Calcium Pumps in Health and Disease

The versatility and universality of calcium signalling

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Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

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Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

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Structure and Regulation of Voltage-Gated Ca 2+ Channels

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Store-Operated Calcium Channels

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TRP Channels

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Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution

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The mitochondrial calcium uniporter is a highly selective ion channel

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Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

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Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.

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Protein degradation by the ubiquitin-proteasome pathway in normal and disease states

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Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences

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Curcumin and cancer: An “old-age” disease with an “age-old” solution

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Amino-acid sequence of a Ca2+ + Mg2+ -dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

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Phospholamban: a crucial regulator of cardiac contractility

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Artemisinins target the SERCA of Plasmodium falciparum

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A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

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Ion motive ATPases. I. Ubiquity, properties, and significance to cell function

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Evolution of Substrate Specificities in the P-Type ATPase Superfamily

Axelsen, K. B., & Palmgren, M. G. (1998) · Journal of Molecular Evolution · doi:10.1007/pl00006286 · Cited by 910

Calcium: still center-stage in hypoxic-ischemic neuronal death

Choi, D. W. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80018-w · Cited by 901

Structural changes in the calcium pump accompanying the dissociation of calcium

Toyoshima, C., & Nomura, H. (2002) · Nature · doi:10.1038/nature00944 · Cited by 894

Purification and Properties of an Adenosine Triphosphatase from Sarcoplasmic Reticulum

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Two Ca2+ ATPase genes: Homologies and mechanistic implications of deduced amino acid sequences

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Cyclopiazonic Acid is a Specific Inhibitor of the Ca2+-ATPase of Sarcoplasmic Reticulum

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Energy Interconversion by the Ca2+-Dependent ATPase of the Sarcoplasmic Reticulum

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Sticky Business

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Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

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Calcium and cancer: targeting Ca2+ transport

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Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps.

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Cadherins as Modulators of Cellular Phenotype

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Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals

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The role of calcium in cell death

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Dilated Cardiomyopathy and Heart Failure Caused by a Mutation in Phospholamban

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Role of Alternative Splicing in Generating Isoform Diversity Among Plasma Membrane Calcium Pumps

Strehler, E. E., & Zacharias, D. A. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.21 · Cited by 590

DREAM is a Ca2+-regulated transcriptional repressor

Carrión, A. M., Link, W. A., Ledo, F., Mellström, B., & Naranjo, J. R. (1999) · Nature · doi:10.1038/18044 · Cited by 573

Location of high affinity Ca2 +-binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca2+-ATPase

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Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease

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The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+ ATPase family

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Cleavage of the Plasma Membrane Na+/Ca2+ Exchanger in Excitotoxicity

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Generation, Control, and Processing of Cellular Calcium Signals

Carafoli, E., Santella, L., Branca, D., & Brini, M. (2001) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/20014091074183 · Cited by 531

Darier-White disease: A review of the clinical features in 163 patients

Burge, S. M., & Wilkinson, J. D. (1992) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(92)70154-8 · Cited by 486

Calcium and cancer: Targeting Ca2+ transport

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Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network.

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Inhibition of the sarcoplasmic reticulum Ca2+ transport ATPase by thapsigargin at subnanomolar concentrations

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Nature and site of phospholamban regulation of the Ca2+ pump of sarcoplasmic reticulum

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The yeast Ca(2+)-ATPase homologue, PMR1, is required for normal Golgi function and localizes in a novel Golgi-like distribution.

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cDNA Cloning, functional expression, and mRNA Tissue Distribution of a Third Organellar Ca2+ Pump

Burk, S. E., Lytton, J., MacLennan, D. H., & Shull, G. E. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51504-0 · Cited by 414

Calcium pump of the plasma membrane is localized in caveolae.

Fujimoto, T. (1993) · The Journal of cell biology · doi:10.1083/jcb.120.5.1147 · Cited by 414

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

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Biogenesis: Plasma membrane calcium ATPase: 15 years of work on the purified enzyme 1

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Partial purification of the Ca2+-Mg2+ ATPase activator from human erythrocytes: Its similarity to the activator of 3′:5′ — cyclic nucleotide phosphodiesterase

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Are desmosomes more than tethers for intermediate filaments?

