Cited by 2,083Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

The DOI matches its Crossref record; 190 of the 192 references it cites were found in a registry or an index.

CORTICAL PLASTICITY: From Synapses to Maps

Buonomano, Dean V., Merzenich, Michael M.·1998·Annual Review of Neuroscience

Open this paper in CoChat — free account

Abstract

It has been clear for almost two decades that cortical representations in adult animals are not fixed entities, but rather, are dynamic and are continuously modified by experience. The cortex can preferentially allocate area to represent the particular peripheral input sources that are proportionally most used. Alterations in cortical representations appear to underlie learning tasks dependent on the use of the behaviorally important peripheral inputs that they represent. The rules governing this cortical representational plasticity following manipulations of inputs, including learning, are increasingly well understood. In parallel with developments in the field of cortical map plasticity, studies of synaptic plasticity have characterized specific elementary forms of plasticity, including associative long-term potentiation and long-term depression of excitatory postsynaptic potentials. Investigators have made many important strides toward understanding the molecular underpinnings of these fundamental plasticity processes and toward defining the learning rules that govern their induction. The fields of cortical synaptic plasticity and cortical map plasticity have been implicitly linked by the hypothesis that synaptic plasticity underlies cortical map reorganization. Recent experimental and theoretical work has provided increasingly stronger support for this hypothesis. The goal of the current paper is to review the fields of both synaptic and cortical map plasticity with an em…

Integrity signals

Registry

Crossref · 10.1146/annurev.neuro.21.1.149

Cites

190 of 190 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Receptive fields and functional architecture of monkey striate cortex
Hubel, D. H., & Wiesel, T. N. (1968) · The Journal of Physiology · doi:10.1113/jphysiol.1968.sp008455 · Cited by 6,685
The Organization of Behavior; A Neuropsychological Theory.
Attneave, F., B., M., & Hebb, D. O. (1950) · The American Journal of Psychology · doi:10.2307/1418888 · Cited by 5,146
The Organization of Behavior: A Neuropsychological Theory
(1950) · JAMA · doi:10.1001/jama.1950.02910470083028 · Cited by 4,272
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
Markram, H., Lübke, J., Frotscher, M., & Sakmann, B. (1997) · Science · doi:10.1126/science.275.5297.213 · Cited by 3,832
Synaptic Activity and the Construction of Cortical Circuits
Katz, L. C., & Shatz, C. J. (1996) · Science · doi:10.1126/science.274.5290.1133 · Cited by 3,048
Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex
Bienenstock, E., Cooper, L., & Munro, P. (1982) · The Journal of Neuroscience · doi:10.1523/jneurosci.02-01-00032.1982 · Cited by 2,896
Untitled work
(1909) · Cited by 2,575
Increased Cortical Representation of the Fingers of the Left Hand in String Players
Elbert, T. R., Pantev, C., Wienbruch, C., Rockstroh, B. S., & Taub, E. (1995) · Science · doi:10.1126/science.270.5234.305 · Cited by 2,053
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.
Dudek, S. M., & Bear, M. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4363 · Cited by 1,708

Show all 192 references

Research works printed but not linked: 8

Buonomano DV, 1996, Soc. Neurosci. Abstr., 22, 1743
Clark SA, 1986, Soc. Neurosci. Abstr., 12, 391
Heinen SJ, 1981, Exp. Brain Res., 83, 670
Merzenich MM. 1987. Dynamic neocortical processes and the origins of higher brain functions. In The Neural and Molecular Bases of Learning , ed. JP Changeux, M Konishi, pp. 337–58. Chichester: Wiley
Merzenich MM, Jenkins WM. 1992. Cortical plasticity, learning, and learning dysfunction. In Maturational Windows and Adult Cortical Plasticity , ed. B Julesz, I Kovacs, pp. 1–26. Reading: Addison-Wesley
Merzenich MM, Recanzone GH, Jenkins WM, Nudo RJ. 1990b. How the brain functionally rewires itself. In Natural and Artificial Parallel Computation , ed. M Arbib, D Robinson, pp. 177–210. Cambridge: MIT Press
Schwaber MK, 1993, Am. J. Otol., 14, 252
Tyler T, 1990, Semin. Neurosci., 2, 365

