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Phenotypic Heterogeneity of the Endothelium: II. Representative Vascular Beds
Abstract
Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics, display remarkable heterogeneity in structure and function. This is the second of a 2-part review on the phenotypic heterogeneity of blood vessel endothelial cells. The first part discusses the scope, the underlying mechanisms, and the diagnostic and therapeutic implications of phenotypic heterogeneity. Here, these principles are applied to an understanding of organ-specific phenotypes in representative vascular beds including arteries and veins, heart, lung, liver, and kidney. The goal is to underscore the importance of site-specific properties of the endothelium in mediating homeostasis and focal vascular pathology, while at the same time emphasizing the value of approaching the endothelium as an integrated system.
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Cites
Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595
Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice
Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., & Tsukita, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302070 · Cited by 1,917
Immune cell migration in inflammation: present and future therapeutic targets
Luster, A. D., Alon, R., & von Andrian, U. H. (2005) · Nature Immunology · doi:10.1038/ni1275 · Cited by 1,313
Endothelial cells and VEGF in vascular development
Coultas, L., Chawengsaksophak, K., & Rossant, J. (2005) · Nature · doi:10.1038/nature04479 · Cited by 1,016
Limmer, A., Ohl, J., Kurts, C., Ljunggren, H.-G., Reiss, Y., Groettrup, M., Momburg, F., Arnold, B., & Knolle, P. A. (2000) · Nature Medicine · doi:10.1038/82161 · Cited by 758
Limmer, A., Ohl, J., Wingender, G., Berg, M., Jüngerkes, F., Schumak, B., Djandji, D., Scholz, K., Klevenz, A., Hegenbarth, S., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200526034 · Cited by 169
Differential Expression of E‐ and P‐Selectin in the Microvasculature of Sickle Cell Transgenic Mice
Wood, K., Russell, J., Hebbel, R. P., & Granger, D. N. (2004) · Microcirculation · doi:10.1080/10739680490437559 · Cited by 42
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Daneman, R., & Prat, A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020412 · Cited by 3,437
Non-viral vectors for gene-based therapy
Yin, H., Kanasty, R. L., Eltoukhy, A. A., Vegas, A. J., Dorkin, J. R., & Anderson, D. G. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3763 · Cited by 3,123
Development, maintenance and disruption of the blood-brain barrier
Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Evolving functions of endothelial cells in inflammation
Pober, J. S., & Sessa, W. C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2171 · Cited by 2,022
Delivery materials for siRNA therapeutics
Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D. (2013) · Nature Materials · doi:10.1038/nmat3765 · Cited by 1,800
Immunity, inflammation and cancer: a leading role for adenosine
Antonioli, L., Blandizzi, C., Pacher, P., & Haskó, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3613 · Cited by 765
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors
Young, M. D., Mitchell, T. J., Vieira Braga, F. A., Tran, M. G. B., Stewart, B. J., Ferdinand, J. R., Collord, G., Botting, R. A., Popescu, D.-M., Loudon, K. W., et al. (2018) · Science · doi:10.1126/science.aat1699 · Cited by 762
Vascular heterogeneity and specialization in development and disease
Potente, M., & Mäkinen, T. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.36 · Cited by 653
Daneman, R., Zhou, L., Agalliu, D., Cahoy, J. D., Kaushal, A., & Barres, B. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013741 · Cited by 577
Butler, J. M., Kobayashi, H., & Rafii, S. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2791 · Cited by 578
Vascular endothelial cell development and diversity
Trimm, E., & Red-Horse, K. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00770-1 · Cited by 537
Spatial heterogeneity in the mammalian liver
Ben-Moshe, S., & Itzkovitz, S. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0134-x · Cited by 485
Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges
Pulgar, V. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.01019 · Cited by 482
Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease
Yamazaki, Y., & Kanekiyo, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091965 · Cited by 451
Serum albumin in health and disease: esterase, antioxidant, transporting and signaling properties
Belinskaia, D. A., Voronina, P. A., Shmurak, V. I., Jenkins, R. O., & Goncharov, N. V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910318 · Cited by 416
Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells
Halpern, K. B., Shenhav, R., Massalha, H., Toth, B., Egozi, A., Massasa, E. E., Medgalia, C., David, E., Giladi, A., Moor, A. E., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4231 · Cited by 368
Broken Barriers: A New Take on Sepsis Pathogenesis
