Cited by 130Parkinson's Disease Mechanisms and TreatmentsGastrointestinal motility and disordersDeep Brain Stimulation and Movement Disorders

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Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments

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Poirier, Andrée-Anne, Aubé, Benoit, Côté, Mélissa, Morin, Nicolas, Di Paolo, Thérèse, Soulet, Denis·2016·Parkinson s Disease

DOI 10.1155/2016/6762528PMC PMC5168460

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Abstract

A diagnosis of Parkinson's disease is classically established after the manifestation of motor symptoms such as rigidity, bradykinesia, and tremor. However, a growing body of evidence supports the hypothesis that nonmotor symptoms, especially gastrointestinal dysfunctions, could be considered as early biomarkers since they are ubiquitously found among confirmed patients and occur much earlier than their motor manifestations. According to Braak's hypothesis, the disease is postulated to originate in the intestine and then spread to the brain via the vagus nerve, a phenomenon that would involve other neuronal types than the well-established dopaminergic population. It has therefore been proposed that peripheral nondopaminergic impairments might precede the alteration of dopaminergic neurons in the central nervous system and, ultimately, the emergence of motor symptoms. Considering the growing interest in the gut-brain axis in Parkinson's disease, this review aims at providing a comprehensive picture of the multiple gastrointestinal features of the disease, along with the therapeutic approaches used to reduce their burden. Moreover, we highlight the importance of gastrointestinal symptoms with respect to the patients' responses towards medical treatments and discuss the various possible adverse interactions that can potentially occur, which are still poorly understood.

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See all 130

Authors: Poirier, A.-A., Aubé, B., Côté, M., Morin, N., Di Paolo, T., & Soulet, D.
Affiliations: Centre hospitalier de l'Université Laval (CA)
Axe Neurosciences, Centre de Recherche du CHU de Québec (Pavillon CHUL), Quebec City, QC, Canada
Université Laval (CA)
Corresponding author: Soulet, Denis
ORCID: Poirier, Andrée-Anne
Côté, Mélissa
Soulet, Denis
Venue: Parkinson s Disease
Publisher: Wiley
Published: 2016
Volume: 2016
Pages: 1-23
ISSN: 2042-0080 (ISSN-L)
2090-8083
DOI: 10.1155/2016/6762528
PMC: PMC5168460
OpenAlex: W2560353112
Cited by: 130
References: 217
Citations by year: 2026: 2 · 2025: 10 · 2024: 9 · 2023: 18 · 2022: 19 · 2021: 19 · 2020: 21 · 2019: 17 · 2018: 9 · 2017: 6
FWCI: 1.48
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Parkinson s Disease (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Canadian Institute of Health Research
Canadian Foundation for Innovation
Fonds de la Recherche du Québec-Santé
Parkinson Québec
Société Parkinson Canada and La Fondation du CHU de Québec
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords: gastrointestinal dysfunction, non-motor symptoms, gut-brain axis, Braak hypothesis, vagus nerve, early biomarkers, gastrointestinal symptoms, treatment side effects

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Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments

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