Prediction of Creatinine Clearance from Serum Creatinine

Cockcroft, Donald W., Gault, Henry·1976·Nephron

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Abstract

A formula has been developed to predict creatinine clearance (Ccr) from serum creatinine (Scr) in adult males: (see article)(15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18-92. Values for Ccr were predicted by this formula and four other methods and the results compared with the means of two 24-hour Ccr's measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr's of 0.83; on average, the difference predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction.

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Authors: Cockcroft, D. W., & Gault, H.
Venue: Nephron
Publisher: S. Karger AG
Published: 1976
Volume: 16
Issue: 1
Pages: 31-41
ISSN: 1660-8151 (ISSN-L)
1423-0186
0028-2766
DOI: 10.1159/000180580
OpenAlex: W1550111394
Cited by: 15,309
References: 0
FWCI: 679.62
Type: journal article
Language: en
Open access: closed
Licence: karger.com/pages/terms-and-conditions (vor)
karger.com/pages/terms-and-conditions (tdm)

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Prediction of Creatinine Clearance from Serum Creatinine

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