Effects of Monounsaturated Fatty Acids on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis
Abstract
The appropriate pattern of macronutrient distribution for dietary protocols aimed at treating or preventing obesity and its associated cardiovascular diseases is still a controversial topic of discussion. Recommendations considering a specific percentage or range for monounsaturated fatty acids (MUFA) are rare. It was the aim of this study to analyze long-term, randomized, controlled dietary intervention trials and to investigate the effects of MUFA on the biomarkers of obesity and cardiovascular risk factors. Dietary regimens with a high amount of MUFA (>12%) were compared to those with ≤12%. The biomarkers taken into account were weight, waist circumference, fat mass, total cholesterol, LDL cholesterol, HDL cholesterol, triacylglycerols, systolic and diastolic blood pressure, as well as C-reactive protein. A total of 12 studies met the inclusion criteria. Data analysis was performed using the Review Manager 5.0.25 software. Significant differences between high- and low-MUFA protocols could be observed with respect to fat mass [–1.94 kg (confidence interval –3.72, –0.17), p = 0.03], systolic blood pressure [–2.26 mm Hg (confidence interval –4.28, –0.25), p = 0.03] and diastolic blood pressure [–1.15 mm Hg (confidence interval –1.96, –0.34), p = 0.005] favoring the dietary protocols with >12% MUFA. Therefore, MUFA might represent a useful tool in the design of dietary regimens for obesity and cardiovascular disease.
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Monounsaturated fat improves BP and cholesterol and, when consumed in place of saturated fat, lowers glucose among those predisposed to insulin resistance.
“Monounsaturated fat improves BP and cholesterol353 and, when consumed in place of saturated fat, lowers glucose among those predisposed to insulin resistance.354”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [354]
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Peng, M., Xu, W., Tan, P., Du, J., Mai, K., Zhou, H., Zhang, Y., Nian, R., Macq, B. M. M., & Ai, Q. (2017) · Aquaculture · doi:10.1016/j.aquaculture.2017.06.032 · Cited by 73 · see citing works
Zhao, X., Xiang, X., Huang, J., Ma, Y., Sun, J., & Zhu, D. (2021) · ACS Omega · doi:10.1021/acsomega.0c05544 · Cited by 71 · see citing works
Effects of Dietary Fat Intake on HDL Metabolism
Yanai, H., Katsuyama, H., Hamasaki, H., Abe, S., Tada, N., & Sako, A. (2014) · Journal of Clinical Medicine Research · doi:10.14740/jocmr2030w · Cited by 68 · see citing works
House, J. S., Méndez, M. A., Maguire, R. L., Gonzalez-Nahm, S., Huang, Z., Daniels, J. L., Murphy, S. K., Fuemmeler, B. F., Wright, F. A., & Hoyo, C. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00107 · Cited by 68 · see citing works
Aljuraiban, G. S., Gibson, R., Chan, D. S. M., Horn, L. V., & Chan, Q. M. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.09.011 · Cited by 70 · see citing works
Cao, X., Xia, J., Zhou, Y., Wang, Y., Xia, H., Wang, S., Liao, W., & Sun, G. (2022) · Foods · doi:10.3390/foods11131982 · Cited by 59 · see citing works
Posicionamento sobre o Consumo de Gorduras e Saúde Cardiovascular – 2021
Izar, M. C. D. O., Lottenberg, A. M., Giraldez, V. Z. R., Santos, R. D., Machado, R. M., Bertolami, A., Assad, M. H. V., Saraiva, J. F. K., Faludi, A. Á., Moreira, A. S. B., et al. (2021) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20201340 · Cited by 65 · see citing works
Enkhmaa, B., Surampudi, P. N., Anuurad, E., & Berglund, L. (2015) · Europe PMC (PubMed Central) · Cited by 50 · see citing works
JCS 2023 Guideline on the Primary Prevention of Coronary Artery Disease
Fujiyoshi, A., Kohsaka, S., Hata, J., Hara, M., Kai, H., Masuda, D., Miyamatsu, N., Nishio, Y., Ogura, M., Sata, M., et al. (2024) · Circulation Journal · doi:10.1253/circj.cj-23-0285 · Cited by 47 · see citing works
Guerendiain, M., Montes, R., López‐Belmonte, G., Martín‐Matillas, M., Castellote, A. I., Martín-Bautista, E., Martí, A., Martínez, J. A., Moreno, L. A., Garagorri, J. M., et al. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.11.006 · Cited by 44 · see citing works
