Cited by 259Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetesDiabetes Management and Research

The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.

Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors.

Open access

Clausen, J O, Borch-Johnsen, K, Ibsen, H, Bergman, R N, Hougaard, P, Winther, K, Pedersen, O·1996·Journal of Clinical Investigation

DOI 10.1172/jci118903PMC PMC507542

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Insulin sensitivity and insulin secretion are traits that are both genetically and environmentally determined. AIM: The aim of this study was to describe the distribution of the insulin sensitivity index (Si), the acute insulin response, and glucose effectiveness (Sg) in young healthy Caucasians and to estimate the relative impact of anthropometric and environmental determinants on these variables. METHODS: The material included 380 unrelated Caucasian subjects (18-32 yr) with measurement of Si, Sg and insulin secretion during a combined intravenous glucose (0.3 grams/kg body weight) and tolbutamide (3 mg/kg body weight) tolerance test. RESULTS: The distributions of Si and acute insulin response were skewed to the right, whereas the distribution of Sg was Gaussian distributed. Sg was 15% higher in women compared with men (P < 0.001). Waist circumference, body mass index, maximal aerobic capacity, and women's use of oral contraceptives were the most important determinants of Si. Approximately one-third of the variation of Si could be explained by these factors. Compared with individuals in the upper four-fifths of the distribution of Si, subjects with Si in the lowest fifth had higher waist circumference, higher blood pressure, lower VO2max, and lower glucose tolerance and fasting dyslipidemia and dysfibrinolysis. Only 10% of the variation in acute insulin response could be explained by measured determinants. CONCLUSION: Estimates of body fat, maximal aerobic capacity, and women's use of oral contraceptives explain about one-third of the variation in Si in a population-based sample of young healthy Caucasians.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci118903

Cites

78 of 78 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Antihyperlipidemic and Biochemical Activities of Mcy Protein in Streptozotocin Induced Diabetic Rats
Marella, S., Maddirela, D. R., Badri, K. R., Kumar, M. V. J., & Chippada, A. R. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373954 · Cited by 5,938
Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555
Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.
Hubert, H. B., Feinleib, M., McNamara, P. M., & Castelli, W. P. (1983) · Circulation · doi:10.1161/01.cir.67.5.968 · Cited by 4,241
Cardiovascular Survey Methods.
Rose, G., & Blackburn, H. (1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-69-6-1335_2 · Cited by 3,090
Pathogenesis of NIDDM. A balanced overview.
DeFronzo, R. A., Bonadonna, R. C., & Ferrannini, E. (1992) · Diabetes Care · doi:10.2337/diacare.15.3.318 · Cited by 2,085
Quantitative estimation of insulin sensitivity.
Bergman, R. N., Ider, Y. Z., Bowden, C. R., & Cobelli, C. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.236.6.e667 · Cited by 1,874 · cited 1×
“If the measured insulin values were 50% lower for all the measured insulin values during the IVGTT, then the calculated insulin sensitivity index would be 50% higher compared with the insulin sensitivity index value measured, if a nonspecific insulin assay was used (47).”
Self-citation
Obesity, Fat Distribution, and Weight Gain as Risk Factors for Clinical Diabetes in Men
Chan, J. M., Rimm, E. B., Colditz, G. A., Stampfer, M. J., & Willett, W. C. (1994) · Diabetes Care · doi:10.2337/diacare.17.9.961 · Cited by 1,808
Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose
Bergman, R. N., Phillips, L. S., & Cobelli, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110398 · Cited by 1,640
Self-citation

Show all 73 references

Research works printed but not linked: 1

Björntorp and N.D. Brodoff, editors. J.B. Lippincott Co., Philadelphia. 343- 351.

