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Effect of lower sodium intake on health: systematic review and meta-analyses
Open accessAbstract
OBJECTIVE: To assess the effect of decreased sodium intake on blood pressure, related cardiovascular diseases, and potential adverse effects such as changes in blood lipids, catecholamine levels, and renal function. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Cochrane Central Register of Controlled Trials, Medline, Embase, WHO International Clinical Trials Registry Platform, the Latin American and Caribbean health science literature database, and the reference lists of previous reviews. STUDY SELECTION: Randomised controlled trials and prospective cohort studies in non-acutely ill adults and children assessing the relations between sodium intake and blood pressure, renal function, blood lipids, and catecholamine levels, and in non-acutely ill adults all cause mortality, cardiovascular disease, stroke, and coronary heart disease. STUDY APPRAISAL AND SYNTHESIS: Potential studies were screened independently and in duplicate and study characteristics and outcomes extracted. When possible we conducted a meta-analysis to estimate the effect of lower sodium intake using the inverse variance method and a random effects model. We present results as mean differences or risk ratios, with 95% confidence intervals. RESULTS: We included 14 cohort studies and five randomised controlled trials reporting all cause mortality, cardiovascular disease, stroke, or coronary heart disease; and 37 randomised controlled trials measuring blood pressure, renal function, blood lipids, and catecholamine levels in adults. Nine controlled trials and one cohort study in children reporting on blood pressure were also included. In adults a reduction in sodium intake significantly reduced resting systolic blood pressure by 3.39 mm Hg (95% confidence interval 2.46 to 4.31) and resting diastolic blood pressure by 1.54 mm Hg (0.98 to 2.11). When sodium intake was <2 g/day versus ≥ 2 g/day, systolic blood pressure was reduced by 3.47 mm Hg (0.76 to 6.18) and diastolic blood pressure by 1.81 mm Hg (0.54 to 3.08). Decreased sodium intake had no significant adverse effect on blood lipids, catecholamine levels, or renal function in adults (P>0.05). There were insufficient randomised controlled trials to assess the effects of reduced sodium intake on mortality and morbidity. The associations in cohort studies between sodium intake and all cause mortality, incident fatal and non-fatal cardiovascular disease, and coronary heart disease were non-significant (P>0.05). Increased sodium intake was associated with an increased risk of stroke (risk ratio 1.24, 95% confidence interval 1.08 to 1.43), stroke mortality (1.63, 1.27 to 2.10), and coronary heart disease mortality (1.32, 1.13 to 1.53). In children, a reduction in sodium intake significantly reduced systolic blood pressure by 0.84 mm Hg (0.25 to 1.43) and diastolic blood pressure by 0.87 mm Hg (0.14 to 1.60). CONCLUSIONS: High quality evidence in non-acutely ill adults shows that reduced sodium intake reduces blood pressure and has no adverse effect on blood lipids, catecholamine levels, or renal function, and moderate quality evidence in children shows that a reduction in sodium intake reduces blood pressure. Lower sodium intake is also associated with a reduced risk of stroke and fatal coronary heart disease in adults. The totality of evidence suggests that most people will likely benefit from reducing sodium intake.
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“Nearly all observational studies demonstrate a positive association between very high sodium intakes (e.g., 4000+ mg/d) and CVD events, in particular stroke.305-307”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [305]
In the citing paper
“In meta-analyses of longitudinal studies, high sodium intakes associate with incident total stroke, stroke mortality, and CHD mortality (Figure 7).305-307”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [306]
In the citing paper
“In meta-analyses of prospective observational studies, the lowest mean intakes associated with lower risk of CVD events ranged from 1787 to 2391 mg/d.305”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [305]
In the citing paper
“Nearly all observational studies demonstrate a positive association between very high sodium intakes (e.g., 4000+ mg/d) and CVD events, in particular stroke.305-307”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [306]
In the citing paper
“In meta-analyses of longitudinal studies, high sodium intakes associate with incident total stroke, stroke mortality, and CHD mortality (Figure 7).305-307”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [305]
In the citing paper
“Meta-analyses of CVD event trials did not report a significant reduction in CVD with lower sodium intake, but the included trials were underpowered to detect moderate risk reductions (258).”
From Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System (2015) · cites this paper as [258]
In the citing paper
“Meta-analyses of CVD event trials did not report a significant reduction in CVD with lower sodium intake, but the included trials were underpowered to detect moderate risk reductions (258).”
From Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System (2015) · cites this paper as [258]
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2 retracted
Reduced dietary salt for the prevention of cardiovascular disease
Taylor, R. S., Ashton, K. E., Moxham, T., Hooper, L., & Ebrahim, S. B. J. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009217.pub2 · Cited by 311
Self-citationRetractedReduced dietary salt for the prevention of cardiovascular disease
Taylor, R. S., Ashton, K. E., Moxham, T., Hooper, L., & Ebrahim, S. B. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009217 · Cited by 223
Self-citationRetractedMeasuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00136 · Cited by 10,349
Global status report on noncommunicable diseases 2010.
