Cited by 1,503Gut microbiota and healthGastrointestinal motility and disordersTryptophan and brain disorders

The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.

Gut/brain axis and the microbiota

Open access

Mayer, Emeran A., Tillisch, Kirsten, Gupta, Arpana·2015·Journal of Clinical Investigation

Open this paper in CoChat — free account Open PDF

Abstract

Tremendous progress has been made in characterizing the bidirectional interactions between the central nervous system, the enteric nervous system, and the gastrointestinal tract. A series of provocative preclinical studies have suggested a prominent role for the gut microbiota in these gut-brain interactions. Based on studies using rodents raised in a germ-free environment, the gut microbiota appears to influence the development of emotional behavior, stress- and pain-modulation systems, and brain neurotransmitter systems. Additionally, microbiota perturbations by probiotics and antibiotics exert modulatory effects on some of these measures in adult animals. Current evidence suggests that multiple mechanisms, including endocrine and neurocrine pathways, may be involved in gut microbiota-to-brain signaling and that the brain can in turn alter microbial composition and behavior via the autonomic nervous system. Limited information is available on how these findings may translate to healthy humans or to disease states involving the brain or the gut/brain axis. Future research needs to focus on confirming that the rodent findings are translatable to human physiology and to diseases such as irritable bowel syndrome, autism, anxiety, depression, and Parkinson's disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci76304

Cites

141 of 141 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Bacterial Community Variation in Human Body Habitats Across Space and Time
Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009) · Science · doi:10.1126/science.1177486 · Cited by 3,231
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119
The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791

Flagged first, then by citations

Show all 141 references

Research works printed but not linked: 3

Kiliaan, 1998, Am J Physiol., 275, G1037
Stephens, 1989, Am J Physiol., 256, G377
Yang, 1992, Am J Physiol., 262, G216

