2019.07.020 · Cited by 37
Cholesterol and Alzheimer's disease
Wolozin, B. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300525 · Cited by 33
Waku, T., Hagiwara, T., Tamura, N., Atsumi, Y., Urano, Y., Suzuki, M., Iwami, T., Sato, K., Yamamoto, M., Noguchi, N., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103180 · Cited by 30
Rye, M. B., Bertilsson, H., Andersen, M. K., Rise, K., Bathen, T. F., Drabløs, F., & Tessem, M.-B. (2018) · BMC Cancer · doi:10.1186/s12885-018-4373-y · Cited by 21
Structural insights into a StART-like domain in Lam4 and its interaction with sterol ligands
Gatta, A. T., Sauerwein, A. C., Zhuravleva, A., Levine, T. P., & Matthews, S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.109 · Cited by 18
Leishmania Dices Away Cholesterol for Survival
Descoteaux, A., Moradin, N., & Arango Duque, G. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.02.018 · Cited by 13
Metadata
- Authors
- Simons, K., & Ikonen, E.
- Venue
- Science
- Published
- 2000-12
- Volume
- 290
- Issue
- 5497
- Pages
- 1721-1726
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990394752
- Cited by
- 1,275
- References
- 5
- FWCI
- 63.16
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
