The Transforming Growth Factor-beta Family

Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.

Postlethwaite, A. E., Keski-Oja, J., Moses, H. L., & Kang, A. H. (1987) · The Journal of experimental medicine · doi:10.1084/jem.165.1.251 · Cited by 777

Cell adhesion protein receptors as targets for transforming growth factor-$beta; action

IGNOTZ, R. (1987) · Cell · doi:10.1016/0092-8674(87)90146-2 · Cited by 485

Regulation of Cell Adhesion Receptors by Transforming Growth Factor-β

Ignotz, R. A., Heino, J., & Massagué, J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31270-x · Cited by 269

Myofibroblasts and mechano-regulation of connective tissue remodelling

Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290

Regulation of Wound Healing by Growth Factors and Cytokines

WERNER, S., & GROSE, R. (2003) · Physiological Reviews · doi:10.1152/physrev.2003.83.3.835 · Cited by 3,629

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

Hannon, G. J., & Beach, D. (1994) · Nature · doi:10.1038/371257a0 · Cited by 1,950

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

Sanford, L. P., Ormsby, I., Groot, A. C. G.-D., Sariola, H., Friedman, R., Boivin, G. P., Cardell, E. L., & Doetschman, T. (1997) · Development · doi:10.1242/dev.124.13.2659 · Cited by 1,447

A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype

Waterman, R. S., Tomchuck, S. L., Henkle, S. L., & Betancourt, A. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010088 · Cited by 1,238

Reactive microgliosis

Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

Reynisdóttir, I., Polyak, K., Iavarone, A., & Massagué, J. (1995) · Genes & Development · doi:10.1101/gad.9.15.1831 · Cited by 962

Mechanisms of normal and tumor-derived angiogenesis

Papetti, M., & Herman, I. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00389.2001 · Cited by 809

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation.

Laiho, M., DeCaprio, J. A., Ludlow, J. W., Livingston, D. M., & Massague, J. (1990) · Cell · doi:10.1016/0092-8674(90)90251-9 · Cited by 797

Transforming Growth Factor-β1 to the Bone

Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0001 · Cited by 710

Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components

Vukicevic, S., Kleinman, H. K., Luyten, F. P., Roberts, A. B., Roche, N. S., & Reddi, A. H. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90397-q · Cited by 696

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

Peles, E., Bacus, S. S., Koski, R. A., Lu, H. S., Wen, D., Ogden, S. G., Levy, R. B., & Yarden, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90131-u · Cited by 524

Drug-induced acute interstitial nephritis

Rossert, J. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.060002804.x · Cited by 488

Overcoming TGFβ-mediated immune evasion in cancer

Tauriello, D. V. F., Sancho, E., & Batlle, E. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00413-6 · Cited by 377

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

Diebold, R. J., Eis, M. J., Yin, M., Ormsby, I., Boivin, G. P., Darrow, B. J., Saffitz, J. E., & Doetschman, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12215 · Cited by 278

TGF‐β Latency: Biological Significance and Mechanisms of Activation

Gleizes, P., Munger, J. S., Nunes, I., Harpel, J. G., Mazzieri, R., Noguera, I., & Rifkin, D. B. (1997) · STEM CELLS · doi:10.1002/stem.150190 · Cited by 266

Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression

Li, P.-X., Wong, J., Ayed, A., Ngo, D., Brade, A. M., Arrowsmith, C., Austin, R. C., & Klamut, H. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909580199 · Cited by 254

Prominent role of TGF-β1 in thrombopoietin-induced myelofibrosis in mice

Chagraoui, H., Komura, E., Tulliez, M., Giraudier, S., Vainchenker, W., & Wendling, F. (2002) · Blood · doi:10.1182/blood-2002-04-1133 · Cited by 238

Antitumor Activity of EBV-specific T Lymphocytes Transduced With a Dominant Negative TGF-β Receptor

Foster, A. E., Dotti, G., Lu, A., Khalil, M., Brenner, M. K., Heslop, H. E., Rooney, C. M., & Bollard, C. M. (2008) · Journal of Immunotherapy · doi:10.1097/cji.0b013e318177092b · Cited by 210

TGF-β family co-receptor function and signaling

Nickel, J., Ten Dijke, P., & Mueller, T. D. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx126 · Cited by 198

Wound-Healing Studies in Transgenic and Knockout Mice

Grose, R., & Werner, S. (2004) · Molecular Biotechnology · doi:10.1385/mb:28:2:147 · Cited by 197

Delayed Wound Healing in Immunodeficient TGF-β1 Knockout Mice

Crowe, M. J., Doetschman, T., & Greenhalgh, D. G. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00010.x · Cited by 194

Increased Expression of Integrin αvβ5 Induces the Myofibroblastic Differentiation of Dermal Fibroblasts

Asano, Y., Ihn, H., Yamane, K., Jinnin, M., & Tamaki, K. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.041306 · Cited by 175

