Cited by 156Lipid metabolism and disordersLipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

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Detection, Quantification, and Characterization of Potentially Atherogenic Triglyceride-Rich Remnant Lipoproteins

Cohn, Jeffrey S., Marcoux, Caroline, Davignon, Jean·1999·Arteriosclerosis, Thrombosis, and Vascular Biology

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Abstract

Abstract —Triglyceride-rich lipoprotein (TRL) remnants are formed in the circulation when apolipoprotein (apo) B-48–containing chylomicrons of intestinal origin or apoB-100–containing VLDL of hepatic origin are converted by lipoprotein lipase, and to a lesser extent by hepatic lipase, into smaller and more dense particles. Compared with their nascent precursors, TRL remnants are depleted of triglyceride, phospholipid, and C apolipoproteins and are enriched in cholesteryl esters and apoE. They can thus be identified, separated, and/or quantified in plasma according to their density, charge, size, specific lipid components, apolipoprotein composition, and/or apolipoprotein immunospecificity. Each of these approaches has contributed to our current understanding of the compositional characteristics of TRL remnants and their potential to promote atherosclerosis. An ongoing search is nevertheless under way for more accurate and clinically applicable remnant lipoprotein assays that will be able to better define coronary artery disease risk in patients with hypertriglyceridemia.

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Watts, G. F., Mandalia, S., Brunt, J. N. H., Slavin, B. M., COLTART, D. J., & Lewis, B. (1993) · Metabolism · doi:10.1016/0026-0495(93)90199-x · Cited by 146
Association of Postprandial Triglyceride and Retinyl Palmitate Responses With Asymptomatic Carotid Artery Atherosclerosis in Middle-aged Men and Women
Sharrett, A. R., Chambless, L. E., HEISS, G. M., Paton, C. C., & Patsch, W. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.12.2122 · Cited by 143
Quantification of postprandial triglyceride-rich lipoproteins in healthy men by retinyl ester labeling and simultaneous measurement of apolipoproteins B-48 and B-100
Karpe, F., Bell, M., Björkegren, J., & Hamsten, A. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.2.199 · Cited by 143
A Mouse Model with Features of Familial Combined Hyperlipidemia
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Quantitative determination of human apolipoprotein Cc-III by electroimmunoassay
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Role of apolipoprotein E in the lipolytic conversion of beta-very low density lipoproteins to low density lipoproteins in type III hyperlipoproteinemia.
Ehnholm, C., Mahley, R. W., Chappell, D. A., Weisgraber, K. H., Ludwig, E. H., & Witztum, J. L. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.17.5566 · Cited by 137
Plasma clearance of chylomicrons labeled with retinyl palmitate in healthy human subjects.
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Association of Postprandial Triglyceride and Retinyl Palmitate Responses With Newly Diagnosed Exercise-Induced Myocardial Ischemia in Middle-Aged Men and Women
Ginsberg, H. N., Jones, J., Blaner, W. S., Thomas, A., Karmally, W., Fields, L., Blood, D. K., & Begg, M. D. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.11.1829 · Cited by 128
Atherosclerosis and arterial influx of lipoproteins
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Relationship between apolipoproteins and chemical components of lipoproteins in survivors of myocardial infarction
Avogaro, P., Bon, G. B., Cazzolato, G., & Rorai, E. (1980) · Atherosclerosis · doi:10.1016/0021-9150(80)90094-5 · Cited by 125
Plasma apolipoprotein A-I, A-II, B, E and C-III containing particles in men with premature coronary artery disease
GENESTJR, J., Bard, J., Fruchart, J., Ordovás, J. M., WILSON, P., & Schaefer, E. J. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90109-g · Cited by 122
Postprandial Triglyceride Response in Young Adult Men and Familial Risk for Coronary Atherosclerosis
Uiterwaal, C. S. P. M., Grobbee, D. E., Witteman, J. C. M., van Stiphout, W.-A. H. J., Krauss, X. H., Havekes, L. M., de Bruijn, A. M., van Tol, A., & Albert Hofman, D. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-8-199410150-00004 · Cited by 121
The association of increased levels of intermediate-density lipoproteins with smoking and with coronary artery disease.