Sorted by citations

Items 101–200 of 1,000

Milk fat globule membrane: the role of its various components in infant health and development
Brink, L., & Lönnerdal, B. L. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108465 · Cited by 193
Gut Microbiota and Brain Function: An Evolving Field in Neuroscience: Table 1.
Foster, J. A., Lyte, M., Meyer, E., & Cryan, J. F. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv114 · Cited by 188
Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women
Worby, C. J., Schreiber, H. L., Straub, T. J., van Dijk, L. R., Bronson, R. A., Olson, B. S., Pinkner, J. S., Obernuefemann, C. L. P., Muñoz, V. L., Paharik, A. E., et al. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01107-x · Cited by 188
The impact of dietary macronutrient intake on cognitive function and the brain
Muth, A.-K., & Park, S. Q. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.04.043 · Cited by 213
The Gut-Brain Axis, the Human Gut Microbiota and Their Integration in the Development of Obesity
Bliss, E., & Whiteside, E. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00900 · Cited by 196
Brain structure and response to emotional stimuli as related to gut microbial profiles in healthy women
Tillisch, K., Mayer, E. A., Gupta, A., Gill, Z., Brazeilles, R., Le Nevé, B., van Hylckama Vlieg, J. E. T., Guyonnet, D., Derrien, M., & Labus, J. S. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000493 · Cited by 185
Self-citation
Gastrointestinal symptoms and autism spectrum disorder: links and risks – a possible new overlap syndrome
Wasilewska, J., & Klukowski, M. (2015) · Pediatric Health Medicine and Therapeutics · doi:10.2147/phmt.s85717 · Cited by 191
The role of gut microbiota in health and disease: In vitro modeling of host-microbe interactions at the aerobe-anaerobe interphase of the human gut
von Martels, J. Z. H., Sadabad, M. S., Bourgonje, A. R., Blokzijl, T., Dijkstra, G. D. H., Faber, K. N., & Harmsen, H. J. M. (2017) · Anaerobe · doi:10.1016/j.anaerobe.2017.01.001 · Cited by 186
Alteration of Gut Microbiota and Inflammatory Cytokine/Chemokine Profiles in 5-Fluorouracil Induced Intestinal Mucositis
Li, H., Lŭ, L., Wang, X., Qin, L., Wang, P., Qiu, S., Wu, H., Huang, F., Zhang, B., Shi, H., et al. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00455 · Cited by 184
‘NetShift’: a methodology for understanding ‘driver microbes’ from healthy and disease microbiome datasets
Kuntal, B. K., Chandrakar, P., Sadhu, S., & Mande, S. S. (2018) · The ISME Journal · doi:10.1038/s41396-018-0291-x · Cited by 179
Effect of Cigarette Smoke on Gut Microbiota: State of Knowledge
Gui, X., Yang, Z., & Li, M. D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.673341 · Cited by 199
Stress and the gut microbiota-brain axis
Molina‐Torres, G., Rodríguez-Arrastia, M. J., Román, P., Sánchez‐Labraca, N., & Cardona, D. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000478 · Cited by 189
Linking the Gut Microbial Ecosystem with the Environment: Does Gut Health Depend on Where We Live?
Tasnim, N., Abulizi, N., Pither, J., Hart, M. M., & Gibson, D. L. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01935 · Cited by 188
Abnormal gut microbiota composition contributes to cognitive dysfunction in SAMP8 mice
Zhan, G., Yang, N., Li, S., Huang, N., Fang, X., Zhang, J., Zhu, B., Yang, L., Yang, C., & Luo, A. (2018) · Aging · doi:10.18632/aging.101464 · Cited by 175
Gut microbiota and dietary patterns in children with attention-deficit/hyperactivity disorder
Wang, L., Yang, C., Chou, W., Lee, M., Chou, M., Kuo, H., Yeh, Y., Lee, S.-Y., Huang, L., & Li, S. (2019) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-019-01352-2 · Cited by 174
The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence
Lee, K., Vuong, H. E., Nusbaum, D. J., Hsiao, E. Y., Evans, C. J., & Taylor, A. M. W. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0211-9 · Cited by 172
The Role of Gut Dysbiosis in the Pathophysiology of Neuropsychiatric Disorders
Anand, N., Gorantla, V. R., & Chidambaram, S. B. (2022) · Cells · doi:10.3390/cells12010054 · Cited by 194
Infant colic: mechanisms and management
Zeevenhooven, J., Browne, P. D., L’Hoir, M. P., de Weerth, C., & Benninga, M. A. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0008-7 · Cited by 193
Intestinal Health of Pigs Upon Weaning: Challenges and Nutritional Intervention
Zheng, L., Duarte, M. E., Loftus, A. S., & Kim, S. W. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.628258 · Cited by 168
Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress
Kato-Kataoka, A., Nishida, K., Takada, M., Suda, K., Kawai, M., Shimizu, K., Kushiro, A., Hoshi, R., Watanabe, O., Igarashi, T., et al. (2016) · Beneficial Microbes · doi:10.3920/bm2015.0100 · Cited by 166