Alwan, A. (2011) · Cited by 8,494
Sacks, F. M., Svetkey, L. P., Vollmer, W. M., Appel, L. J., Bray, G. A., Harsha, D., Obarzanek, E., Conlin, P. R., Miller, E. R., Simons-Morton, D. G., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101043440101 · Cited by 5,638
Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1. The Cochrane Collaboration
Higgins, J., Green, S. R., & Higgins, J. (2008) · Cited by 5,544
Diet, nutrition and the prevention of chronic diseases
Joint, W. (2002) · Medical Entomology and Zoology · Cited by 4,890
Funnel plots for detecting bias in meta-analysis
Sterne, J. A. C., & Egger, M. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(01)00377-8 · Cited by 3,779
Sick individuals and sick populations
Rose, G. (2001) · International Journal of Epidemiology · doi:10.1093/ije/30.3.427 · Cited by 3,736
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Italian Journal of Public Health · doi:10.2427/5768 · Cited by 3,374
Evaluating non-randomised intervention studies
Deeks, J., Dinnes, J., D'Amico, R., Sowden, A., Sakarovitch, C., Song, F., Petticrew, M., & Altman, D. (2003) · Health Technology Assessment · doi:10.3310/hta7270 · Cited by 2,907
Sick individuals and sick populations
ROSE, G. (1985) · International Journal of Epidemiology · doi:10.1093/ije/14.1.32 · Cited by 2,701
A Re-Evaluation of Random-Effects Meta-Analysis
Higgins, J. P. T., Thompson, S. G., & Spiegelhalter, D. J. (2009) · Journal of the Royal Statistical Society Series A: Statistics in Society · doi:10.1111/j.1467-985x.2008.00552.x · Cited by 2,569 · cited 2×
“31 32 We used funnel plots to assess whether there was small study bias.”
BackgroundMethodInfluentialThe case of the misleading funnel plot
Lau, J., Ioannidis, J. P. A., Terrin, N., Schmid, C. H., & Olkin, I. (2006) · BMJ · doi:10.1136/bmj.333.7568.597 · Cited by 1,766
Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies
Strazzullo, P., D'Elia, L., Kandala, N.-B., & Cappuccio, F. P. (2009) · BMJ · doi:10.1136/bmj.b4567 · Cited by 1,580
Self-citation(2016) · Human Rights Documents online · doi:10.1163/2210-7975_hrd-9841-2014001 · Cited by 1,579
The Atlas of Heart Disease and Stroke
Mackay, J., Mensah, G. A., & Mendis, S. (2004) · Medical Entomology and Zoology · Cited by 1,550
Tracking of Blood Pressure From Childhood to Adulthood
Chen, X., & Wang, Y. (2008) · Circulation · doi:10.1161/circulationaha.107.730366 · Cited by 1,512
Rose, G. A., Stamler, J., Stamler, R., Elliott, P., Marmot, M. G., Pyörälä, K., Kesteloot, H., Joossens, J. V., Hansson, L. ‐., Mancia, G., et al. (1988) · Cited by 1,281
Self-citationThe atlas of heart disease and stroke
Beevers, D. G. (2005) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001852 · Cited by 1,251
Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations
Vasan, R. S. (2006) · Circulation · doi:10.1161/circulationaha.104.482570 · Cited by 1,212
Whelton, P. K., Appel, L. J., Espeland, M. A., Applegate, W. B., Ettinger, Jr., Kostis, J. B., Kumanyika, S., Lacy, C. R., Johnson, K. C., Folmar, S., et al. (1998) · JAMA · doi:10.1001/jama.279.11.839 · Cited by 1,200
Egger, M., Jüni, P., Bartlett, C., Holenstein, F., & Sterne, J. (2003) · Health Technology Assessment · doi:10.3310/hta7010 · Cited by 1,181
Cook, N. R., Cutler, J. A., Obarzanek, E., Buring, J. E., Rexrode, K. M., Kumanyika, S. K., Appel, L. J., & Whelton, P. K. (2007) · BMJ · doi:10.1136/bmj.39147.604896.55 · Cited by 1,179
Salt intakes around the world: implications for public health
Brown, I. J., Tzoulaki, I., Candeias, V., & Elliott, P. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp139 · Cited by 1,173
Self-citationHe, F. J., & MacGregor, G. A. (2009) · Journal of Human Hypertension · doi:10.1038/jhh.2008.144 · Cited by 1,123