GSteiner, LSchwartz, SShumak, & MPoapst (1987) · Circulation · Cited by 119
Biological variability in concentrations of serum lipids: sources of variation among results from published studies and composite predicted values
Smith, S. J., Cooper, G. R., Myers, G. L., & Sampson, E. J. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.6.1012 · Cited by 118
Apolipoprotein E secretion by macrophages: its potential physiological functions
Mazzone, T. (1996) · Current Opinion in Lipidology · doi:10.1097/00041433-199610000-00008 · Cited by 116
Triglycerides: a risk factor for coronary heart disease
Davignon, J., & Cohn, J. S. (1996) · Atherosclerosis · doi:10.1016/0021-9150(96)05858-3 · Cited by 116
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Plasma lipoprotein distribution of apoC-III in normolipidemic and hypertriglyceridemic subjects: comparison of the apoC-III to apoE ratio in different lipoprotein fractions
Fredenrich, A., Giroux, L.-M., Tremblay, M., Krimbou, L., Davignon, J., & Cohn, J. S. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37424-1 · Cited by 115
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Apolipoproteins C–III and E in apoB- and non-apoB-containing lipoproteins in two populations at contrasting risk for myocardial infarction: the ECTIM study. Etude Cas Temoins sur 'Infarctus du Myocarde
Luc, G., Fievet, C., Arveiler, D., Evans, A. E., Bard, J. M., Cambien, F., Fruchart, J. C., & Ducimetiere, P. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37594-5 · Cited by 114
Increased frequency of lipoprotein disorders similar to type iii hyperlipoproteinemia in survivors of myocardial infarction in Japan
Kameda, K., MATSUZAWA, Y., KUBO, M., Ishikawa, K., Maejima, I., Yamamura, T., Yamamoto, A. C., & Tarui, S. (1984) · Atherosclerosis · doi:10.1016/0021-9150(84)90171-0 · Cited by 113
Evaluation of an immunoseparation method for quantitative measurement of remnant-like particle-cholesterol in serum and plasma
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Triglyceride
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Apolipoprotein E-enriched lipoprotein subclasses in normolipidemic subjects.
Gibson, J. C., Rubinstein, A., Bukberg, P. R., & Brown, W. V. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37934-7 · Cited by 108
Antiatherosclerotic and Antioxidative Effects of Captopril in Apolipoprotein E-Deficient Mice
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Remnants of lipoproteins of intestinal and hepatic origin in familial dysbetalipoproteinemia.
Kane, J. P., Chen, G. C., Hamilton, R. L., Hardman, D. A., Malloy, M. J., & Havel, R. J. (1983) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.3.1.47 · Cited by 106
Oxidized Lipids in the Diet Accelerate the Development of Fatty Streaks in Cholesterol-Fed Rabbits
Staprãns, I., Rapp, J. H., Pan, X.-M., Hardman, D. A., & Feingold, K. R. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.4.533 · Cited by 105
Remnant lipoprotein cholesterol and triglyceride reference ranges from the Framingham Heart Study
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Lipoprotein lipase increases lipoprotein binding to the artery wall and increases endothelial layer permeability by formation of lipolysis products.
Rutledge, J. C., Woo, M. M., Rezai, A. A., Curtiss, L. K., & Goldberg, I. J. (1997) · Circulation Research · doi:10.1161/01.res.80.6.819 · Cited by 101
Evidence for the distribution of apolipoprotein E between lipoprotein classes in human normocholesterolemic plasma and for the origin of unassociated apolipoprotein E (Lp-E).
