Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Cited by (159)

Items 101–159 of 159

  1. The chemistry of senescence
    Lozano-Torres, Beatriz, Estepa-Fernández, Alejandra, Rovira, Miguel, Orzáez, Mar, Serrano, Manuel, Martínez-Máñez, Ramón, Sancenón, Félix · 2019 · Nature Reviews Chemistry
  2. NADPH Oxidases and Mitochondria in Vascular Senescence
    Salazar, Gloria · 2018 · International Journal of Molecular Sciences
  3. Identifying specific functional roles for senescence across cell types
    2024
  4. Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis
    Khosla, Sundeep, Farr, Joshua N, Kirkland, James L · 2018 · The Journal of Clinical Endocrinology & Metabolism
  5. Cellular senescence links aging and diabetes in cardiovascular disease
    Shakeri, Hadis, Lemmens, Katrien, Gevaert, Andreas B., De Meyer, Guido R. Y., Segers, Vincent F. M. · 2018 · American Journal of Physiology-Heart and Circulatory Physiology
  6. Oxidation resistance 1 is a novel senolytic target
    Zhang, Xin, Zhang, Suping, Liu, Xingui, Wang, Yingying, Chang, Jianhui, Zhang, Xuan, Mackintosh, Samuel G., Tackett, Alan J., He, Yonghan, Lv, Dongwen et al. · 2018 · Aging Cell
  7. Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
    Song, Shuling, Tchkonia, Tamara, Jiang, Jing, Kirkland, James L., Sun, Yu · 2020 · Advanced Science
  8. Exercise reduces circulating biomarkers of cellular senescence in humans
    Englund, Davis A., Sakamoto, Ayumi E., Fritsche, Chad M., Heeren, Amanda A., Zhang, Xu, Kotajarvi, Brian R., Lecy, Denise R., Yousefzadeh, Matthew J., Schafer, Marissa J., White, Thomas A. et al. · 2021 · Aging Cell
  9. Senolytics for Cancer Therapy: Is All that Glitters Really Gold?
    Carpenter, Valerie J., Saleh, Tareq, Gewirtz, David A. · 2021 · Cancers
  10. Defective base excision repair of oxidative DNA damage in vascular smooth muscle cells promotes atherosclerosis
    Shah, Aarti, Gray, Kelly, Figg, Nichola, Finigan, Alison, Starks, Lakshi, Bennett, Martin · 2018 · Circulation
  11. Immunology of the ageing kidney
    Sato, Yuki, Yanagita, Motoko · 2019 · Nature Reviews Nephrology
  12. Age- and tissue-specific expression of senescence biomarkers in mice.
    Hudgins, Adam D., Tazearslan, Cagdas, Tare, Archana, Zhu, Yizhou, Huffman, Derek, Suh, Yousin · 2018 · Frontiers in Genetics
  13. Mouse Models to Disentangle the Hallmarks of Human Aging
    Folgueras, Alicia R., Freitas-Rodríguez, Sandra, Velasco, Gloria, López-Otín, Carlos · 2018 · Circulation Research
  14. Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies
    Gaikwad, Sagar, Senapati, Sudipta, Haque, Md. Anzarul, Kayed, Rakez · 2024 · Alzheimer's & Dementia
  15. Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence
    Ogrodnik, Mikolaj, Salmonowicz, Hanna, Jurk, Diana, Passos, João F. · 2019 · Trends in Biochemical Sciences