Global status report on noncommunicable diseases
Chan, M. (2010) · Cited by 1,065
Stamler, R., Nissinen, A. M., Uusitalo, U. M., Rose, G., Pietinen, P., & Stamler, J. (1988) · Cited by 1,042
Elliott, P., Stamler, J., Nichols, R., Dyer, A. R., Stamler, R., Kesteloot, H., & Marmot, M. (1996) · BMJ · doi:10.1136/bmj.312.7041.1249 · Cited by 855
Self-citationImplications of Small Reductions in Diastolic Blood Pressure for Primary Prevention
Cook, N. R. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430070053006 · Cited by 828
The Effects of Nonpharmacologic Interventions on Blood Pressure of Persons With High Normal Levels
Whelton, P. K. (1992) · JAMA · doi:10.1001/jama.1992.03480090061028 · Cited by 768
Dickinson, H. O., Mason, J. M., Nicolson, D. J., Campbell, F., Beyer, F. R., Cook, J. V., Williams, B., & Ford, G. A. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000199800.72563.26 · Cited by 759
Effect of longer-term modest salt reduction on blood pressure
He, F. J., Li, J., & MacGregor, G. A. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004937.pub2 · Cited by 756
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2002) · Journal of Health Services Research & Policy · doi:10.1258/1355819021927674 · Cited by 755
Alderman, M. H., Madhavan, S., Ooi, W. L., Cohen, H. W., Sealey, J. E., & Laragh, J. H. (1991) · New England Journal of Medicine · doi:10.1056/nejm199104183241605 · Cited by 722
Graudal, N. A., Hubeck-Graudal, T., & Jurgens, G. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004022.pub4 · Cited by 620
Murray, C. J. L., Lauer, J. A., Hutubessy, R. C. W., Niessen, L. W., Tomijima, N., Rodgers, A., Lawes, C. M. M., & EVANS, D. B. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12655-4 · Cited by 602
Urinary sodium excretion and cardiovascular mortality in Finland: a prospective study
Tuomilehto, J. O., Jousilahti, P., Rastenytė, D., Moltchanov, V., Tanskanen, A. J., Pietinen, P., & Nissinen, A. M. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04199-4 · Cited by 580
Brenner and Rector's The Kidney
Bazilinski, N. (2000) · JAMA · doi:10.1001/jama.284.1.100 · Cited by 577
Stolarz-Skrzypek, K. (2011) · JAMA · doi:10.1001/jama.2011.574 · Cited by 569
Urinary sodium and potassium excretion and risk of cardiovascular events
O'Donnell, M. J., Yusuf, S., Mente, A., Gao, P., Mann, J. F., Teo, K., McQueen, M., Sleight, P., Sharma, A. M., Dans, A., et al. (2011) · JAMA · doi:10.1001/jama.2011.1729 · Cited by 564
Anderson, C. A. M., Appel, L. J., Okuda, N., Brown, I., Chan, Q. M., Zhao, L., Ueshima, H., Kesteloot, H., Miura, K., Curb, J. D., et al. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.02.007 · Cited by 543
Self-citationRandomized trials of sodium reduction: an overview
Cutler, J., Follmann, D. A., & Allender, P. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.2.643s · Cited by 523
Dietary Sodium Intake and Subsequent Risk of Cardiovascular Disease in Overweight Adults
He, J. (1999) · JAMA · doi:10.1001/jama.282.21.2027 · Cited by 499
Joint Effects of Sodium and Potassium Intake on Subsequent Cardiovascular Disease
Cook, N. R. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.523 · Cited by 431
Importance of Salt in Determining Blood Pressure in Children
He, F. J., & MacGregor, G. A. (2006) · Hypertension · doi:10.1161/01.hyp.0000245672.27270.4a · Cited by 407
Sodium and potassium intake and balance in adults consuming self-selected diets
Holbrook, J. T., Patterson, K. Y., Bodner, J. E., Douglas, L. W., Veillon, C., Kelsay, J., Mertz, W., & Smith, J. (1984) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/40.4.786 · Cited by 396
How Far Should Salt Intake Be Reduced?