Alterations in Serum Lipid Profile Patterns in Oral Lichen Planus
López‐Jornet, P., Camacho‐Alonso, F., & Rodríguez-Martínes, M. A. (2012) · American Journal of Clinical Dermatology · doi:10.2165/11633600-000000000-00000 · Cited by 43 · see citing works
Mediterranean Diet and Workplace Health Promotion
Korre, M., Tsoukas, M. A., Frantzeskou, E., Yang, J., & Kales, S. N. (2014) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-014-0416-3 · Cited by 43 · see citing works
Hannon, B. A., Thompson, S. V., An, R., & Terán-Garcı́a, M. (2017) · Annals of Nutrition and Metabolism · doi:10.1159/000477216 · Cited by 42 · see citing works
Wang, Q., Liu, R., Chang, M., Zhang, H., Jin, Q., & Wang, X. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1854673 · Cited by 40 · see citing works
Capítulo 3 - Avaliação Clínica e Complementar
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Figueiredo, C., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160153 · Cited by 36 · see citing works
Abdullah, M. M. H., Jew, S., & Jones, P. J. H. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nuw062 · Cited by 36 · see citing works
Soriguer, F., Rojo-Martínez, G., Goday, A., Bosch-Comas, A., Bordiú, E., Caballero-Díaz, F., Calle-Pascual, A., Carmena, R., Casamitjana, R., Castaño, L., et al. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.130 · Cited by 34 · see citing works
Poudyal, H., & Brown, L. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.07.002 · Cited by 34 · see citing works
Ros, E., López‐Miranda, J., Picó, C., Rubio, M. Á., Babió, N., Sala‐Vila, A., Pérez‐Jiménez, F., Escrich, E., Bulló, M., Solanas, M., et al. (2015) · PubMed · doi:10.3305/nh.2015.32.2.9202 · Cited by 39 · see citing works
Dietary fatty acids, dietary patterns, and lipoprotein metabolism
Lamarche, B., & Couture, P. (2014) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000139 · Cited by 33 · see citing works
Othman, N. A., Manaf, M. A., Harith, S., & Ishak, W. R. W. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2018.1451408 · Cited by 33 · see citing works
Olive oil promotes wound healing of mice pressure injuries through NOS-2 and Nrf2
Schanuel, F. S., Saguie, B. O., & Monte‐Alto‐Costa, A. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0845 · Cited by 32 · see citing works
Dietary fats and cardiovascular health: a summary of the scientific evidence and current debate
Fattore, E., & Massa, E. (2018) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2018.1455813 · Cited by 31 · see citing works
Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival
Marrano, N., Spagnuolo, R., Biondi, G., Cignarelli, A., Perrini, S., Vincenti, L., Laviola, L., Giorgino, F., & Natalicchio, A. (2021) · Plants · doi:10.3390/plants10020286 · Cited by 31 · see citing works
Capítulo 14 – Crise Hipertensiva
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Figueiredo, C., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160164 · Cited by 30 · see citing works
Alotaibi, M., Shao, J., Pauciulo, M. W., Nichols, W. C., Hemnes, A. R., Malhotra, A., Kim, N. H., Yuan, J. X. ‐., Fernandes, T. M., Kerr, K. M., et al. (2021) · CHEST Journal · doi:10.1016/j.chest.2022.08.2230 · Cited by 28 · see citing works
Avocado and Cardiovascular Health
Weschenfelder, C., dos Santos, J. L., de Souza, P. A. L., de Campos, V. P., & Marcadenti, A. (2015) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2015.57010 · Cited by 28 · see citing works
Nishi, S. K., Kendall, C. W. C., Bazinet, R. P., Bashyam, B., Ireland, C., Augustin, L. S. A., Mejía, S. B., Sievenpiper, J. L., & Jenkins, D. J. A. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.04.001 · Cited by 28 · see citing works
van Baak, M. A. (2013) · Thrombosis and Haemostasis · doi:10.1160/th13-01-0045 · Cited by 26 · see citing works
Dietary fat and fatty foods in the prevention of non-communicable diseases: A review of the evidence
Schwingshackl, L., Heseker, H., Kiesswetter, E., & Koletzko, B. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.08.002 · Cited by 47 · see citing works
