Cited by 926Inflammasome and immune disordersAtherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 226 of the 226 references it cites were found in a registry or an index.

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Grebe, Alena, Hoss, Florian, Latz, Eicke·2018·Circulation Research

Abstract

Inflammation is an important driver of atherosclerosis, the underlying pathology of cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is suggested to improve cardiovascular outcomes in patients with cardiovascular diseases. This concept was recently proven by CANTOS (Canakinumab Anti-Inflammatory Thrombosis Outcomes Study), which demonstrated the therapeutic potential of the monoclonal IL (interleukin)-1β–neutralizing antibody canakinumab. IL-1β and other IL-1 family cytokines are important vascular and systemic inflammatory mediators, which contribute to atherogenesis. The NLRP3 (NOD [nucleotide oligomerization domain]-, LRR [leucine-rich repeat]-, and PYD [pyrin domain]-containing protein 3) inflammasome, an innate immune signaling complex, is the key mediator of IL-1 family cytokine production in atherosclerosis. NLRP3 is activated by various endogenous danger signals abundantly present in atherosclerotic lesions, such as oxidized low-density lipoprotein and cholesterol crystals. Consequently, NLRP3 inflammasome activation contributes to the vascular inflammatory response driving atherosclerosis development and progression. Here, we review the mechanisms of NLRP3 inflammasome activation and proinflammatory IL-1 family cytokine production in the context of atherosclerosis and discuss treatment possibilities in light of the positive outcomes of the CANTOS trial.

Overview

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Crossref · 10.1161/circresaha.118.311362

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226 of 226 references verified0 citation errors · 0 not checkable

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Citations

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  1. 10.1001/jama.1993.03500230097036 · DOI

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Metadata

Authors
Grebe, A., Hoss, F., & Latz, E.
Affiliations
  • University Hospital Bonn (DE)
  • University of Massachusetts Chan Medical School (US)
Venue
Circulation Research
Published
2018-06-08
Volume
122
Issue
12
Pages
1722-1740
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
OpenAlex
W2807678985
Cited by
926
References
226
Citations by year
2026: 102 · 2025: 122 · 2024: 144 · 2023: 146 · 2022: 150 · 2021: 121 · 2020: 90 · 2019: 36 · 2018: 13
FWCI
6.35
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
  • DZNE Pub (submittedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL112661)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
NLRP3 inflammasome, IL-1β, atherosclerosis, inflammation, canakinumab, CANTOS trial, innate immunity, oxidized LDL, cholesterol crystals, IL-1 family cytokines, atherogenesis, cardiovascular disease
MeSH terms
NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Antibodies, Monoclonal, Humans, Inflammation, Interleukin-1, Interleukin-6, Disease Progression, Interleukin-18, Atherosclerosis, Mice, Interleukin-1beta, Inflammasomes, Antibodies, Monoclonal, Humanized

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