Sorted by citations

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes
Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166
Slow-wave sleep and the risk of type 2 diabetes in humans
Tasali, E., Leproult, R., Ehrmann, D. A., & Van Cauter, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706446105 · Cited by 921
Insulin resistance: a metabolic pathway to chronic liver disease
Bugianesi, E., McCullough, A. J., & Marchesini, G. (2005) · Hepatology · doi:10.1002/hep.20920 · Cited by 900
Adipose tissue as a buffer for daily lipid flux
Frayn, K. (2002) · Diabetologia · doi:10.1007/s00125-002-0873-y · Cited by 752
Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach
Bays, H., Mandarino, L., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030723 · Cited by 664
Low Levels of Leisure-Time Physical Activity and Cardiorespiratory Fitness Predict Development of the Metabolic Syndrome
Laaksonen, D. E., Lakka, H.-M., Salonen, J. T., Niskanen, L. K., Rauramaa, R., & Lakka, T. A. (2002) · Diabetes Care · doi:10.2337/diacare.25.9.1612 · Cited by 657
Estrogen Regulation of Growth Hormone Action
Leung, K., Johannsson, G., Leong, G. M., & Ho, K. K. Y. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0035 · Cited by 550
How to measure insulin sensitivity
Ferrannini, E., & Mari, A. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816070-00001 · Cited by 510
Low Physical Activity Accentuates the Effect of the FTO rs9939609 Polymorphism on Body Fat Accumulation
Andreasen, C. H., Stender-Petersen, K. L., Mogensen, M. S., Torekov, S. S., Wegner, L., Andersen, G., Nielsen, A. L., Albrechtsen, A., Borch-Johnsen, K., Rasmussen, S. S., et al. (2008) · Diabetes · doi:10.2337/db07-0910 · Cited by 476
Self-citation
Increased Fat Intake, Impaired Fat Oxidation, and Failure of Fat Cell Proliferation Result in Ectopic Fat Storage, Insulin Resistance, and Type 2 Diabetes Mellitus
Ravussin, É., & Smith, S. R. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04292.x · Cited by 466
Insulin Resistance versus Insulin Deficiency in Non-Insulin-Dependent Diabetes Mellitus: Problems and Prospects
Ferrannini, E. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.4.0336 · Cited by 451
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review
Palomba, S., Falbo, A., Zullo, F., & Orio, F. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0030 · Cited by 426
Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus
Heilbronn, L. K., Smith, S. R., & Ravussin, É. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802853 · Cited by 416
Insulin Resistance Syndrome Predicts the Risk of Coronary Heart Disease and Stroke in Healthy Middle-Aged Men
Pyörälä, M., Miettinen, H., Halonen, P. M., Laakso, M., & Pyörälà, K. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.538 · Cited by 349
Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver
Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00431-8 · Cited by 359
What is the Relationship Between Exercise and Metabolic Abnormalities?
Carroll, S., & Dudfield, M. (2004) · Sports Medicine · doi:10.2165/00007256-200434060-00004 · Cited by 334
Methods for clinical assessment of insulin sensitivity and β-cell function
Pacini, G., & Mari, A. (2003) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/s1521-690x(03)00042-3 · Cited by 310
Link between obesity and type 2 diabetes
Golay, A., & Ybarra, J. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.07.010 · Cited by 301
Gender Differences in Skeletal Muscle Substrate Metabolism â€“ Molecular Mechanisms and Insulin Sensitivity
Lundsgaard, A.-M., & Kiens, B. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00195 · Cited by 289
The impact of ethnicity on type 2 diabetes
Abate, N. I., & Chandalia, M. (2002) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(02)00190-3 · Cited by 282
The Natural Course of β-Cell Function in Nondiabetic and Diabetic Individuals
Festa, A., Williams, K., D’Agostino, R., Wagenknecht, L. E., & Haffner, S. M. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1100 · Cited by 268