He, F. J., & MacGregor, G. A. (2003) · Hypertension · doi:10.1161/01.hyp.0000102864.05174.e8 · Cited by 382
Effects of Dietary Sodium and Hydrochlorothiazide on the Antiproteinuric Efficacy of Losartan
Vogt, L., Waanders, F., Boomsma, F., de Zeeuw, D., & Navis, G. J. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007060693 · Cited by 374
DOUBLE-BLIND RANDOMISED CROSSOVER TRIAL OF MODERATE SODIUM RESTRICTION IN ESSENTIAL HYPERTENSION
MacGregor, G. A., Best, F., Cam, J., Markandu, N. D., Elder, D., Sagnella, G., & Squires, M. (1982) · The Lancet · doi:10.1016/s0140-6736(82)91389-7 · Cited by 370
CONTROLLED, RANDOMISED TRIAL OF THE EFFECT OF DIETARY FAT ON BLOOD PRESSURE
Puska, P. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91556-8 · Cited by 345
HYPERTENSION TREATED BY SALT RESTRICTION
Morgan, T. O., Adam, W. R., Gillies, A. H. B., Wilson, M., Morgan, G., & Carney, S. (1978) · The Lancet · doi:10.1016/s0140-6736(78)90479-8 · Cited by 341
Tunstall-Pedoe, H., Woodward, M., Tavendale, R., Brook, R. A., & McCluskey, M. K. (1997) · BMJ · doi:10.1136/bmj.315.7110.722 · Cited by 317
Dietary salt intake and mortality in patients with type 2 diabetes
Ekinci, E. I., Clarke, S., Thomas, M. C., Moran, J. L., Cheong, K., MacIsaac, R. J., & Jerums, G. (2011) · Diabetes Care · doi:10.2337/dc10-1723 · Cited by 309
Effect of longer-term modest salt reduction on blood pressure
He, F. J., & MacGregor, G. A. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004937 · Cited by 308
Effect of potassium-enriched salt on cardiovascular mortality and medical expenses of elderly men
Chang, H., Hu, Y.-W., Yue, C.-S. J., Wen, Y., Yeh, W., Hsu, L.-S., Tsai, S.-Y., & Pan, W. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1289 · Cited by 298
Moderate sodium restriction and diuretics in the treatment of hypertension
Parijs, J. V., Joossens, J. V., der Linden, L. V., Verstreken, G., & Amery, A. K. P. C. (1973) · American Heart Journal · doi:10.1016/0002-8703(73)90522-x · Cited by 293
Alderman, M. H., Madhavan, S., Cohen, H. W., Sealey, J. E., & Laragh, J. H. (1995) · Hypertension · doi:10.1161/01.hyp.25.6.1144 · Cited by 292
MacGregor, G. A., Sagnella, G. A., Markandu, N. D., Singer, D. R. J., & Cappuccio, F. P. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91852-7 · Cited by 270
Self-citationSodium Intake and Risk of Death From Stroke in Japanese Men and Women
Nagata, C., Takatsuka, N., Shimizu, N., & Shimizu, H. (2004) · Stroke · doi:10.1161/01.str.0000130425.50441.b0 · Cited by 269
He, F. J., Marciniak, M., Visagie, E., Markandu, N. D., Anand, V., Dalton, R. N., & MacGregor, G. A. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.133223 · Cited by 249
The Hypertension Prevention Trial: Three-Year Effects of Dietary Changes on Blood Pressure
Hypertension Prevention Trial Research Group Hypertension Prevention Trial Research Group (1990) · Archives of Internal Medicine · doi:10.1001/archinte.150.1.153 · Cited by 249
Paterna, S., Parrinello, G., Fasullo, S., Sarullo, F. M., & Pasquale, P. D. (2008) · Clinical Science · doi:10.1042/cs20070193 · Cited by 242
Gates, P. E., Tanaka, H., Hiatt, W. R., & Seals, D. R. (2004) · Hypertension · doi:10.1161/01.hyp.0000132767.74476.64 · Cited by 236
Umesawa, M., Iso, H., Date, C., Yamamoto, A., Toyoshima, H., Watanabe, Y., Kikuchi, S., Koizumi, A., Kondo, T., Inaba, Y., et al. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.195 · Cited by 217
The Hypertension Prevention Trial: Three-Year Effects of Dietary Changes on Blood Pressure
Hypertension Prevention Trial Research Group (1990) · Archives of Internal Medicine · doi:10.1001/archinte.1990.00390130131021 · Cited by 212
Advice to reduce dietary salt for prevention of cardiovascular disease
Hooper, L., Bartlett, C., Smith, G. D., & Ebrahim, S. B. J. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003656.pub2 · Cited by 206
Self-citationSodium Intake and Mortality in the NHANES II Follow-up Study
Cohen, H. W., Hailpern, S. M., Fang, J., & Alderman, M. H. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.10.042 · Cited by 204
Double-blind randomised trial of modest salt restriction in older people
Cappuccio, F. P., Markandu, N. D., Carney, C., Sagnella, G. A., & MacGregor, G. A. (1997) · The Lancet · doi:10.1016/s0140-6736(97)02264-2 · Cited by 184
Self-citationDietary and other risk factors for stroke in Hawaiian Japanese men.
Kagan, A., Popper, J. S., Rhoads, G. G., & Yano, K. (1985) · Stroke · doi:10.1161/01.str.16.3.390 · Cited by 181
Geleijnse, J. M., Witteman, J. C. M., Stijnen, T., Kloos, M., Albert Hofman, D., & Grobbee, D. E. (2007) · European Journal of Epidemiology · doi:10.1007/s10654-007-9186-2 · Cited by 175
Graudal, N. A., Hubeck-Graudal, T., & Jurgens, G. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004022.pub3 · Cited by 170
Modest Salt Reduction Reduces Blood Pressure and Urine Protein Excretion in Black Hypertensives
Swift, P. A., Markandu, N. D., Sagnella, G. A., He, F. J., & MacGregor, G. A. (2005) · Hypertension · doi:10.1161/01.hyp.0000172662.12480.7f · Cited by 169
Cohen, H. W., Hailpern, S. M., & Alderman, M. H. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0645-6 · Cited by 166
Caldeira, D., Carneiro, A. V., & Costa, J. N. (2014) · PubMed · Cited by 155
Incidence of stroke in Taiwan.