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Acidic phospholipids, unsaturated fatty acids, and limited proteolysis mimic the effect of calmodulin on the purified erythrocyte Ca2+ - ATPase.

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Molecular cloning of two isoforms of the plasma membrane Ca2+-transporting ATPase from rat brain. Structural and functional domains exhibit similarity to Na+,K+- and other cation transport ATPases.

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Troponin

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NO/redox disequilibrium in the failing heart and cardiovascular system

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Complete primary structure of a human plasma membrane Ca2+ pump.

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Working out the strength and flexibility of desmosomes

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Targeted Ablation of Plasma Membrane Ca2+-ATPase (PMCA) 1 and 4 Indicates a Major Housekeeping Function for PMCA1 and a Critical Role in Hyperactivated Sperm Motility and Male Fertility for PMCA4

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[The calcium pump of the "relaxing granules" of muscle and its dependence on ATP-splitting].

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Highly effective SNP-based association mapping and management of recessive defects in livestock

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Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

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Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice.

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Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca2+ pump

Sudbrak, R. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.7.1131 · Cited by 321

Balance and Hearing Deficits in Mice with a Null Mutation in the Gene Encoding Plasma Membrane Ca2+-ATPase Isoform 2

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SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

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Calcineurin: From structure to function

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Reduced Ca2+-Sensitivity of SERCA 2a in Failing Human Myocardium due to Reduced Serin-16 Phospholamban Phoshorylation

Schwinger, R. H. G., Münch, G., Bölck, B., Karczewski, P., Krause, E.-G., & Erdmann, E. (1999) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1998.0897 · Cited by 287

Polarized Calcium Signaling in Exocrine Gland Cells

Petersen, O. H., & Tepikin, A. V. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100618 · Cited by 285

Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice

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Phospholamban Inhibitory Function Is Activated by Depolymerization

Kimura, Y., Kurzydlowski, K., Tada, M., & MacLennan, D. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15061 · Cited by 282

Identification of a peptide inhibitor of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.

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Plasma Membrane Ca2+ ATPase 4 Is Required for Sperm Motility and Male Fertility

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Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective micropipette.

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Impaired Cardiac Performance in Heterozygous Mice with a Null Mutation in the Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2 (SERCA2) Gene

Periasamy, M., Reed, T. D., Liu, L. H., Ji, Y., Loukianov, E., Paul, R. J., Nieman, M. L., Riddle, T., Duffy, J. J., Doetschman, T., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2556 · Cited by 266

Identification and primary structure of a calmodulin binding domain of the Ca2+ pump of human erythrocytes.

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A single amino acid residue can determine the sensitivity of SERCAs to artemisinins

Uhlemann, A.-C., Cameron, A., Eckstein-Ludwig, U., Fischbarg, J., Iserovich, P., Zuniga, F. A., East, M., Lee, A., Brady, L., Haynes, R. K., et al. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb947 · Cited by 256

The calcium ion and cell death.

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Cardiac Neuronal Nitric Oxide Synthase Isoform Regulates Myocardial Contraction and Calcium Handling

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The SERCA pump as a therapeutic target: Making a “smart bomb” for prostate cancer

Denmeade, S. R., & Isaacs, J. T. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.1.1505 · Cited by 244

Ca2+-dependent redox modulation of SERCA 2b by ERp57

Li, Y., & Camacho, P. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200307010 · Cited by 243

Desmosomes: Intercellular Adhesive Junctions Specialized for Attachment of Intermediate Filaments

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Mutations in the gene–encoding SERCA1, the fast–twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPase, are associated with Brody disease

Odermatt, A., Taschner, P. E. M., Khanna, V. K., Busch, H. F. M., Karpati, G., Jablecki, C. K., Breuning, M. H., & MacLennan, D. H. (1996) · Nature Genetics · doi:10.1038/ng1096-191 · Cited by 240

Mutations in PMR1 suppress oxidative damage in yeast cells lacking superoxide dismutase

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Cytosolic Phosphorylation of Calnexin Controls Intracellular Ca2+ Oscillations via an Interaction with Serca2b

