The meaning of weaning: Influence of the weaning period on behavioral development in mice
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Maternal care during the first week postpartum has long-term consequences for offspring development in rodents. However, mother-infant interactions continue well beyond this period, with several physiological and behavioral changes occurring between days 18 and 28 PN. In the present study, we investigate the long-term effects on offspring behavior of being weaned at day 21 PN versus day 28 PN. We found that male and female offspring engage in higher initial levels of social interaction if weaned at day 28 PN, as well as sexually dimorphic changes in exploratory behavior. Females who were themselves weaned earlier also appeared to wean their own pups earlier. Sex-specific effects of weaning age were found on levels of oxytocin and vasopressin V1a receptor density in the hypothalamus, central nucleus of the amygdala and nucleus accumbens. These results indicate that altering weaning age in mice may be a useful model for investigating the development of sexual dimorphism in neurobiology and behavior.
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In rodents there is a major shift in the location and density of OT receptors following parturition in the dams and after weaning in the pups.
“For example, in rodents there is a major shift in the location and density of OT receptors following parturition in the dams and after weaning in the pups (72,73).”
From Oxytocin and the development of parenting in humans (2010) · cites this paper as [72]
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Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works
Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708 · see citing works
Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999) · Science · doi:10.1126/science.286.5442.1155 · Cited by 1,965 · see citing works
Attachment and development: A prospective, longitudinal study from birth to adulthood
Sroufe, L. A. (2005) · Attachment & Human Development · doi:10.1080/14616730500365928 · Cited by 1,685 · see citing works
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · see citing works
Neural mechanisms of aggression
Nelson, R. J., & Trainor, B. C. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2174 · Cited by 1,021 · see citing works
Champagne, F. A., Francis, D. D., Mar, A., & Meaney, M. J. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00149-5 · Cited by 1,021 · see citing works
Epigenetic mechanisms and the transgenerational effects of maternal care
Champagne, F. A. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.03.003 · Cited by 812 · see citing works
A review of 25 years of the social interaction test
File, S. E., & Seth, P. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01273-1 · Cited by 744 · see citing works
Champagne, F., Diorio, J., Sharma, S., & Meaney, M. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221224598 · Cited by 707 · see citing works
Champagne, F. A., Weaver, I. C. G., Diorio, J., Dymov, S., Szyf, M., & Meaney, M. J. (2006) · Endocrinology · doi:10.1210/en.2005-1119 · Cited by 675 · see citing works
Bielsky, I. F., Hu, S.-B., Szegda, K. L., Westphal, H., & Young, L. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300360 · Cited by 531 · see citing works
Francis, D. D., Champagne, F. C., & Meaney, M. J. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00599.x · Cited by 496 · see citing works
Bale, T. L., Davis, A. M., Auger, A. P., Dorsa, D. M., & McCarthy, M. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02546.2001 · Cited by 446 · see citing works
Long-term Biobehavioral Effects of Maternal Separation in the Rat: Consistent or Confusing?