Bacterial Signaling to the Nervous System through Toxins and Metabolites
Yang, N. J., & Chiu, I. M. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.12.023 · Cited by 167
Interactions between host and gut microbiota in domestic pigs: a review
Patil, Y. D., Gooneratne, R., & Ju, X. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1690363 · Cited by 163
Taxonomer: an interactive metagenomics analysis portal for universal pathogen detection and host mRNA expression profiling
Flygare, S., Simmon, K., Miller, C., Qiao, Y., Kennedy, B., Di Sera, T., Graf, E. H., Tardif, K. D., Kapusta, A., Rynearson, S., et al. (2016) · Genome Biology · doi:10.1186/s13059-016-0969-1 · Cited by 164
Moderate Traumatic Brain Injury Alters the Gastrointestinal Microbiome in a Time-Dependent Manner
Nicholson, S. E., Watts, L. T., Burmeister, D. M., Merrill, D., Sayyadioskoie, S., Zou, Y., Lai, Z., Grandhi, R., Lewis, A. M., Newton, L. M., et al. (2018) · Shock · doi:10.1097/shk.0000000000001211 · Cited by 163
Psychobiotic Lactobacillus plantarum JYLP-326 relieves anxiety, depression, and insomnia symptoms in test anxious college via modulating the gut microbiota and its metabolism
Zhu, R., Fang, Y., Li, H., Liu, Y., Wei, J., Zhang, S., Wang, L., Fan, R., Wang, L., Li, S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1158137 · Cited by 166
Morphine tolerance is attenuated in germfree mice and reversed by probiotics, implicating the role of gut microbiome
Zhang, L., Meng, J., Ban, Y. J., Jalodia, R., Chupikova, I., Fernández, I., Brito, N., Sharma, U., Abreu, M. T., Ramakrishnan, S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901182116 · Cited by 164
Intestinal in vitro and ex vivo Models to Study Host-Microbiome Interactions and Acute Stressors
Pearce, S., Coia, H. G., Karl, J. P., Pantoja-Feliciano, I. G., Zachos, N. C., & Racicot, K. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01584 · Cited by 167
Microbiota metabolites modulate the T helper 17 to regulatory T cell (Th17/Treg) imbalance promoting resilience to stress-induced anxiety- and depressive-like behaviors
Westfall, S., Caracci, F., Zhao, D., Wu, Q.-L., Frolinger, T., Simon, J. E., & Pasinetti, G. M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.10.013 · Cited by 164
On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death
Kell, D. B., & Pretorius, E. (2015) · Integrative Biology · doi:10.1039/c5ib00158g · Cited by 170
Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives
Chu, F., Shi, M., Lang, Y., Shen, D., Jin, T., Zhu, J., & Cui, L. (2018) · Mediators of Inflammation · doi:10.1155/2018/8168717 · Cited by 164
Clostridium butyricum Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior in Mice via the Gut-Brain Axis
Sun, J., Wang, F., Hu, X., Yang, C., Xu, H., Yao, Y., & Liu, J. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b02462 · Cited by 161
Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis?
Forsythe, P., Kunze, W., & Bienenstock, J. (2016) · BMC Medicine · doi:10.1186/s12916-016-0604-8 · Cited by 162
Gut Microbiota Dysfunction as Reliable Non-invasive Early Diagnostic Biomarkers in the Pathophysiology of Parkinson's Disease: A Critical Review
Nair, A. T., Ramachandran, V., Joghee, N. M., Shanish Antony, A., & Ramalingam, G. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm17105 · Cited by 164
Patients with Acne Vulgaris Have a Distinct Gut Microbiota in Comparison with Healthy Controls
Deng, Y., Wang, H., Zhou, J. W., Mou, Y., Wang, G., & Xiong, X. (2018) · Acta Dermato Venereologica · doi:10.2340/00015555-2968 · Cited by 166
The microbiota-gut-brain axis as a key regulator of neural function and the stress response: Implications for human and animal health
Wiley, N., Dinan, T. G., Ross, R. P., Stanton, C., Clarke, G. A., & Cryan, J. F. (2017) · Journal of Animal Science · doi:10.2527/jas.2016.1256 · Cited by 190
Psychobiotics: The Next-Generation Probiotics for the Brain
Sharma, R., Gupta, D., Mehrotra, R., & Mago, P. (2021) · Current Microbiology · doi:10.1007/s00284-020-02289-5 · Cited by 164
Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression
Bertollo, A. G., Santos, C. F., Bagatini, M. D., & Ignácio, Z. M. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1541075 · Cited by 183
Emerging Evidence for Pathogenesis of Sporadic Cerebral Small Vessel Disease
Ihara, M., & Yamamoto, Y. (2016) · Stroke · doi:10.1161/strokeaha.115.009627 · Cited by 155
Changes in gut and plasma microbiome following exercise challenge in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Shukla, S. K., Cook, D., Meyer, J., Vernon, S. D., Le, T., Clevidence, D., Robertson, C. E., Schrodi, S. J., Yale, S., & Frank, D. N. (2015) · PLOS ONE · doi:10.1371/journal.pone.0145453 · Cited by 137
Gastrointestinal disorders associated with migraine: A comprehensive review