Ultraviolet Irradiation Alters Transforming Growth Factor β/Smad Pathway in Human Skin In Vivo

Quan, T., He, T., Kang, S., Voorhees, J. J., & Fisher, G. J. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01834.x · Cited by 169

Transforming growth factor-β1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-κB, JNK, and Ras signaling pathways

Park, J.-I., Lee, M.-G., Cho, K., Park, B.-J., Chae, K.-S., Byun, D.-S., Ryu, B.-K., Park, Y.-K., & Chi, S.-G. (2003) · Oncogene · doi:10.1038/sj.onc.1206478 · Cited by 168

Estrogen deficiency, T cells and bone loss

Pacifici, R. (2008) · Cellular Immunology · doi:10.1016/j.cellimm.2007.06.008 · Cited by 146

Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1).

Böttner, M., Laaff, M., Schechinger, B., Rappold, G., Unsicker, K., & Suter-Crazzolara, C. (1999) · Gene · doi:10.1016/s0378-1119(99)00309-1 · Cited by 144

Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention

Brioche, T., Pagano, A. F., Py, G., & Chopard, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.04.006 · Cited by 129

Induction of platelet‐derived growth factor A and B chains and over‐expression of their receptors in human pancreatic cancer

Ebert, M., Yokoyama, M., Friess, H., Kobrin, M. S., Büchler, M. W., & Korc, M. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910620507 · Cited by 125

Identification of a Gene Family Regulated by Transforming Growth Factor-β

Brunner, A., Chinn, J., Neubauer, M., & Purchio, A. F. (1991) · DNA and Cell Biology · doi:10.1089/dna.1991.10.293 · Cited by 124

Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment

Brown, N. F., & Marshall, J. F. (2019) · Cancers · doi:10.3390/cancers11091221 · Cited by 116

Hepatic senescence, the good and the bad

Huda, N., Liu, G., Hong, H., Yan, S., Khambu, B., & Yin, X.-M. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i34.5069 · Cited by 100

Iron Chelation by Deferoxamine Prevents Renal Interstitial Fibrosis in Mice with Unilateral Ureteral Obstruction

Ikeda, Y., Ozono, I., Tajima, S., Imao, M., Horinouchi, Y., Izawa-Ishizawa, Y., Kihira, Y., Miyamoto, L., Ishizawa, K., Tsuchiya, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089355 · Cited by 98

Disabled-2 (Dab2) Mediates Transforming Growth Factor β(TGFβ)-stimulated Fibronectin Synthesis through TGFβ-activatedKinase 1 and Activation of the JNKPathway

Hocevar, B. A., Prunier, C., & Howe, P. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501150200 · Cited by 97

The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation

Melrose, J., Shu, C., Whitelock, J. M., & Lord, M. S. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.01.008 · Cited by 96

Reducing mammary cancer risk through premature stem cell senescence

Boulanger, C. A., & Smith, G. H. (2001) · Oncogene · doi:10.1038/sj.onc.1204312 · Cited by 93

Regulation of Notch signaling genes during BMP2-induced differentiation of osteoblast precursor cells

de Jong, D. S., Steegenga, W. T., Hendriks, J. M. A., van Zoelen, E. J. J., Olijve, W., & Dechering, K. J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.150 · Cited by 74

Constitutive phosphorylation of focal adhesion kinase is involved in the myofibroblast differentiation of scleroderma fibroblasts

Mimura, Y., Ihn, H., Jinnin, M., Asano, Y., Yamane, K., & Tamaki, K. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23701.x · Cited by 70

Transforming growth factor-beta potently inhibits the viability- promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells

Jacobsen, F., Stokke, T., & Jacobsen, S. (1995) · Blood · doi:10.1182/blood.v86.8.2957.2957 · Cited by 71

Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor-beta in fetal hepatocytes in primary culture

Fabregat, I., Sanchez, A., Alvarez, A. M., Nakamura, T., & Benito, M. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00266-9 · Cited by 70

Autoinduction of mRNA and protein expression for transforming growth factor-?s in cultured cardiac cells

FLANDERS, K. (1995) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(95)90087-x · Cited by 41

Hypoplasia of endocrine and exocrine pancreas in homozygous transgenic TGF-β1

Moritani, M., Yamasaki, S., Kagami, M., Suzuki, T., Yamaoka, T., Sano, T., Hata, J.-I., & Itakura, M. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.08.007 · Cited by 37

Cuff electrode implantation around the sciatic nerve is associated with an upregulation of TNF-α and TGF-β1

Vince, V., Thil, M.-A., Gérard, A.-C., Veraart, C., Delbeke, J., & Colin, I. M. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.10.010 · Cited by 35

Exogenous Smad3 Accelerates Wound Healing in a Rabbit Dermal Ulcer Model

Sumiyoshi, K., Nakao, A., Setoguchi, Y., Okumura, K., & Ogawa, H. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22730.x · Cited by 31