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Effect of muscle mass decrease on age-related BMR changes
Abstract
The long known and often studied decrease in basal metabolic rate (BMR) with age was recently shown related to changes in the proportion of lean-to-fat tissue mass in the body. Earlier studies from this laboratory showed the decline in basal 0, consumption (basal 00,) to be accounted for by a decline in lean body mass (LBM). The purpose of the present study was to identify and account for that component of the lean body responsible for the age-related decrease in basal vo, in 959 participants in the Baltimore Longitudinal Study aged from 20 to 97 yr, An age-independent linear relation was found between paired values of basal voz, a measure of total metabolic activity, and 24-h creatinine excretion, a measure proportional to skeletal muscle mass. The relation is quanti-fied by basal Tie, = 99.1 + 0.079 (creatinine excretion), where basal vo, is expressed in mllmin (STPD) and creatinine excre-
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Metadata
- Authors
- Tzankoff, S. P., & Norris, A. H.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1977-12-01
- Volume
- 43
- Issue
- 6
- Pages
- 1001-1006
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1933184123
- Cited by
- 401
- References
- 0
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
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