Self-citationZhou, J. C., Han, D., Jin, J., Xie, S., Yang, Y. X., & Zhu, X. (2014) · Aquaculture · doi:10.1016/j.aquaculture.2014.03.029 · Cited by 25 · see citing works
Kwon, H. N., & Choi, C. B. (2015) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2015.44.12.1806 · Cited by 25 · see citing works
Supriyanto, S., Imran, Z., Ardiansyah, R., Auliyai, B., Pratama, A. R., & Kadha, F. (2022) · Agronomy · doi:10.3390/agronomy12030636 · Cited by 25 · see citing works
Schwingshackl, L., Heseker, H., Kiesswetter, E., & Koletzko, B. V. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.10.011 · Cited by 25 · see citing works
Self-citationOlive fruit and olive oil composition and their functional compounds
Paiva‐Martins, F., & Kiritsakis, A. K. (2017) · doi:10.1002/9781119135340.ch5 · Cited by 23 · see citing works
Dietary Lipids, Gut Microbiota, and Their Metabolites: Insights from Recent Studies
Mohammadi, F., & Rudkowska, I. (2025) · Nutrients · doi:10.3390/nu17040639 · Cited by 22 · see citing works
Oleic Acid in the Diet and What It Does: Implications for Diabetes and Its Complications
Granado-Casas, M., & Mauricio, D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813822-9.00014-x · Cited by 23 · see citing works
Fat and fatty acids – a scoping review for Nordic Nutrition Recommendations 2023
Retterstøl, K., & Rosqvist, F. (2024) · Food & Nutrition Research · doi:10.29219/fnr.v68.9980 · Cited by 22 · see citing works
Olive Oil: Antioxidant Compounds and Their Potential Effects over Health
Kabaran, S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80993 · Cited by 22 · see citing works
7th Brazilian Guideline of Arterial Hypertension: Chapter 6 - Non-pharmacological treatment
Malachias, M., Franco, R., Forjaz, C., Pierin, A., Gowdak, M., Klein, M., & Matsudo, V. K. R. (2016) · The Scientific Electronic Library Online (Fundação de Amparo à Pesquisa do Estado de São Paulo) · Cited by 21 · see citing works
Capítulo 9 - Hipertensão Arterial na gestação
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Poli‐de‐Figueiredo, C. E., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160159 · Cited by 21 · see citing works
Silva, O. L. L., Macedo, A. R. G., Nunes, E. D. S. C. D. L., Campos, K. D., Araújo, L. C. C., Tiburço, X., Pinto, A. S. O., Joele, M. R. S. P., Ferreira, M. D. S., Silva, A., et al. (2020) · Aquaculture Research · doi:10.1111/are.14577 · Cited by 19 · see citing works
Huang, H., Zhou, G., Pu, R., Cui, Y., & Liao, D. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1888689 · Cited by 19 · see citing works
Enns, J. E., Hanke, D., Park, A., Zahradka, P. C., & Taylor, C. G. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.12.002 · Cited by 19 · see citing works
The Secrets of the Mediterranean Diet. Does [Only] Olive Oil Matter?
Mazzocchi, A., Leone, L., Agostoni, C. V., & Pali‐Schöll, I. (2021) · doi:10.1201/9781003180449-27 · Cited by 18 · see citing works
Type 1 Diabetic Subjects with Diabetic Retinopathy Show an Unfavorable Pattern of Fat Intake
Granado-Casas, M., Ramírez‐Morros, A., Martín, M., Real, J., Alonso, N., Valldeperas, X., Traveset, A., Rubinat, E., Alcubierre, N., Hernández, M., et al. (2018) · Nutrients · doi:10.3390/nu10091184 · Cited by 18 · see citing works
Nakamura, Y., Ueshima, H., Okuda, N., Miura, K., Kita, Y., Miyagawa, N., Yoshita, K., Nakagawa, H., Sakata, K., Saitoh, S., et al. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0969-z · Cited by 18 · see citing works
Tokgözoğlu, L. S., Hekimsoy, V., Costabile, G., Calabrese, I., & Riccardi, G. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_353 · Cited by 20 · see citing works
The powerful story against cardiovascular diseases: Dietary factors
Kisioglu, B., & Nergiz‐Unal, R. (2017) · Food Reviews International · doi:10.1080/87559129.2017.1410172 · Cited by 15 · see citing works
Capítulo 6 - Tratamento não medicamentoso
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Figueiredo, C., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160156 · Cited by 14 · see citing works
Oki, É., Norde, M. M., Carioca, A. A. F., de Souza, J. M. P., Castro, I. A., Marchioni, D. M. L., Fisberg, R. M., & Rogero, M. M. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517001416 · Cited by 14 · see citing works