Castro, G., & Fielding, C. J. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37844-5 · Cited by 98
Plasma Concentration of Apolipoprotein E in Intermediate-Sized Remnant-Like Lipoproteins in Normolipidemic and Hyperlipidemic Subjects
Cohn, J. S., Tremblay, M., Amiot, M., Bouthillier, D., Roy, M., Genest, J. J., & Davignon, J. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.1.149 · Cited by 96
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Lipolysis of triglyceride-rich lipoproteins activates coagulant factor XII: A study in familial lipoprotein-lipase deficiency
Mitropoulos, K. A., Miller, G. J., Watts, G. F., & Durrington, P. N. (1992) · Atherosclerosis · doi:10.1016/0021-9150(92)90015-9 · Cited by 96
Remnant-like Particle Cholesterol Levels in Patients with Dysbetalipoproteinemia or Coronary Artery Disease
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Apolipoprotein composition as the basis for classifying plasma lipoproteins. Characterization of ApoA- and ApoB-containing lipoprotein families
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Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis
Hofker, M. H., van Vlijmen, B. J. M., & Havekes, L. M. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00266-9 · Cited by 92
Isolation and properties of nascent lipoproteins from highly purified rat hepatocytic Golgi fractions
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Apolipoprotein E: genetic variants provide insights into its structure and function
Mahley, R. W., Innerarity, T. L., Rail, S. C., Weisgraber, K. H., & Taylor, J. M. (1990) · Current Opinion in Lipidology · doi:10.1097/00041433-199004000-00002 · Cited by 88
Lipoprotein and receptor interactions in vivo
Herz, J., & Willnow, T. E. (1995) · Current Opinion in Lipidology · doi:10.1097/00041433-199504000-00007 · Cited by 88
McCollum Award Lecture, 1993: Triglyceride-rich lipoproteins and atherosclerosis—new perspectives
Havel, R. J. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.4.795 · Cited by 87
Presence of multiple subpopulations of lipoproteins of intermediate density in normal subjects
Musliner, T. A., Giotas, C., & Krauss, R. M. (1986) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.6.1.79 · Cited by 87
Quantitation of human apolipoprotein C-III and its subspecie by radioimmunoassay and analytical isoelectric focusing: abnormal plasma triglyceride-rich lipoprotein apolipoprotein C-III subspecie concentrations in hypertriglyceridemia.
Kashyap, M. L., Srivastava, L., Hynd, B. A., Gartside, P. S., & Perisutti, G. (1981) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37352-1 · Cited by 84
Effect of heparin-induced lipolysis on the distribution of apolipoprotein e among lipoprotein subclasses. Studies with patients deficient in hepatic triglyceride lipase and lipoprotein lipase.
Rubinstein, A., Gibson, J. C., Paterniti, J. R., Kakis, G., Little, A., Ginsberg, H. N., & Brown, W. V. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111751 · Cited by 83
Characterization of monoclonal antibodies against human apolipoprotein E.
Milne, R. W., DOUSTE‐BLAZY, P., Marcel, Y. L., & Retegui, L. A. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110225 · Cited by 80
The effect of oxidized lipids in the diet on serum lipoprotein peroxides in control and diabetic rats.
Staprãns, I., Rapp, J. H., Pan, X.-M., & Kr, F. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116632 · Cited by 80
Cholesterol efflux from macrophages and other cells
von Eckardstein, A. (1996) · Current Opinion in Lipidology · doi:10.1097/00041433-199610000-00009 · Cited by 77
Uptake of Remnant Like Particles (RLP) in Diabetic Patients from Mouse Peritoneal Macrophages
Tomono, S., Kawazu, S., Kato, N., Ono, T., Ishii, C., Ito, Y., Shimizu, M., Shimoyama, M., Nakano, T., & Nakajima, K. (1994) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.1.98 · Cited by 76
Quantification of apolipoproteins B-100, B-48, and E in human triglyceride-rich lipoproteins
Kotite, L., Bergeron, N., & Havel, R. J. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40071-9 · Cited by 75
Cholesterol accumulation in J774 macrophages induced by triglyceride-rich lipoproteins. Comparison of very low density lipoprotein from subjects with type III, IV, and V hyperlipoproteinemias.
Huff, M. W., Evans, A. J., Sawyez, C. G., Wolfe, B. M. J., & Nestel, P. J. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.2.221 · Cited by 74
Lipolytic surface remnants of triglyceride-rich lipoproteins are cytotoxic to macrophages but not in the presence of high density lipoprotein. A possible mechanism of atherogenesis?