Sorted by citations

Items 401–500 of 1,002

The Potential for Utilizing the “Mirror Neurone System” to Enhance Recovery of the Severely Affected Upper Limb Early after Stroke: A Review and Hypothesis
Pomeroy, V. M., Clark, C. A., Miller, J. S. G., Baron, J., Markus, H. S., & Tallis, R. C. (2005) · Neurorehabilitation and neural repair · doi:10.1177/1545968304274351 · Cited by 103
Brain Imaging Studies of the Anatomical and Functional Consequences of Preterm Birth for Human Brain Development
Peterson, B. S. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1301.023 · Cited by 104
Inosine Alters Gene Expression and Axonal Projections in Neurons Contralateral to a Cortical Infarct and Improves Skilled Use of the Impaired Limb
Zai, L., Ferrari, C., Subbaiah, S., Havton, L. A., Coppola, G., Strittmatter, S., Irwin, N., Geschwind, D., & Benowitz, L. I. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0414-09.2009 · Cited by 104
“, 2005) and other types of CNS injury (Raisman, 1969; Lynch et al., 1976; Darian-Smith and Gilbert, 1994; Buonomano and Merzenich, 1998; Z’Graggen et al., 2000; Weidner et al., 2001; Bareyre et al., 2004).”
Background
Functional Organization of Primary Somatosensory Cortex Depends on the Focus of Attention
Braun, C., Haug, M., Wiech, K., Birbaumer, N., Elbert, T. R., & Roberts, L. E. (2002) · NeuroImage · doi:10.1006/nimg.2002.1277 · Cited by 104
Different forms of homeostatic plasticity are engaged with distinct temporal profiles
Karmarkar, U. R., & Buonomano, D. V. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04692.x · Cited by 107
Self-citation
Non-Invasive Brain Stimulation: Enhancing Motor and Cognitive Functions In Healthy Old Subjects
Zimerman, M., & Hummel, F. C. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00149 · Cited by 105
“These processes are most likely based on unmasking of excitatory connections within the cortex allowing rapid changes in motor representations (Huntley, 1997) by reducing the activity of existing inhibitory ones (Buonomano and Merzenich, 1998).”
Sensory Experience and Cortical Rewiring
Barnes, S. J., & Finnerty, G. T. (2009) · The Neuroscientist · doi:10.1177/1073858409343961 · Cited by 104
Adding electrical stimulation during standard rehabilitation after stroke to improve motor function. A systematic review and meta-analysis
Sharififar, S., Shuster, J. J., & Bishop, M. D. (2018) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2018.06.005 · Cited by 103
Peripherally Induced Reconditioning of the Central Nervous System: A Proposed Mechanistic Theory for Sustained Relief of Chronic Pain with Percutaneous Peripheral Nerve Stimulation
Deer, T. R., Eldabe, S. S., Falowski, S. M., Huntoon, M. A., Staats, P. S., Cassar, I. R., Crosby, N. D., & Boggs, J. W. (2021) · Journal of Pain Research · doi:10.2147/jpr.s297091 · Cited by 103
Language Specificity in Speech Perception: Perception of Mandarin Tones by Native and Nonnative Listeners
Huang, T., & Johnson, K. A. (2011) · Phonetica · doi:10.1159/000327392 · Cited by 101
“As many studies [e.g. Buonomano and Merzenich, 1998; Kilgard and Merzenich, 1998; Stiles, 2000; Zhang et al., 2006] have shown, our neural system exhibits remarkable plasticity, even late in life.”
Background
Cortical Plasticity Following Nerve Transfer in the Upper Extremity
Anastakis, D. J., Malessy, M. J. A., Chen, R. E., Davis, K. D., & Mikulis, D. J. (2008) · Hand Clinics · doi:10.1016/j.hcl.2008.04.005 · Cited by 104
“Unmasking can produce changes that occur immediately following deafferentation and are likely caused by reduction of GABA-ergic inhibition to preexisting projections from adjacent cortical regions, or unmasking at subcortical levels leading to activation of thalamocortical projections not previously activated by the d…”
Background
Transcutaneous electrical stimulation on acupuncture points improves muscle function in subjects after acute stroke: A randomized controlled trial
Yan, T., & Hui-Chan, C. (2009) · Journal of Rehabilitation Medicine · doi:10.2340/16501977-0325 · Cited by 103
“In this context, the increased afferent signals triggered by repeated TES in our study might produce long-term potentiation and induce neural plasticity (20, 24).”
BackgroundInfluential