  16. Aging-induced biological changes and cardiovascular diseases.
    Fajemiroye, James Oluwagbamigbe, Cunha, Luiz Carlos da, Saavedra-Rodríguez, Roberto, Rodrigues, Karla Lima, Naves, Lara Marques, Mourão, Aline Andrade, Silva, Elaine Fernanda da, Williams, Nabofa Enivwenaye Egide, Martins, José Luis Rodrigues, Sousa, Romes Bittencourt et al. · 2018 · BioMed Research International
  17. Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions
    Tripathi, Utkarsh, Misra, Avanish, Tchkonia, Tamar, Kirkland, James L. · 2021 · Mechanisms of Ageing and Development
  18. Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions
    Englund, Davis A., Zhang, Xu, Aversa, Zaira, LeBrasseur, Nathan K. · 2021 · Mechanisms of Ageing and Development
  19. The role of senescent T cells in immunopathology
    Covre, Luciana P., De Maeyer, Roel P. H., Gomes, Daniel C. O., Akbar, Arne N. · 2020 · Aging Cell
  20. p21 induces a senescence program and skeletal muscle dysfunction
    Englund, Davis A., Jolliffe, Alyssa, Aversa, Zaira, Zhang, Xu, Sturmlechner, Ines, Sakamoto, Ayumi E., Zeidler, Julianna D., Warner, Gina M., McNinch, Colton, White, Thomas A. et al. · 2023 · Molecular Metabolism
  21. Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy
    Sugihara, Hidetoshi, Teramoto, Naomi, Nakamura, Katsuyuki, Shiga, Takanori, Shirakawa, Taku, Matsuo, Masafumi, Ogasawara, Masashi, Nishino, Ichizo, Matsuwaki, Takashi, Nishihara, Masugi et al. · 2020 · Scientific Reports
  22. Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
    Amaya-Montoya, Mateo, Pérez-Londoño, Agustín, Guatibonza-García, Valentina, Vargas-Villanueva, Andrea, Mendivil, Carlos O. · 2020 · Advances in Therapy
  23. Efficacy and limitations of senolysis in atherosclerosis
    Garrido, Abel Martin, Kaistha, Anuradha, Uryga, Anna K, Oc, Sebnem, Foote, Kirsty, Shah, Aarti, Finigan, Alison, Figg, Nichola, Dobnikar, Lina, Jørgensen, Helle et al. · 2022 · Cardiovascular Research
  24. Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation
    Liu, Xingui, Wang, Yingying, Zhang, Xuan, Gao, Zhengya, Zhang, Suping, Shi, Peizhong, Zhang, Xin, Song, Lin, Hendrickson, Howard, Zhou, Daohong et al. · 2018 · Bioorganic & Medicinal Chemistry
  25. Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis
    Childs, Bennett G., Zhang, Cheng, Shuja, Fahad, Sturmlechner, Ines, Trewartha, Shawn, Velasco, Raul Fierro, Baker, Darren J., Li, Hu, van Deursen, Jan M. · 2021 · Nature Aging
  26. The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications
    Basisty, Nathan, Kale, Abhijit, Patel, Sandip, Campisi, Judith, Schilling, Birgit · 2020 · Expert Review of Proteomics
  27. Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth
    Li, Yi, Zhao, Huan, Huang, Xiuzhen, Tang, Juan, Zhang, Shaohua, Li, Yan, Liu, Xiuxiu, He, Lingjuan, Ju, Zhengyu, Lui, Kathy O. et al. · 2018 · Cell Research
  28. Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory Phenotype (SASP) Factors
    Narzt, Marie-Sophie, Pils, Vera, Kremslehner, Christopher, Nagelreiter, Ionela-Mariana, Schosserer, Markus, Bessonova, Emilia, Bayer, Alina, Reifschneider, Raffaela, Terlecki-Zaniewicz, Lucia, Waidhofer-Söllner, Petra et al. · 2021 · Journal of Investigative Dermatology
  29. Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues
    Yousefzadeh, Matthew J., Wilkinson, John E., Hughes, Brian, Gadela, Namrata, Ladiges, Warren C., Vo, Nam, Niedernhofer, Laura J., Huffman, Derek M., Robbins, Paul D. · 2020 · GeroScience
  30. Therapeutic Potential of Senolytics in Cardiovascular Disease
    Dookun, Emily, Passos, João F., Arthur, Helen M., Richardson, Gavin D. · 2022 · Cardiovascular Drugs and Therapy
  31. Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies
    Cherry, Christopher, Andorko, James I., Krishnan, Kavita, Mejías, Joscelyn C., Nguyen, Helen Hieu, Stivers, Katlin B., Gray-Gaillard, Elise F., Ruta, Anna, Han, Jin, Hamada, Naomi et al. · 2023 · GeroScience
  32. Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension
    Rocha, Lorena Raquel, Nguyen Huu, Viet Anh, Palomino La Torre, Claudia, Xu, Qianlan, Jabari, Mary, Krawczyk, Michal, Weinreb, Robert N., Skowronska‐Krawczyk, Dorota · 2020 · Aging Cell
  33. Obesity accelerates cardiovascular ageing
    Ruperez, Celia, Madeo, Frank, de Cabo, Rafael, Kroemer, Guido, Abdellatif, Mahmoud · 2025 · European Heart Journal
  34. Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain
    Kiss, Tamas, Nyúl-Tóth, Ádám, DelFavero, Jordan, Balasubramanian, Priya, Tarantini, Stefano, Faakye, Janet, Gulej, Rafal, Ahire, Chetan, Ungvari, Anna, Yabluchanskiy, Andriy et al. · 2022 · GeroScience
  35. Epigenetic regulation in cell senescence
    Cheng, Li-Qin, Zhang, Zhu-Qin, Chen, Hou-Zao, Liu, De-Pei · 2017 · Journal of Molecular Medicine
  36. Targeting aging and age-related diseases with vaccines
    Wu, Ruochen, Sun, Fei, Zhang, Weiqi, Ren, Jie, Liu, Guang-Hui · 2024 · Nature Aging
  37. Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis
    Natarajan, Pradeep, Jaiswal, Siddhartha, Kathiresan, Sekar · 2018 · Circulation Genomic and Precision Medicine
  38. Adipose tissue aging is regulated by an altered immune system
    Zhang, Yi-Xiang, Ou, Min-Yi, Yang, Zi-Han, Sun, Yu, Li, Qing-Feng, Zhou, Shuang-Bai · 2023 · Frontiers in Immunology
  39. Osteocyte Cellular Senescence
    Farr, Joshua N., Kaur, Japneet, Doolittle, Madison L., Khosla, Sundeep · 2020 · Current Osteoporosis Reports
  40. Restoration of hippocampal neural precursor function by ablation of senescent cells in the aging stem cell niche
    Fatt, Michael P., Tran, Lina M., Vetere, Gisella, Storer, Mekayla A., Simonetta, Jaclin V., Miller, Freda D., Frankland, Paul W., Kaplan, David R. · 2022 · Stem Cell Reports
  41. Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: The role of Quercetin in modulating these processes
    Bientinesi, Elisa, Lulli, Matteo, Becatti, Matteo, Ristori, Sara, Margheri, Francesca, Monti, Daniela · 2022 · Mechanisms of Ageing and Development
  42. Cardiovascular disease and the biology of aging
    Moturi, Shria, Ghosh-Choudhary, Shohini K., Finkel, Toren · 2022 · Journal of Molecular and Cellular Cardiology
  43. Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies
    Ya, Jingyuan, Bayraktutan, Ulvi · 2023 · International Journal of Molecular Sciences
  44. Roadmap for alleviating the manifestations of ageing in the cardiovascular system
    Liberale, Luca, Tual-Chalot, Simon, Sedej, Simon, Ministrini, Stefano, Georgiopoulos, Georgios, Grunewald, Myriam, Bäck, Magnus, Bochaton-Piallat, Marie-Luce, Boon, Reinier A., Ramos, Gustavo Campos et al. · 2025 · Nature Reviews Cardiology
  45. The struggle of a good friend getting old: cellular senescence in viral responses and therapy
    Kohli, Jaskaren, Veenstra, Iris, Demaria, Marco · 2021 · The EMBO Reports
  46. Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males
    Walker, Emily M., Cha, Jeeyeon, Tong, Xin, Guo, Min, Liu, Jin-Hua, Yu, Sophia, Iacovazzo, Donato, Mauvais-Jarvis, Franck, Flanagan, Sarah E., Korbonits, Márta et al. · 2021 · Cell Reports
  47. DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice
    Herman, Allison B., Tsitsipatis, Dimitrios, Anerillas, Carlos, Mazan-Mamczarz, Krystyna, Carr, Angelica E., Gregg, Jordan M., Wang, Mingyi, Zhang, Jing, Michel, Marc, Henry-Smith, Charnae’ A. et al. · 2023 · Journal of Clinical Investigation
  48. Insights from In Vivo Studies of Cellular Senescence
    Prieto, Luis I., Graves, Sara I., Baker, Darren J. · 2020 · Cells
  49. Senescent cells enhance newt limb regeneration by promoting muscle dedifferentiation
    Walters, Hannah E., Troyanovskiy, Konstantin E., Graf, Alwin M., Yun, Maximina H. · 2023 · Aging Cell
  50. Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence
    Malavolta, Marco, Costarelli, Laura, Giacconi, Robertina, Basso, Andrea, Piacenza, Francesco, Pierpaoli, Elisa, Provinciali, Mauro, Ogo, Ogo A., Ford, Dianne · 2017 · Experimental Gerontology
  51. Senopathies-Diseases Associated with Cellular Senescence
    Lushchak, Oleh, Schosserer, Markus, Grillari, Johannes · 2023 · Biomolecules
  52. Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice
    Mazan-Mamczarz, Krystyna, Tsitsipatis, Dimitrios, Childs, Bennett G., Carr, Angelica E., Dos Santos, Carla Rocha, Anerillas, Carlos, Romero, Brigette, Gregg, Jordan M., Henry-Smith, Charnae’, Okereke, Ada N. et al. · 2025 · Nature Aging
  53. In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers
    Samakkarnthai, Parinya, Saul, Dominik, Zhang, Lei, Aversa, Zaira, Doolittle, Madison L., Sfeir, Jad G., Kaur, Japneet, Atkinson, Elizabeth J., Edwards, James R., Russell, Graham G. et al. · 2023 · Aging
  54. Context‐dependent roles of cellular senescence in normal, aged, and disease states
    Moiseeva, Victoria, Cisneros, Andrés, Cobos, Aina Calls, Tarrega, Aida Beà, Oñate, Claudia Santos, Perdiguero, Eusebio, Serrano, Antonio L., Muñoz‐Cánoves, Pura · 2023 · The FEBS Journal
  55. Target Sestrin2 to rescue the damaged organ: mechanistic insight into its function
    Ala, Moein, Eftekhar, Seyed Parsa · 2021 · Oxidative Medicine and Cellular Longevity
  56. SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging
    Tran, Khoa A., Gilbert, Michael, Vazquez, Berta N., Ianni, Alessandro, Garcia, Benjamin A., Vaquero, Alejandro, Berger, Shelley L. · 2025 · Molecular Cell
  57. Hemin-induced transient senescence via DNA damage response: a neuroprotective mechanism against ferroptosis in intracerebral hemorrhage
    Malojirao, Vikas H., Vasquez, Velmarini, Kodavati, Manohar, Mitra, Joy, Provasek, Vincent, Voh, Anh Tran Tram, Liopo, Anton V., Derry, Paul J., Mikheev, Andrei M., Rostomily, Robert C. et al. · 2025 · Communications Biology
  58. Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming
    Zhang, Weidong, Song, Shijie, Zhang, Yue, Pan, Yong, Hu, Dahai, Wang, Yunchuan · 2026 · npj Aging
  59. Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortex
    Sloan, Nicholas X., Mares, Jason, Daly, Aidan C., Grier, Shaunice, Haq, Imdadul, Jackson, Christopher A., Barretto, Natalie, Casel, Obadele, Kang, Kristy, Khiste, Shruti et al. · 2026 · Cell Genomics