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Cited by 305Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

Neuronal activity in monkey striatum related to the expectation of predictable environmental events

Apicella, P., Scarnati, E., Ljungberg, T., Schultz, W.·1992·Journal of Neurophysiology
DOI 10.1152/jn.1992.68.3.945
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Abstract

1. This study investigated neuronal activity in the striatum preceding predictable environmental events and behavioral reactions. Monkeys performed in a delayed go-nogo task that included separate time periods during which animals expected signals of behavioral significance, prepared for execution or inhibition of arm reaching movements, and expected the delivery of reward. In the task, animals were instructed by a green light cue to perform an arm reaching movement when a trigger stimulus came on approximately 3 s later (go situation). Movement was withheld after the same trigger light when the instruction cue had been red (nogo situation). Liquid reward was delivered on correct performance in both situations. 2. A total of 1,173 neurons were studied in the striatum (caudate nucleus and putamen) of 3 animals, of which 615 (52%) showed some change in activity during task performance. This report describes how the activity of 193 task-related neurons increased in advance of at least 1 component of the task, namely the instruction cue, the trigger stimulus, or the delivery of liquid reward. These neurons were found in dorsal and anterior parts of caudate and putamen and were slightly more frequent in the proximity of the internal capsule. 3. The activity of 16 neurons increased in both go and nogo trials before the onset of the instruction and subsided shortly after this signal. These activations may be related to the expectation of the instruction as the first signal in each trial. 4. The activity of 15 neurons increased between the instruction and the trigger stimulus in both go and nogo trials. These activations may be related to the expectation of the trigger stimulus independent of an arm movement. Further 56 neurons showed sustained activations only when the instruction requested a movement reaction. Activations were absent in trials in which the movement was withheld. Twenty-one of these neurons were tested with 2 different movement targets, 5 of which showed activity related to the direction of movement. These activations may be related to the preparation of movement or expectation of the specific movement triggering signal. The activity of an additional 20 neurons was unmodulated before the trigger stimulus in movement trials but increased in the interval between the no-movement instruction and the trigger stimulus for withholding the movement. These activations may be related to the preparation of movement inhibition as specific nogo reaction.(ABSTRACT TRUNCATED AT 400 WORDS)

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  • In a neurophysiological experiment, striatal activity was recorded while monkeys performed a Go/NoGo task; the authors found that the striatum could be important for preparing to stop a response and then implementing inhibitory control over a sustained period.

    “In a neurophysiological experiment, striatal activity was recorded, while monkeys were performing a Go/NoGo task. The authors found that the striatum could be important for preparing to stop a response (under working memory) and then implementing inhibitory control over a sustained period (Apicella et al. 1992).”

    From Large-scale functional neural network correlates of response inhibition: an fMRI meta-analysis (2017) · cites this paper as Apicella et al. 1992

  • Dopamine neurons contrast strongly with non-dopamine neurons in the striatum and frontal cortex, which show wide varieties of activations and depressions at different time points before and after different stimuli and behavioural events.

    “In this respect, dopamine neurons contrast strongly with non-dopamine neurons in the striatum and frontal cortex, which show wide varieties of activations and depressions at different time points before and after different stimuli and behavioural events114,147–149.”

    From Dopamine reward prediction-error signalling: A two-component response (2016) · cites this paper as [148]

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Authors
Apicella, P., Scarnati, E., Ljungberg, T., & Schultz, W.
Affiliations
University of Fribourg (CH)
ORCID
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
1992-09-01
Volume
68
Issue
3
Pages
945-960
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.1992.68.3.945
OpenAlex
W1897438103
Cited by
305
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 7 · 2021: 6 · 2020: 34 · 2019: 2 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 17 · 2014: 7 · 2013: 11 · 2012: 9
FWCI
2.94
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
striatum, caudate nucleus, putamen, neuronal activity, expectations, anticipatory activity, go/no-go task, arm reaching, motor preparation, movement inhibition, reward anticipation, internal capsule, single-unit recording, monkeys
MeSH terms
Animals, Arm, Behavior, Animal, Corpus Striatum, Cues, Environment, Eye Movements, Forecasting, Macaca fascicularis, Male, Movement, Muscles, Neurons, Reward

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