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Sarcolipin Regulates the Activity of SERCA1, the Fast-twitch Skeletal Muscle Sarcoplasmic Reticulum Ca2+-ATPase

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Purification of the Ca2+-stimulated ATPase activator from human erythrocytes. Its membership in the class of Ca2+-binding modulator proteins

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Abnormal intracellular Ca2+homeostasis and disease

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Bcl-2-dependent modulation of Ca2+ homeostasis and store-operated channels in prostate cancer cells

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Modulations in Epidermal Calcium Regulate the Expression of Differentiation-Specific Markers

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Differential Modulation of SERCA2 Isoforms by Calreticulin

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Cardiac adenoviral S100A1 gene delivery rescues failing myocardium

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Myocardial fiber necrosis due to intracellular Ca overload-a new principle in cardiac pathophysiology.

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Calcium signaling in the cell nucleus

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The plasma membrane Ca2+ pump contains a site that interacts with its calmodulin-binding domain.

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Plasma Membrane Ca2+-ATPase Isoform 2a Is the PMCA of Hair Bundles

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The purified Ca2+ pump of human erythrocyte membranes catalyzes an electroneutral Ca2+-H+ exchange in reconstituted liposomal systems.

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Modeling of the inhibitory interaction of phospholamban with the Ca 2+ ATPase

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Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury

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Islet Secretory Defect in Insulin Receptor Substrate 1 Null Mice Is Linked With Reduced Calcium Signaling and Expression of Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA)-2b and -3

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Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines

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Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis

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Downstream Regulatory Element Antagonist Modulator Regulates Ca2+Homeostasis and Viability in Cerebellar Neurons

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The Sarcolemmal Calcium Pump Inhibits the Calcineurin/Nuclear Factor of Activated T-cell Pathway via Interaction with the Calcineurin A Catalytic Subunit

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The mutation of Pro789 to Leu reduces the activity of the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) and is associated with Brody disease

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Depletion of Manganese within the Secretory Pathway Inhibits O-Linked Glycosylation in Mammalian Cells

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Localization of plasma membrane and secretory calcium pumps in the mammary gland

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Plasma Membrane Calcium ATPase Overexpression in Arterial Smooth Muscle Increases Vasomotor Responsiveness and Blood Pressure

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Insulin Receptor Substrate Proteins Create a Link between the Tyrosine Phosphorylation Cascade and the Ca2+-ATPases in Muscle and Heart

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Targeted Disruption of the ATP2A1 Gene Encoding the Sarco(endo)plasmic Reticulum Ca2+ ATPase Isoform 1 (SERCA1) Impairs Diaphragm Function and Is Lethal in Neonatal Mice

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TRPV6 Is a Ca2+ Entry Channel Essential for Ca2+-induced Differentiation of Human Keratinocytes

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Identification, Expression, Function, and Localization of a Novel (Sixth) Isoform of the Human Sarco/Endoplasmic Reticulum Ca2+ATPase 3 Gene

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Ca2+-dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+-ATPase2a and phospholamban in the human heart

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Low Endolymph Calcium Concentrations in deafwaddler2J Mice Suggest that PMCA2 Contributes to Endolymph Calcium Maintenance

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Drastic reduction of sarcalumenin in Dp427 (dystrophin of 427 kDa)-deficient fibres indicates that abnormal calcium handling plays a key role in muscular dystrophy

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Expression, Purification, and Characterization of Isoform 1 of the Plasma Membrane Ca2+ Pump

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Calcium Controls the Transcription of Its Own Transporters and Channels in Developing Neurons

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The sarco(endo)plasmic reticulum Ca2+‐ATPase mRNA isoform, SERCA 3, is expressed in endothelial and epithelial cells in various organs

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Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling

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P-Type ATPases

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The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction

Jiang, F., Yin, K., Wu, K., Zhang, M., Wang, S., Cheng, H., Zhou, Z., & Xiao, B. (2021) · Nature Communications · doi:10.1038/s41467-021-21178-4 · Cited by 283

Multifunctional carbon-nanotube cellular endoscopes.

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The role of Ca2+ in the pathophysiology of pancreatitis

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