Lehmann, J., & Feldon, J. (2000) · Reviews in the Neurosciences · doi:10.1515/revneuro.2000.11.4.383 · Cited by 443 · see citing works
Francis, D. D., Young, L. J., Meaney, M. J., & Insel, T. R. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.0007-1331.2002.00776.x · Cited by 415 · see citing works
Champagne, F. A., & Meaney, M. J. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.6.1353 · Cited by 381 · see citing works
Self-citationLong-term behavioural and molecular alterations associated with maternal separation in rats
Lippmann, M., Bress, A., Nemeroff, C. B., Plotsky, P. M., & Monteggia, L. M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05522.x · Cited by 355 · see citing works
Brain vasopressin is an important regulator of maternal behavior independent of dams’ trait anxiety
Bosch, O. J., & Neumann, I. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807412105 · Cited by 280 · see citing works
The Maternal Separation Paradigm and Adult Emotionality and Cognition in Male and Female Wistar Rats
Lehmann, J., Pryce, C. R., Bettschen, D., & Feldon, J. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00150-1 · Cited by 260 · see citing works
Vasopressin, oxytocin and social behaviour
Keverne, E. B., & Curley, J. P. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.006 · Cited by 215 · see citing works
Early experience affects the intergenerational transmission of infant abuse in rhesus monkeys
Dario Maestripieri, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504122102 · Cited by 213 · see citing works
Maternal contributions to the development of masculine sexual behavior in laboratory rats
Moore, C. (1984) · Developmental Psychobiology · doi:10.1002/dev.420170403 · Cited by 211 · see citing works
CUSHING, B., & KRAMER, K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.001 · Cited by 209 · see citing works
Martin, P. (1984) · Animal Behaviour · doi:10.1016/s0003-3472(84)80245-6 · Cited by 204 · see citing works
Egashira, N., Tanoue, A., Matsuda, T., Koushi, E., Harada, S., Takano, Y., Tsujimoto, G., 三島, 健., Iwasaki, K., & Fujiwara, M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.12.009 · Cited by 193 · see citing works
K�nig, B., & Markl, H. S. (1987) · Behavioral Ecology and Sociobiology · doi:10.1007/bf00292161 · Cited by 176 · see citing works
Ferdman, N., MURMU, R., Bock, J., Braun, K., & Leshem, M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.03.011 · Cited by 173 · see citing works
Natural variations in postpartum maternal care in inbred and outbred mice
Champagne, F. A., Curley, J. P., Keverne, E. B., & Bateson, P. P. G. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.03.014 · Cited by 160 · see citing works
Cameron, N. M., Corpo, A. D., Diorio, J. C., McAllister, K., Sharma, S., & Meaney, M. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002210 · Cited by 155 · see citing works
McCarthy, M. M., Kleopoulos, S. P., Mobbs, C. V., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000126689 · Cited by 142 · see citing works
Early experience and cross‐generational continuity of mother‐infant contact in vervet monkeys
Fairbanks, L. A. (1989) · Developmental Psychobiology · doi:10.1002/dev.420220703 · Cited by 136 · see citing works
Maternal influences on the sexual behavior and reproductive success of the female rat
Cameron, N. M., Fish, E. W., & Meaney, M. J. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.02.013 · Cited by 122 · see citing works
Laviola, G., & Terranova, M. L. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00021-9 · Cited by 109 · see citing works
A description of the ontogeny of mouse agonistic behavior.
Terranova, M. L., Giovanni Laviola, A., Acetis, L. D., & Alleva, E. (1998) · Journal of comparative psychology · doi:10.1037/0735-7036.112.1.3 · Cited by 107 · see citing works
Early weaning induces anxiety and aggression in adult mice
Kikusui, T., Takeuchi, Y., & Mori, Y. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2003.12.016 · Cited by 103 · see citing works
Nephew, B. C., & Bridges, R. S. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.06.013 · Cited by 100 · see citing works
Kikusui, T., Isaka, Y., & Mori, Y. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.03.013 · Cited by 97 · see citing works
Bielsky, I. F., Hu, S.-B., & Young, L. J. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.005 · Cited by 91 · see citing works
Windle, R. J., Gamble, L. E., Kershaw, Y. M., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2006) · Endocrinology · doi:10.1210/en.2005-1079 · Cited by 90 · see citing works
Multidimensional structure of anxiety-related behavior in early-weaned rats
Kanari, K., Kikusui, T., Takeuchi, Y., & Mori, Y. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.05.008 · Cited by 88 · see citing works
Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors
Harding, S. M., & McGinnis, M. Y. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.03.008 · Cited by 84 · see citing works
Early weaning augments neuroendocrine stress responses in mice
Kikusui, T., Nakamura, K., Kakuma, Y., & Mori, Y. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.007 · Cited by 82 · see citing works
Intergenerational Transmission of Parental Bonding Among Women
Miller, L., KRAMER, R. A., Warner, V., WICKRAMARATNE, P. J., & Weissman, M. M. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199708000-00022 · Cited by 81 · see citing works
Kikusui, T., Kiyokawa, Y., & Mori, Y. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.031 · Cited by 77 · see citing works
Immature siblings and mother-infant relationships among free-ranging rhesus monkeys on Cayo Santiago
Berman, C. M. (1992) · Animal Behaviour · doi:10.1016/0003-3472(92)90031-4 · Cited by 62 · see citing works
Effects of early weaning on anxiety and autonomic responses to stress in rats
Ito, A., Kikusui, T., Takeuchi, Y., & Mori, Y. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.023 · Cited by 62 · see citing works
Dugger, B. N., Morris, J. A., Jordan, C. L., & Breedlove, S. M. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.10.001 · Cited by 62 · see citing works
Repeated agonistic encounters in hamsters modulate AVP V1a receptor binding
COOPER, M., KAROM, M., HUHMAN, K., & ELLIOTTALBERS, H. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.04.012 · Cited by 61 · see citing works
Differences in maternal behavior of rats and the sociosexual development of the offspring
Birke, L. I. A., & Sadler, D. (1987) · Developmental Psychobiology · doi:10.1002/dev.420200111 · Cited by 58 · see citing works
Patterns of maternal effort in mouse lines bidirectionally selected for aggression
Benus, R. F., & RÖNDIGS, M. (1996) · Animal Behaviour · doi:10.1006/anbe.1996.0006 · Cited by 50 · see citing works
∂-Opioid modulation of social interactions in juvenile mice weaned at different ages
Terranova, M. L., & Giovanni Laviola, A. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00447-4 · Cited by 49 · see citing works
Contextual determinants of female–female mounting in laboratory rats
FANG, J., & Clemens, L. G. (1999) · Animal Behaviour · doi:10.1006/anbe.1998.1025 · Cited by 48 · see citing works
Early separation of young rats from the mother and the development of play fighting
Janus, K. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90375-1 · Cited by 46 · see citing works
Nakamura, K., Kikusui, T., TAKEUCHI, Y., & MORI, Y. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.10.002 · Cited by 43 · see citing works
Shimozuru, M., Kodama, Y., Iwasa, T., Kikusui, T., Takeuchi, Y., & Mori, Y. (2007) · Developmental Psychobiology · doi:10.1002/dev.20202 · Cited by 43 · see citing works
Terranova, M. L., & Giovanni Laviola, A. (1995) · Animal Behaviour · doi:10.1016/0003-3472(95)80042-5 · Cited by 43 · see citing works
Adriani, W. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00300-7 · Cited by 37 · see citing works
Iwata, E., Kikusui, T., Takeuchi, Y., & Mori, Y. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.03.013 · Cited by 33 · see citing works
Sex and estrogenic effects on coexpression of mRNAs in single ventromedial hypothalamic neurons
Devidze, N., Mong, J. A., Jasnow, A. M., Kow, L., & Pfaff, D. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507144102 · Cited by 32 · see citing works
Kodama, Y., Kikusui, T., Takeuchi, Y., & Mori, Y. (2008) · Developmental Psychobiology · doi:10.1002/dev.20289 · Cited by 32 · see citing works
Vertical Transmission of Acquired Ulcer Susceptibility in the Rat
Skolnick, N. J., Ackerman, S. H., Hofer, M. A., & Weiner, H. (1980) · Science · doi:10.1126/science.7189606 · Cited by 31 · see citing works
The Influence of Early Weaning on Aggressive Behavior in Mice
Nakamura, K., Kikusui, T., Takeuchi, Y., & Mori, Y. (2003) · Journal of Veterinary Medical Science · doi:10.1292/jvms.65.1347 · Cited by 29 · see citing works
Counsilman, J. J., & Lim, L. M. (1985) · Animal Behaviour · doi:10.1016/s0003-3472(85)80037-3 · Cited by 28 · see citing works
Early experience and maternal behavior in rats
Brunelli, S. A., Shindledecker, R. D., & Hofer, M. A. (1989) · Developmental Psychobiology · doi:10.1002/dev.420220308 · Cited by 23 · see citing works
Joffe, J. M., & Levine, S. (1973) · Behavioral Biology · doi:10.1016/s0091-6773(73)80158-0 · Cited by 20 · see citing works
Askew, A., González, F., Stahl, J. M., & Karom, M. C. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.08.001 · Cited by 19 · see citing works
Giovanni Laviola, A., & Dell’Omo, G. (1997) · Psychobiology · doi:10.3758/bf03331923 · Cited by 18 · see citing works
