Senescent intimal foam cells are deleterious at all stages of atherosclerosis
Childs, Bennett G., Baker, Darren J., Wijshake, Tobias, Conover, Cheryl A., Campisi, Judith, van Deursen, Jan M.·2016·Science
Cited by (159)
Items 101–159 of 159
- The chemistry of senescenceLozano-Torres, Beatriz, Estepa-Fernández, Alejandra, Rovira, Miguel, Orzáez, Mar, Serrano, Manuel, Martínez-Máñez, Ramón, Sancenón, Félix · 2019 · Nature Reviews Chemistry
- NADPH Oxidases and Mitochondria in Vascular SenescenceSalazar, Gloria · 2018 · International Journal of Molecular Sciences
- Identifying specific functional roles for senescence across cell types2024
- Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related OsteoporosisKhosla, Sundeep, Farr, Joshua N, Kirkland, James L · 2018 · The Journal of Clinical Endocrinology & Metabolism
- Cellular senescence links aging and diabetes in cardiovascular diseaseShakeri, Hadis, Lemmens, Katrien, Gevaert, Andreas B., De Meyer, Guido R. Y., Segers, Vincent F. M. · 2018 · American Journal of Physiology-Heart and Circulatory Physiology
- Oxidation resistance 1 is a novel senolytic targetZhang, Xin, Zhang, Suping, Liu, Xingui, Wang, Yingying, Chang, Jianhui, Zhang, Xuan, Mackintosh, Samuel G., Tackett, Alan J., He, Yonghan, Lv, Dongwen et al. · 2018 · Aging Cell
- Targeting Senescent Cells for a Healthier Aging: Challenges and OpportunitiesSong, Shuling, Tchkonia, Tamara, Jiang, Jing, Kirkland, James L., Sun, Yu · 2020 · Advanced Science
- Exercise reduces circulating biomarkers of cellular senescence in humansEnglund, Davis A., Sakamoto, Ayumi E., Fritsche, Chad M., Heeren, Amanda A., Zhang, Xu, Kotajarvi, Brian R., Lecy, Denise R., Yousefzadeh, Matthew J., Schafer, Marissa J., White, Thomas A. et al. · 2021 · Aging Cell
- Senolytics for Cancer Therapy: Is All that Glitters Really Gold?Carpenter, Valerie J., Saleh, Tareq, Gewirtz, David A. · 2021 · Cancers
- Defective base excision repair of oxidative DNA damage in vascular smooth muscle cells promotes atherosclerosisShah, Aarti, Gray, Kelly, Figg, Nichola, Finigan, Alison, Starks, Lakshi, Bennett, Martin · 2018 · Circulation
- Immunology of the ageing kidneySato, Yuki, Yanagita, Motoko · 2019 · Nature Reviews Nephrology
- Age- and tissue-specific expression of senescence biomarkers in mice.Hudgins, Adam D., Tazearslan, Cagdas, Tare, Archana, Zhu, Yizhou, Huffman, Derek, Suh, Yousin · 2018 · Frontiers in Genetics
- Mouse Models to Disentangle the Hallmarks of Human AgingFolgueras, Alicia R., Freitas-Rodríguez, Sandra, Velasco, Gloria, López-Otín, Carlos · 2018 · Circulation Research
- Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studiesGaikwad, Sagar, Senapati, Sudipta, Haque, Md. Anzarul, Kayed, Rakez · 2024 · Alzheimer's & Dementia
- Expansion and Cell-Cycle Arrest: Common Denominators of Cellular SenescenceOgrodnik, Mikolaj, Salmonowicz, Hanna, Jurk, Diana, Passos, João F. · 2019 · Trends in Biochemical Sciences
- Aging-induced biological changes and cardiovascular diseases.Fajemiroye, James Oluwagbamigbe, Cunha, Luiz Carlos da, Saavedra-Rodríguez, Roberto, Rodrigues, Karla Lima, Naves, Lara Marques, Mourão, Aline Andrade, Silva, Elaine Fernanda da, Williams, Nabofa Enivwenaye Egide, Martins, José Luis Rodrigues, Sousa, Romes Bittencourt et al. · 2018 · BioMed Research International
- Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research QuestionsTripathi, Utkarsh, Misra, Avanish, Tchkonia, Tamar, Kirkland, James L. · 2021 · Mechanisms of Ageing and Development
- Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directionsEnglund, Davis A., Zhang, Xu, Aversa, Zaira, LeBrasseur, Nathan K. · 2021 · Mechanisms of Ageing and Development
- The role of senescent T cells in immunopathologyCovre, Luciana P., De Maeyer, Roel P. H., Gomes, Daniel C. O., Akbar, Arne N. · 2020 · Aging Cell
- p21 induces a senescence program and skeletal muscle dysfunctionEnglund, Davis A., Jolliffe, Alyssa, Aversa, Zaira, Zhang, Xu, Sturmlechner, Ines, Sakamoto, Ayumi E., Zeidler, Julianna D., Warner, Gina M., McNinch, Colton, White, Thomas A. et al. · 2023 · Molecular Metabolism
- Cellular senescence-mediated exacerbation of Duchenne muscular dystrophySugihara, Hidetoshi, Teramoto, Naomi, Nakamura, Katsuyuki, Shiga, Takanori, Shirakawa, Taku, Matsuo, Masafumi, Ogasawara, Masashi, Nishino, Ichizo, Matsuwaki, Takashi, Nishihara, Masugi et al. · 2020 · Scientific Reports
- Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A ReviewAmaya-Montoya, Mateo, Pérez-Londoño, Agustín, Guatibonza-García, Valentina, Vargas-Villanueva, Andrea, Mendivil, Carlos O. · 2020 · Advances in Therapy
- Efficacy and limitations of senolysis in atherosclerosisGarrido, Abel Martin, Kaistha, Anuradha, Uryga, Anna K, Oc, Sebnem, Foote, Kirsty, Shah, Aarti, Finigan, Alison, Figg, Nichola, Dobnikar, Lina, Jørgensen, Helle et al. · 2022 · Cardiovascular Research
- Senolytic activity of piperlongumine analogues: Synthesis and biological evaluationLiu, Xingui, Wang, Yingying, Zhang, Xuan, Gao, Zhengya, Zhang, Suping, Shi, Peizhong, Zhang, Xin, Song, Lin, Hendrickson, Howard, Zhou, Daohong et al. · 2018 · Bioorganic & Medicinal Chemistry
- Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosisChilds, Bennett G., Zhang, Cheng, Shuja, Fahad, Sturmlechner, Ines, Trewartha, Shawn, Velasco, Raul Fierro, Baker, Darren J., Li, Hu, van Deursen, Jan M. · 2021 · Nature Aging
- The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applicationsBasisty, Nathan, Kale, Abhijit, Patel, Sandip, Campisi, Judith, Schilling, Birgit · 2020 · Expert Review of Proteomics
- Embryonic senescent cells re-enter cell cycle and contribute to tissues after birthLi, Yi, Zhao, Huan, Huang, Xiuzhen, Tang, Juan, Zhang, Shaohua, Li, Yan, Liu, Xiuxiu, He, Lingjuan, Ju, Zhengyu, Lui, Kathy O. et al. · 2018 · Cell Research
- Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory Phenotype (SASP) FactorsNarzt, Marie-Sophie, Pils, Vera, Kremslehner, Christopher, Nagelreiter, Ionela-Mariana, Schosserer, Markus, Bessonova, Emilia, Bayer, Alina, Reifschneider, Raffaela, Terlecki-Zaniewicz, Lucia, Waidhofer-Söllner, Petra et al. · 2021 · Journal of Investigative Dermatology
- Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissuesYousefzadeh, Matthew J., Wilkinson, John E., Hughes, Brian, Gadela, Namrata, Ladiges, Warren C., Vo, Nam, Niedernhofer, Laura J., Huffman, Derek M., Robbins, Paul D. · 2020 · GeroScience