Plasticity in the Developing Auditory Cortex: Evidence from Children with Sensorineural Hearing Loss and Auditory Neuropathy Spectrum Disorder
Cardon, G. J., Campbell, J., & Sharma, A. (2012) · Journal of the American Academy of Audiology · doi:10.3766/jaaa.23.6.3 · Cited by 104
“…Boulder, CO 80309-0409; Phone: 303-492-5089; Fax: 303- 492-3274; E-mail: anu.sharma@colorado.edu This research was supported by NIH grant R01 DC006257 to A.S. environmental input rather than innate mechanisms (see Buonomano and Merzenich, 1998, for a review; Hartmann et al, 1997; Kral, 2007).”
Background
The neural basis of visual object learning
de Beeck, H. O., & Baker, C. I. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.11.002 · Cited by 106
“The pervasive role of experience in visual processing Sensory information processing in adult mammalian brains is highly malleable [ 1 ] with neural processing at all levels adapting to both the short- and long-term properties of the incoming information.”
Environmental noise exposure degrades normal listening processes
Zhou, X., & Merzenich, M. M. (2012) · Nature Communications · doi:10.1038/ncomms1849 · Cited by 106
Self-citation
Improving Hand Function in Stroke Survivors: A Pilot Study of Contralaterally Controlled Functional Electric Stimulation in Chronic Hemiplegia
Knutson, J. S., Harley, M. Y., Hisel, T. Z., & Chae, J. (2007) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2007.01.003 · Cited by 102
Immobilization induces changes in presynaptic control of group Ia afferents in healthy humans
Lundbye‐Jensen, J., & Nielsen, J. B. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.156547 · Cited by 108
“Experience-driven central nervous plasticity has been extensively documented at a cortical level in relation to motor learning (Buonomano & Merzenich, 1998; Sanes & Donoghue, 2000) and there is growing evidence that the cortical plasticity accompanying motor skill learning is paralleled by changes…”
Background
Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice
Hasan, M. T., Hernández-González, S., Dogbevia, G., Treviño, M., Bertocchi, I., Gruart, A., & Delgado-Garcia, J. M. (2013) · Nature Communications · doi:10.1038/ncomms3258 · Cited by 111
Sustained increase of somatosensory cortex excitability by tactile coactivation studied by paired median nerve stimulation in humans correlates with perceptual gain
Höffken, O., Veit, M., Knossalla, F., Lissek, S., Bliem, B., Ragert, P., Dinse, H. R., & Tegenthoff, M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.140079 · Cited by 101
Internal body state influences topographical plasticity of sensory representations in the rat gustatory cortex
Accolla, R., & Carleton, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708927105 · Cited by 101
“Our results are in general agreement with learning-induced cortical map plasticity reported in other sensory areas (1, 22).”
BackgroundResultInfluential
Enhanced reading by training with imposed time constraint in typical and dyslexic adults
Breznitz, Z., Shaul, S., Horowitz‐Kraus, T., Sela, I., Nevat, M., & Karni, A. (2013) · Nature Communications · doi:10.1038/ncomms2488 · Cited by 100
Perception of Average Value in Multiclass Scatterplots
Gleicher, M. L., Correll, M., Nothelfer, C. E., & Franconeri, S. (2013) · IEEE Transactions on Visualization and Computer Graphics · doi:10.1109/tvcg.2013.183 · Cited by 101
“Our experiments seek to confirm these performance predictions.”
Result
The Cortical Representation of the Hand in Macaque and Human Area S-I: High Resolution Optical Imaging
Shoham, D., & Grinvald, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06820.2001 · Cited by 101
Estradiol-dependent modulation of auditory processing and selectivity in songbirds
Maney, D. L., & Pinaud, R. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.12.002 · Cited by 100
“Which stimuli are behaviorally relevant is in many cases learned, and sensory systems revised accordingly – for example by increasing the neural space devoted to the representation of a stimulus (for reviews, see [29,52,91,160,216]) or the magnitude of the neural response to that stimulus [75,87,181].”
Background
Neurobiology of Rehabilitation
Dobkin, B. H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1315.024 · Cited by 97
