Tryptophan Metabolites Along the Microbiota-Gut-Brain Axis: An Interkingdom Communication System Influencing the Gut in Health and Disease

Alterations of gut microbiota in patients with irritable bowel syndrome: A systematic review and meta‐analysis

Zhuang, X., Xiong, L., Li, L., Li, M., & Chen, M. (2016) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13471 · Cited by 191

AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice

Goettel, J. A., Gandhi, R., Kenison, J. E., Yeste, A., Murugaiyan, G., Sambanthamoorthy, S., Griffith, A. E., Patel, B., Shouval, D. S., Weiner, H. L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.082 · Cited by 191

L-Tryptophan: Biochemical, nutritional and pharmacological aspects

Sainio, E., Pulkki, K. J., & Young, S. N. (1996) · Amino Acids · doi:10.1007/bf00806091 · Cited by 190

Serotonin and GI Disorders: An Update on Clinical and Experimental Studies

Manocha, M. M., & Khan, W. I. (2012) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2012.8 · Cited by 185

Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells

Habib, A. M., Richards, P., Rogers, G. J., Reimann, F. M., & Gribble, F. M. (2013) · Diabetologia · doi:10.1007/s00125-013-2887-z · Cited by 184

Interferon-γ–triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells

Jürgens, B., Hainz, U., Fuchs, D., Felzmann, T., & Heitger, A. (2009) · Blood · doi:10.1182/blood-2008-12-195073 · Cited by 176

Serotonin in the gastrointestinal tract

Camilleri, M. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32831e9c8e · Cited by 175

Pharmacological interventions targeting anhedonia in patients with major depressive disorder: A systematic review

Cao, B., Zhu, J., Zuckerman, H., Rosenblat, J. D., Brietzke, E., Pan, Z., Subramanieapillai, M., Park, C., Lee, Y., & McIntyre, R. S. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.01.002 · Cited by 175

Amine neuromediators, their precursors, and oxidation products in the culture of Escherichia coli k-12

Shishov, V. A., Kirovskaya, T. A., Kudrin, V. S., & Oleskin, A. V. (2009) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683809050068 · Cited by 174

Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells

Martin‐Gallausiaux, C., Larraufie, P., Jarry, A., Béguet-Crespel, F., Marinelli, L., Ledue, F., Reimann, F. M., Blottière, H. M., & Lapaque, N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02838 · Cited by 174

Microbiota‐derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo

Jennis, M., Cavanaugh, C., Leo, G. C., Mabus, J. R., Lenhard, J. M., & Hornby, P. J. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13178 · Cited by 173

Honor Thy Gut Symbionts Redux

Gordon, J. I. (2012) · Science · doi:10.1126/science.1224686 · Cited by 172

Role of microbiota and tryptophan metabolites in the remote effect of intestinal inflammation on brain and depression

Waclawiková, B., & El Aidy, S. (2018) · Pharmaceuticals · doi:10.3390/ph11030063 · Cited by 172

Physiological studies of tryptophan transport and tryptophanase operon induction in Escherichia coli

Yanofsky, C., Horn, V., & Gollnick, P. D. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.19.6009-6017.1991 · Cited by 170

Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders

O’Farrell, K., & Harkin, A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.12.004 · Cited by 170

The human intestinal microbiome at extreme ages of life. Dietary intervention as a way to counteract alterations

Salazar, N., Arboleya, S., Valdés, L., Stanton, C., Ross, P., Ruiz, L., Gueimonde, M., & de los Reyes-Gavilán, C. G. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00406 · Cited by 166

Dietary and pharmacological treatment of abdominal pain in IBS

Camilleri, M., & Boeckxstaens, G. E. (2017) · Gut · doi:10.1136/gutjnl-2016-313425 · Cited by 165

Enteroendocrine Cells: Sensing Gut Microbiota and Regulating Inflammatory Bowel Diseases

Yu, Y., Yang, W., Li, Y., & Cong, Y. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz217 · Cited by 165

Conversion of L ‐tryptophan to serotonin and melatonin in human melanoma cells

Slominski, A. T., Semak, I. V., Pisarchik, A. V., Sweatman, T. W., Szczesniewski, A., & Wortsman, J. (2002) · FEBS Letters · doi:10.1016/s0014-5793(01)03319-1 · Cited by 164

Antibiotic-induced dysbiosis alters host-bacterial interactions and leads to colonic sensory and motor changes in mice

Aguilera, M., Cerdà-Cuéllar, M., & Martínez, V (2015) · Gut Microbes · doi:10.4161/19490976.2014.990790 · Cited by 162

Irritable bowel syndrome: a model of the brain-gut interactions.