Lee, H., Jang, H. B., Yoo, M., Chung, K., & Lee, H.-J. (2019) · Nutrients · doi:10.3390/nu11081928 · Cited by 12 · see citing works
Kaikkonen, J., Jula, A., Mikkilä, V., Juonala, M., Viikari, J. S. A., Moilanen, T. P. S., Nikkari, T., Kähönen, M. A. P., Lehtimäki, T. J., & Raitakari, O. T. (2013) · Journal of Nutrition · doi:10.3945/jn.112.172866 · Cited by 11 · see citing works
Rincón‐Cervera, M. Á., Bravo, R., Freitas, R. A. M. S., López‐Arana, S., & de Camargo, A. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823569-0.00005-9 · Cited by 11 · see citing works
The Role of Diet in the Prevention and Treatment of Cardiovascular Disease
Richter, C. K., Skulas‐Ray, A. C., & Kris‐Etherton, P. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802928-2.00027-8 · Cited by 12 · see citing works
Godhamgaonkar, A. A., Wadhwani, N. S., Randhir, K., Selukar, S. S., Dalvi, S., Dangat, K. D., Wagh, G. N., Lalwani, S. K., Chandhiok, N., Kulkarni, B., et al. (2023) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2023.102583 · Cited by 10 · see citing works
Wang, N. C., Bagheri, M., Olszewski, T., Friese, K. A., Smith, H., Robles, M. E., Wang, C., Brooks, A., Bordenstein, S. R., Ferguson, J. F., et al. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.05.013 · Cited by 10 · see citing works
Olive Oil Lipophenols Induce Insulin Secretion in 832/13 β-Cell Models
Caroleo, M. C., Plastina, P., Fazio, A., Torre, C. L., Manetti, F., & Cione, E. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13071085 · Cited by 10 · see citing works
Henderson, G. C., Evans, N. P., Grange, R. W., & Tuazon, M. A. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514000129 · Cited by 10 · see citing works
Capítulo 10 - Hipertensão na Criança e no Adolescente
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Figueiredo, C., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160160 · Cited by 9 · see citing works
Bioactive lipids: Chemistry, biochemistry, and biological properties
Salsinha, A. S., Machado, M., Rodríguez-Alcalá, L. M., Gomes, A., & Pintado, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824043-4.00014-2 · Cited by 11 · see citing works
Nikolay, S., Schubert, M., Erlenbusch, N., Weber, L., Smit, I., & Matthäus, B. (2025) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.202400005 · Cited by 8 · see citing works
Kouvari, M., Notara, V., Panagiotakos, D. B., Michalopoulou, M., Vassileiou, N., Papataxiarchis, E., Tzanoglou, D., Mantas, Y., Kogias, Y., Stravopodis, P., et al. (2015) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12324 · Cited by 8 · see citing works
Serum fatty acids profile and association with early-onset coronary artery disease
Xuan, C., Tian, Q., Li, H., Guo, J., He, G., & Lun, L. (2021) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223211033102 · Cited by 8 · see citing works
- Authors
- Schwingshackl, L., Strasser, B., & Hoffmann, G.
- Affiliations
- UMIT TIROL - Private University for Health Sciences and Health Technology (AT)
- Venue
- Annals of Nutrition and Metabolism
- Publisher
- S. Karger AG
- Published
- 2011
- Volume
- 59
- Issue
- 2-4
- Pages
- 176-186
- ISSN
- 0250-6807 (ISSN-L)
- 1421-9697
- OpenAlex
- W2014433485
- Cited by
- 150
- References
- 53
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 13 · 2021: 15 · 2020: 6 · 2019: 9 · 2018: 12 · 2017: 11 · 2016: 15 · 2015: 14 · 2014: 12 · 2013: 14 · 2012: 4
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
- Keywords
- monounsaturated fatty acids, dietary fat composition, obesity, cardiovascular risk factors, weight loss, fat mass, waist circumference, blood pressure, cholesterol, triglycerides, C-reactive protein, dietary intervention, macronutrient distribution
- MeSH terms
- Adipose Tissue, Blood Pressure, Body Weight, C-Reactive Protein, Energy Intake, Cardiovascular Diseases, Dietary Fats, Unsaturated, Fatty Acids, Monounsaturated, Humans, Cholesterol, HDL, Cholesterol, LDL, Obesity, Risk Factors, Triglycerides, Biomarkers, Randomized Controlled Trials as Topic, Waist Circumference
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