Chapter 59 Paired associative stimulation
Claßen, J., Wolters, A., Stefan, K., Wycislo, M., Sandbrink, F., Schmidt, A., & Kunesch, E. (2004) · Supplements to Clinical neurophysiology · doi:10.1016/s1567-424x(09)70395-2 · Cited by 100
Histoire de l’implant cochléaire
Chouard, C. H. (2010) · Annales françaises d Oto-rhino-laryngologie et de Pathologie Cervico-faciale · doi:10.1016/j.aforl.2010.09.003 · Cited by 99
Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System
Augustin, S. M., & Lovinger, D. M. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00508 · Cited by 100
Perceptual training improves syllable identification in new and experienced hearing aid users
Stecker, G. C., Bowman, G. A., Yund, E. W., Herron, T. J., Roup, C. M., & Woods, D. L. (2006) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2005.11.0171 · Cited by 96
Transcranial Direct Current Stimulation Augments Perceptual Sensitivity and 24-Hour Retention in a Complex Threat Detection Task
Falcone, B., Coffman, B. A., Clark, V. P., & Parasuraman, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034993 · Cited by 98
“First, anodal stimulation with tDCS may increase neuronal plasticity [32,33], thereby enhancing the rate of learning compared to sham stimulation, and therefore also to retention of learning.”
Background
The emergence of a new paradigm in ape language research
Shanker, S. G., & King, B. J. (2002) · Behavioral and Brain Sciences · doi:10.1017/s0140525x02000110 · Cited by 100
Wiring Stability of the AdultDrosophilaOlfactory Circuit after Lesion
Berdnik, D., Chihara, T., Couto, A., & Luo, L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4941-05.2006 · Cited by 101
Receptive Fields in the Rat Piriform Cortex
Wilson, D. A. (2001) · Chemical Senses · doi:10.1093/chemse/26.5.577 · Cited by 98
Neural Science
Albright, T. D., Jessell, T. M., Kandel, E. R., & Posner, M. I. (2000) · Cell · doi:10.1016/s0092-8674(00)00251-8 · Cited by 98
Neural Darwinism and consciousness
Seth, A. K., & Baars, B. J. (2004) · Consciousness and Cognition · doi:10.1016/j.concog.2004.08.008 · Cited by 102
Brain plasticity and motor practice in cognitive aging
Cai, L., Chan, J. S. Y., Yan, J. H., & Peng, K. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00031 · Cited by 112
“…the existing cortical structures or mechanisms via neurogenesis, gliogenesis, or by changing the strength of inter-neuronal connections (synaptogenesis) (Buonomano and Merzenich, 1998; Cotman and Berchtold, 2002; Dong and Greenough, 2004; Voelcker-Rehage and Willimczik, 2006; Ponti et al., 2008).”
BackgroundInfluential
A randomized study of computerized working memory training and effects on functioning in everyday life for patients with brain injury
Björkdahl, A., Åkerlund, E., Svensson, S., & Esbjörnsson, E. (2013) · Brain Injury · doi:10.3109/02699052.2013.830196 · Cited by 98
Harnessing plasticity to understand learning and treat disease
Kilgard, M. P. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.09.002 · Cited by 93
Principles of recovery from traumatic brain injury: Reorganization of functional networks
Castellanos, N. P., Leyva, I., Buldú, J. M., Bajo, R., Paúl, N., Cuesta, P., Ordóñez, V. E., Pascua, C. L., Boccaletti, S., Maestú, F., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.12.046 · Cited by 96
“Functional connectivity patterns have been proved to be altered by brain injury but, could they also reflect the capability of brain to compensate for such injury?One could think that it is possible, since brain plasticity produces changes at multiple levels of neuronal reorganization, from synapses to corticalmaps an…”
Pairing Speech Sounds With Vagus Nerve Stimulation Drives Stimulus-specific Cortical Plasticity
Engineer, C. T., Engineer, N. D., Riley, J. R., Seale, J. D., & Kilgard, M. P. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.01.408 · Cited by 95
“The tuning properties of these neurons can be altered by a variety of conditions [2].”
Background
Neural representations of the body in 60‐day‐old human infants
Meltzoff, A. N., Saby, J. N., & Marshall, P. J. (2018) · Developmental Science · doi:10.1111/desc.12698 · Cited by 95