Mulak, A., & Bonaz, B. L. (2004) · PubMed · Cited by 161

Lactobacillus johnsonii inhibits indoleamine 2,3‐dioxygenase and alters tryptophan metabolite levels in BioBreeding rats

Valladares, R. B., Bojilova, L., Potts, A. H., Cameron, E., Gardner, C. L., Lorca, G. L., & González, C. F. (2013) · The FASEB Journal · doi:10.1096/fj.12-223339 · Cited by 160

Serum Analysis of Tryptophan Catabolism Pathway: Correlation With Crohnʼs Disease Activity

Gupta, N., Thaker, A. I., Kanuri, N. D., Riehl, T. E., Rowley, C. W., Stenson, W. F., & Ciorba, M. A. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21849 · Cited by 159

Characterization of an Indoleamine 2,3-Dioxygenase Induced by Gamma-Interferon in Cultured Human Fibroblasts

Pfefferkorn, E., Rebhun, S., & Eckel, M. E. (1986) · Journal of Interferon Research · doi:10.1089/jir.1986.6.267 · Cited by 157

A Rapid and Specific Method for the Detection of Indole in Complex Biological Samples

Darkoh, C., Chappell, C., Gonzales, C., & Okhuysen, P. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.02787-15 · Cited by 156

Modulation of the microbiota-gut-brain axis by probiotics in a murine model of inflammatory bowel disease

Emge, J. R., Huynh, K., Miller, E. N., Kaur, M., Reardon, C., Barrett, K. E., & Gareau, M. G. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00086.2016 · Cited by 152

Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease

Jones, S. P., Franco, N. F., Varney, B., Sundaram, G., Brown, D. A., de Bie, J., Lim, C. K., Guillemin, G. J., & Brew, B. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131389 · Cited by 151

Serotonin and the regulation of mammalian energy balance

Donovan, M. H., & Tecott, L. H. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00036 · Cited by 150

Production of biogenic amines by Morganella morganii, Klebsíella pneumoniae and Hafnia alvei using a rapid HPLC method

Özoğul, F. (2004) · European Food Research and Technology · doi:10.1007/s00217-004-0988-0 · Cited by 149

The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases

Jager, P. L. D., Franchimont, D. P., Waliszewska, A., Bitton, A., Cohen, A., Langelier, D., Bélaïche, J., Vermeire, S., Farwell, L. M., Goris, A., et al. (2007) · Genes and Immunity · doi:10.1038/sj.gene.6364398 · Cited by 148

The microbiota-derived metabolite indole decreases mucosal inflammation and injury in a murine model of NSAID enteropathy

Whitfield-Cargile, C., Cohen, N. D., Chapkin, R. S., Weeks, B. R., Davidson, L. A., Goldsby, J. S., Hunt, C. L., Steinmeyer, S. H., Menon, R., Suchodolski, J. S., et al. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1156827 · Cited by 148

A Gut Feeling for Obesity: 7TM Sensors on Enteroendocrine Cells

Engelstoft, M. S., Egerod, K. L., Holst, B., & Schwartz, T. W. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.11.004 · Cited by 147

Overview of Glutamatergic Dysregulation in Central Pathologies

Miladinovic, T., Nashed, M. G., & Singh, G. (2015) · Biomolecules · doi:10.3390/biom5043112 · Cited by 145

Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis

Sofia, M. A., Ciorba, M. A., Meckel, K. R., Lim, C. K., Guillemin, G. J., Weber, C. R., Bissonnette, M., & Pekow, J. R. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy103 · Cited by 145

The role of serotonin in intestinal luminal sensing and secretion

Hansen, M. B., & Witte, A. ‐. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01870.x · Cited by 144

Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice

Smith, C. J., Emge, J. R., Berzins, K., Lung, L., Khamishon, R., Shah, P., Rodrigues, D. M., Sousa, A. J., Reardon, C., Sherman, P. M., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00238.2014 · Cited by 143

Impaired Uptake of Serotonin by Platelets From Patients With Irritable Bowel Syndrome Correlates With Duodenal Immune Activation

Foley, S., Garsed, K. C., Singh, G., Duroudier, N. P., Swan, C., Hall, I. P., Zaitoun, A. M., Bennett, A. J., Marsden, C. A., Holmes, G. K. T., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.052 · Cited by 140

Role of central vagal 5-HT3 receptors in gastrointestinal physiology and pathophysiology

Browning, K. N. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00413 · Cited by 138

MORPHOLOGICAL AND PHYSIOLOGICAL CHARACTERIZATION OF GERMFREE LIFE*

Gordon, H. A. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb53104.x · Cited by 135

The role of NMDA receptors in the pathophysiology and treatment of mood disorders

Ghasemi, M., Phillips, C., Trillo, L., Miguel, Z. D., Das, D., & Salehi, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.017 · Cited by 132

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

Hoshi, N., Schenten, D., Nish, S. A., Walther, Z., Gagliani, N., Flavell, R. A., Reizis, B., Shen, Z., Fox, J. G., Iwasaki, A., et al. (2012) · Nature Communications · doi:10.1038/ncomms2113 · Cited by 131

Catabolic Pathway for the Production of Skatole and Indoleacetic Acid by the Acetogen Clostridium drakei , Clostridium scatologenes , and Swine Manure

Whitehead, T. R., Price, N. P. J., Drake, H. L., & Cotta, M. A. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02458-07 · Cited by 131

Bacterial Toxins and the Nervous System: Neurotoxins and Multipotential Toxins Interacting with Neuronal Cells

Popoff, M. R., & Poulain, B. (2010) · Toxins · doi:10.3390/toxins2040683 · Cited by 130

IL1β‐ and LPS‐induced serotonin secretion is increased in EC cells derived from Crohn’s disease

Kidd, M., Gustafsson, B. I., Drozdov, I., & Modlin, I. M. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01210.x · Cited by 130

Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort

Clarke, G. A., Fitzgerald, P., Cryan, J. F., Cassidy, E., Quigley, E. M. M., & Dinan, T. G. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-6 · Cited by 130

Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis

Takamura, T., Harama, D., Fukumoto, S., Nakamura, Y., Shimokawa, N., Ishimaru, K., Ikegami, S., Makino, S., Kitamura, M., & Nakao, A. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2010.165 · Cited by 127

Psychological Stress-Induced, IDO1-Dependent Tryptophan Catabolism: Implications on Immunosuppression in Mice and Humans

Kiank, C., Zeden, J.-P., Drude, S., Domańska, G., Fusch, G., Otten, W., & Schuett, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011825 · Cited by 127

Role of toll like receptors in irritable bowel syndrome: differential mucosal immune activation according to the disease subtype

Belmonte, L., Beutheu Youmba, S., Bertiaux-Vandaële, N., Antonietti, M., Lecleire, S., Zalar, A., Gourcerol, G., Leroi, A.-M., Déchelotte, P., Coëffier, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042777 · Cited by 126

Role of glutamatergic neurotransmission in the enteric nervous system and brain-gut axis in health and disease

Filpa, V., Moro, E., Protasoni, M., Crema, F., Frigo, G., & Giaroni, C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.08.024 · Cited by 124

Antibiotic-induced dysbiosis of the microbiota impairs gut neuromuscular function in juvenile mice

Caputi, V., Marsilio, I., Filpa, V., Cerantola, S., Orso, G., Bistoletti, M., Paccagnella, N., De Martin, S., Montopoli, M., Dall'Acqua, S., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13965 · Cited by 124

A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome

Clarke, G. A., McKernan, D. P., Gaszner, G., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00090 · Cited by 123

The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic Lactobacillus reuteri DSM 17938

Perez‐Burgos, A., Wang, L., McVey Neufeld, K., Mao, Y., Ahmadzai, M., Janssen, L. J., Stanisz, A. M., Bienenstock, J., & Kunze, W. A. (2015) · The Journal of Physiology · doi:10.1113/jp270229 · Cited by 123

Regulation of nitric-oxide synthase mRNA expression by interferon-gamma and picolinic acid.

Melillo, G., Cox, G. W., Biragyn, A., Sheffler, L. A., & Varesio, L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37169-7 · Cited by 122

Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon‐gamma, severity of symptoms and psychiatric co‐morbidity

Fitzgerald, P., Eugene, M. C., Clarke, G. A., Scully, P., Barry, S., Eamonn, M. M. Q., Shanahan, F., Cryan, J. F., & Dinan, T. G. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01195.x · Cited by 122

The Tryptophan Catabolite Picolinic Acid Selectively Induces the Chemokines Macrophage Inflammatory Protein-1α and -1β in Macrophages

Bosco, M. C., Rapisarda, A., Massazza, S., Melillo, G., Young, H. A., & Varesio, L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.3283 · Cited by 121

Quinolinic acid inhibits glutamate uptake into synaptic vesicles from rat brain

Tavares, R. G., Tasca, C. I., dos Santos, C. E. S., Wajner, M., Souza, D. O., & Dutra‐Filho, C. S. (2000) · Neuroreport · doi:10.1097/00001756-200002070-00005 · Cited by 117

Infant Early Gut Colonization by Lachnospiraceae: High Frequency of Ruminococcus gnavus

Sagheddu, V., Patrone, V., Miragoli, F., Puglisi, E., & Morelli, L. (2016) · Frontiers in Pediatrics · doi:10.3389/fped.2016.00057 · Cited by 116

Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria.