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Wang, X., Tsai, T.-C., Deng, F., Wei, X., Chai, J., Knapp, J., APPLE, J. K., Maxwell, C. V. V., Lee, J. A., Li, Y., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0721-7 · Cited by 528 · see citing works
Oxytocin and the development of parenting in humans
Gordon, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.02.005 · Cited by 469 · see citing works
Curley, J. P., & Champagne, F. A. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.11.001 · Cited by 257 · see citing works
Oxytocin and social motivation
Gordon, I., Martin, C., Feldman, R., & Leckman, J. F. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.07.007 · Cited by 211 · see citing works
Social influences on neurobiology and behavior: Epigenetic effects during development
Curley, J. P., Jensen, C. L., Rahia Mashoodh, A., & Champagne, F. A. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.06.005 · Cited by 195 · see citing works
Curley, J. P. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.025.2009 · Cited by 184 · see citing works
Developmental experiences and the oxytocin receptor system
Bales, K. L., & Perkeybile, A. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.013 · Cited by 142 · see citing works
Lebron-Milad, K., Abbs, B., Milad, M. R., Linnman, C., Rougemount-Bücking, A., Zeidan, M. A., Holt, D. J., & Goldstein, J. M. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-7 · Cited by 138 · see citing works
Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders
Grinevich, V., Desarménien, M. G., Chini, B., Tauber, M., & Muscatelli, F. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00164 · Cited by 121 · see citing works
Early Adversity and the Neotenous Human Brain
Tottenham, N. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.06.018 · Cited by 120 · see citing works
Duan, J., Huang, Y., Tan, X., Chai, T., Wu, J., Zhang, H., Li, Y., Hu, X., Zheng, P., Ji, P., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01428-1 · Cited by 97 · see citing works
Of mice and rats: Key species variations in the sexual differentiation of brain and behavior
Bonthuis, P. J., Cox, K. H., Searcy, B. T., Kumar, P., Tobet, S. A., & Rissman, E. F. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.05.001 · Cited by 90 · see citing works
Developmental Effects of Serotonin 1A Autoreceptors on Anxiety and Social Behavior
Donaldson, Z. R., Piel, D., Santos, T. L., Richardson-Jones, J. W., Leonardo, E. D., Beck, S. G., Champagne, F. A., & Hen, R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.185 · Cited by 84 · see citing works
Perkeybile, A. M., Delaney-Busch, N., Hartman, S., Grimm, K. J., & Bales, K. L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00191 · Cited by 76 · see citing works
Maternal imprints and the origins of variation
Champagne, F. A. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.02.016 · Cited by 74 · see citing works
Affiliation, Aggression, and Selectivity of Peer Relationships in Meadow and Prairie Voles
Lee, N. S., Goodwin, N. L., Freitas, K. E., & Beery, A. K. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00052 · Cited by 68 · see citing works
Parathan, P., Wang, Y., Leembruggen, A. J. L., Bornstein, J. C., & Foong, J. P. P. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.10.011 · Cited by 64 · see citing works
Effects of weaning age and housing conditions on phenotypic differences in mice
Bailoo, J. D., Voelkl, B., Varholick, J. A., Novak, J., Murphy, E., Rosso, M., Palme, R., & Würbel, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-68549-3 · Cited by 63 · see citing works
Sensory input, sex and function shape hypothalamic cell type development
Kaplan, H. S., Logeman, B. L., Zhang, K., Yawitz, T. A., Santiago, C., Sohail, N., Talay, M., Seo, C., Naumenko, S., Sui, S. J. H., et al. (2025) · Nature · doi:10.1038/s41586-025-08603-0 · Cited by 53 · see citing works
Lepelletier, F.-X., Tauber, C., Nicolas, C., Solinas, M., Castelnau, P., Belzung, C., Emond, P., Cortese, S., Faraone, S. V., Chalon, S., et al. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu044 · Cited by 47 · see citing works
Curley, J. P., Rock, V., Moynihan, A. M., Bateson, P., Keverne, E. B., & Champagne, F. A. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9334-4 · Cited by 46 · see citing works
Self-citationImpulse for animal welfare outside the experiment
Lewejohann, L., Schwabe, K., Häger, C., & Jirkof, P. (2020) · Laboratory Animals · doi:10.1177/0023677219891754 · Cited by 44 · see citing works
X-chromosome dosage affects male sexual behavior
Bonthuis, P. J., Cox, K. H., & Rissman, E. F. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.003 · Cited by 41 · see citing works
Can breastfeeding affect the rest of our life?