Beta cell function and its relation to insulin action in humans: a critical appraisal
Ferrannini, E., & Mari, A. (2004) · Diabetologia · doi:10.1007/s00125-004-1381-z · Cited by 260
Studies of Association of Variants Near the HHEX, CDKN2A/B, and IGF2BP2 Genes With Type 2 Diabetes and Impaired Insulin Release in 10,705 Danish Subjects
Grarup, N., Rose, C. S., Galijatovic, E. A. A., Andersen, G., Nielsen, A. L., Albrechtsen, A., Clausen, J. O., Rasmussen, S. S., Jørgensen, T., Sandbæk, A., et al. (2007) · Diabetes · doi:10.2337/db07-0856 · Cited by 263
Self-citation
Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets
Hall, E., Volkov, P., Dayeh, T., Esguerra, J. L. S., Salö, S., Eliasson, L., Rönn, T., Bacos, K., & Ling, C. (2014) · Genome Biology · doi:10.1186/s13059-014-0522-z · Cited by 249
Dysfunctional fat cells, lipotoxicity and type 2 diabetes
Defronzo, R. A. (2004) · International Journal of Clinical Practice · doi:10.1111/j.1368-504x.2004.00389.x · Cited by 236
Obesity, Body Fat Distribution, Insulin Sensitivity and Islet β-Cell Function as Explanations for Metabolic Diversity
Kahn, S. E., Prigeon, R. L., Schwartz, R. S., Fujimoto, W. Y., Knopp, R. H., Brunzell, J. D., & Porte, D. (2001) · Journal of Nutrition · doi:10.1093/jn/131.2.354s · Cited by 240
Adipose tissue and the insulin resistance syndrome
Frayn, K. N. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200195 · Cited by 225
High-carbohydrate–low-glycaemic index dietary advice improves glucose disposition index in subjects with impaired glucose tolerance
Wolever, T. M. S., & Mehling, C. (2002) · British Journal of Nutrition · doi:10.1079/bjn2002568 · Cited by 214
Independent Influence of Age on Basal Insulin Secretion in Nondiabetic Humans
Iozzo, P., Beck‐Nielsen, H., Laakso, M., Smith, U., Yki‐Järvinen, H., & Ferrannini, E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.3.5542 · Cited by 215
Beneficial Effects of a Three-Month Structured Exercise Training Program on Cardiopulmonary Functional Capacity in Young Women with Polycystic Ovary Syndrome
Vigorito, C., Giallauria, F., Palomba, S., Cascella, T., Manguso, F., Lucci, R., De Lorenzo, A., Tafuri, D., Lombardi, G., Colao, A., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2794 · Cited by 211
The Metabolic Syndrome, Cardiopulmonary Fitness, and Subcutaneous Trunk Fat as Independent Determinants of Arterial Stiffness
Ferreira, I., Henry, R. M. A., Twisk, J. W. R., van Mechelen, W., Kemper, H. C. G., & Stehouwer, C. D. A. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.8.875 · Cited by 200
Testing the Accelerator Hypothesis
Kibirige, M. S., Metcalf, B. S., Renuka, R., & Wilkin, T. J. (2003) · Diabetes Care · doi:10.2337/diacare.26.10.2865 · Cited by 192
Adaptation of colonic fermentation and glucagon-like peptide-1 secretion with increased wheat fibre intake for 1 year in hyperinsulinaemic human subjects
Freeland, K. R., Wilson, C., & Wolever, T. M. S. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509991462 · Cited by 187
Independent association of insulin resistance with larger amounts of intermuscular adipose tissue and a greater acute insulin response to glucose in African American than in white nondiabetic women
Albu, J., Kovera, A. J., Allen, L., Wainwright, M., Berk, E. S., Raja-Khan, N. T., Janumala, I., Burkey, B. F., Heshka, S., & Gallagher, D. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.6.1210 · Cited by 179
Maximal Estimated Cardiorespiratory Fitness, Cardiometabolic Risk Factors, and Metabolic Syndrome in the Aerobics Center Longitudinal Study
Earnest, C. P., Artero, E. G., Sui, X., Lee, D.-C., Church, T. S., & Blair, S. N. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.11.006 · Cited by 170
The Effects of Fat and Protein on Glycemic Responses in Nondiabetic Humans Vary with Waist Circumference, Fasting Plasma Insulin, and Dietary Fiber Intake
Moghaddam, E., Vogt, J. A., & Wolever, T. M. S. (2006) · Journal of Nutrition · doi:10.1093/jn/136.10.2506 · Cited by 175
