The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Relationship Between Duration of Untreated Psychosis and Outcome in First-Episode Schizophrenia: A Critical Review and Meta-Analysis
Abstract
OBJECTIVE: The duration of untreated psychosis may influence response to treatment, reflecting a potentially malleable progressive pathological process. The authors reviewed the literature on the association of duration of untreated psychosis with symptom severity at first treatment contact and with treatment outcomes and conducted a meta-analysis examining these relationships. METHOD: English-language articles on duration of untreated psychosis published in peer-reviewed journals through July 2004 were reviewed. Studies that quantitatively assessed the duration of untreated psychosis; identified study subjects who met the criteria for nonaffective psychotic disorders at or close to first treatment; employed cross-sectional analyses of duration of untreated psychosis and of baseline symptoms, neurocognition, brain morphology, or functional measures or prospectively analyzed symptom change, response, or relapse; assessed psychopathology with clinician-rated instruments; and reported subjects' diagnoses (a total of 43 publications from 28 sites) were included in the meta-analysis. RESULTS: Shorter duration of untreated psychosis was associated with greater response to antipsychotic treatment, as measured by severity of global psychopathology, positive symptoms, negative symptoms, and functional outcomes. At the time of treatment initiation, duration of initially untreated psychosis was associated with the severity of negative symptoms but not with the severity of positive symptoms, general psychopathology, or neurocognitive function. CONCLUSIONS: Duration of untreated psychosis may be a potentially modifiable prognostic factor. Understanding the mechanism by which duration of untreated psychosis influences prognosis may lead to better understanding of the pathophysiology of schizophrenia and to improved treatment strategies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378
The Global Assessment Scale: A Procedure for Measuring Overall Severity of Psychiatric Disturbance
Endicott, J. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770060086012 · Cited by 4,982
Natural Course of Schizophrenic Disorders: A 15-Year Followup of a Dutch Incidence Cohort
Wiersma, D., Nienhuis, F. J., Slooff, C. J., & Giel, R. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033315 · Cited by 649
Independent predictors of cognitive decline in healthy elderly persons
Marquis, S., Moore, M. M., Howieson, D. B., Sexton, G., Payami, H., Kaye, J. A., & Camicioli, R. (2002) · Archives of Neurology · doi:10.1001/archneur.59.4.601 · Cited by 344
Cited by
The Impact of Mental Illness Stigma on Seeking and Participating in Mental Health Care
Corrigan, P. W., Druss, B. G., & Perlick, D. A. (2014) · Psychological Science in the Public Interest · doi:10.1177/1529100614531398 · Cited by 1,642
Penttilä, M., Jääskeläinen, E., Hirvonen, N., Isohanni, M., & Miettunen, J. (2014) · British Journal of Psychiatry · doi:10.1192/bjp.bp.113.127753 · Cited by 716
Early intervention in psychosis: concepts, evidence and future directions
MCGORRY, P. D., KILLACKEY, E., & YUNG, A. (2008) · World Psychiatry · doi:10.1002/j.2051-5545.2008.tb00182.x · Cited by 581
Bird, V., Premkumar, P., Kendall, T., Whittington, C., Mitchell, J., & Kuipers, E. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.074526 · Cited by 468
Early-Onset Bipolar Disorder and Treatment Delay Are Risk Factors for Poor Outcome in Adulthood
Post, R. M., Leverich, G. S., Kupka, R. W., Keck, P. E., McElroy, S. L., Altshuler, L. L., Frye, M. A., Luckenbaugh, D. A., Rowe, M., Grunze, H., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04994yel · Cited by 360
Guidelines for the Pharmacotherapy of Schizophrenia in Adults
Remington, G., Addington, D., Honer, W., Ismail, Z., Raedler, T., & Teehan, M. (2017) · The Canadian Journal of Psychiatry · doi:10.1177/0706743717720448 · Cited by 332
Eack, S. M., Greenwald, D. P., Hogarty, S. S., Cooley, S. J., DiBarry, A. L., Montrose, D. M., & Keshavan, M. S. (2009) · Psychiatric Services · doi:10.1176/ps.2009.60.11.1468 · Cited by 289
Santesteban-Echarri, O., Paino, M., Rice, S., González-Blanch, C., McGorry, P., Gleeson, J., & Alvarez-Jimenez, M. (2017) · Clinical Psychology Review · doi:10.1016/j.cpr.2017.09.007 · Cited by 268
The acute efficacy of antipsychotics in schizophrenia: a review of recent meta-analyses
Haddad, P. M., & Correll, C. U. (2018) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125318781475 · Cited by 259
Clinical predictors of therapeutic response to antipsychotics in schizophrenia
Carbon, M., & Correll, C. U. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.4/mcarbon · Cited by 257
Howes, O. D., Whitehurst, T., Shatalina, E., Townsend, L., Onwordi, E. C., Mak, T. L. A., Arumuham, A., O’Brien, O., Lobo, M., Vano, L., et al. (2021) · World Psychiatry · doi:10.1002/wps.20822 · Cited by 243
Perkins, D. O., Jeffries, C. D., Addington, J., Bearden, C. E., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., Mathalon, D. H., McGlashan, T. H., Seidman, L. J., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu099 · Cited by 238
Self-citationBuilding the mental health workforce capacity needed to treat adults with serious mental illnesses
Olfson, M. (2016) · Health Affairs · doi:10.1377/hlthaff.2015.1619 · Cited by 170
Birnbaum, M. L., Ernala, S. K., Rizvi, A. F., De Choudhury, M., & Kane, J. M. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.7956 · Cited by 168
“Results from the Recovery After Initial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) trial [31] suggest that the median duration of untreated psychosis is 74 weeks [32] and support the established hypothesis that lengthy duration of untreated psychosis (DUP) leads to worse outcomes [31,33].”
BackgroundAdolescent Neurodevelopment and Vulnerability to Psychosis
Patel, P. K., Leathem, L. D., Currin, D. L., & Karlsgodt, K. H. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.06.028 · Cited by 152
Duration of untreated illness as a key to early intervention in schizophrenia: a review.
Murru, A., & Carpiniello, B. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2016.10.003 · Cited by 135
Oliver, D., Davies, C., Crossland, G., Lim, S., Gifford, G., McGuire, P., & Fusar-Poli, P. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx166 · Cited by 126
Early Cognitive Experience Prevents Adult Deficits in a Neurodevelopmental Schizophrenia Model
Lee, H., Dvorak, D., Kao, H.-Y., Duffy, Á. M., Scharfman, H. E., & Fenton, A. A. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.016 · Cited by 122
Dell’Osso, B., Glick, I. D., Baldwin, D. S., & Altamura, A. C. (2013) · Psychopathology · doi:10.1159/000338608 · Cited by 118
Transforming the Treatment of Schizophrenia in the United States: The RAISE Initiative
Dixon, L. B., Goldman, H. H., Srihari, V. H., & Kane, J. M. (2018) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050817-084934 · Cited by 112
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript 2005, Perkins et al. 2005).”
BackgroundThe prevention of schizophrenia
Yung, A. R., Killackey, E., Hetrick, S. E., Parker, A. G., Schultze-Lutter, F., Klosterkoetter, J., Purcell, R., & Mcgorry, P. D. (2007) · International Review of Psychiatry · doi:10.1080/09540260701797803 · Cited by 104
Anderson, K. K., Norman, R., MacDougall, A., Edwards, J., Palaniyappan, L., Lau, C., & Kurdyak, P. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17050480 · Cited by 103
Potkin, S., Bera, R., Zubek, D., & Lau, G. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-261 · Cited by 98
Treatment seeking and unmet need for care among persons reporting psychosis-like experiences
DeVylder, J. E., Oh, H. Y., Corcoran, C. M., & Lukens, E. P. (2014) · Psychiatric Services · doi:10.1176/appi.ps.201300254 · Cited by 82
Specificity of Incident Diagnostic Outcomes in Patients at Clinical High Risk for Psychosis
Webb, J. R., Addington, J., Perkins, D. O., Bearden, C. E., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., Heinssen, R. K., Seidman, L. J., Tarbox, S. I., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv091 · Cited by 77
Self-citationOutcomes for 236 patients from a 2‐year early intervention in psychosis service
Turner, M. A., Boden, J. M., Smith‐Hamel, C., & Mulder, R. T. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01386.x · Cited by 66
Mueser, K. T., DeTore, N. R., Kredlow, M. A., Bourgeois, M. L., Penn, D. L., & Hintz, K. (2020) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13102 · Cited by 54
Ussorio, D., Giusti, L., Wittekind, C. E., Bianchini, V., Malavolta, M., Pollice, R., Casacchia, M., & Roncone, R. (2016) · Psychology and Psychotherapy: Theory, Research and Practice · doi:10.1111/papt.12059 · Cited by 51
How do people experience early intervention services for psychosis? A meta-synthesis.
Hansen, H., Stige, S. H., Davidson, L., Moltu, C., & Veseth, M. (2018) · Qualitative Health Research · doi:10.1177/1049732317735080 · Cited by 49
Service Engagement in First Episode Psychosis: Clinical and Premorbid Correlates
MacBeth, A., Gumley, A., Schwannauer, M., & Fisher, R. (2013) · Journal of Nervous & Mental Disease · doi:10.1097/nmd.0b013e31828e0e19 · Cited by 43
Self-Stigma of Mental Illness in High School Youth
Hartman, L. I., Michel, N. M., Winter, A., Young, R. E., Flett, G. L., & Goldberg, J. O. (2013) · Canadian Journal of School Psychology · doi:10.1177/0829573512468846 · Cited by 45
Kurdyak, P., Gandhi, S., Holder, L., Rashid, M., Saunders, N., Chiu, M., Guttmann, A., & Vigod, S. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.5902 · Cited by 38
Time-to-treatment of mental disorders in a community sample of Dutch adolescents. A TRAILS study
Raven, D., Jörg, F., Visser, E., Oldehinkel, A. J., & Schoevers, R. A. (2017) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796016000226 · Cited by 36
Hui, C. L., Lau, W. W., Leung, C., Chang, W., Tang, J. Y., Wong, G. H., Chan, S. K., Lee, E. H., & Chen, E. Y. (2015) · Early Intervention in Psychiatry · doi:10.1111/eip.12094 · Cited by 36
Perceived and experienced stigma in first-episode psychosis: A 1-year follow-up study
Simonsen, C., Aminoff, S. R., Vaskinn, A., Barrett, E. A., Faerden, A., Ueland, T., Andreassen, O. A., Romm, K. L., & Melle, I. (2019) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2019.152134 · Cited by 28
Ramsay Wan, C., Broussard, B., Haggard, P., & Compton, M. T. (2014) · Psychiatric Services · doi:10.1176/appi.ps.201300206 · Cited by 24
Preventing discrimination based on psychiatric risk biomarkers
Brannan, C., Foulkes, A. L., & Lázaro‐Muñoz, G. (2019) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32629 · Cited by 22
Morton, N. K., & Zubek, D. (2013) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/02793695-20130215-01 · Cited by 16
O'Donoghue, B., Lyne, J., Kinsella, A., Turner, N., O'Callaghan, E., & Clarke, M. (2014) · Early Intervention in Psychiatry · doi:10.1111/eip.12063 · Cited by 16
Hamasaki, Y., Nakayama, T., Hikida, T., & Murai, T. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03049-w · Cited by 11
Tijdig herkennen en behandelen van borderlineproblematiek bij jongeren met MBT-early
Hutsebaut, J., Feenstra, D., Keur, E., Schäfer, B., & Bales, D. (2017) · Tijdschrift voor Psychotherapie · doi:10.1007/s12485-017-0216-6 · Cited by 5
Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study
Ferrari, A. J., Saha, S., McGrath, J. J., Norman, R., Baxter, A. J., Vos, T., & Whiteford, H. A. (2012) · Population Health Metrics · doi:10.1186/1478-7954-10-16 · Cited by 1
Metadata
- Authors
- Perkins, D. O., Gu, H., Boteva, K., & Lieberman, J. A.
- Venue
- American Journal of Psychiatry
- Published
- 2005-10-01
- Volume
- 162
- Issue
- 10
- Pages
- 1785-1804
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2116594433
- Cited by
- 1,346
- References
- 4
- FWCI
- 28.23
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