Lisboa, P., Miranda, R. A., Souza, L., & Moura, E. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108821 · Cited by 34 · see citing works
Frank Beach award winner: Neuroendocrinology of group living
Beery, A. K. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.11.002 · Cited by 36 · see citing works
Laboratory macaques: When to wean?
Prescott, M. J., Nixon, M. E., Farningham, D. A. H., Naiken, S., & Griffiths, M. (2011) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2011.11.001 · Cited by 34 · see citing works
Importance of the lactation period in developmental programming in rodents
Rodríguez-González, G. L., Bautista, C. J., Rojas-Torres, K. I., Nathanielsz, P. W., & Zambrano, E. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa041 · Cited by 33 · see citing works
Maternal Weaning Modulates Emotional Behavior and Regulates the Gut-Brain Axis
Farshim, P. P., Walton, G., Chakrabarti, B., Givens, D. I., Saddy, D., Kitchen, I., Swann, J. R., & Bailey, A. (2016) · Scientific Reports · doi:10.1038/srep21958 · Cited by 32 · see citing works
Richter, S. H., Kästner, N., Loddenkemper, D.-H., Kaiser, S., & Sachser, N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167652 · Cited by 30 · see citing works
Postnatal and Adult Neurogenesis in Mammals, Including Marsupials
Bartkowska, K., Tepper, B., Turlejski, K., & Djavadian, R. L. (2022) · Cells · doi:10.3390/cells11172735 · Cited by 30 · see citing works
Gaskill, B. N., Stottler, A. M., Garner, J. P., Winnicker, C., Mulder, G. B., & Pritchett‐Corning, K. R. (2017) · Lab Animal · doi:10.1038/laban.1225 · Cited by 30 · see citing works
Separating the effects of shelter from additional cage enhancements for group-housed BALB/cJ mice
Swetter, B. J., Karpiak, C. P., & Cannon, J. T. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.03.067 · Cited by 29 · see citing works
Máté, Z., Poles, M. Z., Szabó, G., Bagyánszki, M., Talapka, P., Fekete, É., & Bódi, N. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1552-7 · Cited by 25 · see citing works
Rymut, H. E., Rund, L. A., Bolt, C. R., Villamil, M. B., Southey, B. R., Johnson, R. W., & Rodriguez‐Zas, S. L. (2021) · Animals · doi:10.3390/ani11082274 · Cited by 27 · see citing works
Leaving home: A study of laboratory mouse pup independence
Bechard, A. R., & Mason, G. J. (2010) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2010.04.006 · Cited by 24 · see citing works
Keever-Keigher, M. R., Zhang, P., Bolt, C. R., Rymut, H. E., Antonson, A. M., Caputo, M. P., Houser, A. K., Hernandez, A. G., Southey, B. R., Rund, L. A., et al. (2021) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkab113 · Cited by 24 · see citing works
Perinatal western‐type diet and associated gestational weight gain alter postpartum maternal mood
Bolton, J. L., Wiley, M. G., Ryan, B., Truong, S., Strait, M., Baker, D. C., Yang, N. Y., Ilkayeva, O., O’Connell, T. M., Wroth, S. W., et al. (2017) · Brain and Behavior · doi:10.1002/brb3.828 · Cited by 22 · see citing works
Postnatal maternal care predicts divergent weaning strategies and the development of social behavior
Franks, B., Champagne, F. A., & Curley, J. P. (2015) · Developmental Psychobiology · doi:10.1002/dev.21326 · Cited by 22 · see citing works
Does early weaning shape future endocrine and metabolic disorders? Lessons from animal models
Souza, L. L., de Moura, E. G., & Lisboa, P. C. (2020) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174420000410 · Cited by 20 · see citing works
Expression of Caytaxin Protein in Cayman Ataxia Mouse Models Correlates with Phenotype Severity