Combined oral contraceptives in the treatment of polycystic ovary syndrome
Vrbíková, J., & Cibula, D. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi005 · Cited by 166
Insulin sensitivity differs among ethnic groups with a compensatory response in beta-cell function.
Chiu, K. C., Cohan, P., Lee, N. P., & Chuang, L. M. (2000) · Diabetes Care · doi:10.2337/diacare.23.9.1353 · Cited by 154
Ethnicity, type 2 diabetes & migrant Asian Indians.
Abate, N., & Chandalia, M. (2007) · PubMed · Cited by 150
G-allele of Intronic rs10830963 inMTNR1BConfers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release
Sparsø, T., Bonnefond, A., Galijatovic, E. A. A., Bouatia‐Naji, N., Holmkvist, J., Thørner, L. W., Grarup, N., Gjesing, A. P., Banasik, K., Cavalcanti-Proença, C., et al. (2009) · Diabetes · doi:10.2337/db08-1660 · Cited by 146
Self-citation
Body Composition Is the Main Determinant for the Difference in Type 2 Diabetes Pathophysiology Between Japanese and Caucasians
Møller, J. B., Pedersen, M., Tanaka, H., Ohsugi, M., Overgaard, R. V., Lynge, J., Almind, K., Vasconcelos, N.-M., Poulsen, P., Keller, C., et al. (2013) · Diabetes Care · doi:10.2337/dc13-0598 · Cited by 146
Signals From the Embryonic Mouse Pancreas Induce Differentiation of Human Embryonic Stem Cells Into Insulin-Producing β-Cell–Like Cells
Brolén, G., Heins, N., Edsbagge, J., & Semb, H. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2867 · Cited by 140
Metabolic diseases and associated complications: sex and gender matter
Kautzky‐Willer, A., & Handisurya, A. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02161.x · Cited by 138
The effect of exercise training on leptin levels in obese males
Pasman, W. J., Westerterp‐Plantenga, M. S., & Saris, W. H. M. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.2.e280 · Cited by 137
Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) gene in relation to insulin sensitivity among glucose tolerant Caucasians
Ek, J., Andersen, G., Urhammer, S. A., Hansen, L., Carstensen, B., Borch‐Johnsen, K., Drivsholm, T., Berglund, L., Hansen, T. K., Lithell, H., et al. (2001) · Diabetologia · doi:10.1007/s001250100629 · Cited by 135
Self-citation
Effect of donor age on function of isolated human islets
Ihm, S.-H., Matsumoto, I., Sawada, T., Nakano, M., Zhang, H. J., Ansite, J. D., Sutherland, D. E. R., & Hering, B. J. (2006) · Diabetes · doi:10.2337/db05-1333 · Cited by 130
β-Cell Function Following Human Islet Transplantation for Type 1 Diabetes
Rickels, M. R., Schutta, M. H., Markmann, J. F., Barker, C. F., Naji, A., & Teff, K. L. (2005) · Diabetes · doi:10.2337/diabetes.54.1.100 · Cited by 129
Reduced Sleep Duration or Quality: Relationships With Insulin Resistance and Type 2 Diabetes
Tasali, E., Leproult, R., & Spiegel, K. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.10.002 · Cited by 129
Physical fitness and clustering of risk factors associated with the metabolic syndrome
WHALEY, M. H., Kampert, J. B., Kohl, H. W., & Blair, S. N. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199902000-00013 · Cited by 122
Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes
Jacobsson, J. A., Danielsson, P., Svensson, V., Kloviņš, J., Gyllensten, U. B., Marcus, C., Schiöth, H. B., & Fredriksson, R. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.01.087 · Cited by 124
Fat and carbohydrate balances during adaptation to a high-fat diet
Smith, S. R., de Jonge, L., Zachwieja, J. J., Roy, H. J., Nguyen, T., Rood, J. C., WINDHAUSER, M. M., & Bray, G. A. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.450 · Cited by 122
Mathematical models of diabetes progression
Gaetano, A. D., Hardy, T. A., Beck, B., Abu-Raddad, E., Palumbo, P. J., Bue‐Valleskey, J. M., & Pørksen, N. K. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90444.2008 · Cited by 120
Mitochondrial Complex I Impairment in Leukocytes from Polycystic Ovary Syndrome Patients with Insulin Resistance
Víctor, V. M., Rocha, M., Bañuls, C., Sánchez-Serrano, M., Solá, E., Gomez, M., & Hernández‐Mijares, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0466 · Cited by 120
MECHANISMS IN ENDOCRINOLOGY: Skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes: a causal mechanism or an innocent bystander?
Brøns, C., & Grunnet, L. G. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0488 · Cited by 114
Gender Factors Affect Fatty Acids-Induced Insulin Resistance in Nonobese Humans: Effects of Oral Steroidal Contraception1
Perseghin, G., Scifo, P., Pagliato, E., Battezzati, A., Benedini, S., Soldini, L., Testolin, G., Del Maschio, A., & Luzi, L. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7666 · Cited by 112
Relationship between Exercise Training-Induced Increase in Insulin Sensitivity and Adiponectinemia in Healthy Men
Yatagai, T., Nishida, Y., Nagasaka, S., Nakamura, T., Tokuyama, K., Shindo, M., Tanaka, H., & Ishibashi, S. (2003) · Endocrine Journal · doi:10.1507/endocrj.50.233 · Cited by 106
Development of hyperinsulinemia and insulin resistance during the early stage of weight gain
Erdmann, J., Kallabis, B., Oppel, U., Sypchenko, O., Wagenpfeil, S., & Schusdziarra, V. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00560.2007 · Cited by 103
Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function
Hansen, S. K., Párrizas, M., Jensen, M. L., Průhová, Š., Ek, J., Boj, S. F., Johansen, A., Maestro, M. A., Rivera, F., Eiberg, H., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15085 · Cited by 104
Self-citation
Physical activity, anthropometric factors and risk of pancreatic cancer: Results from the Canadian enhanced cancer surveillance system
Hanley, A. J., Johnson, K. C., Villeneuve, P. J., & Mao, Y. (2001) · International Journal of Cancer · doi:10.1002/ijc.1446 · Cited by 102
Adipose tissue fatty acid metabolism in insulin-resistant men
Bickerton, A. S. T., Roberts, R., Fielding, B. A., Tornqvist, H. E., Blaak, E. E., Wagenmakers, A. J. M., Gilbert, M., Humphreys, S. M., Karpe, F., & Frayn, K. N. (2008) · Diabetologia · doi:10.1007/s00125-008-1040-x · Cited by 99
Obesity and metabolic disease: is adipose tissue the culprit?
Frayn, K. N. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2004403 · Cited by 100
Metabolic clustering, physical activity and fitness in nonsmoking, middle-aged men
Carroll, S., Cooke, C. B., & BUTTERLY, A. R. J. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200012000-00018 · Cited by 96
Islet dysfunction in insulin resistance involves impaired insulin secretion and increased glucagon secretion in postmenopausal women with impaired glucose tolerance.
Larsson, H. E., & Åhrén, B. (2000) · Diabetes Care · doi:10.2337/diacare.23.5.650 · Cited by 98
The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians.
Rasmussen, S. K., Urhammer, S. A., Pizzuti, A., Echwald, S. M., Ekstrøm, C. T., Hansen, L., Hansen, T. F., Borch‐Johnsen, K., Frittitta, L., Trischitta, V., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1608 · Cited by 88
Self-citation
Influence of Increasing BMI on Insulin Sensitivity and Secretion in Normotolerant Men and Women of a Wide Age Span
Kautzky‐Willer, A., Brazzale, A. R., Moro, E., Vrbíková, J., Bendlová, B., Sbrignadello, S., Tura, A., & Pacini, G. (2012) · Obesity · doi:10.1038/oby.2011.384 · Cited by 90
Assessment of insulin secretion in relation to insulin resistance
Mari, A., Åhrén, B., & Pacini, G. (2005) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000171130.23441.59 · Cited by 89
Islet adaptation to insulin resistance: mechanisms and implications for intervention
Åhrén, B., & Pacini, G. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2004.00361.x · Cited by 86
Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function
Hansen, S. K., Párrizas, M., Jensen, M. L., Průhová, Š., Ek, J., Boj, S. F., Johansen, A., Maestro, M. A., Rivera, F., Eiberg, H., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215085 · Cited by 85
Self-citation
Cardiopulmonary Impairment in Young Women with Polycystic Ovary Syndrome