- Therapeutic Potential of Senolytics in Cardiovascular DiseaseDookun, Emily, Passos, João F., Arthur, Helen M., Richardson, Gavin D. · 2022 · Cardiovascular Drugs and Therapy
- Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologiesCherry, Christopher, Andorko, James I., Krishnan, Kavita, Mejías, Joscelyn C., Nguyen, Helen Hieu, Stivers, Katlin B., Gray-Gaillard, Elise F., Ruta, Anna, Han, Jin, Hamada, Naomi et al. · 2023 · GeroScience
- Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertensionRocha, Lorena Raquel, Nguyen Huu, Viet Anh, Palomino La Torre, Claudia, Xu, Qianlan, Jabari, Mary, Krawczyk, Michal, Weinreb, Robert N., Skowronska‐Krawczyk, Dorota · 2020 · Aging Cell
- Obesity accelerates cardiovascular ageingRuperez, Celia, Madeo, Frank, de Cabo, Rafael, Kroemer, Guido, Abdellatif, Mahmoud · 2025 · European Heart Journal
- Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brainKiss, Tamas, Nyúl-Tóth, Ádám, DelFavero, Jordan, Balasubramanian, Priya, Tarantini, Stefano, Faakye, Janet, Gulej, Rafal, Ahire, Chetan, Ungvari, Anna, Yabluchanskiy, Andriy et al. · 2022 · GeroScience
- Epigenetic regulation in cell senescenceCheng, Li-Qin, Zhang, Zhu-Qin, Chen, Hou-Zao, Liu, De-Pei · 2017 · Journal of Molecular Medicine
- Targeting aging and age-related diseases with vaccinesWu, Ruochen, Sun, Fei, Zhang, Weiqi, Ren, Jie, Liu, Guang-Hui · 2024 · Nature Aging
- Clonal Hematopoiesis: Somatic Mutations in Blood Cells and AtherosclerosisNatarajan, Pradeep, Jaiswal, Siddhartha, Kathiresan, Sekar · 2018 · Circulation Genomic and Precision Medicine
- Adipose tissue aging is regulated by an altered immune systemZhang, Yi-Xiang, Ou, Min-Yi, Yang, Zi-Han, Sun, Yu, Li, Qing-Feng, Zhou, Shuang-Bai · 2023 · Frontiers in Immunology
- Osteocyte Cellular SenescenceFarr, Joshua N., Kaur, Japneet, Doolittle, Madison L., Khosla, Sundeep · 2020 · Current Osteoporosis Reports
- Restoration of hippocampal neural precursor function by ablation of senescent cells in the aging stem cell nicheFatt, Michael P., Tran, Lina M., Vetere, Gisella, Storer, Mekayla A., Simonetta, Jaclin V., Miller, Freda D., Frankland, Paul W., Kaplan, David R. · 2022 · Stem Cell Reports
- Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: The role of Quercetin in modulating these processesBientinesi, Elisa, Lulli, Matteo, Becatti, Matteo, Ristori, Sara, Margheri, Francesca, Monti, Daniela · 2022 · Mechanisms of Ageing and Development
- Cardiovascular disease and the biology of agingMoturi, Shria, Ghosh-Choudhary, Shohini K., Finkel, Toren · 2022 · Journal of Molecular and Cellular Cardiology
- Vascular Ageing: Mechanisms, Risk Factors, and Treatment StrategiesYa, Jingyuan, Bayraktutan, Ulvi · 2023 · International Journal of Molecular Sciences
- Roadmap for alleviating the manifestations of ageing in the cardiovascular systemLiberale, Luca, Tual-Chalot, Simon, Sedej, Simon, Ministrini, Stefano, Georgiopoulos, Georgios, Grunewald, Myriam, Bäck, Magnus, Bochaton-Piallat, Marie-Luce, Boon, Reinier A., Ramos, Gustavo Campos et al. · 2025 · Nature Reviews Cardiology
- The struggle of a good friend getting old: cellular senescence in viral responses and therapyKohli, Jaskaren, Veenstra, Iris, Demaria, Marco · 2021 · The EMBO Reports
- Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in malesWalker, Emily M., Cha, Jeeyeon, Tong, Xin, Guo, Min, Liu, Jin-Hua, Yu, Sophia, Iacovazzo, Donato, Mauvais-Jarvis, Franck, Flanagan, Sarah E., Korbonits, Márta et al. · 2021 · Cell Reports
- DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic miceHerman, Allison B., Tsitsipatis, Dimitrios, Anerillas, Carlos, Mazan-Mamczarz, Krystyna, Carr, Angelica E., Gregg, Jordan M., Wang, Mingyi, Zhang, Jing, Michel, Marc, Henry-Smith, Charnae’ A. et al. · 2023 · Journal of Clinical Investigation
- Insights from In Vivo Studies of Cellular SenescencePrieto, Luis I., Graves, Sara I., Baker, Darren J. · 2020 · Cells
- Senescent cells enhance newt limb regeneration by promoting muscle dedifferentiationWalters, Hannah E., Troyanovskiy, Konstantin E., Graf, Alwin M., Yun, Maximina H. · 2023 · Aging Cell
- Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescenceMalavolta, Marco, Costarelli, Laura, Giacconi, Robertina, Basso, Andrea, Piacenza, Francesco, Pierpaoli, Elisa, Provinciali, Mauro, Ogo, Ogo A., Ford, Dianne · 2017 · Experimental Gerontology
- Senopathies-Diseases Associated with Cellular SenescenceLushchak, Oleh, Schosserer, Markus, Grillari, Johannes · 2023 · Biomolecules
- Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in miceMazan-Mamczarz, Krystyna, Tsitsipatis, Dimitrios, Childs, Bennett G., Carr, Angelica E., Dos Santos, Carla Rocha, Anerillas, Carlos, Romero, Brigette, Gregg, Jordan M., Henry-Smith, Charnae’, Okereke, Ada N. et al. · 2025 · Nature Aging
- In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markersSamakkarnthai, Parinya, Saul, Dominik, Zhang, Lei, Aversa, Zaira, Doolittle, Madison L., Sfeir, Jad G., Kaur, Japneet, Atkinson, Elizabeth J., Edwards, James R., Russell, Graham G. et al. · 2023 · Aging
- Context‐dependent roles of cellular senescence in normal, aged, and disease statesMoiseeva, Victoria, Cisneros, Andrés, Cobos, Aina Calls, Tarrega, Aida Beà, Oñate, Claudia Santos, Perdiguero, Eusebio, Serrano, Antonio L., Muñoz‐Cánoves, Pura · 2023 · The FEBS Journal
- Target Sestrin2 to rescue the damaged organ: mechanistic insight into its functionAla, Moein, Eftekhar, Seyed Parsa · 2021 · Oxidative Medicine and Cellular Longevity
- SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver agingTran, Khoa A., Gilbert, Michael, Vazquez, Berta N., Ianni, Alessandro, Garcia, Benjamin A., Vaquero, Alejandro, Berger, Shelley L. · 2025 · Molecular Cell
- Hemin-induced transient senescence via DNA damage response: a neuroprotective mechanism against ferroptosis in intracerebral hemorrhageMalojirao, Vikas H., Vasquez, Velmarini, Kodavati, Manohar, Mitra, Joy, Provasek, Vincent, Voh, Anh Tran Tram, Liopo, Anton V., Derry, Paul J., Mikheev, Andrei M., Rostomily, Robert C. et al. · 2025 · Communications Biology
- Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogrammingZhang, Weidong, Song, Shijie, Zhang, Yue, Pan, Yong, Hu, Dahai, Wang, Yunchuan · 2026 · npj Aging
- Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortexSloan, Nicholas X., Mares, Jason, Daly, Aidan C., Grier, Shaunice, Haq, Imdadul, Jackson, Christopher A., Barretto, Natalie, Casel, Obadele, Kang, Kristy, Khiste, Shruti et al. · 2026 · Cell Genomics