Sikora, K. M., Nosavanh, L. M., Kantheti, P., Burmeister, M., & Hortsch, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050570 · Cited by 18 · see citing works
Kelly, A. M., Saunders, A. G., & Ophir, A. G. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.01.006 · Cited by 18 · see citing works
Orally administered oxytocin alters brain activation and behaviors of pre-weaning mice
Tabbaa, M., & Hammock, E. A. D. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104613 · Cited by 18 · see citing works
Grieb, Z. A., Vitale, E. M., Morrell, J. I., Lonstein, J. S., & Pereira, M. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05441-7 · Cited by 18 · see citing works
Marazziti, D., Diep, P.-T., Carter, C. S., & Carbone, M. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220727120646 · Cited by 16 · see citing works
Han, W., Zheng, Y., Wang, L., & An, C. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578172 · Cited by 15 · see citing works
Lou, D. W., Wang, Q., Huang, M., & Zhou, Z. (2016) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2016.1223241 · Cited by 15 · see citing works
Sex-specific transgenerational effects of morphine exposure on reward and affective behaviors
Brynildsen, J. K., Sanchez, V., Yohn, N. L., Carpenter, M. D., & Blendy, J. A. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112842 · Cited by 14 · see citing works
Borland, J. M. (2025) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2025.101175 · Cited by 12 · see citing works
Commonalities and evolutionary divergences of mandible shape ontogenies in rodents
Dubied, M., Montuire, S., & Navarro, N. (2021) · Journal of Evolutionary Biology · doi:10.1111/jeb.13920 · Cited by 11 · see citing works
Ham, G. X., Lim, K. E., Augustine, G. J., & Leong, V. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13241 · Cited by 10 · see citing works
Bacterial community assembly of specific pathogen-free neonatal mice
Kennedy, E. A., Weagley, J. S., Kim, A. H., Antia, A., DeVeaux, A. L., & Baldridge, M. T. (2025) · Microbiome · doi:10.1186/s40168-025-02043-8 · Cited by 10 · see citing works
Post-weaning infant-to-mother bonding in nutritionally independent female mice
Stroobants, S., Creemers, J. W. M., Bosmans, G., & D’Hooge, R. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227034 · Cited by 9 · see citing works
Maternal Behavior Their Adjustments and Implicated Factors
Pérez-Torrero, E., & Rubio-Navarro, L. (2015) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2015.52004 · Cited by 9 · see citing works
Borazjani, A., Couri, B. M., Kuang, M., Balog, B. M., & Damaser, M. S. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz148 · Cited by 9 · see citing works
Rodriguez‐Zas, S. L., Southey, N. L., Rund, L. A., Antonson, A. M., Nowak, R. A., & Johnson, R. W. (2023) · PLoS ONE · doi:10.1371/journal.pone.0292952 · Cited by 7 · see citing works
Postweaning Grouping as a Strategy to Reduce Singly Housed Male Mice
Grífols, R., Zamora, C., Ortega-Saez, I., & Azkona, G. (2020) · Animals · doi:10.3390/ani10112135 · Cited by 6 · see citing works
Aggression in Laboratory Mice: Potential Influences and How to Manage It
Gaskill, A. B. (2014) · Cited by 6 · see citing works
Type 2 Immunity Regulates Dermal White Adipose Tissue Function
Satzinger, S., Willenborg, S., Ding, X., Klose, C. S. N., Radtke, D., Voehringer, D., & Eming, S. A. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.05.017 · Cited by 5 · see citing works