“Changes in somatotopic body representations following training (or injury) are foundational findings in human cognitive neuroscience (Buonomano & Merzenich, 1998; Bütefisch et al., 2000; Elbert, Pantev, Wienbruch, Rockstroh, & Taub, 1995) as well as in animal models (Kaas & Rothemund, 2006).”
Background
Increased Excitability Induced in the Primary Motor Cortex by Transcranial Ultrasound Stimulation
Gibson, B. C., Sanguinetti, J. L., Badran, B. W., Yu, A. B., Klein, E. P., Abbott, C., Hansberger, J. T., & Clark, V. P. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01007 · Cited by 95
Improved auditory spatial acuity in visually deprived ferrets
King, A. J., & Parsons, C. H. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00821.x · Cited by 98
Neuronal Responses in Cat Primary Auditory Cortex to Electrical Cochlear Stimulation. III. Activation Patterns in Short- and Long-Term Deafness
Raggio, M. W., & Schreiner, C. E. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.6.3506 · Cited by 95
The Neuroscience of Language
Friedemann Pulvermüller, A. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511615528.002 · Cited by 94
Infant brain responses to felt and observed touch of hands and feet: an MEG study
Meltzoff, A. N., Ramírez, R. R., Saby, J. N., Larson, E. B., Taulu, S., & Marshall, P. J. (2018) · Developmental Science · doi:10.1111/desc.12651 · Cited by 94
“A large literature with adult human and nonhuman primates has documented the properties of these “neural body maps” in S1, including demonstrations of experiencedependent plasticity (e.g., Buonomano & Merzenich, 1998; Elbert, Pantev, Wienbruch, Rockstroh, & Taub, 1995; Kaas, 1991).”
Pathophysiology of Pain and Mechanisms of Neuromodulation: A Narrative Review (A Neuron Project)
Karcz, M., Abd-Elsayed, A. A., Chakravarthy, K. V., Aman, M. M., Strand, N. H., Malinowski, M. N., Latif, U., Dickerson, D. M., Suvar, T., Lubenow, T. R., et al. (2024) · Journal of Pain Research · doi:10.2147/jpr.s475351 · Cited by 130
“162 176”
Dendritic synapse location and neocortical spike-timing-dependent plasticity
Froemke, R. C. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00029 · Cited by 99
“Synaptic strength is not fixed, but can be altered by the pattern of neural activity (Buonomano and Merzenich, 1998; Feldman, 2009).”
Neural changes in the auditory cortex of awake guinea pigs after two tinnitus inducers: salicylate and acoustic trauma
Noreña, A. J., Moffat, G., Blanc, J.-L., Pézard, L., & Cazals, Y. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.063 · Cited by 94
Cortical representation of vowels reflects acoustic dissimilarity determined by formant frequencies
Obleser, J., Elbert, T. R., Lahiri, A., & Eulitz, C. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(02)00193-3 · Cited by 91
Rewiring neural interactions by micro-stimulation
Rebesco, J. M. (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00039 · Cited by 94
Central and peripheral nervous system excitability in restless legs syndrome.
Lanza, G., Bachmann, C., Ghorayeb, I., Wang, Y.-P., Ferri, R., & Paulus, W. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2016.05.010 · Cited by 96
Contralaterally Controlled Functional Electrical Stimulation for Upper Extremity Hemiplegia
Knutson, J. S., Harley, M. Y., Hisel, T. Z., Hogan, S. D., Maloney, M. M., & Chae, J. (2011) · Neurorehabilitation and neural repair · doi:10.1177/1545968311419301 · Cited by 93
Enhancing Cognitive Training Through Aerobic Exercise After a First Schizophrenia Episode: Theoretical Conception and Pilot Study
Nuechterlein, K. H., Ventura, J., McEwen, S. C., Gretchen‐Doorly, D., Vinogradov, S., & Subotnik, K. L. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw007 · Cited by 94
Neural Substrates of Sound–Touch Synesthesia after a Thalamic Lesion
Beauchamp, M. S., & Ro, T. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3872-08.2008 · Cited by 94
“Experiment 3 When sensory cortex does not receive inputs from its normal sensory receptors, it can reorganize to become responsive to other inputs (Buonomano and Merzenich, 1998).”
Background
Single-Neuron Discharge Properties and Network Activity in Dissociated Cultures of Neocortex
Giugliano, M., Darbon, P., Arsiero, M., Lüscher, H.-R., & Streit, J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00067.2004 · Cited by 94