Chung, B. H., Segrest, J. P., Smith, K. A., Griffin, F. M., & Brouillette, C. G. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114024 · Cited by 73
David Rubinstein Memorial Lecture: The biochemical and clinical significance of the interrelationship between very low density and high density lipoproteins
Alaupovic, P. (1981) · Canadian Journal of Biochemistry · doi:10.1139/o81-079 · Cited by 69
Cellular binding site and membrane binding proteins for triglyceride-rich lipoproteins in human monocyte-macrophages and THP-1 monocytic cells.
Gianturco, S. H., Ramprasad, M. P., Lin, A. H., Song, R., & Bradley, W. A. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41165-4 · Cited by 64
Epidemiological aspects of high density lipoprotein cholesterol1Presented at the 68th meeting of the European Atherosclerosis Society, Brugge, 8–10 May, 1997.1
Backer, G. D., Bacquer, D. D., & Kornitzer, M. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00310-9 · Cited by 62
Characterization of remnant-like particles isolated by immunoaffinity gel from the plasma of type III and type IV hyperlipoproteinemic patients
Marcoux, C., Tremblay, M., Nakajima, K., Davignon, J., & Cohn, J. S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32142-8 · Cited by 61
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Evidence that cholesteryl ester and triglyceride accumulation in J774 macrophages induced by very low density lipoprotein subfractions occurs by different mechanisms
Evans, A. J., Sawyez, C. G., Wolfe, B. M. J., Connelly, P. W., Maguire, G., & Huff, M. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39692-9 · Cited by 61
Type III dyslipoproteinemia in patients heterozygous for familial hypercholesterolemia and apolipoprotein E2. Evidence for a gene-gene interaction.
Hopkins, P. N., Wu, L., Schumacher, M. C., Emi, M., Hegele, R. A., Hunt, S. C., Lalouel, J.-M., & Williams, R. R. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.5.1137 · Cited by 60
Apolipoprotein B synthesis in humans: Liver synthesizes only apolipoprotein B-100
Edge, S. B., Hoeg, J. M., Schneider, P. D., & Brewer, H. B. (1985) · Metabolism · doi:10.1016/0026-0495(85)90022-8 · Cited by 59
Uptake of type III hypertriglyceridemic VLDL by macrophages is enhanced by oxidation, especially after remnant formation
Whitman, S. C., Miller, D. B., Wolfe, B. M., Hegele, R. A., & Huff, M. W. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.9.1707 · Cited by 59
Isolation and characterization of an apoA-II-containing lipoprotein (LP-A-II:B complex) from plasma very low density lipoproteins of patients with Tangier disease and type V hyperlipoproteinemia.
Alaupovic, P., Knight‐Gibson, C., Wang, C., Downs, D., Koren, E., Brewer, H., & Gregg, R. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42239-4 · Cited by 57
Triglyceride enriched lipoprotein particles correlate with the severity of coronary artery disease
Koren, E., Corder, C. N., Mueller, G., Centurion, H., Hallum, G., Fesmire, J., McConathy, W. D., & Alaupovic, P. (1996) · Atherosclerosis · doi:10.1016/0021-9150(95)05791-9 · Cited by 56
Quantitation of apolipoprotein B-48 in triacylglycerol-rich lipoproteins by a specific enzyme-linked immunosorbent assay
Lovegrove, J. A., Isherwood, S. G., Jackson, K. G., Williams, C. M., & GOULD, B. J. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(96)00039-2 · Cited by 54
Measurement of postprandial remnant-like particles (RLPs) following a fat-loading test
Tanaka, A., Tomie, N., Nakano, T., Nakajima, K., Yui, K., Tamura, M., & Numano, F. (1998) · Clinica Chimica Acta · doi:10.1016/s0009-8981(98)00073-4 · Cited by 54
Apolipoprotein E2 Transgenic Rabbits
Huang, Y., Schwendner, S. W., Rall, S. C., Sanan, D. A., & Mahley, R. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22685 · Cited by 52
Oxidized type IV hypertriglyceridemic VLDL-remnants cause greater macrophage cholesteryl ester accumulation than oxidized LDL
Whitman, S. C., Sawyez, C. G., Miller, D. B., Wolfe, B. M. J., & Huff, M. W. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33868-2 · Cited by 51
Effects of Diet on Apoprotein E Levels and on the Apoprotein E Subspecies in Human Plasma Lipoproteins*