Zamudio-Flores, J., Cerqueda, D., Phillips-Farfán, B. V., Guerrero‐Flores, S., Salinas-García, A. F., Meléndez‐Herrera, E., Mojica, N. S., Kline, A. E., & Lajud, N. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115109 · Cited by 5 · see citing works
Hiadlovská, Z., Hamplová, P., Berchová‐Bímová, K., Macholán, M., & Bímová, B. V. (2021) · Behavioural Processes · doi:10.1016/j.beproc.2021.104316 · Cited by 5 · see citing works
de Guia, R. M., Hassing, A. S., Ma, T., Plucińska, K., Holst, B., Gerhart‐Hines, Z., Emanuelli, B., & Treebak, J. T. (2021) · The FASEB Journal · doi:10.1096/fj.202002740r · Cited by 5 · see citing works
Progress in Research on Brain Development and Function of Mice During Weaning
Zhang, W., Zhang, Y., Zheng, Y., Zheng, M., Sun, N., Yang, X., & Gao, Y. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190125095819 · Cited by 4 · see citing works
Functional constraints channel mandible shape ontogenies in rodents
Dubied, M., Montuire, S., & Navarro, N. (2022) · Royal Society Open Science · doi:10.1098/rsos.220352 · Cited by 4 · see citing works
Rodent and Rabbit Welfare in the Research Environment
Turner, P. V. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385103-1.00012-9 · Cited by 4 · see citing works
Назарова, Г. Г., Ulshina, A. S., Starchenko, K. I., Proskurnyak, L. P., Yuzhik, E. I., & Knyazev, S. P. (2021) · Mammalian Biology · doi:10.1007/s42991-021-00170-x · Cited by 3 · see citing works
Wu, Z., Wang, Q., Yang, F., Wang, J., Zhao, Y., Perrino, B. A., & Chen, J. (2023) · Biomolecules · doi:10.3390/biom13121688 · Cited by 3 · see citing works
Maletta, T. A., Palummieri, M., Correa, J., & Holahan, M. R. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1104866 · Cited by 3 · see citing works
Premachandran, H., Wilkin, J., & Arruda-Carvalho, M. (2024) · Current Protocols · doi:10.1002/cpz1.1040 · Cited by 2 · see citing works
Effect of Rubus idaeus L. Consumption During Pregnancy on Maternal Mice and Their Offspring
Hastings‐Tolsma, M., Stoffel, R. T., Quintana, A. S., Kane, R. R., Turner, J., & Wang, X. (2021) · Journal of Medicinal Food · doi:10.1089/jmf.2021.0078 · Cited by 2 · see citing works
Integration of postnatal craniofacial development and the effects of diet consistency in rodents
Dubied, M., Montuire, S., & Navarro, N. (2025) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2025.0549 · Cited by 2 · see citing works
Wu, R., Zhu, J., Wang, P., Xu, Z., Chen, L., Chen, Y., Jian, X., Wang, Q., Yang, S., & Wei, W. (2024) · Current Zoology · doi:10.1093/cz/zoae071 · Cited by 1 · see citing works
Behavioral comorbidities of early-life seizures: Insights from developmental studies in rats
Grígelová, A., Mikulecká, A., & Kubová, H. (2025) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2025.110307 · Cited by 1 · see citing works
Dory, E. K., Loterstein, Y., Hazani, R., Zalsman, G., & Weller, A. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106114 · Cited by 1 · see citing works
Jiang, L., Qing, Y., Huang, K., Huang, H., Li, C., Mei, Q., & Wu, Q. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47100866 · Cited by 1 · see citing works
Rivero, C. J., Abdelmesih, B., Kong, A., Khan, U., Kislin, M., & Autry, A. E. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105855 · Cited by 1 · see citing works
Ormiston, K., Shinde, N., Sarathy, G., Zhang, A., Bauer, M., Shukla, R., Alsammerai, S., Gupta, A., Bennouna, D., Wesolowski, J., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27041951 · Cited by 1 · see citing works
Ernst, A., & Böswald, L. F. (2026) · Scientific Reports · doi:10.1038/s41598-026-44974-8 · Cited by 1 · see citing works
Organ-specific responses of age-dependent vulnerability to deoxynivalenol in female mice
Kono, I. S., de Lemos, G. A. A., Gerez, J. R., Costa, J. B., Souza, M., Verri, W. A., Jr., Ferraz, C., Gloria, E. M., & Bracarense, A. P. F. R. L. (2026) · Food and Chemical Toxicology · doi:10.1016/j.fct.2026.116263 · Cited by 1 · see citing works
Development of Mechanisms that Regulate Global CNS States: An Introduction
Pfaff, D. W., & Gunnar, M. R. (2009) · Developmental Neuroscience · doi:10.1159/000216535
Effects of Social-Interaction on Reward Sensitivity in Adolescent Mice
Cole, S. L. (2012) · OakTrust (Texas A&M University Libraries)
Oxytocin, Arginine Vasopressin and Autism Spectrum Disorder
Bagasra, O., Heggen, C., & Hossain, M. I. (2018) · Wiley eBooks · doi:10.1002/9781119042280.ch4
Role of Cotton as Nesting Material in Female Mice as a Behavioral Indicator for Pup’s Health
Srivastava, R., & Rastogi, M. (2022) · Current Applied Materials · doi:10.2174/2666731201666220331085608
Jiménez-Cardozo, N., Díaz‐Vesga, M. C., Gallego‐Castillo, S., Alvarez, D., Orozco‐Agredo, J. C., Ortega, J. G., & Morales, C. (2024) · Legume Science · doi:10.1002/leg3.70016
Kelly, A. M. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105763
Parra, K. E., Lafrican, J. J., Rybka, K. A., Neuwirth, A. E., Chait, L. S., Posta, A. V. D., Greenwood, A., Zuloaga, K. L., Justice, N. J., & Zuloaga, D. G. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105799
Ormiston, K., Shinde, N., Sarathy, G., Zhang, A., Bauer, M., Shukla, R. K., Alsammerai, S., Gupta, A., Bennouna, D., Wesolowski, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.09.681352
Oosthuizen, M. K., & Pillay, N. (2026) · Developmental Psychobiology · doi:10.1002/dev.70124
Uchida, H., Ohno, S. N., Takasu, N. N., Nakamura, T. J., Sugimura, M., & Nakamura, W. (2026) · Journal of Oral Biosciences · doi:10.1016/j.job.2026.100787
Mason, G., & Weary, D. M. (2026) · Laboratory Animals · doi:10.1177/00236772261475086
Comparative lifespan trajectories of brain energy metabolism in human and macaque
Pourmajidian, M., Misic, B., & Dagher, A. (2026) · Appetite · doi:10.1016/j.appet.2026.108800
How does housing quality affect maternal investment and reproduction?Preprint
Anandarajan, P., & Mason, G. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.17.759638
- Authors
- Curley, J. P., Jordan, E. R., Swaney, W. T., Izraelit, A., Kammel, S., & Champagne, F. A.
- Affiliations
- Columbia University (US)
- Venue
- Developmental Neuroscience
- Publisher
- S. Karger AG
- Published
- 2009
- Volume
- 31
- Issue
- 4
- Pages
- 318-331
- ISSN
- 0378-5866 (ISSN-L)
- 1421-9859
- PMC
- PMC2820580
- OpenAlex
- W1998429750
- Cited by
- 92
- References
- 69
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 1 · 2013: 3 · 2012: 4
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Developmental Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1dp2od001674-01)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- weaning age, maternal care, postpartum period, social interaction, exploratory behavior, sexual dimorphism, oxytocin, vasopressin V1a receptor, hypothalamus, central amygdala, nucleus accumbens, mother-infant interaction, mice
- MeSH terms
- Age Factors, Animals, Behavior, Animal, Brain, Critical Period, Psychological, Exploratory Behavior, Female, Male, Maternal Behavior, Mice, Inbred C57BL, Neuropsychological Tests, Oxytocin, Social Behavior, Weaning, Receptors, Vasopressin, Mice
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