Neuroscience and adult learning
Cozolino, L., & Sprokay, S. L. (2006) · New Directions for Adult and Continuing Education · doi:10.1002/ace.214 · Cited by 92
Repetitive Transcranial Magnetic Stimulation-Induced Changes in Sensorimotor Coupling Parallel Improvements of Somatosensation in Humans
Pleger, B., Blankenburg, F., Bestmann, S., Ruff, C. C., Wiech, K., Stephan, K. E., Friston, K. J., & Dolan, R. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4097-05.2006 · Cited by 94
Motor control and cerebral hemispheric specialization in highly qualified judo wrestlers
Mikheev, M. M., Möhr, C., Afanasiev, S., Landis, T., & Thut, G. (2002) · Neuropsychologia · doi:10.1016/s0028-3932(01)00227-5 · Cited by 92
Visual Neglect Following Stroke: Current Concepts and Future Focus
Ting, D. S. J., Pollock, A., Dutton, G. N., Doubal, F., Ting, D. S. W., Thompson, M., & Dhillon, B. (2011) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2010.08.001 · Cited by 100
The reorganization of somatosensory and motor cortex after peripheral nerve or spinal cord injury in primates
Kaas, J. H. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)28015-1 · Cited by 91
Dynamic organization of the somatosensory cortex induced by motor activity
Braun, C., Heinz, U., Schweizer, R., Wiech, K., Birbaumer, N., & Topka, H. R. (2001) · Brain · doi:10.1093/brain/124.11.2259 · Cited by 91
Repair of spinal cord injuries: where are we, where are we going?
Fawcett, J. W. (2002) · Spinal Cord · doi:10.1038/sj.sc.3101328 · Cited by 91
Current and future options for the management of phantom-limb pain
Knotková, H., Cruciani, Tronnier, & Rasche (2012) · Journal of Pain Research · doi:10.2147/jpr.s16733 · Cited by 90
Directing neural plasticity to understand and treat tinnitus
Engineer, N. D., Møller, A. R., & Kilgard, M. P. (2012) · Hearing Research · doi:10.1016/j.heares.2012.10.001 · Cited by 90
Age-related changes in primary somatosensory cortex of rats: evidence for parallel degenerative and plastic-adaptive processes
Godde, B., Berkefeld, T., David-Jürgens, M., & Dinse, H. R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00061-1 · Cited by 90
Quantifying the Adequacy of Neural Representations for a Cross-Language Phonetic Discrimination Task: Prediction of Individual Differences
Raizada, R. D. S., Tsao, F., Liu, H.-M., & Kuhl, P. K. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp076 · Cited by 90
Learning-Related Gray and White Matter Changes in Humans
Taubert, M., Villringer, A., & Ragert, P. (2011) · The Neuroscientist · doi:10.1177/1073858411419048 · Cited by 95
A dynamic zone defines interneuron remodeling in the adult neocortex
Lee, W.-C. A., Chen, J. L., Huang, H., Leslie, J. H., Amitai, Y., So, P. T., & Nedivi, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810149105 · Cited by 87
“D decades of evidence for functional plasticity of the adult brain, manifested in our ability to learn and the continual adaptation of primary sensory maps (1, 2), the existence and role of structural remodeling (3, 4) in circuit plasticity remains controversial.”
Background
Improvement of sensorimotor functions in old age by passive sensory stimulation
Kalisch, T. (2008) · Clinical Interventions in Aging · doi:10.2147/cia.s3174 · Cited by 86
“Animal studies ﬁ rst demonstrated that cortical maps are enlarged as a result of training (Recanzone et al 1992, 1993; Dinse and Merzenich 2002).”
Functional reorganization and stability of somatosensory-motor cortical topography in a tetraplegic subject with late recovery
Corbetta, M., Burton, H., Sinclair, R. J., Conturo, T. E., Akbudak, E., & McDonald, J. W. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262669099 · Cited by 89
Alzheimer's disease as a loss of differentiation control in a subset of neurons that retain immature features in the adult brain
Arendt, T. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00216-5 · Cited by 91
A Symbiotic Brain-Machine Interface through Value-Based Decision Making
Mahmoudi, B., & Sanchez, J. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014760 · Cited by 87
“Brain plasticity is an important design factor of BMI and it has been observed in the context of many research areas [47,48].”
Background
Time course of induction of increased human motor cortex excitability by nerve stimulation
McKay, D. R., Brooker, R., Giacomin, P., Ridding, M. C., & Miles, T. S. (2002) · Neuroreport · doi:10.1097/00001756-200207190-00011 · Cited by 88
The Origin of Cortical Surround Receptive Fields Studied in the Barrel Cortex
Fox, K. D., Wright, N. F., Wallace, H., & Glazewski, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-23-08380.2003 · Cited by 88
The crucial role of motivation and emotion in classroom learning
Boekaerts, M. (2010) · Educational research and innovation · doi:10.1787/9789264086487-6-en · Cited by 99
Sensory Loss by Selected Whisker Removal Produces Immediate Disinhibition in the Somatosensory Cortex of Behaving Rats
Kelly, M. K., Carvell, G. E., Kodger, J. M., & Simons, D. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-09117.1999 · Cited by 88
Complexity of sensory environment drives the expression of candidate-plasticity gene, nerve growth factor induced-A
Pinaud, R., Tremere, L. A., Penner, M. R., Hess, F. F., Robertson, H. A., & Currie, R. W. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00094-5 · Cited by 87
Is human face recognition lateralized to the right hemisphere due to neural competition with left-lateralized visual word recognition? A critical review
Rossion, B., & Lochy, A. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02370-0 · Cited by 99
Mindful movement and skilled attention
Clark, D., Schumann, F., & Mostofsky, S. H. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00297 · Cited by 102
“…neuronal hardware adapts in functionally specific ways to the particular experience of the organism (for reviews of a broad range of neuronal plasticity results, see e.g., Kaas, 1991; Buonomano and Merzenich, 1998; Simoncelli and Olshausen, 2001; Sur and Leamey, 2001; PascualLeone et al., 2005).”
Background
Assessment of sensorimotor cortical representation asymmetries and motor skills in violin players
Schwenkreis, P., Tom, S. E., Ragert, P., Pleger, B., Tegenthoff, M., & Dinse, H. R. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05894.x · Cited by 96
Direct and crossed effects of somatosensory stimulation on neuronal excitability and motor performance in humans
Veldman, M. P., Maffiuletti, N. A., Hallett, M., Zijdewind, I., & Hortobágyi, T. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.013 · Cited by 86
Exploration of a novel environment leads to the expression of inducible transcription factors in barrel-related columns.
Staiger, J. F., Bisler, S., Schleicher, A., Gass, P., Stehle, J., & Zilles, K. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00166-4 · Cited by 92
Short-term high-frequency transcutaneous electrical nerve stimulation decreases human motor cortex excitability
Mima, T., Oga, T., Rothwell, J. C., Satow, T., Yamamoto, J., Toma, K., Fukuyama, H., Shibasaki, H., & Nagamine, T. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.10.045 · Cited by 86
Old dogs learning new tricks: Neuroplasticity beyond the juvenile period
Lillard, A. S., & Erişir, A. (2011) · Developmental Review · doi:10.1016/j.dr.2011.07.008 · Cited by 98
“…with research on enriched environments and the development of Hebbian theory (Rosenzweig, 2007), and it is currently a ''hot topic'' in psychology and neuroscience (e.g., Bavelier, Levi, Li, Dan, & Hensch, 2010; Buonomano & Merzenich, 1998; Feldman, 2009; Holtmaat & Svoboda, 2009; Nelson, 1999).”
Background
The Search for General Abilities and Basic Capacities: Theoretical Implications from the Modifiability and Complexity of Mechanisms Mediating Expert Performance
Ericsson, K. A. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511615801.006 · Cited by 87
Augmentation-related brain plasticity
Pino, G. D., Maravita, A., Zollo, L., Guglielmelli, E., & Lazzaro, V. D. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00109 · Cited by 83
“An initial unmasking of already present, but inactive, connections is the effect of increased cortical excitability due to a reduction of GABA-mediated inhibition (Jones, 1993) and an increase of NMDA-mediated activation (Buonomano and Merzenich, 1998).”
Background
Patterned Vision Causes CRE-Mediated Gene Expression in the Visual Cortex through PKA and ERK
Cancedda, L., Putignano, E., Impey, S., Maffei, L., Ratto, G. M., & Pizzorusso, T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07012.2003 · Cited by 84
Patient outcome following a thoracodorsal to musculocutaneous nerve transfer for reconstruction of elbow flexion
Novak, C. B., Mackinnon, S. E., & Tung, T. H. H. (2002) · British Journal of Plastic Surgery · doi:10.1054/bjps.2002.3859 · Cited by 84
Enhanced neural activity in frontal and cerebellar circuits after cognitive training in children with attention‐deficit/hyperactivity disorder
Hoekzema, E. A., Carmona, S., Tremols, V., Gispert, J. D., Guitart‐Masip, M., Fauquet, J., Rovira, M., Bielsa, A., Soliva, J. C., Tomas, X., et al. (2010) · Human Brain Mapping · doi:10.1002/hbm.20988 · Cited by 86
Roles of NMDA receptor NR2A and NR2B subtypes for long‐term depression in the anterior cingulate cortex
Toyoda, H., Zhao, M., & Zhuo, M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04236.x · Cited by 84
Short-term training in the Go/Nogo task: Behavioural and neural changes depend on task demands
Benikos, N., Johnstone, S. J., & Roodenrys, S. J. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.12.001 · Cited by 90
“…which underlie executive functions are amenable to training and experience (for a review see Kelly and Garavan, 2005), superseding the traditionally held belief that the human adult brain is hardwired and resistant to change (Buonomano and Merzenich, 1998; Kelly et al., 2006b; Raskin et al., 2011).”
Background
Sensory Experience Alters Cortical Connectivity and Synaptic Function Site Specifically
Cheetham, C. E. J., Hammond, M. S. L., Edwards, C. E. J., & Finnerty, G. T. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5143-06.2007 · Cited by 85
Light-Induced Structural and Functional Plasticity in Drosophila Larval Visual System
Yuan, Q., Xiang, Y., Yan, Z., Han, C., Jan, L. Y., & Jan, Y. N. (2011) · Science · doi:10.1126/science.1207121 · Cited by 83
Mechanisms underlying human motor system plasticity
Boroojerdi, B., Ziemann, U., Chen, R. E., Bütefisch, C. M., & Cohen, L. G. (2001) · Muscle & Nerve · doi:10.1002/mus.1045 · Cited by 85
Dynamics of Auditory Plasticity after Cochlear Implantation: A Longitudinal Study
Pantev, C., Dinnesen, A. G., Ross, B., Wollbrink, A., & Knief, A. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi081 · Cited by 83
Postsynaptic actin and neuronal plasticity
Matus, A. I. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00018-5 · Cited by 84
Cooperative changes in GABA, glutamate and activity levels: the missing link in cortical plasticity
Arckens, L., Schweigart, G., Qu, Y., Wouters, G., Pow, D. V., Vandesande, F., Eysel, U. T., & Orban, G. A. (2000) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01328.x · Cited by 82
Remapping the Somatosensory Cortex after Stroke: Insight from Imaging the Synapse to Network
Winship, I. R., & Murphy, T. H. (2009) · The Neuroscientist · doi:10.1177/1073858409333076 · Cited by 87
Cellular and network properties in the functioning of the nervous system: from central pattern generators to cognition
Arshavsky, Y. I. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00249-7 · Cited by 84

Authors: Buonomano, D. V., & Merzenich, M. M.
Affiliations: University of California, Los Angeles (US)
University of California, San Francisco (US)
ORCID: Buonomano, Dean V.
Merzenich, Michael M.
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 1998-03
Volume: 21
Issue: 1
Pages: 149-186
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev.neuro.21.1.149
OpenAlex: W2158935809
Cited by: 2,083
References: 192
Citations by year: 2026: 21 · 2025: 27 · 2024: 43 · 2023: 40 · 2022: 45 · 2021: 58 · 2020: 49 · 2019: 73 · 2018: 67 · 2017: 61 · 2016: 61 · 2015: 78 · 2014: 72 · 2013: 95 · 2012: 98
FWCI: 8.24
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (10414)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: cortical plasticity, synaptic plasticity, long-term potentiation, long-term depression, excitatory postsynaptic potentials, learning rules
MeSH terms: Animals, Brain Mapping, Cerebral Cortex, Neuronal Plasticity, Synapses

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

CORTICAL PLASTICITY: From Synapses to Maps

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks