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Anxiolytic-like effect of oxytocin in the simulated public speaking test
Abstract
Oxytocin (OT) is known to be involved in anxiety, as well as cardiovascular and hormonal regulation. The objective of this study was to assess the acute effect of intranasally administered OT on subjective states, as well as cardiovascular and endocrine parameters, in healthy volunteers ( n = 14) performing a simulated public speaking test. OT or placebo was administered intranasally 50 min before the test. Assessments were made across time during the experimental session: (1) baseline (−30 min); (2) pre-test (−15 min); (3) anticipation of the speech (50 min); (4) during the speech (1:03 h), post-test time 1 (1:26 h), and post-test time 2 (1:46 h). Subjective states were evaluated by self-assessment scales. Cortisol serum and plasma adrenocorticotropic hormone (ACTH) were measured. Additionally, heart rate, blood pressure, skin conductance, and the number of spontaneous fluctuations in skin conductance were measured. Compared with placebo, OT reduced the Visual Analogue Mood Scale (VAMS) anxiety index during the pre-test phase only, while increasing sedation at the pre-test, anticipation, and speech phases. OT also lowered the skin conductance level at the pre-test, anticipation, speech, and post-test 2 phases. Other parameters evaluated were not significantly affected by OT. The present results show that OT reduces anticipatory anxiety, but does not affect public speaking fear, suggesting that this hormone has anxiolytic properties.
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“a review of human studies examining the effect of oxytocin on cortisol suggests that oxytocin may exert both anxiogenic and anxiolytic effects, depending on a variety of individual and context variables 77, 78, which are not always reflected in changes in cortisol levels 79, 80.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [80]
In the citing paper
“Behaviorally, OT administration resulted in decreased subjective anxiety during a public speaking stressor in healthy individuals (de Oliveira et al, 2012) and increased (recall of) extinction learning in both rodents (Zoicas et al, 2014) and healthy males (Acheson et al, 2013).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as de Oliveira et al, 2012
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“Another potential mechanismmight be OXT-induced dampening of stress-induced activation of the HPA axis (de Oliveira et al., 2012; Heinrichs et al., 2003; Quirin et al., 2011; Windle et al., 1997).”
Background
Metadata
- Authors
- de Oliveira, D. C., Zuardi, A. W., Graeff, F. G., Queiroz, R. H., & Crippa, J. A.
- Affiliations
- Department of Neurosciences and Behavior, Division of Psychiatry, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
- Universidade de São Paulo (BR)
- National Science and Technology Institute (INCT) for Translational Medicine, CNPq, Ribeirão Preto, São Paulo, Brazil
- ORCID
- Graeff, Frederico G
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2011-05-09
- Volume
- 26
- Issue
- 4
- Pages
- 497-504
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W2023279242
- Cited by
- 154
- References
- 66
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 3 · 2023: 9 · 2022: 5 · 2021: 6 · 2020: 14 · 2019: 8 · 2018: 15 · 2017: 12 · 2016: 17 · 2015: 10 · 2014: 17 · 2013: 12 · 2012: 7
- FWCI
- 16.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, anxiolytic effects, anticipatory anxiety, public speaking anxiety, speech performance, intranasal administration, cortisol, ACTH, heart rate, blood pressure, skin conductance, sedation
- MeSH terms
- Administration, Intranasal, Adrenocorticotropic Hormone, Adult, Fear, Humans, Hydrocortisone, Oxytocin, Speech, Anti-Anxiety Agents
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