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ANGPTL8 has both endocrine and autocrine effects on substrate utilization
Abstract
The angiopoietin-like protein ANGPTL8 (A8) is one of 3 ANGPTLs (A8, A3, A4) that coordinate changes in triglyceride (TG) delivery to tissues by inhibiting lipoprotein lipase (LPL), an enzyme that hydrolyzes TG. Previously we showed that A8, which is expressed in liver and adipose tissue, is required to redirect dietary TG from oxidative to storage tissues following food intake. Here we show that A8 from liver and adipose tissue have different roles in this process. Mice lacking hepatic A8 have no circulating A8, high intravascular LPL activity, low plasma TG levels, and evidence of decreased delivery of dietary lipids to adipose tissue. In contrast, mice lacking A8 in adipose tissue have higher postprandial TG levels and similar intravascular LPL activity and plasma A8 levels and higher levels of plasma TG. Expression of A8, together with A4, in cultured cells reduced A4 secretion and A4-mediated LPL inhibition. Thus, hepatic A8 (with A3) acts in an endocrine fashion to inhibit intravascular LPL in oxidative tissues, whereas A8 in adipose tissue enhances LPL activity by autocrine/paracrine inhibition of A4. These combined actions of A8 ensure that TG stores are rapidly replenished and sufficient energy is available until the next meal.
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ANGPTL4-ANGPTL8 complexes are substantially poorer at inhibiting LPL than ANGPTL4 alone.
“ANGPTL4-ANGPTL8 complexes are substantially poorer at inhibiting LPL than ANGPTL4 alone (39, 54, 138).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [39]
ANGPTL8 reduces secretion of ANGPTL4.
“Oldoni et al. (39) found that ANGPTL8 reduced secretion of ANGPTL4”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [39]
ANGPTL8 interacts directly with ANGPTL4.
“Recently, it has become clear that ANGPTL8 also interacts directly with ANGPTL4”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [39]
In vivo, ANGPTL3-ANGPTL8 complexes form in the liver.
“In vivo, ANGPTL3-ANGPTL8 complexes form in the liver as inferred by the observations that almost all circulating ANGPTL8 comes from the liver (39) and that most circulating ANGPTL8 is complexed with ANGPTL3 (54).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [39]
Mice lacking liver ANGPTL8 have significantly lower plasma triglycerides than wild-type mice in the fed state.
“Oldoni et al. (39) found that mice lacking liver ANGPTL8 had significantly lower plasma triglycerides than wild-type mice in the fed state”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [39]
ANGPTL8 does not promote cleavage of ANGPTL3.
“Although ANGPTL8 was initially reported to promote cleavage of ANGPTL3 (19), follow-up studies showed that this was not the case (36, 39).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [39]
In the absence of adipose ANGPTL8, fed-state plasma triglycerides are elevated compared with wild-type mice.
“Conversely, in the absence of adipose ANGPTL8, fed-state plasma triglycerides were elevated compared with wild-type mice”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [39]
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Cites
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Sorted by citations
Lipoprotein lipase and its regulators: an unfolding story
Wu, S. A., Kersten, S., & Qi, L. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.11.005 · Cited by 225
Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8
Sylvers-Davie, K. L., & Davies, B. S. J. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00195.2021 · Cited by 154
Metadata
- Authors
- Oldoni, F., Cheng, H., Banfi, S., Gusarova, V., Cohen, J. C., & Hobbs, H. H.
- Affiliations
- Departments of Molecular Genetics and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
- Regeneron Pharmaceuticals, Tarrytown, New York, USA.
- Center for Human Nutrition, and
- Venue
- JCI Insight
- Published
- 2020-09-03
- Volume
- 5
- Issue
- 17
- ISSN
- 2379-3708
- PMC
- PMC7526440
- Cited by
- 73
- References
- 2
- Language
- en
- Funders
- Foundation for the National Institutes of Health (5 PO1 HL20948)
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