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Chronic Orthostatic Intolerance: A Disorder With Discordant Cardiac and Vascular Sympathetic Control
Open accessAbstract
Background —Chronic orthostatic intolerance (COI) is a debilitating autonomic condition in young adults. Its neurohumoral and hemodynamic profiles suggest possible alterations of postural sympathetic function and of baroreflex control of heart rate (HR). Methods and Results —In 16 COI patients and 16 healthy volunteers, intra-arterial blood pressure (BP), ECG, central venous pressure (CVP), and muscle sympathetic nerve activity (MSNA) were recorded at rest and during 75° tilt. Spectral analysis of RR interval and systolic arterial pressure (SAP) variabilities provided indices of sympathovagal modulation of the sinoatrial node (ratio of low-frequency to high-frequency components, LF/HF) and of sympathetic vasomotor control (LF SAP ). Baroreflex mechanisms were assessed (1) by the slope of the regression line obtained from changes of RR interval and MSNA evoked by pharmacologically induced alterations in BP and (2) by the index α, obtained from cross-spectral analysis of RR and SAP variabilities. At rest, HR, MSNA, LF/HF, and LF SAP were higher in COI patients, whereas BP and CVP were similar in the two groups. During tilt, BP did not change and CVP fell by the same extent in the 2 groups; the increase of HR and LF/HF was more pronounced in COI patients. Conversely, the increase of MSNA was lower in COI than in control subjects. Baroreflex sensitivity was similar in COI and control subjects at rest; tilt reduced α similarly in both groups. Conclusions —COI is characterized by an overall enhancement of noradrenergic tone at rest and by a blunted postganglionic sympathetic response to standing, with a compensatory cardiac sympathetic overactivity. Baroreflex mechanisms maintain their functional responsiveness. These data suggest that in COI, the functional distribution of central sympathetic tone to the heart and vasculature is abnormal.
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In the citing paper
“A deficiency of the norepinephrine transporter may explain several of the clinical findings in patients with this disorder: the high heart rate in the supine position, the high plasma concentration of norepinephrine in association with the relatively low plasma concentration of dihydroxyphenylglycol, the impaired response of norepinephrine to tyramine, 13 the reduced systemic clearance of norepine”
From Orthostatic Intolerance and Tachycardia Associated with Norepinephrine-Transporter Deficiency (2000) · cites this paper as [27]
Experimental — accuracy not yet measuredIn the citing paper
“A spectral analysis index of sympathetic function and plasma norepinephrine are sometimes higher at supine rest and increase more with HUT in POTS [53;52].”
From Postural tachycardia syndrome: beyond orthostatic intolerance (2015) · cites this paper as [52]
In the citing paper
“Resting sympathetic nerve activity, measured by microneurography, is elevated.”
From Postural tachycardia syndrome: beyond orthostatic intolerance (2015) · cites this paper as [52]
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Self-citation
Metadata
- Authors
- Furlan, R., Jacob, G., Snell, M., Robertson, D., Porta, A., Harris, P., & Mosqueda-Garcia, R.
- Affiliations
- Vanderbilt University (US)
- From the Syncope Service in the Autonomic Dysfunction Unit (M.S., D.R., R.M.-G.) and Division of Clinical Pharmacology (R.F., G.J., D.R., P.H., R.M.-G.), Department of Medicine (D.R., R.M.-G.), Vanderbilt University Medical Center, Nashville, Tenn, and Dipartimento di Bioingegneria, Politecnico di Milano, Milan, Italy (A.P.).
- Venue
- Circulation
- Published
- 1998-11-17
- Volume
- 98
- Issue
- 20
- Pages
- 2154-2159
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2159657770
- Cited by
- 229
- References
- 41
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 12 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 10 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 6 · 2012: 5
- FWCI
- 12.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- autonomic dysfunction, baroreflex sensitivity, muscle sympathetic nerve activity, heart rate variability, blood pressure variability, tilt table, central venous pressure
- MeSH terms
- Adult, Chronic Disease, Female, Hemodynamics, Humans, Male, Posture, Pressoreceptors, Reflex, Sympathetic Nervous System, Tachycardia
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