Hu, H. H., Sheng, W. Y., Chu, F. L., Lan, C.-L., & Chiang, B. N. (1992) · Stroke · doi:10.1161/01.str.23.9.1237 · Cited by 150
Richards, M., Espiner, E., Nicholls, M. G., Ikram, H., Maslowski, A. H., Hamilton, E. J., & Wells, J. E. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91276-5 · Cited by 148
Magnesium, Calcium, Potassium, and Sodium Intakes and Risk of Stroke in Male Smokers
Larsson, S. C. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.5.459 · Cited by 144
Reduced dietary salt for the prevention of cardiovascular disease
Adler, A. J., Taylor, F. C., Martin, N., Gottlieb, S. H., Taylor, R. S., & Ebrahim, S. B. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009217.pub3 · Cited by 128
Sodium and potassium intake and blood pressure change in childhood.
Geleijnse, J. M., Grobbee, D. E., & Hofman, A. (1990) · BMJ · doi:10.1136/bmj.300.6729.899 · Cited by 126
Salt intake, stroke and cardiovascular disease: A meta-analysis of prospective studies
Cappuccio, F. P., D’Elia, L., Kandala, N., & Strazzullo, P. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.09.175 · Cited by 126
Self-citationDietary sodium restriction for mild hypertension in general practice.
Watt, G. C. M., Edwards, C. C., Hart, J. T., Hart, M. M., Walton, P., & Foy, C. (1983) · BMJ · doi:10.1136/bmj.286.6363.432 · Cited by 125
Effect of low sodium diet or potassium supplementation on adolescent blood pressure.
Sinaiko, A. R., Gómez-Marı́n, O., & Prineas, R. J. (1993) · Hypertension · doi:10.1161/01.hyp.21.6.989 · Cited by 115
Effect of Dietary Sodium Intake on Blood Lipids
Harsha, D. W., Sacks, F. M., Obarzanek, E., Svetkey, L. P., Lin, P., Bray, G. A., Aickin, M. G., Conlin, P. R., Miller, E. R., & Appel, L. J. (2004) · Hypertension · doi:10.1161/01.hyp.0000113046.83819.a2 · Cited by 115
Fagerberg, B., Andersson, O., Isaksson, B., & Björntorp, P. A. (1984) · BMJ · doi:10.1136/bmj.288.6410.11 · Cited by 114
Dodson, P. M., Beevers, M., Hallworth, R., Webberley, M. J., Fletcher, R. F., & Taylor, K. G. (1989) · BMJ · doi:10.1136/bmj.298.6668.227 · Cited by 114
Plasma Renin Activity and Ischemic Heart Disease
Meade, T. W., Cooper, J. A., & Peart, W. S. (1993) · New England Journal of Medicine · doi:10.1056/nejm199308263290905 · Cited by 107
&NA; (2001) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200105000-00012 · Cited by 107
Sodium Retention in Black and White Female Adolescents in Response to Salt Intake
Palacios, C. S., Wigertz, K., Martin, B. R., Jackman, L., Pratt, J. H., Peacock, M., McCabe, G. P., & Weaver, C. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031446 · Cited by 105
Alderman, M. H. (2010) · JAMA · doi:10.1001/jama.2010.69 · Cited by 93
Silman, A. J., Mitchell, P., Locke, C., & Humpherson, P. (1983) · The Lancet · doi:10.1016/s0140-6736(83)92463-7 · Cited by 93
Australian National Health and Medical Research Council dietary salt study in mild hypertension.
Chalmers, J. P., Morgan, T. O., Doyle, A. E., Dickson, B. K., Hopper, J. L., Mathews, J. D., Matthews, G. V., Moulds, R. F. W., Myers, J. B., & Nowson, C. A. (1986) · PubMed · Cited by 90
Changing sodium intake in children. The Minneapolis Children's Blood Pressure Study.
Gillum, R. F., Elmer, P. J., & Prineas, R. J. (1981) · Hypertension · doi:10.1161/01.hyp.3.6.698 · Cited by 87
Kumanyika, S., Cook, N. R., Cutler, J. A., Belden, L. K., Brewer, A., Cohen, J., Hebert, P. R., Lasser, V. I., Raines, J., Raczynski, J. M., et al. (2004) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001774 · Cited by 81
Erwteman, T. M., Nagelkerke, N. J. D., Lubsen, J. C., Köster, M., & Dunning, A. J. (1984) · BMJ · doi:10.1136/bmj.289.6442.406 · Cited by 81
Melander, O., von Wowern, F., Frandsen, E., Burri, P., Willsteen, G., Aurell, M., & Hulthén, U. L. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e328013cd50 · Cited by 80
A low-sodium diet supplemented with fish oil lowers blood pressure in the elderly
Cobiac, L., Nestel, P. J., Wing, L. M. H., & Howe, P. R. C. (1992) · Journal of Hypertension · doi:10.1097/00004872-199201000-00014 · Cited by 79
Urinary Sodium and Potassium Excretion and Risk of Cardiovascular Events
Elliott, W. J. (2012) · Yearbook of Cardiology · doi:10.1016/j.ycar.2012.01.076 · Cited by 77
Trials of hypertension prevention phase I design☆☆☆
Satterfield, S., Cutler, J. A., Langford, H. G., Applegate, W. B., Borhani, N. O., Brittain, E., Cohen, J. D., Kuller, L. H., Lasser, N. L., & Oberman, A. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90014-4 · Cited by 74
Suckling, R., He, F. J., Markandu, N. D., & MacGregor, G. A. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06637 · Cited by 74
New evidence relating to the health impact of reducing salt intake
Campbell, N. R. C., Correa‐Rotter, R., Neal, B. C., & Cappuccio, F. P. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.08.001 · Cited by 72
Self-citationSodium Restriction and Potassium Supplementation in Young People with Mildly Elevated Blood Pressure
Grobbee, D. E., Albert Hofman, D., Roelandt, J., Boomsma, F., Schalekamp, M. A. D. H., & Valkenburg, H. A. (1987) · Journal of Hypertension · doi:10.1097/00004872-198702000-00016 · Cited by 72
Blood pressure as an example of a biomarker that functions as a surrogate
Desai, M. G., Stockbridge, N., & Temple, R. (2006) · The AAPS Journal · doi:10.1208/aapsj080117 · Cited by 71
FALL IN BLOOD PRESSURE WITH MODEST REDUCTION IN DIETARY SALT INTAKE IN MILD HYPERTENSION
(1989) · The Lancet · doi:10.1016/s0140-6736(89)90001-9 · Cited by 69
Ruppert, M., Overlack, A., Kolloch, R. E., Kraft, K., bel, B. O. G., & Stumpe, K. O. (1993) · Journal of Hypertension · doi:10.1097/00004872-199307000-00010 · Cited by 62
INTERMAP Appendix Tables, Tables of Contents (Tables A)
Stamler, J., Elliott, P., & Chan, Q. M. (2003) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001634 · Cited by 61
Self-citationEllison, R. C. (1989) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(89)90056-5 · Cited by 60
Lasser, V. I., Raczynski, J. M., Stevens, V. J., Mattfeldt-Beman, M., Kumanyika, S., Evans, M., Danielson, E., Dalcin, A., Batey, D. M., Belden, L. K., et al. (1995) · Annals of Epidemiology · doi:10.1016/1047-2797(94)00060-7 · Cited by 60
Nestel, P. J., Clifton, P. M., Noakes, M., McArthur, R., & Howe, P. R. C. (1993) · Journal of Hypertension · doi:10.1097/00004872-199312000-00011 · Cited by 59
Fotherby, M. D., & Potter, J. F. (1993) · Journal of Hypertension · doi:10.1097/00004872-199306000-00010 · Cited by 58
Bénétos, A., Yang-Yan, X., Cuche, J. L., Hannaert, P. A., & Safar, M. E. (1992) · Journal of Hypertension · doi:10.1097/00004872-199204000-00006 · Cited by 52
Polónia, J. J., & Martins, L. (2009) · Journal of Human Hypertension · doi:10.1038/jhh.2009.64 · Cited by 51
Dietary Sodium Intake and Cardiovascular Mortality: Controversy Resolved?
Alderman, M. H., & Cohen, H. W. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0275-6 · Cited by 49
Andersson, O., Fagerberg, B., & Hedner, T. (1984) · Hypertension · doi:10.1161/01.hyp.6.6.814 · Cited by 49
A factorial study of salt restriction and a low-fat/high-fibre diet in hypertensive subjects
Sciarrone, S. E. G., Beilin, L. J., Rouse, I. L., & Rogers, P. (1992) · Journal of Hypertension · doi:10.1097/00004872-199203000-00013 · Cited by 48
Lack of effect of short-term changes in sodium intake on blood pressure in adolescent schoolchildren
Howe, P. R. C., Cobiac, L., & Smith, R. M. (1991) · Journal of Hypertension · doi:10.1097/00004872-199102000-00014 · Cited by 47
Blood pressure response to dietary sodium restriction in healthy normotensive children
Miller, J. Z., Weinberger, M. H., Daugherty, S. A., Fineberg, N. S., Christian, J. C., & Grim, C. E. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/47.1.113 · Cited by 46
Hypertension treated by sodium restriction
Morgan, T. O., & Myers, J. B. (1981) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1981.tb101026.x · Cited by 46
Coronary Heart Disease: Estimating the Impact of Changes in Risk Factors
McPherson, K., Britton, A. R., & Causer, L. M. (2002) · OpenGrey (Institut de l'Information Scientifique et Technique) · Cited by 45
Gonzalez, M. C., Cohen, H. W., Sealey, J. E., LARAGH, J. H., & Alderman, M. H. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.172 · Cited by 42
Salt restriction: effects on lipids and insulin production in hypertensive patients
Meland, E., LÆRUM, E., Aakvaag, A., Ulvik, R. J., & Høstmark, A. T. (1997) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519709084600 · Cited by 39
McCarron, D. A. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(96)00295-6 · Cited by 38
Volpe, M., Francia, P., Tocci, G., Rubattu, S., Cangianiello, S., Rao, M. A. E., Trimarco, B., & Condorelli, M. (2010) · Clinical Cardiology · doi:10.1002/clc.20813 · Cited by 37
Effects of dietary sodium on blood pressure in IDDM patients with nephropathy
M�hlhauser, I., Prange, K., Sawicki, P. T., Bender, R., Dworschak, A., Schaden, W., & Berger, M. (1996) · Diabetologia · doi:10.1007/bf00403965 · Cited by 37
Does reducing salt intake increase cardiovascular mortality?
He, F. J., Appel, L. J., Cappuccio, F. P., de Wardener, H. E., & MacGregor, G. A. (2011) · Kidney International · doi:10.1038/ki.2011.246 · Cited by 36
Self-citation(2007) · Clinical Governance An International Journal · doi:10.1108/cgij.2007.24812cae.009 · Cited by 35
Trevisan, M., Cooper, R., Ostrow, D. G., Miller, W., Sparks, S. P. A. D. D. L., Leonas, Y., Allen, A. J., Steinhauer, M. J., & Stamler, J. (1981) · Clinical Science · doi:10.1042/cs061029s · Cited by 33
Mild Hypertension: From Drug Trials to Practice.
(1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-2-270_1 · Cited by 33
Preventing stroke: the PRoFESS, ONTARGET, and TRANSCEND trial programs
Diener, H. (2009) · Journal of Hypertension · doi:10.1097/01.hjh.0000357906.60778.7f · Cited by 30
Howe, P. R. C., Lungershausen, Y. K., Cobiac, L., Dandy, G., & Nestel, P. J. (1994) · PubMed · Cited by 28
Cook, N. R., Kumanyika, S., Cutler, J. A., & Whelton, P. K. (2004) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001775 · Cited by 28
Calabrese, E. J., & Tuthill, R. W. (1985) · Toxicology and Industrial Health · doi:10.1177/074823378500100103 · Cited by 26
Weir, M. R., Yadao, A. M., Purkayastha, D., & Charney, A. N. (2010) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248410377173 · Cited by 26
Salt restriction among hypertensive patients: Modest blood pressure effect and no adverse effects
Meland, E., & Aamland, A. (2009) · Scandinavian Journal of Primary Health Care · doi:10.1080/02813430802661795 · Cited by 25
Renin as a biomarker of cardiovascular disease in clinical practice
Volpe, M., Battistoni, A., Chin, D., Rubattu, S., & Tocci, G. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.12.006 · Cited by 25
Metabolic and orthostatic blood pressure responses to a low-sodium diet in elderly hypertensives
Fotherby, M., & Potter, J. (1997) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1000436 · Cited by 24
Dietary Salt Intake and Mortality in Patients With Type 2 Diabetes
Ekinci, E. I., Clarke, S., Thomas, M. C., Cheong, K., Macisaak, R. J., & Lerums, G. (2011) · Obesity and metabolism · doi:10.14341/2071-8713-4842 · Cited by 21
Effects of Replacing Sodium Intake in Subjects on a Low Sodium Diet: A Crossover Study
(1989) · Clinical and Experimental Hypertension · doi:10.3109/10641968909035388 · Cited by 21
Unnecessary Controversy Regarding Dietary Sodium: A Lot About a Little
Campbell, N. R. C., Cappuccio, F. P., & Tobe, S. W. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2011.05.003 · Cited by 18
Self-citationReactivity to norepinephrine and effect of sodium on blood pressure during weight loss.
Fagerberg, B., Andersson, O., Persson, B., & Hedner, T. (1985) · Hypertension · doi:10.1161/01.hyp.7.4.586 · Cited by 17
Brenner and Rector's The Kidney
Skorecki, K., & Chertow, G. M. (2000) · Cited by 16
Review: Plasma renin and the incidence of cardiovascular disease
Meade, T. (2010) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320310365015 · Cited by 14
Richards, M., Nicholls, M. G., Espiner, E. A., Ikram, H., Maslowski, A. H., Hamilton, E. J., & Wells, J. E. (1984) · The Journal of Urology · doi:10.1016/s0022-5347(17)49910-1 · Cited by 12
Bilateral Exophthalmos Revealing a Case of Husband and Wife Sarcoidosis
Astudillo, L. M., Soler, V. J., Sailler, L., Irsutti-Fjørtoft, M., & Arlet-Suau, E. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.11.032 · Cited by 11
Intestinal Glucose Transport in Acute Viral Enteritis in Piglets
Telch, J., Shepherd, R. W., Butler, D. G., Perdue, M. H., Hamilton, J. R., & Gall, D. (1981) · Clinical Science · doi:10.1042/cs0610029 · Cited by 11
Geleijnse, J. M., Witteman, J. C. M., Bak, A. A. A., den Breeijen, J. H., & Grobbee, D. E. (1995) · PubMed · Cited by 10
Geleijnse, J. M. (2003) · American Journal of Hypertension · doi:10.1016/s0895-7061(03)00350-9 · Cited by 9
Dietary sodium restriction for mild hypertension in general practice
MacGregor, G., Markandu, N. D., & Smith, S. J. (1983) · BMJ · doi:10.1136/bmj.286.6380.1824-b · Cited by 6
Dietary sodium restriction for mild hypertension in general practice.
Watt, G. C. M., Hart, J. T., & Foy, C. (1983) · BMJ · doi:10.1136/bmj.286.6371.1146-c · Cited by 6
Suckling, R., He, F. J., Markandu, N. D., & MacGregor, G. A. (2010) · Journal of Hypertension · doi:10.1097/01.hjh.0000378867.74072.1c · Cited by 5
Pirrelli, A., Pieri, R., & Savino, L. (1980) · PubMed · Cited by 1
Flagged first, then by citations
3 of the 163 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- [36]Stamler J, Elliott P, Chan Q, for the INTERMAP Research Group. Intermap appendix tables. J Hum Hyper 2003; 17: 665-758.
- [39]Swift PA, Markandu ND, Sagnella GA, MacGregor GA. A double blind randomised control trial of modest salt reduction in black people with normal blood pressure. J Am Soc Nephrol 2006; 17: 657A.
- [41]Miller JA, Wong F, Dionne J. Dietary sodium modulates renal vasomotor tone in normal humans. J Am Soc Nephrol 1993; 4: 583.
- [105]Tunstall-Pedoe H, Woodward M, Tavandale R, Brook R, McCluskey MK. Comparison of the prediction by 27 different factors of coronary heart disease and death in men and women of the Scottish heart health study: cohort study. BMJ 1997; 315: 722-9. 9314758 PMC2127508
- [115]Howe PR, Jureidini KF, Smith RM. Sodium and blood pressure in children—a short-term dietary intervention study. Proc Nutr Soc Aust 1985; 10: 121-4.
Cited by
Sorted by citations
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2018 ESC/ESH Guidelines for the management of arterial hypertension
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy339 · Cited by 10,286
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Metadata
- Authors
- Aburto, N. J., Ziolkovska, A., Hooper, L., Elliott, P., Cappuccio, F. P., & Meerpohl, J. J.
- Affiliations
- World Health Organization (CH)
- University of East Anglia (GB)
- Imperial College London (GB)
- University of Warwick (GB)
- University Medical Center Freiburg (DE)
- Corresponding author
- Aburto, N. J.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2013-04-03
- Volume
- 346
- Issue
- apr03 3
- Pages
- f1326-f1326
- ISSN
- 1756-1833 (ISSN-L)
- PMC
- PMC4816261
- OpenAlex
- W2167945952
- Cited by
- 1,242
- References
- 163
- Citations by year
- 2026: 26 · 2025: 54 · 2024: 74 · 2023: 80 · 2022: 106 · 2021: 101 · 2020: 115 · 2019: 128 · 2018: 101 · 2017: 110 · 2016: 95 · 2015: 99 · 2014: 106 · 2013: 39
- FWCI
- 12.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion, cc-by-nc)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0611-10136)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007734)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- low sodium intake, dietary sodium reduction, blood pressure, cardiovascular disease, stroke, coronary artery disease, all-cause mortality, serum lipids, catecholamines, renal function, children, hypertension prevention, salt reduction interventions, sodium reduction
- MeSH terms
- Blood Pressure, Cardiovascular Diseases, Catecholamines, Diet, Sodium-Restricted, Female, Humans, Hypertension, Kidney, Male, Prospective Studies, Public Health, Randomized Controlled Trials as Topic, Sodium Chloride, Dietary, Lipid Metabolism
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