Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 410

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Mass Spectrometry–Based Proteomics and Network Biology

Open access
Bensimon, Ariel, Heck, Albert J.R., Aebersold, Ruedi·2012·Annual Review of Biochemistry
DOI 10.1146/annurev-biochem-072909-100424
Open this paper in CoChat — free account

Abstract

In the life sciences, a new paradigm is emerging that places networks of interacting molecules between genotype and phenotype. These networks are dynamically modulated by a multitude of factors, and the properties emerging from the network as a whole determine observable phenotypes. This paradigm is usually referred to as systems biology, network biology, or integrative biology. Mass spectrometry (MS)–based proteomics is a central life science technology that has realized great progress toward the identification, quantification, and characterization of the proteins that constitute a proteome. Here, we review how MS-based proteomics has been applied to network biology to identify the nodes and edges of biological networks, to detect and quantify perturbation-induced network changes, and to correlate dynamic network rewiring with the cellular phenotype. We discuss future directions for MS-based proteomics within the network biology paradigm.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1146/annurev-biochem-072909-100424

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 23 references

Research works printed but not linked: 130

  1. 10.1073/pnas.27.11.499 · DOI · Paper page
  2. 10.1038/nrg2795 · DOI · Paper page
  3. 10.1007/s13238-010-0065-3 · DOI
  4. 10.1146/annurev-biochem-061308-093216 · DOI · Paper page
  5. 10.1016/j.tibtech.2009.11.007 · DOI
  6. 10.1038/nrg2364 · DOI · Paper page
  7. 10.1016/j.cell.2009.08.031 · DOI · Paper page
  8. 10.1126/scisignal.2001350 · DOI
  9. 10.1016/j.cell.2009.12.018 · DOI · Paper page
  10. 10.1002/path.2693 · doi:10.1002/path.2693
  11. 10.1002/humu.21466 · DOI · Paper page
  12. 10.1016/j.cell.2011.03.008 · DOI
  13. 10.1093/carcin/bgp261 · DOI · Paper page
  14. 10.1016/j.cell.2011.03.001 · DOI
  15. 10.1016/j.cell.2011.02.016 · DOI · Paper page
  16. 10.1146/annurev-bioeng-061008-124934 · DOI · Paper page
  17. 10.1038/nbt.1661 · DOI · Paper page
  18. 10.1038/nmeth1088 · DOI · Paper page
  19. 10.1038/nbt.1658 · DOI · Paper page
  20. 10.1002/pmic.200700057 · DOI · Paper page
  21. 10.1002/pmic.201000553 · DOI · Paper page
  22. 10.1074/mcp.M800218-MCP200 · DOI
  23. 10.1016/j.cbpa.2009.08.016 · DOI
  24. 10.1038/msb.2008.61 · DOI · Paper page
  25. 10.1002/jms.1895 · DOI · Paper page
  26. 10.1038/nmeth.1408 · DOI · Paper page
  27. 10.1002/pmic.200800562 · DOI · Paper page
  28. 10.1074/mcp.M110.001537 · DOI · Paper page
  29. 10.1038/nmeth705 · DOI · Paper page
  30. 10.1021/ac900888s · DOI · Paper page
  31. 10.1038/nrm2973 · DOI · Paper page
  32. 10.1038/nbt1300 · DOI · Paper page
  33. 10.1038/msb.2011.84 · DOI
  34. 10.1126/science.1175371 · DOI · Paper page
  35. 10.1016/j.cell.2010.12.001 · DOI · Paper page
  36. 10.1016/j.cell.2010.04.012 · DOI · Paper page
  37. 10.1038/msb.2010.122 · DOI
  38. 10.1126/scisignal.2000475 · DOI · Paper page
  39. 10.1126/scisignal.2001182 · DOI · Paper page
  40. 10.1016/j.stem.2009.05.021 · DOI · Paper page
  41. 10.1038/msb.2011.37 · DOI
  42. 10.1038/nprot.2008.211 · DOI · Paper page
  43. 10.1049/iet-syb:20070075 · DOI
  44. 10.1038/nmeth.1436 · DOI · Paper page
  45. 10.1016/j.copbio.2008.06.005 · DOI
  46. 10.1126/science.292.5518.929 · DOI · Paper page
  47. 10.1073/pnas.0812099106 · DOI
  48. 10.1016/j.drudis.2009.07.001 · DOI
  49. 10.1038/nchembio.216 · DOI · Paper page
  50. 10.1016/j.cell.2010.09.048 · DOI · Paper page
  51. 10.1038/nrm2208 · DOI · Paper page
  52. 10.1146/annurev.biochem.76.061005.090816 · DOI · Paper page
  53. 10.1074/mcp.R000001-MCP201 · DOI · Paper page
  54. 10.1038/nprot.2007.197 · DOI
  55. 10.1073/pnas.1332608100 · DOI · Paper page
  56. 10.1016/j.cell.2011.05.006 · DOI · Paper page