Camara-Lemarroy, C. R., Rodríguez‐Gutiérrez, R., Monreal‐Robles, R., & Marfil-Rivera, A. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i36.8149 · Cited by 155
Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative Remedies
Maffei, M. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217877 · Cited by 150
Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation
Alhasson, F. A., Das, S., Seth, R. K., Dattaroy, D., Chandrashekaran, V., Ryan, C. N., Chan, L. S., Testerman, T. L., Burch, J. B., Hofseth, L. J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172914 · Cited by 152
Drug–gut microbiota interactions: implications for neuropharmacology
Walsh, J., Griffin, B. T., Clarke, G. A., & Hyland, N. P. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14366 · Cited by 155
Gut-Brain-Microbiota Axis: Antibiotics and Functional Gastrointestinal Disorders
Karakan, T., Özkul, C., Akkol, E. K., Bilici, S., Sobarzo‐Sánchez, E., & Capasso, R. (2021) · Nutrients · doi:10.3390/nu13020389 · Cited by 159
Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches
Cheng, N., Rho, J. M., & Masino, S. A. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00034 · Cited by 162
Clostridium butyricum attenuates cerebral ischemia/reperfusion injury in diabetic mice via modulation of gut microbiota
Sun, J., Wang, F., Ling, Z., Yu, X., Chen, W., Li, H., Jin, J., Pang, M., Zhang, H., Yu, J., et al. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.042 · Cited by 146
Organ-On-A-Chip in vitro Models of the Brain and the Blood-Brain Barrier and Their Value to Study the Microbiota-Gut-Brain Axis in Neurodegeneration
Raimondi, I., Izzo, L., Tunesi, M., Comar, M., Albani, D., & Giordano, C. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00435 · Cited by 150
Androgen-induced gut dysbiosis disrupts glucolipid metabolism and endocrinal functions in polycystic ovary syndrome
Han, Q., Wang, J., Li, W., Chen, Z., & Du, Y. (2021) · Microbiome · doi:10.1186/s40168-021-01046-5 · Cited by 156
Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota
Salminen, A. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02289-5 · Cited by 161
Microbiota‐gut‐brain axis as a regulator of reward processes
García‐Cabrerizo, R., Carbia, C., O’Riordan, K. J., Schellekens, H., & Cryan, J. F. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15284 · Cited by 150
Gut hormones in microbiota-gut-brain cross-talk
Sun, L.-J., Li, J.-N., & Nie, Y.-Z. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000706 · Cited by 145
Enteric nervous system: the bridge between the gut microbiota and neurological disorders
Geng, Z.-H., Zhu, Y., Li, Q.-L., Zhao, C., & Zhou, P.-H. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.810483 · Cited by 144
The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review
Mesa, M. D., Loureiro, B., Iglesia, I., Gonzalez, S. F., Llurba, E., García‐Algar, Ó., Solana, M. J., Cabero-Pérez, M. J., Sainz, T., Martínez, L., et al. (2020) · Nutrients · doi:10.3390/nu12010133 · Cited by 151
The gut microbiota-brain axis, psychobiotics and its influence on brain and behaviour: a systematic review
Barrio, C., Arias-Sánchez, S., & Martín-Monzón, I. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105640 · Cited by 143
Microbiota and neurologic diseases: potential effects of probiotics
Umbrello, G., & Esposito, S. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1058-7 · Cited by 147
Role of the Gut Microbiome in Autism Spectrum Disorders
Pulikkan, J., Mazumder, A., & Grace, T. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-05542-4_13 · Cited by 142
5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption
Ma, J., Wang, R., Chen, Y., Wang, Z., & Dong, Y. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02693-1 · Cited by 143
Effects of a Diet-Based Weight-Reducing Program with Probiotic Supplementation on Satiety Efficiency, Eating Behaviour Traits, and Psychosocial Behaviours in Obese Individuals
Sánchez, M., Darimont, C., Panahi, S., Drapeau, V., Marette, A., Taylor, V. H., Doré, J., & Tremblay, A. (2017) · Nutrients · doi:10.3390/nu9030284 · Cited by 138
The Microbiota-Inflammasome Hypothesis of Major Depression
Inserra, A., Rogers, G. B., Licinio, J., & Wong, M. (2018) · BioEssays · doi:10.1002/bies.201800027 · Cited by 134
Microbiota‐dependent and ‐independent effects of dietary fibre on human health
Cai, Y., Folkerts, J., Folkerts, G., Maurer, M., & Braber, S. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14871 · Cited by 142
Adolescent obesity and dietary decision making—a brain-health perspective
Lowe, C. J., Morton, J. B., & Reichelt, A. C. (2020) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(19)30404-3 · Cited by 154
Post-stroke remodeling processes in animal models and humans
Cirillo, C., Brihmat, N., Castel-Lacanal, E., Friec, A. L., Barbieux‐Guillot, M., Raposo, N., Pariente, J., Viguier, A., Simonetta‐Moreau, M., Albucher, J., et al. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19882788 · Cited by 144
Gut microbiota in various childhood disorders: Implication and indications
Saeed, N. K., Al‐Beltagi, M., Bediwy, A. S., El-Sawaf, Y., & Toema, O. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i18.1875 · Cited by 153
Vasoactive Intestinal Polypeptide and Mast Cells Regulate Increased Passage of Colonic Bacteria in Patients With Irritable Bowel Syndrome
Bednarska, O., Walter, S. A., Casado‐Bedmar, M., Ström, M., Salvo‐Romero, E., Vicario, M., Mayer, E. A., & Keita, Å. V. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.06.051 · Cited by 133
Self-citation
Gut microbiota regulates lacteal integrity by inducing VEGF‐C in intestinal villus macrophages
Suh, S. H., Choe, K., Hong, S. P., Jeong, S., Mäkinen, T., Kim, K. S., Alitalo, K. K., Surh, C. D., Koh, G. Y., & Song, J. (2019) · EMBO Reports · doi:10.15252/embr.201846927 · Cited by 134
Ten questions concerning the built environment and mental health
Hoisington, A. J., Stearns‐Yoder, K. A., Schuldt, S., Beemer, C. J., Maestre, J. P., Kinney, K. A., Postolache, T. T., Lowry, C. A., & Brenner, L. A. (2019) · Building and Environment · doi:10.1016/j.buildenv.2019.03.036 · Cited by 143
Disruption of the microbiota across multiple body sites in critically ill children
Rogers, M. B., Firek, B., Shi, M., Yeh, A., Brower–Sinning, R., Aveson, V. G., Kohl, B. L., Fabio, A., Carcillo, J. A., & Morowitz, M. J. (2016) · Microbiome · doi:10.1186/s40168-016-0211-0 · Cited by 127
Organ‐on‐a‐Chip Technology for Reproducing Multiorgan Physiology
Lee, S. H., & Sung, J. H. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700419 · Cited by 130
Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice
Honarpisheh, P., Reynolds, C. R., Conesa, M. P. B., Moruno-Manchon, J. F., Putluri, N., Bhattacharjee, M. B., Urayama, A., McCullough, L. D., & Ganesh, B. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051711 · Cited by 129
The potential of insects as food sources – a review
de Carvalho, N. M., Madureira, A. R., & Pintado, M. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1703170 · Cited by 126
Probiotics and Subclinical Psychological Symptoms in Healthy Participants: A Systematic Review and Meta-Analysis
McKean, J., Naug, H., Nikbakht, E., Amiet, B., & Colson, N. (2017) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2016.0023 · Cited by 125
Posttraumatic stress disorder: does the gut microbiome hold the key?
Leclercq, S., Forsythe, P., & Bienenstock, J. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716635535 · Cited by 121
Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet?
Quigley, E. M. M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.29 · Cited by 125
Fatigue in chronic liver disease: New insights and therapeutic approaches
Swain, M. G., & Jones, D. E. (2018) · Liver International · doi:10.1111/liv.13919 · Cited by 125
Lactobacillus casei BL23 Produces Microvesicles Carrying Proteins That Have Been Associated with Its Probiotic Effect
Rubio, A. P. D., Martínez, J. H., Martínez-Casillas, D. C., Leskow, F. C., Piuri, M., & Pérez, O. E. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01783 · Cited by 125
Immunomodulatory and anti-inflammatory effects of probiotics in multiple sclerosis: a systematic review
Morshedi, M., Hashemi, R., Moazzen, S., Sahebkar, A., & Hosseinifard, E.-S. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1611-4 · Cited by 125
The Role of Microbiome, Dietary Supplements, and Probiotics in Autism Spectrum Disorder
Sivamaruthi, B. S., Suganthy, N., Kesika, P., & Chaiyasut, C. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17082647 · Cited by 133
Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders
Israelyan, N., & Margolis, K. G. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.020 · Cited by 122
Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death
Xu, R., Tan, C., Zhu, J., Zeng, X., Gao, X., Wu, Q., Chen, Q., Wang, H., Zhou, H., He, Y., et al. (2019) · Critical Care · doi:10.1186/s13054-019-2488-4 · Cited by 123
Altered Fecal Microbiome Years after Traumatic Brain Injury
Urban, R. J., Pyles, R. B., Stewart, C. J., Ajami, N. J., Randolph, K. M., Durham, W. J., Danesi, C. P., Dillon, E. L., Summons, J. R., Singh, C. K., et al. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2019.6688 · Cited by 117
A story of liver and gut microbes: how does the intestinal flora affect liver disease? A review of the literature
Giuffrè, M., Campigotto, M., Campisciano, G., Comar, M., & Crocè, L. S. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00161.2019 · Cited by 122
Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease
Pappolla, M. A., Perry, G. L., Fang, X., Zagorski, M. G., Sambamurti, K., & Pöeggeler, B. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105403 · Cited by 124
Live Biotherapeutic Products, A Road Map for Safety Assessment
Rouanet, A., Bolca, S., Bru, A., Claes, I., Cvejic, H., Girgis, H., Harper, A., Lavergne, S. N., Mathys, S., Pane, M., et al. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00237 · Cited by 120
Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice
Ogawa, Y., Miyoshi, C., Obana, N., Yajima, K., Hotta-Hirashima, N., Ikkyu, A., Kanno, S., Soga, T., Fukuda, S., & Yanagisawa, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-76562-9 · Cited by 124
Risk factors in autism: Thinking outside the brain
Matelski, L., & de Water, J. V. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.11.003 · Cited by 126
Neuroinflammation in mouse models of Alzheimer's disease
Saito, T., & Saido, T. C. (2018) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12475 · Cited by 118
Composition and diversity of mucosa‐associated microbiota along the entire length of the pig gastrointestinal tract; dietary influences
Kelly, J., Daly, K., Moran, A. W., Ryan, S., Bravo, D., & Shirazi‐Beechey, S. P. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13619 · Cited by 121
Metagenomic Surveys of Gut Microbiota
Mandal, R. S., Saha, S., & Das, S. (2015) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2015.02.005 · Cited by 123
Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke
Zhao, L., Xiong, Q., Stary, C. M., Mahgoub, O. K., Ye, Y., Gu, L., Xiong, X., & Zhu, S. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1382-3 · Cited by 113
“Therefore the gut-brain-microbiota axis (GBMAx) has been recently been described to underscore the contribution of microbiota in the bidirectional communication of the gut and brain [3].”
Consensus report: faecal microbiota transfer – clinical applications and procedures
König, J., Siebenhaar, A., Högenauer, C., Arkkila, P. E. T., Nieuwdorp, M., Norén, T., Ponsioen, C. Y., Rosien, U., Rossen, N., Satokari, R. M., et al. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13868 · Cited by 115
Type 2 Diabetes Mellitus Associated with Obesity (Diabesity). The Central Role of Gut Microbiota and Its Translational Applications
Ortega, M. A., Fraile‐Μartinez, O., Naya, I., García‐Honduvilla, N., Álvarez‐Mon, M., Buján, J., Asúnsolo, Á., & de la Torre, B. (2020) · Nutrients · doi:10.3390/nu12092749 · Cited by 122
The gut microbiota in osteoarthritis: where do we stand and what can we do?
Hao, X., Shang, X., Liu, J., Chi, R., Zhang, J., & Xu, T. (2021) · Arthritis Research & Therapy · doi:10.1186/s13075-021-02427-9 · Cited by 123
A review of respirable fine particulate matter (PM2.5)-induced brain damage
Li, W., Lin, G., Xiao, Z., Zhang, Y., Li, B., Zhou, Y. J., Ma, Y., & Chai, E. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.967174 · Cited by 125
Bile acids as key modulators of the brain-Gut-Microbiota axis in alzheimer’s disease
Mulak, A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210608 · Cited by 114
A pilot randomized controlled trial to explore cognitive and emotional effects of probiotics in fibromyalgia
Roman, P., Estévez, A. F., Miras, A., Sánchez-Labraca, N., Cañadas, F., Vivas, A. B., & Cardona, D. (2018) · Scientific Reports · doi:10.1038/s41598-018-29388-5 · Cited by 116
Microbiota-gut-brain axis: enteroendocrine cells and the enteric nervous system form an interface between the microbiota and the central nervous system
KUWAHARA, A., MATSUDA, K., KUWAHARA, Y., ASANO, S., INUI, T., & MARUNAKA, Y. (2020) · Biomedical Research · doi:10.2220/biomedres.41.199 · Cited by 112
Autism Spectrum Disorder Associated With Gut Microbiota at Immune, Metabolomic, and Neuroactive Level
García-Gutiérrez, E., Narbad, A., & Rodríguez, J. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.578666 · Cited by 118
Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress?
Sharma, V., Singh, T. G., Garg, N., Dhiman, S., Gupta, S., Rahman, M. H., Najda, A., Walasek-Janusz, M., Kamel, M. S., Albadrani, G. M., et al. (2021) · Biomolecules · doi:10.3390/biom11050678 · Cited by 111
Can we ‘seize’ the gut microbiota to treat epilepsy?
De Caro, C., Iannone, L. F., Citraro, R., Striano, P., De Sarro, G., Constanti, A., Cryan, J. F., & Russo, E. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.002 · Cited by 110
Role of probiotics in the treatment of minimal hepatic encephalopathy in patients with HBV-induced liver cirrhosis
Xia, X., Chen, J., Xia, J., Wang, B., Liu, H., Yang, L., Wang, Y., & Ling, Z. (2018) · Journal of International Medical Research · doi:10.1177/0300060518776064 · Cited by 112

