Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet?

Quigley, Eamonn M. M.

doi:10.1038/nrgastro.2017.29

Cited by 125Gut microbiota and healthGastrointestinal motility and disordersInflammatory Bowel Disease

Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet?

Quigley, Eamonn M. M.·2017·Nature Reviews Gastroenterology & Hepatology

DOI 10.1038/nrgastro.2017.29

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Abstract

Spurred on by ever-evolving developments in analytical methodology, the microbiome, and the gut microbiome in particular, has become the hot topic in biomedical research. Ingenious experiments in animal models have revealed the extent to which the gut microbiota sustains health and how its disruption might contribute to disease pathogenesis. Not surprisingly, associations between the microbiota and disease states in humans have been the subject of considerable interest and many links proposed. However, with rare exceptions, the incrimination of an altered microbiota in disease pathogenesis seems premature at this time given our incomplete understanding of the composition of the gut microbiota in health and the effect of many confounding factors in the interpretation of supposedly abnormal microbial signatures. Future studies must account for these variables and the bidirectionality of host-microorganism interactions in health and disease. In this Perspectives, the status of microbiota signatures in the clinical arena (for facilitating diagnosis or refining prognosis) will be critically assessed and guidance toward future progress provided.

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Factors known to influence gut microbiome composition, such as age, geography, hormone status, and sex, overlap with variable drug pharmacokinetics and impact the relative abundances of genes coding for xenobiotic-metabolizing enzymes.
“Factors that are known to influence the composition of the gut microbiome, such as age and geography, also overlap with variable drug pharmacokinetics and impact on the relative abundances of genes coding for xenobiotic-metabolizing enzymes (Das et al., 2016;Quigley, 2017).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Quigley, 2017

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O’Toole, P. W., & Flemer, B. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.09.003 · Cited by 17 · see citing works

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Microbiota-Brain-Gut Axis and Neurodegenerative Diseases
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Precision Nutrition from the View of the Gut Microbiome
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Authors: Quigley, E. M. M.
Affiliations: Houston Methodist (US)
Corresponding author: Quigley, Eamonn M. M.
ORCID: Quigley, Eamonn M. M.
Venue: Nature Reviews Gastroenterology & Hepatology
Publisher: Springer Science and Business Media LLC
Published: 2017-03-30
Volume: 14
Issue: 5
Pages: 315-320
ISSN: 1759-5045 (ISSN-L)
1759-5053
DOI: 10.1038/nrgastro.2017.29
OpenAlex: W2601263590
Cited by: 125
References: 89
Citations by year: 2026: 7 · 2025: 12 · 2024: 10 · 2023: 12 · 2022: 16 · 2021: 13 · 2020: 19 · 2019: 8 · 2018: 23 · 2017: 5
FWCI: 1.41
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Gastroenterology & Hepatology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords: gut microbiota, gastrointestinal diseases, clinical translation, microbiota signature, diagnosis, prognosis, host-microbe interactions, confounding factors, pathogenesis, dysbiosis
MeSH terms: Gastrointestinal Diseases, Humans, Nutritional Physiological Phenomena, Gastrointestinal Tract, Microbiota

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Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet?

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