  57. 10.1074/mcp.M900517-MCP200 · DOI
  58. 10.1083/jcb.200805092 · DOI · Paper page
  59. 10.1038/nbt1289 · DOI
  60. 10.1038/msb.2008.75 · DOI · Paper page
  61. 10.1073/pnas.0706983105 · DOI · Paper page
  62. 10.1016/j.cell.2009.04.042 · DOI · Paper page
  63. 10.1038/nmeth.1541 · DOI · Paper page
  64. 10.1126/science.1176343 · DOI · Paper page
  65. 10.1126/science.1176495 · DOI · Paper page
  66. 10.1016/j.cell.2010.08.020 · DOI · Paper page
  67. 10.1038/msb.2011.40 · DOI
  68. 10.1186/1471-2164-11-S3-S10 · DOI
  69. 10.1038/msb.2010.41 · DOI
  70. 10.1126/science.1175668 · DOI · Paper page
  71. 10.1038/nmeth1005 · DOI · Paper page
  72. 10.1016/j.cbpa.2009.06.022 · DOI · Paper page
  73. 10.1002/pmic.200800454 · DOI · Paper page
  74. 10.1002/pmic.200300772 · DOI · Paper page
  75. 10.1042/BJ20101974 · DOI
  76. 10.1002/pmic.200900266 · DOI
  77. 10.1038/nprot.2009.194 · doi:10.1038/nprot.2009.194
  78. 10.1126/scisignal.2000482 · DOI · Paper page
  79. 10.1038/nmeth1048 · DOI · Paper page
  80. 10.1073/pnas.0708966105 · DOI · Paper page
  81. 10.1074/jbc.M110.205054 · DOI
  82. 10.1021/ja048659i · DOI
  83. 10.1093/nar/gkm902 · DOI · Paper page
  84. 10.1038/nrmicro2419 · DOI · Paper page
  85. 10.1074/mcp.M900463-MCP200 · DOI
  86. 10.1146/annurev.cellbio.22.010605.093503 · DOI · Paper page
  87. 10.1074/mcp.R110.006882 · DOI
  88. 10.1038/msb.2010.118 · DOI
  89. 10.1016/j.molcel.2011.08.025 · DOI · Paper page
  90. 10.1074/mcp.M111.013284 · DOI · Paper page
  91. 10.1007/978-1-61779-148-2_17 · DOI
  92. 10.1038/nrc2901 · DOI · Paper page
  93. 10.1016/j.cell.2008.08.012 · DOI · Paper page
  94. 10.1038/nbt.1611 · DOI · Paper page
  95. 10.1038/ncb1994 · DOI · Paper page
  96. 10.1016/j.molcel.2009.04.023 · DOI
  97. 10.1016/j.yjmcc.2011.06.003 · DOI
  98. 10.1038/nmeth.1302 · DOI
  99. 10.1016/j.cell.2010.11.017 · DOI · Paper page
  100. 10.1038/nbt.1905 · DOI · Paper page
  101. 10.1038/msb.2009.80 · DOI · Paper page
  102. 10.1126/scisignal.2001034 · DOI · Paper page
  103. 10.1126/science.1199484 · DOI · Paper page
  104. 10.1016/j.ejcb.2009.11.024 · DOI
  105. 10.1126/science.1172867 · DOI · Paper page
  106. 10.1126/scisignal.2000998 · DOI · Paper page
  107. 10.1126/scisignal.2000007 · DOI · Paper page
  108. 10.1126/science.1176615 · DOI · Paper page
  109. 10.1126/scisignal.2000102 · DOI
  110. 10.1038/nbt.1522 · DOI · Paper page
  111. 10.1038/msb.2008.2 · DOI
  112. 10.1016/j.molcel.2009.02.030 · DOI
  113. 10.1371/journal.pcbi.1000639 · DOI
  114. 10.1038/msb.2010.36 · DOI
  115. 10.1016/j.cell.2007.11.025 · DOI · Paper page
  116. 10.1073/pnas.0602101103 · DOI
  117. 10.1038/nbt.1566 · DOI
  118. 10.1038/nbt1328 · DOI · Paper page
  119. 10.1016/j.chembiol.2010.09.010 · DOI
  120. 10.1038/nrm2041 · DOI · Paper page
  121. 10.1126/science.1116598 · DOI · Paper page
  122. 10.1038/msb.2009.87 · DOI · Paper page
  123. 10.1039/b926287c · DOI
  124. 10.1186/1750-2187-3-11 · doi:10.1186/1750-2187-3-11
  125. 10.1038/msb.2008.53 · DOI · Paper page
  126. 10.1371/journal.pcbi.1000591 · DOI
  127. 10.1093/bioinformatics/btq054 · DOI · Paper page
  128. 10.1186/1471-2105-12-78 · DOI
  129. 10.1126/scisignal.2001813 · DOI
  130. 10.1021/pr8010099 · DOI · Paper page

Cited by

See all 410

Metadata

Authors
Bensimon, A., Heck, A. J. R., & Aebersold, R.
Venue
Annual Review of Biochemistry
Publisher
Annual Reviews
Published
2012-07-07
Volume
81
Issue
1
Pages
379-405
ISSN
  • 0066-4154 (ISSN-L)
  • 1545-4509
DOI
10.1146/annurev-biochem-072909-100424
OpenAlex
W2152687832
Cited by
410
References
23
FWCI
2.10
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Mass Spectrometry–Based Proteomics and Network Biology. https://app.cochat.ai/papers/10.1146/annurev-biochem-072909-100424
The paper
Bensimon, A., Heck, A. J. R., & Aebersold, R. (2012). Mass Spectrometry–Based Proteomics and Network Biology. Annual Review of Biochemistry. https://doi.org/10.1146/annurev-biochem-072909-100424

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.