Authors: Mayer, E. A., Tillisch, K., & Gupta, A.
Affiliations: University of California, Los Angeles (US)
VA Greater Los Angeles Healthcare System (US)
Corresponding author: Mayer, Emeran A.
ORCID: Mayer, Emeran A.
Tillisch, Kirsten
Gupta, Arpana
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2015-02-17
Volume: 125
Issue: 3
Pages: 926-938
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci76304
PMC: PMC4362231
OpenAlex: W2001339909
Cited by: 1,503
References: 141
Citations by year: 2026: 144 · 2025: 143 · 2024: 133 · 2023: 128 · 2022: 169 · 2021: 165 · 2020: 160 · 2019: 126 · 2018: 122 · 2017: 90 · 2016: 81 · 2015: 41
FWCI: 10.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (DK 48351)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-48351, DK 64539, R01DK048351, P50DK064539)
National Center for Complementary and Integrative Health (AT007137, R01AT007137)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: gut-brain axis, gut microbiota, enteric nervous system, emotional behavior, stress response, pain modulation, neurotransmitter systems, probiotics, antibiotics, hormone signaling, autonomic nervous system, irritable bowel syndrome, autism spectrum disorder, anxiety, depression, Parkinson's disease
MeSH terms: Animals, Behavior, Brain, Cell Membrane Permeability, Diet, Emotions, Humans, Hypothalamo-Hypophyseal System, Intestinal Mucosa, Pituitary-Adrenal System, Gastrointestinal Tract, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Gut/brain axis and the microbiota

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks