The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Muscle damage and inflammation during recovery from exercise
Open accessAbstract
Unaccustomed exercise consisting of eccentric (i.e., lengthening) muscle contractions often results in muscle damage characterized by ultrastructural alterations in muscle tissue, clinical signs, and symptoms (e.g., reduced muscle strength and range of motion, increased muscle soreness and swelling, efflux of myocellular proteins). The time course of recovery following exercise-induced muscle damage depends on the extent of initial muscle damage, which in turn is influenced by the intensity and duration of exercise, joint angle/muscle length, and muscle groups used during exercise. The effects of these factors on muscle strength, soreness, and swelling are well characterized. By contrast, much less is known about how they affect intramuscular inflammation and molecular aspects of muscle adaptation/remodeling. Although inflammation has historically been viewed as detrimental for recovery from exercise, it is now generally accepted that inflammatory responses, if tightly regulated, are integral to muscle repair and regeneration. Animal studies have revealed that various cell types, including neutrophils, macrophages, mast cells, eosinophils, CD8 and T-regulatory lymphocytes, fibro-adipogenic progenitors, and pericytes help to facilitate muscle tissue regeneration. However, more research is required to determine whether these cells respond to exercise-induced muscle damage. A large body of research has investigated the efficacy of physicotherapeutic, pharmacological, and nutritional interventions for reducing the signs and symptoms of exercise-induced muscle damage, with mixed results. More research is needed to examine if/how these treatments influence inflammation and muscle remodeling during recovery from exercise.
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“Intense and/or prolonged physical exercise triggers a temporary inflammatory response, a physiological reaction of the body to tissue microdamage, which plays a crucial role in the regeneration process1.”
From Impact of a single swimming session on inflammatory response and iron homeostasis in adolescent female athletes during the luteal phase (2025) · cites this paper as [1]
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“as reported in the literature, such damage is not always accompanied by parallel changes in inflammatory cytokine levels, which are typically modulated in response to high-intensity physical activity1.”
From Impact of a single swimming session on inflammatory response and iron homeostasis in adolescent female athletes during the luteal phase (2025) · cites this paper as [1]
In the citing paper
“Together, the rise in MYO and the exercise-induced leukocyte mobilization reflect the presence of at least mild muscle damage and its associated inflammatory response to the applied protocol1.”
From Impact of a single swimming session on inflammatory response and iron homeostasis in adolescent female athletes during the luteal phase (2025) · cites this paper as [1]
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“The processes of muscle damage and inflammation have been extensively reviewed elsewhere (1, 12, 39, 86, 107).”
BackgroundMyofibrillar damage following intense eccentric exercise in man
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“Disruption of Z disks and sarcomeres appears to peak between 1 and 3 days after exercise (21, 30, 72, 117), but may remain elevated up to 6 8 days after exercise (30, 43, 117).”
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IL-7 is expressed and secreted by human skeletal muscle cells
Haugen, F., Norheim, F., Lian, H., Wensaas, A. J., Dueland, S., Berg, O., Funderud, A., Skålhegg, B. S., Raastad, T., & Drevon, C. A. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00094.2009 · Cited by 237 · cited 1×
“Although the functions of these cytokines are less well known, evidence exists that CXCL8 enhances myoblast differentiation (92), IL-7 stimulates satellite cell proliferation and migration (33), and leukemia inhibitor factor increases myoblast proliferation (47).”
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“However, recent research suggests that nonsteroidal anti-inflammatory drugs can improve muscle regeneration through other mechanisms, such as activation of satellite cells (55).”
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Metadata
- Authors
- Peake, J. M., Neubauer, O., Della Gatta, P. A., & Nosaka, K.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2017-03-01
- Volume
- 122
- Issue
- 3
- Pages
- 559-570
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2562503458
- Cited by
- 764
- References
- 15
- FWCI
- 29.39
- Type
- journal article
- Language
- en
- Open access
- green
- Funders
- Queensland Academy of Sport
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