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Cited by 916

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Fibrinogen, viscosity, and white blood cell count are major risk factors for ischemic heart disease. The Caerphilly and Speedwell collaborative heart disease studies.

Open access
Yarnell, J W, Baker, I A, Sweetnam, P M, Bainton, D, O'Brien, J R, Whitehead, P J, Elwood, P C·1991·Circulation
DOI 10.1161/01.cir.83.3.836
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Abstract

BACKGROUND: Recent studies have suggested that hemostatic factors and white blood cell count are predictive of ischemic heart disease (IHD). The relations of fibrinogen, viscosity, and white blood cell count to the incidence of IHD in the Caerphilly and Speedwell prospective studies are described. METHODS AND RESULTS: The two studies have a common core protocol and are based on a combined cohort of 4,860 middle-aged men from the general population. The first follow-up was at a nearly constant interval of 5.1 years in Caerphilly and 3.2 years in Speedwell; 251 major IHD events had occurred. Age-adjusted relative odds of IHD for men in the top 20% of the distribution compared with the bottom 20% were 4.1 (95% confidence interval, 2.6-6.5) for fibrinogen, 4.5 (95% confidence interval, 2.8-7.4) for viscosity, and 3.2 (95% confidence interval, 2.0-4.9) for white blood cell count. Associations with IHD were similar in men who had never smoked, exsmokers, and current smokers, and the results suggest that at least part of the effect of smoking on IHD is mediated through fibrinogen, viscosity, and white blood cell count. Multivariate analysis shows that white blood cell count is an independent risk factor for IHD as is either fibrinogen or viscosity, or possibly both. Jointly, these three variables significantly improve the fit of a logistic regression model containing all the main conventional risk factors. Further, a model including age, smoking habits, fibrinogen, viscosity, and white blood cell count predicts IHD as well as one in which the three hemostatic/rheological variables are replaced by total cholesterol, diastolic pressure, and body mass index. CONCLUSION: Jointly, fibrinogen, viscosity, and white blood cell count are important risk factors for IHD.

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Metadata

Authors
Yarnell, J. W., Baker, I. A., Sweetnam, P. M., Bainton, D., O'Brien, J. R., Whitehead, P. J., & Elwood, P. C.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1991-03
Volume
83
Issue
3
Pages
836-844
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.83.3.836
OpenAlex
W2048391479
Cited by
916
References
1
FWCI
57.04
Type
journal article
Language
en
Open access
bronze

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