Orio, F., Giallauria, F., Palomba, S., Cascella, T., Manguso, F., Vuolo, L., Russo, T., Tolino, A., Lombardi, G., Colao, A., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0216 · Cited by 84
Time of day difference in postprandial glucose and insulin responses: Systematic review and meta-analysis of acute postprandial studies
Leung, G. K. W., Huggins, C. E., Ware, R. S., & Bonham, M. P. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1683856 · Cited by 82
Relationships Among Age, Proinsulin Conversion, and β-Cell Function in Nondiabetic Humans
Fritsche, A., Madaus, A., Stefan, N., Tschritter, O., Maerker, E., Teigeler, A., Häring, H. U., & Stümvoll, M. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s234 · Cited by 80
Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians.
Rasmussen, S., Urhammer, S., Berglund, L., Jensen, J., Hansen, L., Echwald, S., Borch-Johnsen, K., Horikawa, Y., Mashima, H., Lithell, H., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3561 · Cited by 86
Self-citation
The -238 and -308 G->A Polymorphisms of the Tumor Necrosis Factor Gene Promotor Are Not Associated with Features of the Insulin Resistance Syndrome or Altered Birth Weight in Danish Caucasians
Rasmussen, S. K., Urhammer, S. A., Jensen, J. N., Hansen, T. F., Borch‐Johnsen, K., & Pedersen, O. B. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.4.6563 · Cited by 80
Self-citation
Comparison of Glucostatic Parameters After Hypocaloric Diet or Bariatric Surgery and Equivalent Weight Loss
Plum, L., Ahmed, L., Febres, G., Bessler, M., Inabnet, W., Kunreuther, E., McMahon, D., & Korner, J. (2011) · Obesity · doi:10.1038/oby.2011.134 · Cited by 82
Analysis of the relationship between fasting serum uric acid and the insulin sensitivity index in a population-based sample of 380 young healthy Caucasians
Clausen, J. O., Borch‐Johnsen, K., Ibsen, H., & Pedersen, O. B. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1380063 · Cited by 76
Self-citation
Shedding of TNF-α receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus
Fernández‐Real, J. M., Lainez, B., Vendrell, J. J., Rigla, M., Castro, A., Peñarroja, G., Broch, M., Pérez, A., Richart, C., Engel, P., et al. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00444.2001 · Cited by 77
Evaluation of Abdominal Fat Distribution in Noninsulin-Dependent Diabetes Mellitus: Relationship to Insulin Resistance 1
Gautier, J., Mourier, A., de Kerviler, É., Tarentola, A., Bigard, X. A., Villette, J., Guézennec, C. Y., & Cathelineau, G. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.4.4713 · Cited by 76
An empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics
Tura, A., Sbrignadello, S., Succurro, E., Groop, L., Sesti, G., & Pacini, G. (2010) · Diabetologia · doi:10.1007/s00125-009-1547-9 · Cited by 71
Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: Impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance
Urhammer, S. A., Dalgaard, L. T., Sørensen, T. I. A., Møller, A. M., Andersen, T., Tybjærg‐Hansen, A., Hansen, T. F., Clausen, J. O., Vestergaard, H., & Pedersen, O. B. (1997) · Diabetologia · doi:10.1007/s001250050811 · Cited by 72
Self-citation
Physiological determinants of VO2max and the methods to evaluate it: A critical review
Lee, J., & Zhang, X. L. (2021) · Science & Sports · doi:10.1016/j.scispo.2020.11.006 · Cited by 93
Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4α in Caucasians with maturity onset NIDDM
Møller, A. M., Urhammer, S. A., Dalgaard, L. T., Reneland, R., Berglund, L., Hansen, T. F., Clausen, J. O., Lithell, H., & Pedersen, O. B. (1997) · Diabetologia · doi:10.1007/s001250050778 · Cited by 69
Self-citation
Relation of low cardiorespiratory fitness to the metabolic syndrome in middle-aged men
Kullo, I. J., Hensrud, D. D., & Allison, T. G. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02617-6 · Cited by 64
Impaired adaptation of first-phase insulin secretion in postmenopausal women with glucose intolerance
Åhrén, B., & Pacini, G. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.4.e701 · Cited by 66
Glucose intolerance is predicted by low insulin secretion and high glucagon secretion: outcome of a prospective study in postmenopausal Caucasian women
Larsson, H. E., & Åhrén, B. (2000) · Diabetologia · doi:10.1007/s001250050029 · Cited by 65
Type 2 diabetes and cardiovascular disease: getting to the fat of the matterThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigators' Forum.
Goralski, K. B., & Sinal, C. J. (2007) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y06-092 · Cited by 66
The potential role of olive oil‐derived MUFA in insulin sensitivity
Tierney, A. C., & Roche, H. M. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700143 · Cited by 64
Effect of exercise training on long-term weight maintenance in weight-reduced men
Pasman, W. J., Saris, W. H. M., Muls, E., Vansant, G. A. A. M., & Westerterp‐Plantenga, M. S. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90004-5 · Cited by 62
Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity
Almind, K., Frederiksen, S., Bernal, D., Hansen, T. F., Ambye, L., Urhammer, S. A., Ekstrøm, C. T., Berglund, L., Reneland, R., Lithell, H., et al. (1999) · Diabetologia · doi:10.1007/s001250051299 · Cited by 61
Self-citation
Insulin Resistance in Non-Obese Subjects Is Associated with Activation of the JNK Pathway and Impaired Insulin Signaling in Skeletal Muscle
Masharani, U. B., Maddux, B. A., Li, X., Sakkas, G. K., Mulligan, K. M., Schambelan, M., Goldfine, I. D., & YOUNGREN, J. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019878 · Cited by 62
Exercise hypoglycemia in nondiabetic subjects.
Brun, J. ‐., Dumortier, M., Fédou, C., & Mercier, J. G. (2001) · PubMed · Cited by 59
Reduced Skeletal Muscle Oxygen Uptake and Reduced β-Cell Function
Thamer, C., Stümvoll, M., Niess, A. M., Tschritter, O., Haap, M. M., Becker, R., Shirkavand, F., Bachmann, O. P., Kristian, R. E. T. T., Volk, A., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.7.2126 · Cited by 59
Insulin Resistance in Type 2 Diabetes: Association with Truncal Obesity, Impaired Fitness, and Atypical Malonyl Coenzyme A Regulation
Båvenholm, P., Kuhl, J., Pigon, J., Saha, A. K., Ruderman, N. B., & Efendić, S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020330 · Cited by 59
Comparison of Measured and Estimated Indices of Insulin Sensitivity and Cell Function: Impact of Ethnicity on Insulin Sensitivity and Cell Function in Glucose-Tolerant and Normotensive Subjects
Chiu, K. C., Chuang, L., & Yoon, C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.4.7432 · Cited by 59
Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen
Tao, Z., & Cheng, Z. (2023) · Clinical Science · doi:10.1042/cs20210519 · Cited by 58
Effect of Sex and Dietary Organic Zinc on Growth Performance, Carcass Traits, Tissue Mineral Content, and Blood Parameters of Broiler Chickens
Salim, H. M., Lee, H. R., Jo, C., Lee, S. K., & Lee, B. D. (2011) · Biological Trace Element Research · doi:10.1007/s12011-011-9282-8 · Cited by 55
The metabolic syndrome in smokers. The D.E.S.I.R. study
Geslain-Biquez, C., Vol, S., Tichet, J., Caradec, A., D’Hour, A., & Balkau, B. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70031-9 · Cited by 55
Exercise hemorheology as a three acts play with metabolic actors: is it of clinical relevance?
Brun, J. ‐. (2002) · PubMed · Cited by 54
Insulin and Amylin Release Are Both Diminished in First-Degree Relatives of Subjects With Type 2 Diabetes
Knowles, N. G., Landchild, M. A., Fujimoto, W. Y., & Kahn, S. E. (2002) · Diabetes Care · doi:10.2337/diacare.25.2.292 · Cited by 51
Polycystic ovary syndrome and insulin resistance: Thrifty genes struggling with over-feeding and sedentary life style?
Holte, J. (1998) · Journal of Endocrinological Investigation · doi:10.1007/bf03350784 · Cited by 52
Sex-specific differences in diabetes prevention: a systematic review and meta-analysis
Glechner, A., Harreiter, J., Gartlehner, G., Rohleder, S., Kautzky, A., Tuomilehto, J. O., Noord, M. V., Kaminski-Hartenthaler, A., & Kautzky‐Willer, A. (2014) · Diabetologia · doi:10.1007/s00125-014-3439-x · Cited by 56