Falko, J. M., Schonfeld, G., Witztum, J. L., Kolar, J. B., Weidman, S. W., & Steelman, R. J. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-50-3-521 · Cited by 46
Plasma remnant-like particle lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects
Marcoux, C., Tremblay, M., Fredenrich, A., Jacques, H., Krimbou, L., Nakajima, K., Davignon, J., & Cohn, J. S. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00042-2 · Cited by 45
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A New Approach for the Detection of Type III Hyperlipoproteinemia by RLP-Cholesterol Assay
Nakajima, K., SAITO, T., Tamura, A., Suzuki, M., Nakano, T., Adachi, M., Tanaka, A., Tada, N., Nakamura, H., & Murase, T. (1994) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.1.30 · Cited by 45
The investigation of “mid-band” lipoproteins using polyacrylamide gel electrophoresis
Mead, M., & Dangerfield, W. G. (1974) · Clinica Chimica Acta · doi:10.1016/0009-8981(74)90027-8 · Cited by 43
Relative contribution of triglyceride-rich lipoprotein particle size and number to plasma triglyceride concentration.
Poapst, M. E., Reardon, M., & Steiner, G. A. (1985) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.5.4.381 · Cited by 43
A change in apolipoprotein B expression is required for the binding of apolipoprotein E to very low density lipoprotein.
Ishikawa, Y., Fielding, C. J., & Fielding, P. E. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69131-8 · Cited by 41
Remnant-like lipoproteins stimulate whole blood platelet aggregation in vitro
Knöfler, R., Nakano, T., Nakajima, K., Takada, Y., & Takada, A. (1995) · Thrombosis Research · doi:10.1016/0049-3848(95)00044-5 · Cited by 41
The possible role of remnant-like particles as a risk factor for sudden cardiac death
Takeichi, S., Nakajima, Y., Osawa, M., Yukawa, N., Saito, T., Seto, Y., Nakano, T., Adachi, M., Jitsukata, K., Horiuchi, K., et al. (1997) · International Journal of Legal Medicine · doi:10.1007/s004140050070 · Cited by 41
Resistance of a very low density lipoprotein subpopulation from familial dysbetalipoproteinemia to in vitro lipolytic conversion to the low density lipoprotein density fraction.
Chung, B. H., & Segrest, J. P. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37898-6 · Cited by 40
Plasma lipoprotein distribution of apolipoprotein E in familial hypercholesterolemia.
Gibson, J. C., Goldberg, R. B., Rubinstein, A., Ginsberg, H. N., Brown, W. V., Baker, S. G., Joffe, B. I., & Seftel, H. C. (1987) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.7.4.401 · Cited by 40
Cholesteryl ester accumulation in mouse peritoneal macrophages induced by β-migrating very low density lipoproteins from patients with atypical dysbetalipoproteinemia
Bersot, T. P., Innerarity, T. L., Mahley, R. W., & Havel, R. J. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111026 · Cited by 40
Characteristics of coronary artery disease and lipoprotein abnormalities in patients with heterozygous familial hypercholesterolemia associated with diabetes mellitus or impaired glucose tolerance
Yanagi, K., Yamashita, S., Kihara, S., Nakamura, T., Nozaki, S., Nagai, Y., Funahashi, T., Kameda-Takemura, K., Ueyama, Y., Jiao, S., et al. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)00076-2 · Cited by 31
Quantitative Determination of Different Apolipoprotein B Containing Lipoproteins by an Enzyme Linked Immunosorbent Assay: Apo B with Apo C-III and Apo B with Apo E
Kandoussi, A., Cachera, C., Parsy, D., Bard, J., Fruchart, J., & Tacquet, A. (1991) · Journal of Immunoassay · doi:10.1080/01971529108055075 · Cited by 31
An increase of serum remnant-like particles in non-insulin-dependent diabetic patients with microalbuminuria
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Serum lipid and lipoprotein levels in Japanese patients with familial hypercholesterolemia
Mabuchi, H., Tatami, R., Ueda, K., Ueda, R., Haba, T., KAMETANI, T., Watanabe, A., WAKASUGI, T., Ito, S., Koizumi, J., et al. (1979) · Atherosclerosis · doi:10.1016/0021-9150(79)90009-1 · Cited by 31
Inherited Disorders of Lipid Transport
Schonfeld, G. (1990) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30323-2 · Cited by 29
Quick method of determining lipoproteins, including those of intermediate density, in serum.
