The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Increased Occipital Cortex GABA Concentrations in Depressed Patients After Therapy With Selective Serotonin Reuptake Inhibitors
Abstract
OBJECTIVE: Studies have demonstrated low concentrations of gamma-aminobutyric acid (GABA) in the plasma and CSF of individuals with major depression, and low GABA concentrations have also been found in the occipital cortex of depressed subjects. The goal of this study was to determine whether these occipital cortex GABA concentrations are altered after administration of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression. METHOD: By means of proton magnetic resonance spectroscopy, occipital cortex GABA concentrations were measured in 11 medication-free depressed patients before initiation of treatment with SSRI medications and after an average of 2 months of treatment. RESULTS: A significant increase in occipital cortex GABA concentrations was seen after SSRI treatment. CONCLUSIONS: SSRI treatment of major depression is associated with increased occipital cortex GABA concentrations. This appears to result in a normalization of low pretreatment GABA concentrations, an effect that may contribute to a common mechanism of antidepressant action.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sanacora, G., Mason, G. F., Rothman, D. L., Behar, K. L., Hyder, F., Petroff, O. A. C., Berman, R. M., Charney, D. S., & Krystal, J. H. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.11.1043 · Cited by 627
Self-citation
Cited by
The GABAergic deficit hypothesis of major depressive disorder
Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934
Streeter, C. C., Gerbarg, P. L., Saper, R. B., Ciraulo, D. A., & Brown, R. P. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.01.021 · Cited by 694
Rajkowska, G., O'Dwyer, G., Teleki, Z., Stockmeier, C. A., & Miguel-Hidalgo, J. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301234 · Cited by 430
Taylor, M. J., Freemantle, N., Geddes, J. R., & Bhagwagar, Z. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1217 · Cited by 406
Fee, C., Banasr, M., & Sibille, E. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.024 · Cited by 329
Price, R. B., Shungu, D. C., Mao, X., Nestadt, P., Kelly, C., Collins, K. A., Murrough, J. W., Charney, D. S., & Mathew, S. J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.025 · Cited by 270
Evidence of Cortical Inhibitory Deficits in Major Depressive Disorder
Levinson, A. J., Fitzgerald, P. B., Favalli, G., Blumberger, D. M., Daigle, M., & Daskalakis, Z. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.025 · Cited by 261
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232
Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: A meta-analysis
Yildiz-Yesiloglu, A., & Ankerst, D. P. (2006) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2005.12.004 · Cited by 232
GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders
Sibille, E., Morris, H. M., Kota, R. S., & Lewis, D. A. (2011) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001616 · Cited by 217
Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression
Karolewicz, B., Maciag, D., O'Dwyer, G., Stockmeier, C. A., Feyissa, A. M., & Rajkowska, G. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990587 · Cited by 203
Fuchs, T., Jefferson, S. J., Hooper, A., Yee, P.-H., Maguire, J., & Luscher, B. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.188 · Cited by 204
Pham, T. H., & Gardier, A. M. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.017 · Cited by 186
Reduced somatostatin in subgenual anterior cingulate cortex in major depression
Tripp, A., Kota, R. S., Lewis, D. A., & Sibille, E. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.014 · Cited by 190
Evans, J. W., Szczepanik, J., Brutsché, N., Park, L. T., Nugent, A. C., & Zarate, C. A. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.027 · Cited by 173
Convergent Mechanisms Underlying Rapid Antidepressant Action
Zanos, P., Thompson, S. M., Duman, R. S., Zarate, C. A., & Gould, T. D. (2018) · CNS Drugs · doi:10.1007/s40263-018-0492-x · Cited by 171
Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development
Frieder, A., Fersh, M., Hainline, R., & Deligiannidis, K. M. (2019) · CNS Drugs · doi:10.1007/s40263-019-00605-7 · Cited by 156
Küçükibrahimoğlu, E., Saygın, M. Z., Çalışkan, M., Kaplan, O. K., Ünsal, C., & Gören, M. Z. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-009-0650-7 · Cited by 155
GABAergic Control of Depression-Related Brain States
Luscher, B., & Fuchs, T. (2015) · Advances in Pharmacology · doi:10.1016/bs.apha.2014.11.003 · Cited by 149
Milak, M. S., Proper, C. J., Mulhern, S. T., Parter, A. L., Kegeles, L. S., Ogden, R. T., Mao, X., Rodriguez, C. I., Oquendo, M. A., Suckow, R. F., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.83 · Cited by 144
Pham, T. H., Defaix, C., Xu, X., Deng, S.-X., Fabresse, N., Alvarez, J.-C., Landry, D. W., Brachman, R. A., Denny, C. A., & Gardier, A. M. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.020 · Cited by 131
Effect of paroxetine on enhanced contextual fear induced by single prolonged stress in rats
Takahashi, T., Morinobu, S., Iwamoto, Y., & Yamawaki, S. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0545-6 · Cited by 138
Soumier, A., & Sibille, E. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.76 · Cited by 136
Cai, K., Nanga, R. P., Lamprou, L., Schinstine, C., Elliott, M., Hariharan, H., Reddy, R., & Epperson, C. N. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.142 · Cited by 128
Bhagwagar, Z., & Cowen, P. J. (2008) · Psychological Medicine · doi:10.1017/s0033291707001250 · Cited by 124
Blumberger, D. M., Mulsant, B. H., Fitzgerald, P. B., Rajji, T. K., Ravindran, A. V., Young, L. T., Levinson, A. J., & Daskalakis, Z. J. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.579163 · Cited by 118
Pollack, M. H., Jensen, J. E., Simon, N. M., Kaufman, R. E., & Renshaw, P. F. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.11.023 · Cited by 112
Guirado, R., Perez-Rando, M., Sanchez-Matarredona, D., Castrén, E., & Nacher, J. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000406 · Cited by 103
Lefaucheur, J. P., Lucas, B., Andraud, F., Hogrel, J. Y., Bellivier, F., Del Cul, A., Rousseva, A., Leboyer, M., & Paillère-Martinot, M. L. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.03.001 · Cited by 103
Neurochemistry of major depression: a study using magnetic resonance spectroscopy
Godlewska, B. R., Near, J., & Cowen, P. J. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3687-y · Cited by 97
Rosso, I. M., Weiner, M. R., Crowley, D. J., Silveri, M. M., Rauch, S. L., & Jensen, J. E. (2014) · Depression and Anxiety · doi:10.1002/da.22155 · Cited by 101
de Groote, L., & Linthorst, A. C. E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.06.030 · Cited by 100
Ghosal, S., Duman, C. H., Liu, R.-J., Wu, M., Terwilliger, R., Girgenti, M. J., Wohleb, E., Fogaca, M. V., Teichman, E. M., Hare, B., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104669 · Cited by 89
Klumpers, U. M. H., Veltman, D. J., Drent, M. L., Boellaard, R., Comans, E. F. I., Meynen, G., Lammertsma, A. A., & Hoogendijk, W. J. G. (2010) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-009-1292-9 · Cited by 95
Romeo, B., Choucha, W., Fossati, P., & Rotge, J.-Y. (2018) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160228 · Cited by 94
Li, X., & Wang, J. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00299-2 · Cited by 89
Changes in cerebrospinal fluid neurochemistry during pregnancy
Altemus, M., Fong, J., Yang, R., Damast, S., Luine, V., & Ferguson, D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.002 · Cited by 83
Pozzi, L., Dorocic, I. P., Wang, X., Carlén, M., & Meletis, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083879 · Cited by 74
Neurophysiological mechanisms of electroconvulsive therapy for depression
Kato, N. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.01.014 · Cited by 65
Kühn, S., Schubert, F., Mekle, R., Wenger, E., Ittermann, B., Lindenberger, U., & Gallinat, J. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1057-0 · Cited by 59
Direct Alteration of a Specific Inhibitory Circuit of the Hippocampus by Antidepressants
Méndez, P., Pazienti, A., Szabó, G., & Bacci, A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1720-12.2012 · Cited by 53
The dose makes the poison: From glutamate-mediated neurogenesis to neuronal atrophy and depression
Rubio-Casillas, A., & Fernández-Guasti, A. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0066 · Cited by 49
Sustained Molecular Pathology Across Episodes and Remission in Major Depressive Disorder
Scifo, E., Pabba, M., Kapadia, F., Ma, T., Lewis, D. A., Tseng, G. C., & Sibille, E. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.008 · Cited by 41
Cognitive behavioral therapy-related increases in cortical inhibition in problematic perfectionists
Radhu, N., Daskalakis, Z. J., Guglietti, C. L., Farzan, F., Barr, M. S., Arpin-Cribbie, C. A., Fitzgerald, P. B., & Ritvo, P. (2012) · Brain Stimulation · doi:10.1016/j.brs.2011.01.006 · Cited by 30
Bell, C. J. M., Mehta, M., Mirza, L., Young, A. H., & Beck, K. (2025) · Psychopharmacology · doi:10.1007/s00213-024-06735-1 · Cited by 28
Flores-Ramos, M., Alcauter, S., López-Titla, M., Bernal-Santamaría, N., Calva-Coraza, E., & Edden, R. A. E. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.08.033 · Cited by 21
Dai, F., Wengler, K., He, X., Wang, J., Yang, J., Parsey, R. V., & DeLorenzo, C. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03292-9 · Cited by 12
Benham, R. S., Hewage, N. B., Suckow, R. F., Engin, E., & Rudolph, U. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.063 · Cited by 11
Metadata
- Authors
- Sanacora, G., Mason, G. F., Rothman, D. L., & Krystal, J. H.
- Venue
- American Journal of Psychiatry
- Published
- 2002-04-01
- Volume
- 159
- Issue
- 4
- Pages
- 663-665
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2162933869
- Cited by
- 494
- References
- 1
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
