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The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems
Abstract
An understanding of the interactions between nanoparticles and biological systems is of significant interest. Studies aimed at correlating the properties of nanomaterials such as size, shape, chemical functionality, surface charge, and composition with biomolecular signaling, biological kinetics, transportation, and toxicity in both cell culture and animal experiments are under way. These fundamental studies will provide a foundation for engineering the next generation of nanoscale devices. Here, we provide rationales for these studies, review the current progress in studies of the interactions of nanomaterials with biological systems, and provide a perspective on the long-term implications of these findings.
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“There is clear evidence that each of these parameters also influences the nature of the biomolecules bound [139–141], and that different coronas lead to different biodistributions of NPs in vivo, as indicated above and demonstrated by Wang et al. [142]”
From Particle toxicology and health - where are we? (2019) · cites this paper as [139]
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Metadata
- Authors
- Albanese, A., Tang, P. S., & Chan, W. C. W.
- Venue
- Annual Review of Biomedical Engineering
- Publisher
- Annual Reviews
- Published
- 2012-08-15
- Volume
- 14
- Issue
- 1
- Pages
- 1-16
- ISSN
- 1523-9829
- 1545-4274
- Cited by
- 3,633
- References
- 2
- Language
- en
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