Fontanals-Ferrer, N., Serrat-Serrat, J., Sorribas-Vivas, A., Gonzalez-Garcia, C., González‐Sastre, F., & Gómez-Gerique, J. A. (1988) · Clinical Chemistry · doi:10.1093/clinchem/34.9.1749 · Cited by 28
Remnant-Like Particle Cholesterol May Indicate Atherogenic Risk in Patients on Chronic Hemodialysis
Oda, H., Yorioka, N., Okushin, S., Nishida, Y., Kushihata, S., Ito, T., & Yamakido, M. (2008) · The Nephron journals/Nephron journals · doi:10.1159/000190133 · Cited by 27
Triglyceride-rich lipoproteins and their role in atherogenesis
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Remnant‐like Particles and Restenosis of Coronary Arteries after PTCA
Tanaka, A., Ejiri, N., Fujinuma, Y., Yui, K., Tamura, M., Nakajima, K., MOROHOSHI, M., Fujisawa, K., UCHIMURA, I., & Numano, F. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb17369.x · Cited by 22
Selective isolation of human plasma low-density lipoprotein particles containing apolipoproteins B and E by use of a monoclonal antibody to apolipoprotein B
Koren, E., Alaupovic, P., Lee, D. M., Dashti, N., Kloer, H. U., & Wen, G. (1987) · Biochemistry · doi:10.1021/bi00384a012 · Cited by 22
Plasma lipoproteins in familial dysbetalipoproteinemia associated with apolipoproteins E2(Arg158-->Cys), E3-Leiden, and E2(Lys146-->Gln), and effects of treatment with simvastatin.
Zhao, S. P., Smelt, A. H., Van den Maagdenberg, A. M., Van Tol, A., Vroom, T. F., Gevers Leuven, J. A., Frants, R. R., Havekes, L. M., Van der Laarse, A., & Van 't Hooft, F. M. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.11.1705 · Cited by 22
Comparison of four procedures for separating apolipoprotein A- and apolipoprotein B-containing lipoproteins in plasma.
Puchois, P., Luley, C., & Alaupovic, P. (1987) · Clinical Chemistry · doi:10.1093/clinchem/33.9.1597 · Cited by 21
Uptake by J774 Macrophages of Very-Low-Density Lipoproteins Isolated From ApoE-Deficient Mice Is Mediated by a Distinct Receptor and Stimulated by Lipoprotein Lipase
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Authors: Cohn, J. S., Marcoux, C., & Davignon, J.
Affiliations: Montreal Clinical Research Institute (CA)
ORCID: Cohn, Jeffrey S.
Davignon, Jean
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-10
Volume: 19
Issue: 10
Pages: 2474-2486
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.19.10.2474
OpenAlex: W2162381401
Cited by: 156
References: 187
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 5 · 2012: 3
FWCI: 1.09
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Heart and Stroke Foundation of Canada
Otsuka America
Medical Research Council Canada
Medical Research Council
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: atherogenic lipoproteins, apolipoprotein E, apolipoprotein B-48, apolipoprotein B-100, lipoprotein lipase, hepatic lipase, chylomicrons, VLDL, hypertriglyceridemia, coronary artery disease risk, atherosclerosis
MeSH terms: Arteriosclerosis, Humans, Lipoproteins, Triglycerides

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Detection, Quantification, and Characterization of Potentially Atherogenic Triglyceride-Rich Remnant Lipoproteins

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