Goldenberg, N. M., Steinberg, B. E., Slutsky, A. S., & Lee, W. L. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002011 · Cited by 324
Barrett, E. J., Eggleston, E. M., Inyard, A. C., Wang, H., Li, G., Chai, W., & Liu, Z. (2009) · Diabetologia · doi:10.1007/s00125-009-1313-z · Cited by 323
Essential Regulation of CNS Angiogenesis by the Orphan G Protein–Coupled Receptor GPR124
Kuhnert, F., Mancuso, M. R., Shamloo, A., Wang, H.-T., Choksi, V., Florek, M., Su, H., Fruttiger, M., Young, W. L., Heilshorn, S. C., et al. (2010) · Science · doi:10.1126/science.1196554 · Cited by 301
Cho, J. G., Lee, A., Chang, W., Lee, M.-S., & Kim, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00294 · Cited by 284
Paunovska, K., Sago, C. D., Monaco, C. M., Hudson, W. H., Castro, M. G., Rudoltz, T. G., Kalathoor, S., Vanover, D. A., Santangelo, P. J., Ahmed, R., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b00432 · Cited by 277
Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells
Sabbagh, M. F., Heng, J. S., Luo, C., Castanon, R. G., Nery, J. R., Rattner, A., Goff, L. A., Ecker, J. R., & Nathans, J. (2018) · eLife · doi:10.7554/elife.36187 · Cited by 245
Intravascular immunity: the host–pathogen encounter in blood vessels
Hickey, M. J., & Kubes, P. (2009) · Nature Reviews Immunology · doi:10.1038/nri2532 · Cited by 251
Retinoic Acid Induces Blood–Brain Barrier Development
Mizee, M. R., Wooldrik, D., Lakeman, K. A. M., van het Hof, B., Drexhage, J. A. R., Geerts, D., Bugiani, M., Aronica, E., Mebius, R. E., Prat, A., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1338-12.2013 · Cited by 203
Rantakari, P., Auvinen, K., Jäppinen, N., Kapraali, M., Valtonen, J., Karikoski, M., Gerke, H., Iftakhar-E-Khuda, I., Keuschnigg, J., Umemoto, E., et al. (2015) · Nature Immunology · doi:10.1038/ni.3101 · Cited by 203
Murine coagulation factor VIII is synthesized in endothelial cells
Everett, L. A., Cleuren, A. C. A., Khoriaty, R. N., & Ginsburg, D. (2014) · Blood · doi:10.1182/blood-2014-02-554501 · Cited by 190
The in vivo endothelial cell translatome is highly heterogeneous across vascular beds
Cleuren, A. C. A., van der Ent, M. A., Jiang, H., Hunker, K. L., Yee, A., Siemieniak, D. R., Molema, G., Aird, W. C., Ganesh, S. K., & Ginsburg, D. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912409116 · Cited by 152
Self-citationReview: in vitro microvessel models
Bogorad, M. I., DeStefano, J., Karlsson, J., Wong, A. D., Gerecht, S., & Searson, P. C. (2015) · Lab on a Chip · doi:10.1039/c5lc00832h · Cited by 145
Fung, K. Y., Wang, C., Nyegaard, S., Heit, B., Fairn, G. D., & Lee, W. L. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00841 · Cited by 129
Single-cell transcriptomics for the assessment of cardiac disease
Miranda, A. M. A., Janbandhu, V., Maatz, H., Kanemaru, K., Cranley, J., Teichmann, S. A., Hübner, N., Schneider, M. D., Harvey, R. P., & Noseda, M. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00805-7 · Cited by 117
Wu, S., Jian, M.-Y., Xu, Y.-C., Zhou, C., Al-Mehdi, A.-B., Liedtke, W., Shin, H.-S., & Townsley, M. I. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00015.2009 · Cited by 94
Structure and Response to Flow of the Glycocalyx Layer
Cruz-Chu, E. R., Malafeev, A., Pajarskas, T., Pivkin, I. V., & Koumoutsakos, P. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2013.09.060 · Cited by 87
Lewis, V. O., Ozawa, M. G., Deavers, M. T., Wang, G., Shintani, T., Arap, W., & Pasqualini, R. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4845 · Cited by 79
Aranguren, X. L., Beerens, M., Coppiello, G., Wiese, C., Vandersmissen, I., Lo Nigro, A., Verfaillie, C. M., Gessler, M., & Luttun, A. (2013) · Journal of Cell Science · doi:10.1242/jcs.116293 · Cited by 77
Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice
Herrnberger, L., Seitz, R., Kuespert, S., Bösl, M. R., Fuchshofer, R., & Tamm, E. R. (2012) · Histochemistry and Cell Biology · doi:10.1007/s00418-012-0987-3 · Cited by 76
Molecular heterogeneity of tumor endothelium
Aird, W. C. (2009) · Cell and Tissue Research · doi:10.1007/s00441-008-0672-y · Cited by 66
Self-citationUnraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization
de Haan, W., Øie, C., Benkheil, M., Dheedene, W., Vinckier, S., Coppiello, G., Aranguren, X. L., Beerens, M., Jaekers, J., Topal, B., et al. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00215.2019 · Cited by 57
Mannucci, E., & Silverii, G. A. (2023) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15226 · Cited by 16
Denzer, L., Muranyi, W., Herold, R., Stump-Guthier, C., Ishikawa, H., Sticht, C., Schroten, H., Schwerk, C., & Weichert, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041779 · Cited by 3
Metadata
- Authors
- Aird, W. C.
- Venue
- Circulation Research
- Published
- 2007-02-02
- Volume
- 100
- Issue
- 2
- Pages
- 174-190
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2152877944
- Cited by
- 1,257
- References
- 7
- FWCI
- 41.13
- Type
- journal article
- Language
- en
- Open access
- closed
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