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The Immunological Synapse
Abstract
The adaptive immune response is initiated by the interaction of T cell antigen receptors with major histocompatibility complex molecule-peptide complexes in the nanometer scale gap between a T cell and an antigen-presenting cell, referred to as an immunological synapse. In this review we focus on the concept of immunological synapse formation as it relates to membrane structure, T cell polarity, signaling pathways, and the antigen-presenting cell. Membrane domains provide an organizational principle for compartmentalization within the immunological synapse. T cell polarization by chemokines increases T cell sensitivity to antigen. The current model is that signaling and formation of the immunological synapse are tightly interwoven in mature T cells. We also extend this model to natural killer cell activation, where the inhibitory NK synapse provides a striking example in which inhibition of signaling leaves the synapse in its nascent, inverted state. The APC may also play an active role in immunological synapse formation, particularly for activation of naïve T cells.
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Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
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Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235
Cannabinoid-based drugs as anti-inflammatory therapeutics
Klein, T. W. (2005) · Nature Reviews Immunology · doi:10.1038/nri1602 · Cited by 728
LXR signaling couples sterol metabolism to proliferation in the acquired immune response
Bensinger, S. J., Bradley, M. N., Joseph, S. B., Zelcer, N., Janssen, E. M., Hausner, M. A., Shih, R., Parks, J. S., Edwards, P. A., Jamieson, B. D., et al. (2008) · Cell · doi:10.1016/j.cell.2008.04.052 · Cited by 711
Wilen, C. B., Tilton, J. C., & Doms, R. W. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006866 · Cited by 654
Le Floc’h, A., Allinne, J., Nagashima, K., Scott, G., Birchard, D., Asrat, S., Bai, Y., Lim, W. K., Martin, J., Huang, T., et al. (2020) · Allergy · doi:10.1111/all.14151 · Cited by 545
Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities
Nickoloff, B. J., & Nestle, F. O. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422147 · Cited by 544
Role of cholesterol in synapse formation and function
Pfrieger, F. W. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00024-5 · Cited by 325
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Yoshihara, Y., De Roo, M., & Muller, D. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.013 · Cited by 292
Tuning immune responses: diversity and adaptation of the immunological synapse
Friedl, P., den Boer, A. T., & Gunzer, M. (2005) · Nature Reviews Immunology · doi:10.1038/nri1647 · Cited by 276
Kawakami, N., Nägerl, U. V., Odoardi, F., Bonhoeffer, T., Wekerle, H., & Flügel, A. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050011 · Cited by 248
Stebbins, C. C., Watzl, C., Billadeau, D. D., Leibson, P. J., Burshtyn, D. N., & Long, E. O. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.17.6291-6299.2003 · Cited by 245
Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses
Javier, R. T., & Rice, A. P. (2011) · Journal of Virology · doi:10.1128/jvi.05410-11 · Cited by 198
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Courtney, A. H., Shvets, A. A., Lu, W., Griffante, G., Mollenauer, M., Horkova, V., Lo, W.-L., Yu, S., Stepanek, O., Chakraborty, A. K., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aaw8151 · Cited by 161
Ghittoni, R., Patrussi, L., Pirozzi, K., Pellegrini, M., Lazzerini, P. E., Capecchi, P. L., Pasini, F. L., & Baldari, C. T. (2005) · The FASEB Journal · doi:10.1096/fj.04-2702fje · Cited by 154
Lymphocytes and the foreign body response: lymphocyte enhancement of macrophage adhesion and fusion
Brodbeck, W. G., MacEwan, M., Colton, E., Meyerson, H., & Anderson, J. M. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30313 · Cited by 146
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Wu, L., Martin, T. D., Carrington, M., & KewalRamani, V. N. (2004) · Virology · doi:10.1016/j.virol.2003.09.028 · Cited by 131
Immunological synapse and microclusters: the site for recognition and activation of T cells
Saito, T., & Yokosuka, T. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.03.014 · Cited by 124
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Wei, S. H., Parker, I., Miller, M. J., & Cahalan, M. D. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00076.x · Cited by 117
Weng, J., Krementsov, D. N., Khurana, S., Roy, N. H., & Thali, M. (2009) · Journal of Virology · doi:10.1128/jvi.00163-09 · Cited by 89
MacEwan, M. R., Brodbeck, W. G., Matsuda, T., & Anderson, J. M. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30316 · Cited by 63
LFA-1 Engagement Triggers T Cell Polarization at the HIV-1 Virological Synapse
Starling, S., & Jolly, C. (2016) · Journal of Virology · doi:10.1128/jvi.01152-16 · Cited by 33
Taye, M., Lee, W., Caetano-Anolles, K., Dessie, T., Cho, S., Jong Oh, S., Lee, H.-K., & Kim, H. (2018) · Cogent Food & Agriculture · doi:10.1080/23311932.2018.1552552 · Cited by 26
ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion
Jung, S. H., Yoo, E. H., Yu, M. J., Song, H. M., Kang, H. Y., Cho, J.-Y., & Lee, J. R. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501913 · Cited by 19
HIV-Captured DCs Regulate T Cell Migration and Cell-Cell Contact Dynamics to Enhance Viral Spread
Koh, W. H., Lopez, P., Ajibola, O., Parvarchian, R., Mohammad, U., Hnatiuk, R., Kindrachuk, J., & Murooka, T. T. (2020) · iScience · doi:10.1016/j.isci.2020.101427 · Cited by 17
Transmission of pseudorabies virus from immune-masked blood monocytes to endothelial cells
Van de Walle, G. R., Favoreel, H. W., Nauwynck, H. J., Mettenleiter, T. C., & Pensaert, M. B. (2003) · Journal of General Virology · doi:10.1099/vir.0.18796-0 · Cited by 15
Metadata
- Authors
- Bromley, S. K., Burack, W. R., Johnson, K. G., Somersalo, K., Sims, T. N., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2001-04
- Volume
- 19
- Issue
- 1
- Pages
- 375-396
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2116364705
- Cited by
- 979
- References
- 1
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- closed
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