Cited by 381Neuroendocrine regulation and behaviorStress Responses and CortisolAnimal Behavior and Reproduction

Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty

Champagne, Frances A., Meaney, Michael J.·2007·Behavioral Neuroscience

Abstract

Cross-fostering studies in the rat have illustrated the importance of the postnatal environment in mediating the transmission of maternal licking/grooming (LG) from mother to offspring. The authors addressed the question of how postweaning social conditions can alter the patterns of maternal behavior. Juvenile female offspring of high LG and low LG mothers were placed in either standard, enriched, or impoverished postweaning environments for 50 consecutive days and then mated and observed with their own litters. Analysis of LG behavior indicated that the effect of postweaning environment was dependent on the level of postnatal mother-infant interaction. Postweaning isolation reduced exploratory behavior, maternal LG, and oxytocin receptor binding in the offspring of high LG mothers, whereas social enrichment enhanced exploration, LG behavior, and oxytocin receptor binding of low LG offspring. These effects were also transmitted to the next generation of offspring. Thus, maternal LG and the neural mechanisms that regulate this behavior exhibited a high degree of plasticity in response to changes in environment both within and beyond the postnatal period, with implications for the transmission of behavioral response to novelty and maternal care across generations.

Integrity signals

Registry

Crossref · 10.1037/0735-7044.121.6.1353

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Nulliparous OTKO mice display decreased levels of retrieval and licking and grooming of pups compared to wild-types.

    “Later, however, more detailed studies of these mice revealed that nulliparous OTKO mice displayed decreased levels of retrieval and licking and grooming of pups compared to wild-types [19].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Champagne, F. A., & Meaney, M. J.
Affiliations
Columbia University (US)
Venue
Behavioral Neuroscience
Published
2007-12
Volume
121
Issue
6
Pages
1353-1363
ISSN
  • 0735-7044 (ISSN-L)
  • 1939-0084
OpenAlex
W2149154059
Cited by
381
References
75
Citations by year
2026: 10 · 2025: 10 · 2024: 12 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 58 · 2019: 12 · 2018: 22 · 2017: 20 · 2016: 22 · 2015: 32 · 2014: 24 · 2013: 24 · 2012: 22
FWCI
26.09
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioral Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Keywords
transgenerational effects, maternal care, social enrichment, social isolation, exploratory behavior, mother-infant interaction, cross-fostering, behavioral plasticity, rats
MeSH terms
Age Factors, Analysis of Variance, Animals, Behavior, Animal, Exploratory Behavior, Female, Male, Maternal Behavior, Mother-Child Relations, Pregnancy, Protein Binding, Sex Factors, Social Environment, Receptors, Oxytocin, Rats, Long-Evans, Recognition, Psychology, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review