Cited by 154Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

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Anxiolytic-like effect of oxytocin in the simulated public speaking test

de Oliveira, Danielle CG, Zuardi, Antonio W, Graeff, Frederico G, Queiroz, Regina HC, Crippa, José AS·2012·Journal of Psychopharmacology

DOI 10.1177/0269881111400642

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Abstract

Oxytocin (OT) is known to be involved in anxiety, as well as cardiovascular and hormonal regulation. The objective of this study was to assess the acute effect of intranasally administered OT on subjective states, as well as cardiovascular and endocrine parameters, in healthy volunteers ( n = 14) performing a simulated public speaking test. OT or placebo was administered intranasally 50 min before the test. Assessments were made across time during the experimental session: (1) baseline (−30 min); (2) pre-test (−15 min); (3) anticipation of the speech (50 min); (4) during the speech (1:03 h), post-test time 1 (1:26 h), and post-test time 2 (1:46 h). Subjective states were evaluated by self-assessment scales. Cortisol serum and plasma adrenocorticotropic hormone (ACTH) were measured. Additionally, heart rate, blood pressure, skin conductance, and the number of spontaneous fluctuations in skin conductance were measured. Compared with placebo, OT reduced the Visual Analogue Mood Scale (VAMS) anxiety index during the pre-test phase only, while increasing sedation at the pre-test, anticipation, and speech phases. OT also lowered the skin conductance level at the pre-test, anticipation, speech, and post-test 2 phases. Other parameters evaluated were not significantly affected by OT. The present results show that OT reduces anticipatory anxiety, but does not affect public speaking fear, suggesting that this hormone has anxiolytic properties.

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Authors: de Oliveira, D. C., Zuardi, A. W., Graeff, F. G., Queiroz, R. H., & Crippa, J. A.
Affiliations: Department of Neurosciences and Behavior, Division of Psychiatry, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Universidade de São Paulo (BR)
National Science and Technology Institute (INCT) for Translational Medicine, CNPq, Ribeirão Preto, São Paulo, Brazil
ORCID: Graeff, Frederico G
Venue: Journal of Psychopharmacology
Publisher: SAGE Publications
Published: 2011-05-09
Volume: 26
Issue: 4
Pages: 497-504
ISSN: 0269-8811 (ISSN-L)
1461-7285
DOI: 10.1177/0269881111400642
OpenAlex: W2023279242
Cited by: 154
References: 66
Citations by year: 2026: 5 · 2025: 11 · 2024: 3 · 2023: 9 · 2022: 5 · 2021: 6 · 2020: 14 · 2019: 8 · 2018: 15 · 2017: 12 · 2016: 17 · 2015: 10 · 2014: 17 · 2013: 12 · 2012: 7
FWCI: 16.93
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (publishedVersion)
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, anxiolytic effects, anticipatory anxiety, public speaking anxiety, speech performance, intranasal administration, cortisol, ACTH, heart rate, blood pressure, skin conductance, sedation
MeSH terms: Administration, Intranasal, Adrenocorticotropic Hormone, Adult, Fear, Humans, Hydrocortisone, Oxytocin, Speech, Anti-Anxiety Agents

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Anxiolytic-like effect of oxytocin in the simulated public speaking test

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