Authors: Clausen, J. O., Borch-Johnsen, K., Ibsen, H., Bergman, R. N., Hougaard, P., Winther, K., & Pedersen, O.
Affiliations: University of Copenhagen (DK)
University of Southern California (US)
Novo Nordisk (Denmark) (DK)
Steno Diabetes Center Copenhagen (DK)
ORCID: Bergman, R N
Winther, K
Pedersen, O
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1996-09-01
Volume: 98
Issue: 5
Pages: 1195-1209
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci118903
PMC: PMC507542
OpenAlex: W2070800088
Cited by: 259
References: 73
Citations by year: 2026: 1 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 10 · 2015: 6 · 2014: 9 · 2013: 8 · 2012: 8
FWCI: 9.13
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Bristol-Myers Squibb
Hjerteforeningen
Fondation pour la Recherche Médicale
Frimodt-Heineke Fonden
Diabetesforeningen
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK029867, DK29867)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: insulin sensitivity index, acute insulin response, glucose effectiveness, insulin secretion, insulin sensitivity, fat mass, waist circumference, body mass index, maximal aerobic capacity, physical fitness, oral contraceptives, sex differences, lifestyle factors, healthy young adults, dyslipidemia, blood pressure, glucose tolerance
MeSH terms: Insulin Secretion, Adolescent, Adult, Arteriosclerosis, Demography, Denmark, Diabetes Mellitus, Female, Glucose, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Life Style, Male, Metabolic Clearance Rate, Physical Fitness, Sex Characteristics, Epidemiologic Factors, Body Mass Index, Statistics, Nonparametric, White People

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks