The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
DHEA and DHEA‐S: A Review
Abstract
Dehydroepiandrosterone (DHEA) and its sulfated metabolite DHEA‐S are endogenous hormones secreted by the adrenal cortex in response to adrenocorticotrophin (ACTH). Much has been published regarding potential effects on various systems. Despite the identification of DHEA and DHEA‐S more than 50 years ago, there is still considerable controversy as to their biological significance. This article reviews the metabolism and physiology of DHEA and DHEA‐S, the influence of age and gender on concentrations, and changes in endogenous concentrations associated with disease states and other factors, including diet and exercise. This article is unique in that it also summarizes the influence of drugs on DHEA and DHEA‐S concentrations, as well as concentrations of DHEA and DHEA‐S observed after the administration of DHEA by various routes. Sections of the article specifically address DHEA and DHEA‐S concentrations as they relate to stress, central nervous system function and psychiatric disorders, insulin sensitivity, immunological function, and cardiovascular disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Labrie, F., Bélanger, A., Cusan, L., Gomez, J.-L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4160 · Cited by 713
Enzymology of human cytosolic sulfotransferases
Falany, C. N. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.4.9068609 · Cited by 604
Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle
ABRAHAM, G. E. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-2-340 · Cited by 436
Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it
Flood, J. F., Morley, J. E., & Roberts, E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1567 · Cited by 436
Field, A. E., Colditz, G. A., Willett, W. C., Longcope, C., & McKinlay, J. B. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.5.7962322 · Cited by 421
Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men
Orentreich, N., Brind, J. L., Vogelman, J. H., Andres, R., & Baldwin, H. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400863 · Cited by 417
NESTLER, J. E., BARLASCINI, C. O., CLORE, J. N., & BLACKARD, W. G. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-1-57 · Cited by 414
Labrie, F., Bélanger, A., Cusan, L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4161 · Cited by 350
The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women
MORTOLA, J. F., & YEN, S. S. C. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-3-696 · Cited by 311
Dehydroepiandrosterone and its sulfate enhance memory retention in mice.
Flood, J. F., Smith, G. E., & Roberts, E. (1988) · Brain Research · doi:10.1016/0006-8993(88)91129-8 · Cited by 227
Cited by
Feldman, H. A., Longcope, C., Derby, C. A., Johannes, C. B., Araujo, A. B., Coviello, A. D., Bremner, W. J., & McKinlay, J. B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8201 · Cited by 1,861
The stress system in the human brain in depression and neurodegeneration
Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984
Maninger, N., Wolkowitz, O. M., Reus, V. I., Epel, E. S., & Mellon, S. H. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.11.002 · Cited by 769
Steroid sulfatase: molecular biology, regulation, and inhibition
Reed, M. J., Purohit, A., Woo, L. W. L., Newman, S. P., & Potter, B. V. L. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0003 · Cited by 524
Goodyer, I. M., Herbert, J., Tamplin, A., & Altham, P. M. E. (2000) · British Journal of Psychiatry · doi:10.1192/bjp.177.6.499 · Cited by 436
The Regulation of Steroid Action by Sulfation and Desulfation
Mueller, J. W., Gilligan, L. C., Idkowiak, J., Arlt, W., & Foster, P. A. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1036 · Cited by 419
ZELCER, N., REID, G., WIELINGA, P., KUIL, A., van der HEIJDEN, I., SCHUETZ, J. D., & BORST, P. (2003) · Biochemical Journal · doi:10.1042/bj20021886 · Cited by 281
Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome
Papadopoulos, A. S., & Cleare, A. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.153 · Cited by 280
Low cortisol, high DHEA, and high levels of stimulated TNF‐α, and IL‐6 in women with PTSD
Gill, J., Vythilingam, M., & Page, G. G. (2008) · Journal of Traumatic Stress · doi:10.1002/jts.20372 · Cited by 240
11-Oxygenated androgens in health and disease
Turcu, A. F., Rege, J., Auchus, R. J., & Rainey, W. E. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0336-x · Cited by 217
Dehydroepiandrosterone (DHEA): Hypes and Hopes
Rutkowski, K., Sowa, P., Rutkowska-Talipska, J., Kuryliszyn-Moskal, A., & Rutkowski, R. (2014) · Drugs · doi:10.1007/s40265-014-0259-8 · Cited by 216
Barad, D., Brill, H., & Gleicher, N. (2007) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-007-9178-x · Cited by 207
Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications
Pataky, M. W., Young, W. F., & Nair, K. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.07.033 · Cited by 207
DHEA and DHEA-S response to acute psychosocial stress in healthy men and women
Lennartsson, A.-K., Kushnir, M. M., Bergquist, J., & Jonsdottir, I. H. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.03.003 · Cited by 173
HPA- and HPT-axis alterations in chronic posttraumatic stress disorder
Olff, M., Güzelcan, Y., de Vries, G.-J., Assies, J., & Gersons, B. P. R. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.09.003 · Cited by 153
Adrenarche and the evolution of human life history
Campbell, B. (2006) · American Journal of Human Biology · doi:10.1002/ajhb.20528 · Cited by 150
Feldman, H. A., Johannes, C. B., Araujo, A. B., Mohr, B. A., Longcope, C., & McKinlay, J. B. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.1.79 · Cited by 141
Bosdou, J. K., Venetis, C. A., Kolibianakis, E. M., Toulis, K. A., Goulis, D. G., Zepiridis, L., & Tarlatzis, B. C. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr051 · Cited by 141
Ukkola, O., Gagnon, J., Rankinen, T., Thompson, P., Hong, Y., Leon, A., Rao, D., Skinner, J., Wilmore, J., & Bouchard, C. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1450001 · Cited by 138
Psychosocial and endocrine features of chronic first-episode major depression in 8–16 year olds
Goodyer, I. M., Park, R. J., & Herbert, J. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01120-9 · Cited by 130
Serum Androgen Levels in Elite Female Athletes
Bermon, S., Garnier, P. Y., Hirschberg, A. L., Robinson, N., Giraud, S., Nicoli, R., Baume, N., Saugy, M., Fénichel, P., Bruce, S. J., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1391 · Cited by 125
Steroid sulfatase inhibitors for estrogen- and androgen-dependent cancers
Purohit, A., & Foster, P. A. (2012) · Journal of Endocrinology · doi:10.1530/joe-11-0266 · Cited by 126
11-oxygenated C19 steroids Do not decline with age in women
Nanba, A. T., Rege, J., Ren, J., Auchus, R. J., Rainey, W. E., & Turcu, A. F. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02527 · Cited by 113
Hasson, D., Anderberg, U. M., Theorell, T., & Arnetz, B. B. (2005) · BMC Public Health · doi:10.1186/1471-2458-5-78 · Cited by 98
Strous, R. D., Maayan, R., Lapidus, R., Goredetsky, L., Zeldich, E., Kotler, M., & Weizman, A. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.03.005 · Cited by 92
Endogenous concentrations of DHEA and DHEA-S Decrease with remission of depression in older adults
Fabian, T. J., Dew, M. A., Pollock, B. G., Reynolds, C. F., Mulsant, B. H., Butters, M. A., Zmuda, M. D., Linares, A. M., Trottini, M., & Kroboth, P. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01198-2 · Cited by 87
Self-citationPerceived stress and physiological dysregulation in older adults
Goldman, N., Glei, D. A., Seplaki, C., Liu, I.-W., & Weinstein, M. (2005) · Stress · doi:10.1080/10253890500141905 · Cited by 80
Sex differences in 11-oxygenated androgen patterns across adulthood
Davio, A., Woolcock, H., Nanba, A. T., Rege, J., O’Day, P., Ren, J., Zhao, L., Ebina, H., Auchus, R., Rainey, W. E., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa343 · Cited by 76
Miller, K. K. M., Cai, J., Ripp, S. L., Pierce, W. M., Rushmore, T. H., & Prough, R. A. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.32.3.305 · Cited by 73
Predictors of lapse in first week of smoking abstinence in PTSD and non-PTSD smokers
Beckham, J. C., Calhoun, P. S., Dennis, M. F., Wilson, S. M., & Dedert, E. A. (2013) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts252 · Cited by 61
Lowered DHEA-S plasma levels in adult individuals with autistic disorder
Strous, R. D., Golubchik, P., Maayan, R., Mozes, T., Tuati-Werner, D., Weizman, A., & Spivak, B. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.12.004 · Cited by 59
Charoensri, S., Chailurkit, L., Muntham, D., & Bunnag, P. (2017) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2017.01.001 · Cited by 37
Khan, R. S., Dine, K., Luna, E., Ahlem, C., & Shindler, K. S. (2014) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.14-14672 · Cited by 33
Järvelä-Reijonen, E., Puttonen, S., Karhunen, L., Sairanen, E., Laitinen, J., Kolehmainen, M., Pihlajamäki, J., Kujala, U. M., Korpela, R., Ermes, M., et al. (2020) · International Journal of Behavioral Medicine · doi:10.1007/s12529-020-09891-8 · Cited by 27
DHEA in prenatal and postnatal life: implications for brain and behavior
Quinn, T., Greaves, R., Badoer, E., & Walker, D. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.03.001 · Cited by 28
Laureti, S., Falorni, A., & Santeusanio, F. (2003) · Journal of Endocrinological Investigation · doi:10.1007/bf03345252 · Cited by 27
Dehydroepiandrosterone and cardiovascular disease
Mannella, P., Simoncini, T., Caretto, M., & Genazzani, A. R. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.05.001 · Cited by 24
Edo, N., Morita, K., Ishiwata, C., Nakajima, R., Sayama, Y., Suzuki, T., Sakamoto, M., Okamoto, K., Uchino, T., Ozawa, Y., et al. (2021) · Endocrine Journal · doi:10.1507/endocrj.ej21-0140 · Cited by 5
Metadata
- Authors
- Kroboth, P. D., Salek, F. S., Pittenger, A. L., Fabian, T. J., & Frye, R. F.
- Venue
- The Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1999-04
- Volume
- 39
- Issue
- 4
- Pages
- 327-348
- ISSN
- 0021-9754 (ISSN-L)
- 0091-2700
- 1552-4604
- OpenAlex
- W2121084290
- Cited by
- 518
- References
- 17
- FWCI
- 11.91
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
