Reducing NF-κB Signaling Nutritionally is Associated with Expedited Recovery of Skeletal Muscle Function After Damage
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CONTEXT: The early events regulating the remodeling program following skeletal muscle damage are poorly understood. OBJECTIVE: The objective of this study was to determine the association between myofibrillar protein synthesis (myoPS) and nuclear factor-kappa B (NF-κB) signaling by nutritionally accelerating the recovery of muscle function following damage. DESIGN, SETTING, PARTICIPANTS, AND INTERVENTIONS: Healthy males and females consumed daily postexercise and prebed protein-polyphenol (PP; n = 9; 4 females) or isocaloric maltodextrin placebo (PLA; n = 9; 3 females) drinks (parallel design) 6 days before and 3 days after 300 unilateral eccentric contractions of the quadriceps during complete dietary control. MAIN OUTCOME MEASURES: Muscle function was assessed daily, and skeletal muscle biopsies were taken after 24, 27, and 36 hours for measurements of myoPS rates using deuterated water, and gene ontology and NF-κB signaling analysis using a quantitative reverse transcription PCR (RT-qPCR) gene array. RESULTS: Eccentric contractions impaired muscle function for 48 hours in PLA intervention, but just for 24 hours in PP intervention (P = 0.047). Eccentric quadricep contractions increased myoPS compared with the control leg during postexercise (24-27 hours; 0.14 ± 0.01 vs 0.11 ± 0.01%·h-1, respectively; P = 0.075) and overnight periods (27-36 hours; 0.10 ± 0.01 vs 0.07 ± 0.01%·h-1, respectively; P = 0.020), but was not further increased by PP drinks (P > 0.05). Protein-polyphenol drinks decreased postexercise and overnight muscle IL1R1 (PLA = 2.8 ± 0.4, PP = 1.1 ± 0.4 and PLA = 1.9 ± 0.4, PP = 0.3 ± 0.4 log2 fold-change, respectively) and IL1RL1 (PLA = 4.9 ± 0.7, PP = 1.6 ± 0.8 and PLA = 3.7 ± 0.6, PP = 0.7 ± 0.7 log2 fold-change, respectively) messenger RNA expression (P < 0.05) and downstream NF-κB signaling compared with PLA. CONCLUSION: Protein-polyphenol drink ingestion likely accelerates recovery of muscle function by attenuating inflammatory NF-κB transcriptional signaling, possibly to reduce aberrant tissue degradation rather than increase myoPS rates.
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Skeletal muscle protein synthesis signaling, via activation of the mTORC1 pathway, is stimulated in the range of 1-7 days post-damage in response to various eccentric or lengthening contraction protocols in rodents and humans.
“Skeletal muscle protein synthesis signaling, via activation of the mTORC1 pathway, is stimulated in the range of 1–7 days post-damage in response to various eccentric or lengthening contraction protocols in rodents and humans (57–61).”
From Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice (2021) · cites this paper as [59]
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Siantoro, G., Pramono, B. A., Suyoko, A., Samudra, F. E., Lestari, B., Nirwansyah, W. T., Ciptorini, A. D., Arisanti, R. R. S., & Ayubi, N. (2024) · Physical Education Theory and Methodology · doi:10.17309/tmfv.2024.4.07 · Cited by 1 · see citing works
Haigh, F. A., Whelehan, G., West, S., Apicella, M. C. A., Wilkinson, K., van der Heijden, I., Jameson, T. S. O., Pavis, G. F., Monteyne, A. J., Dirks, M. L., et al. (2024) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2024-0152 · Cited by 1 · see citing works
Self-citationConstantin‐Teodosiu, D. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac052 · Cited by 1 · see citing works
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Jameson, T. S. O., Caldow, M. K., Stephens, F. B., Denehy, L., Lynch, G. S., Koopman, R., Krajčová, A., Urban, T., Berney, S., Duska, F., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24515814
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- Authors
- Jameson, T. S. O., Pavis, G. F., Dirks, M. L., Lee, B. P., Abdelrahman, D. R., Murton, A. J., Porter, C., Alamdari, N., Mikus, C. R., Wall, B. T., & Stephens, F. B.
- Affiliations
- University of Exeter (GB)
- The University of Texas Medical Branch at Galveston (US)
- Beachbody LLC, Santa Monica, CA 90404, USA
- Corresponding author
- Stephens, Francis B
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2021-02-26
- Volume
- 106
- Issue
- 7
- Pages
- 2057-2076
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC8208676
- OpenAlex
- W3134760527
- Cited by
- 25
- References
- 69
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 4
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (submittedVersion, cc-by)
- Funders
- University of Exeter
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- NF-κB signaling, skeletal muscle injury, muscle recovery, myofibrillar protein synthesis, eccentric exercise, interleukin-1 receptor, ST2, muscle inflammation, muscle remodeling, dietary protein, polyphenols, muscle function, quadriceps, muscle protein degradation
- MeSH terms
- Beverages, Dietary Proteins, Female, Humans, Male, Muscle Contraction, Muscle Proteins, Protein Biosynthesis, Signal Transduction, NF-kappa B, Muscle, Skeletal, Recovery of Function, Quadriceps Muscle, Resistance Training, Young Adult, Polyphenols, Myalgia, Sports Nutritional Physiological Phenomena, Healthy Volunteers
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