Maes, M. H. J., & Leunis, J. (2008) · PubMed · Cited by 115

Physiological responses of guinea-pig myenteric neurons secondary to the release of endogenous serotonin by tryptamine

Takaki, M., Mawe, G. M., Barasch, J. M., Gershon, M. D., & Gershon, M. D. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90059-4 · Cited by 114

The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition

Zanos, P., Piantadosi, S. C., Wu, H., Pribut, H. J., Dell, M. J., Can, A., Snodgrass, H. R., Zarate, C. A., Schwarcz, R. M., & Gould, T. D. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.225664 · Cited by 114

Serotonin and colonic motility

Kendig, D. M., & Grider, J. R. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12617 · Cited by 113

Diverse effects of gut-derived serotonin in intestinal inflammation

Shajib, M. S., Baranov, A., & Khan, W. I. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00414 · Cited by 109

Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice

Bistoletti, M., Caputi, V., Baranzini, N., Marchesi, N., Filpa, V., Marsilio, I., Cerantola, S., Terova, G., Baj, A., Grimaldi, A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212856 · Cited by 109

Migration and turnover of entero‐endocrine and caveolated cells in the epithelium of the descending colon, as shown by radioautography after continuous infusion of 3 H‐thymidine into mice

Tsubouchi, S., & Leblond, C. P. (1979) · American Journal of Anatomy · doi:10.1002/aja.1001560403 · Cited by 107

Neuroanatomy of lower gastrointestinal pain disorders.

Vermeulen, W., Man, J. G. D., Pelckmans, P., & de Winter, B. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i4.1005 · Cited by 105

Changes in number of serotonin-containing cells and serotonin levels in the intestinal mucosa of rats with colitis induced by dextran sodium sulfate

Oshima, S., Fujimura, M., & Fukimiya, M. (1999) · Histochemistry and Cell Biology · doi:10.1007/s004180050445 · Cited by 103

Learning deficits induced by chronic intraventricular infusion of quinolinic acid — protection by MK-801 and memantine

Misztal, M., Frankiewicz, T., Parsons, C. G., & Danysz, W. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00682-6 · Cited by 103

Visceral pain: gut microbiota, a new hope?

Pusceddu, M. M., & Gareau, M. G. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0476-7 · Cited by 102

The Function of Lactic Acid Bacteria on Biogenic Amines Production by Food-Borne Pathogens in Arginine Decarboxylase Broth

Özoğul, F., Küley, E., Özoğul, Y., & Özoğul, İ. (2012) · Food Science and Technology Research · doi:10.3136/fstr.18.795 · Cited by 100

The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease

Zinger, A., Barcia, C., Herrero, M. T., & Guillemin, G. J. (2011) · Parkinson s Disease · doi:10.4061/2011/716859 · Cited by 99

Mucosal Immunity and Gastrointestinal Antigen Processing

Mayer, L. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001001-00002 · Cited by 99

SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine

Kerckhoffs, A. P. M., Linde, J. J. M. T., Akkermans, L. M. A., & Samsom, M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00153.2011 · Cited by 98

Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder

Savitz, J. B., Dantzer, R., Meier, T. B., Wurfel, B. E., Victor, T. A., McIntosh, S. A., Ford, B. N., Morris, H. M., Bodurka, J., Teague, T. K., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.07.609 · Cited by 97

Kynurenine pathway metabolism and immune activation: Peripheral measurements in psychiatric and co-morbid conditions

Strasser, B., Becker, K., Fuchs, D., & Gostner, J. M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.030 · Cited by 97

The actions of interferon and antiinflammatory agents on induction of indoleamine 2,3-dioxygenase in human peripheral blood monocytes

Ozaki, Y., EDELSTEIN, M. P., & Duch, D. S. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)91431-8 · Cited by 96

Tumor Necrosis Factor-alpha and Lipopolysaccharide Enhance Interferon-Induced Antichlamydial Indoleamine Dioxygenase Activity Independently

Currier, A. R., Ziegler, M., Riley, M., Babcock, T., Telbis, V. P., & Carlin, J. (2000) · Journal of Interferon and Cytokine Research · doi:10.1089/107999000312306 · Cited by 92

Efficacy and safety of 5-hydroxytryptamine 3 receptor antagonists in irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials

Zheng, Y., Yu, T., Tang, Y., Xiong, W., Shen, X., Jiang, L., & Lin, L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172846 · Cited by 92

Diversity of enteroendocrine cells investigated at cellular and subcellular levels: the need for a new classification scheme

Fothergill, L. J., & Furness, J. B. (2018) · Histochemistry and Cell Biology · doi:10.1007/s00418-018-1746-x · Cited by 91

Different inhibitory effects of kynurenic acid and a novel kynurenic acid analogue on tumour necrosis factor-α (TNF-α) production by mononuclear cells, HMGB1 production by monocytes and HNP1-3 secretion by neutrophils

Tiszlavicz, Z., Németh, B., Fülöp, F., Vécsei, L., Tápai, K., Ocsovszky, I., & Mándi, Y. (2011) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-011-0605-2 · Cited by 89

Social isolation‐induced increase in NMDA receptors in the hippocampus exacerbates emotional dysregulation in mice

Chang, C., Hsiao, Y., Chen, Y., Yu, Y., & Gean, P. (2014) · Hippocampus · doi:10.1002/hipo.22384 · Cited by 87

Visceral Inflammation and Immune Activation Stress the Brain

Holzer, P., Farzi, A., Hassan, A. M., Zenz, G., Jačan, A., & Reichmann, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01613 · Cited by 84

Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs

Kaszaki, J., Palásthy, Z., érczes, D., Rácz, A., Torday, C., Varga, G., Vécsei, L., & Boros, M. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00989.x · Cited by 82

Regulation of virulence: the rise and fall of gastrointestinal pathogens

Kitamoto, S., Nagao‐Kitamoto, H., Kuffa, P., & Kamada, N. (2015) · Journal of Gastroenterology · doi:10.1007/s00535-015-1141-5 · Cited by 82

Enhancement of intestinal inflammation in mice lacking interleukin 10 by deletion of the serotonin reuptake transporter

Haub, S., Ritze, Y., Bergheim, I., Pabst, O., Gershon, M. D., & Bischoff, S. C. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01479.x · Cited by 80

Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota

Arike, L., Seiman, A., van der Post, S., Rodríguez-Piñeiro, A. M., Ermund, A., Schütte, A., Bäckhed, F., Johansson, M., & Hansson, G. C. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.068 · Cited by 78

Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies

Sundaram, G., Brew, B. J., Jones, S. P., Adams, S., Lim, C. K., & Guillemin, G. J. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0204-5 · Cited by 77

Enzymic Synthesis of Niacin Nucleotides from 3-Hydroxyanthranilic Acid in Mammalian Liver

Nishizuka, Y., & Hayaishi, O. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84026-7 · Cited by 76

IL-10 Secretion and Sensitivity in Normal Human Intestine and Inflammatory Bowel Disease

Gasché, C., Bakos, S., Dejaco, C., Tillinger, W., Zakeri, S. M., & Reinisch, W. (2000) · Journal of Clinical Immunology · doi:10.1023/a:1006672114184 · Cited by 75

N-Methyl-d-aspartate receptor antagonism decreases motility and inflammatory activation in the early phase of acute experimental colitis in the rat

Varga, G., Érces, D., Fazekas, B., löp, M. F. ⁄., Kovács, T., Kaszaki, J., löp, F. F. ⁄., vécsei, L., & Boros, M. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01390.x · Cited by 75

Urinary intermediates of tryptophan as indicators of the gut microbial metabolism

Pavlová, T., Vidová, V., Vašků, J. B., Janků, P., Almáši, M., Klánová, J., & Spáčil, Z. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.08.022 · Cited by 75

Autonomic nervous system and secretion across the intestinal mucosal surface

Xue, J., Askwith, C., Javed, N. H., & Cooke, H. J. (2007) · Autonomic Neuroscience · doi:10.1016/j.autneu.2007.02.001 · Cited by 73

Picolinic acid, a catabolite of tryptophan, as the second signal in the activation of IFN- gamma -primed macrophages.

Varesio, L., Clayton, M., Blasi, E., Ruffmann, R., & Radzioch, D. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.12.4265 · Cited by 72

Bifidobacterium brevereduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner

Hughes, K. R., Harnisch, L. C., Alcon-Giner, C., Mitra, S., Wright, C. J., Ketskemety, J., van Sinderen, D., Watson, A. J. M., & Hall, L. J. (2017) · Open Biology · doi:10.1098/rsob.160155 · Cited by 72

Involvement of serotonin and calcium channels in the intestinal fluid secretion evoked by bile salt and cholera toxin

Peregrin, A. T., Ahlman, H., Jodal, M., & Lundgren, O. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702615 · Cited by 71

Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (II)

Chandran, P., Satthaporn, S., Robins, A., & Eremin, O. (2003) · The Surgeon · doi:10.1016/s1479-666x(03)80091-4 · Cited by 70

Human Indoleamine 2,3-Dioxygenase Is a Catalyst of Physiological Heme Peroxidase Reactions

Freewan, M., Rees, M. D., Plaza, T. S. S., Glaros, E. N., Lim, Y. J., Wang, X., Yeung, A. W. S., Witting, P. K., Terentis, A. C., & Thomas, S. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.410993 · Cited by 68

Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus

Brooks, A. K., Lawson, M. A., Smith, R. A. J., Janda, T. M., Kelley, K. W., & McCusker, R. H. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0563-1 · Cited by 67

Kynurenines and intestinal neurotransmission: the role of N-methyl-d-aspartate receptors

Kaszaki, J., Érces, D., Varga, G., Szabó, A., Vécsei, L., & Boros, M. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0658-x · Cited by 64

Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion

Csáti, A., Edvinsson, L. I., Vécsei, L., Toldi, J., Fülöp, F., Tajti, J., & Warfvinge, K. (2015) · The Journal of Headache and Pain · doi:10.1186/s10194-015-0581-x · Cited by 64

Probiotics in functional gastrointestinal disorders: what are the facts?

Quigley, E. M. M. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.08.007 · Cited by 63

HISTAMINE AND 5‐HYDROXYTRYPTAMINE IN THE INTESTINAL TRACT OF GERM‐FREE ANIMALS, ANIMALS HARBOURING ONE MICROBIAL SPECIES AND CONVENTIONAL ANIMALS

BEAVER, M. H., & WOSTMANN, B. S. (1962) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1962.tb01443.x · Cited by 63

Decreased levels of kynurenic acid in the intestinal mucosa of IBS patients: Relation to serotonin and psychological state

Keszthelyi, D., Troost, F. J., Jonkers, D. M. A. E., Kruimel, J. W., Leue, C., & Masclee, A. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.01.008 · Cited by 62

IDO1 Plays an Immunosuppressive Role in 2,4,6-Trinitrobenzene Sulfate–Induced Colitis in Mice

Takamatsu, M., Hirata, A., Ohtaki, H., Hoshi, M., Hatano, Y., Tomita, H., Kuno, T., Saito, K., & Hara, A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203306 · Cited by 61

Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways

Caputi, V., Marsilio, I., Cerantola, S., Roozfarakh, M., Lante, I., Galuppini, F., Rugge, M., Napoli, E., Giulivi, C., Orso, G., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00350 · Cited by 60

NMDA and quisqualate modulation of visceral nociception in the rat

Kolhekar, R., & Gebhart, G. F. (1994) · Brain Research · doi:10.1016/0006-8993(94)90700-5 · Cited by 59

Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway

Wang, Q., Yang, K., Han, B., Sheng, B., Yin, J., Pu, A., Li, L., Sun, L., Yu, M., Qiu, Y., et al. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3262 · Cited by 59

Memantine and Kynurenic Acid: Current Neuropharmacological Aspects

Majláth, Z., Török, N., Toldi, J., & Vécsei, L. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666151113123221 · Cited by 57

Mechanisms of Oral Tolerance

Commins, S. P. (2015) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2015.07.013 · Cited by 56

Modulation of spinal visceral nociceptive transmission by NMDA receptor activation in the rat

Kolhekar, R., & Gebhart, G. F. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.6.2344 · Cited by 56

Redox Properties of Tryptophan Metabolism and the Concept of Tryptophan Use in Pregnancy

Xu, K., Liu, H., Bai, M., Gao, J., Wu, X., & Yin, Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071595 · Cited by 55

Macrophages in the Small Intestinal Muscularis Externa of Embryos, Newborn and Adult Germ-Free Mice

Mikkelsen, H. B., Garbarsch, C., Tranum‐Jensen, J., & Thuneberg, L. (2004) · Journal of Molecular Histology · doi:10.1023/b:hijo.0000039840.86420.b7 · Cited by 54

Factors Affecting the Lymphoid Cells in the Small Intestinal Epithelium of the Mouse

Glaister, J. R. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000231071 · Cited by 53

Tachykinin: recent developments and novel roles in health and disease

Onaga, T. (2014) · BioMolecular Concepts · doi:10.1515/bmc-2014-0008 · Cited by 53

Biochemical mechanisms leading to tryptophan 2,3‐dioxygenase activation

Li, J. S., Han, Q., Fang, J., Rizzi, M., James, A. A., & Li, J. (2007) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.20159 · Cited by 52

Exendin-4, a GLP-1 Receptor Agonist, Interacts with Proteins and Their Products of Digestion to Suppress Food Intake in Rats

Aziz, A. A., & Anderson, G. H. (2003) · Journal of Nutrition · doi:10.1093/jn/133.7.2326 · Cited by 52

Anxiety but not depression predicts poor outcomes in inflammatory bowel disease

Narula, N., Pinto-Sanchez, M. I., Calo, N. C., Ford, A. C., Bercik, P., Reinisch, W., & Moayyedi, P. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy385 · Cited by 52

Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine

Forrest, C. M., McNair, K., Pisar, M., Khalil, O. S., Darlington, L. G., & Stone, T. W. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.022 · Cited by 51

Prenatal inhibition of the kynurenine pathway leads to structural changes in the hippocampus of adult rat offspring

Khalil, O. S., Pisar, M., Forrest, C. M., Vincenten, M. C. J., Darlington, L. G., & Stone, T. W. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12535 · Cited by 51

Exposure to a Social Stressor Induces Translocation of Commensal Lactobacilli to the Spleen and Priming of the Innate Immune System

Lafuse, W. P., Gearinger, R. L., Fisher, S., Nealer, C., Mackos, A. R., & Bailey, M. T. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601269 · Cited by 51

Evidence of altered mucosa-associated and fecal microbiota composition in patients with Irritable Bowel Syndrome

Sundin, J., Aziz, I., Nordlander, S., Polster, A. V., Hu, Y. O. O., Hugerth, L. W., Pennhag, A. A. L., Engstrand, L. G., Törnblom, H., Simrén, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-57468-y · Cited by 50

Colonic epithelial response to injury requires Myd88 signaling in myeloid cells

Malvin, N. P., Seno, H., & Stappenbeck, T. S. (2012) · Mucosal Immunology · doi:10.1038/mi.2011.65 · Cited by 49

Antimicrobial activity of picolinic acid against extracellular and intracellular Mycobacterium avium complex and its combined activity with clarithromycin, rifampicin and fluoroquinolones

Cai, S., Sato, K., Shimizu, T., Yamabe, S., Hiraki, M., Sano, C., & Tomioka, H. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki418 · Cited by 49

Increased serum free tryptophan in patients with diarrhea-predominant irritable bowel syndrome

Christmas, D. M., Badawy, A. A. ‐., Hince, D., Davies, S., Probert, C. S., Creed, T., Smithson, J., Afzal, M., Nutt, D., & Potokar, J. P. (2010) · Nutrition Research · doi:10.1016/j.nutres.2010.09.009 · Cited by 48

Gut Inflammation: Current Update on Pathophysiology, Molecular Mechanism and Pharmacological Treatment Modalities

Gyires, K., Toth, E., & Zadori, S. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990417 · Cited by 47

Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll‐like Receptor Stimulation in Peripheral Monocytes

Orhan, F., Bhat, M., Sandberg, K., Ståhl, S., Piehl, F., Karolinska Schizophrenia Project (KaSP) consortium, Svensson, C., Erhardt, S., & Schwieler, L. (2016) · Scandinavian Journal of Immunology · doi:10.1111/sji.12479 · Cited by 47

Effect ofLactobacillus rhamnosusGG supernatant on serotonin transporter expression in rats with post-infectious irritable bowel syndrome

Cao, Y.-N., Feng, L., Liu, Y.-Y., Jiang, K., Zhang, M.-J., Gu, Y., Wang, B., Gao, J., Wang, Z., & Wang, Y. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i3.338 · Cited by 47

Intracisternal injection of a TRH analogue stimulates gastric luminal serotonin release in rats

Stephens, R. L., & Taché, Y. (1989) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1989.256.2.g377 · Cited by 46

The pathogenic potential of Pseudomonas fluorescens MFN1032 on enterocytes can be modulated by serotonin, substance P and epinephrine

Biaggini, K., Barbey, C., Borrel, V., Feuilloley, M., Déchelotte, P., & Connil, N. (2015) · Archives of Microbiology · doi:10.1007/s00203-015-1135-y · Cited by 46

Tryptophan metabolic profile in term and preterm breast milk: implications for health

O’Rourke, L., Clarke, G., Nolan, A. M., Watkins, C., Dinan, T. G., Stanton, C., Ross, R. P., & Ryan, C. A. (2018) · Journal of Nutritional Science · doi:10.1017/jns.2017.69 · Cited by 46

The Opposite Effects of Kynurenic Acid and Different Kynurenic Acid Analogs on Tumor Necrosis Factor-α (TNF-α) Production and Tumor Necrosis Factor-Stimulated Gene-6 (TSG-6) Expression

Mándi, Y., Endrész, V., Mosolygó, T., Burián, K., Lantos, I., Fülöp, F., Szatmári, I., Lőrinczi, B., Balog, A., & Vécsei, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01406 · Cited by 46

N-methyl-d-aspartate receptor antagonist therapy suppresses colon motility and inflammatory activation six days after the onset of experimental colitis in rats

Érces, D., Varga, G., Fazekas, B., Kovács, T., Tőkés, T., Tiszlavicz, L., Fülöp, F., Vécsei, L., Boros, M., & Kaszaki, J. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.06.044 · Cited by 45

Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway.

Pisar, M., Forrest, C., Khalil, O. S., McNair, K., Vincenten, M. C., Qasem, S., Darlington, L., & Stone, T. W. (2014) · Brain Research · doi:10.1016/j.brainres.2014.06.016 · Cited by 45

Changes in hyaluronan deposition in the rat myenteric plexus after experimentally-induced colitis

Filpa, V., Bistoletti, M., Caon, I., Moro, E., Grimaldi, A., Moretto, P., Baj, A., Giron, M. C., Karousou, E. G., Viola, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-18020-7 · Cited by 44

Nitric oxide regulates homeoprotein OTX1 and OTX2 expression in the rat myenteric plexus after intestinal ischemia-reperfusion injury

Filpa, V., Carpanese, E., Marchet, S., Pirrone, C., Conti, A., Rainero, A., Moro, E., Chiaravalli, A. M., Zucchi, I., Moriondo, A., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00386.2016 · Cited by 40

N-Methyl D-Aspartate Receptor Antagonist Kynurenic Acid Affects Human Cortical Development

Bagasrawala, I., Zečević, N., & Radonjić, N. V. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00435 · Cited by 39

Use of antibiotics in infancy and childhood and risk of recurrent abdominal pain—a S wedish birth cohort study

Uusijärvi, A., Bergström, A., Simrén, M., Ludvigsson, J. F., Kull, I., Wickman, M. C., Alm, J. S., & Olén, O. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12340 · Cited by 38

Intestinal bacterial biofilms modulate mucosal immune responses

Sartor, R. B. (2018) · Journal of Immunological Sciences · doi:10.29245/2578-3009/2018/2.1122 · Cited by 38

PRESENCE OF NEGLECTED BACTERIA IN THE INFANT GUT MICROBIOTA

Sagheddu, V. (2017) · DocTA - Doctoral Theses Archive · Cited by 37

Characterization of skatole-producing microbial populations in enriched swine lagoon slurry

Cook, K. L., Rothrock, M. J., Loughrin, J. H., & Doerner, K. C. (2007) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2007.00299.x · Cited by 34

E. coli-mediated gut inflammation in genetically predisposed Crohn's disease patients

Barnich, N., Denizot, J., & Darfeuille-Michaud, A. (2013) · Pathologie Biologie · doi:10.1016/j.patbio.2010.01.004 · Cited by 34

The Colonic Tissue Levels of TLR2, TLR4 and Nitric Oxide in Patients with Irritable Bowel Syndrome

ak, E. K. C., Akbal, E., Köklü, S., l, B. E. U., & Can, M. (2016) · Internal Medicine · doi:10.2169/internalmedicine.55.5716 · Cited by 32

Hippocampal AMPAR s involve the central sensitization of rats with irritable bowel syndrome

Chen, A., Chen, Y., Tang, Y., Bao, C.-J., Cui, Z., Xiao, M., & Lin, C. (2017) · Brain and Behavior · doi:10.1002/brb3.650 · Cited by 32

Neurochemical characterization of myenteric neurons in the juvenile gilthead sea bream (Sparus aurata) intestine

Ceccotti, C., Giaroni, C., Bistoletti, M., Viola, M., Crema, F., & Terova, G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201760 · Cited by 31

Interactions between the Kynurenine and the Endocannabinoid System with Special Emphasis on Migraine

Nagy-Grócz, G., Zádor, F., Dvorácskó, S., Bohár, Z., Benyhe, S., Tömböly, C., Párdutz, Á., & Vécsei, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081617 · Cited by 30

Interaction between NMDA glutamatergic and nitrergic enteric pathways during in vitro ischemia and reperfusion

Filpa, V., Carpanese, E., Marchet, S., Prandoni, V., Moro, E., Lecchini, S., Frigo, G., Giaroni, C., & Crema, F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.01.021 · Cited by 27

Antagonism of Ionotropic Glutamate Receptors Attenuates Chemical Ischemia-Induced Injury in Rat Primary Cultured Myenteric Ganglia

Carpanese, E., Moretto, P., Filpa, V., Marchet, S., Moro, E., Crema, F., Frigo, G., & Giaroni, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113613 · Cited by 27

Kynurenic acid actions in brain and periphery

Moroni, F., Fossati, S., Chiarugi, A., & Cozzi, A. (2007) · International Congress Series · doi:10.1016/j.ics.2007.07.016 · Cited by 27

Protein kinase c modulates NMDA receptors in the myenteric plexus of the guinea pig ileum during in vitro ischemia and reperfusion

Giaroni, C., Zanetti, E., Giuliani, D., Oldrini, R., Marchet, S., Moro, E., Borroni, P., Trinchera, M., Crema, F., Lecchini, S., et al. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01644.x · Cited by 25

Neuroimmune Modulation of Gut Function

Shea‐Donohue, T., & Urban, J. F. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_109 · Cited by 25

Constitutively Active 5-HT Receptors: An Explanation of How 5-HT Antagonists Inhibit Gut Motility in Species Where 5-HT is Not an Enteric Neurotransmitter?

Spencer, N. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00487 · Cited by 24

A novel synthesis of N -hydroxy-3-aroylindoles and 3-aroylindoles

Ieronimo, G., Palmisano, G., Maspero, A., Marzorati, A., Scapinello, L., Masciocchi, N., Cravotto, G., Barge, A., Simonetti, M., Ameta, K. L., et al. (2018) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob01471j · Cited by 23

Marine Toxins and Nociception: Potential Therapeutic Use in the Treatment of Visceral Pain Associated with Gastrointestinal Disorders

Baj, A., Bistoletti, M., Bosi, A., Moro, E., Giaroni, C., & Crema, F. (2019) · Toxins · doi:10.3390/toxins11080449 · Cited by 23

Purinergic signalling and development of the autonomic nervous system

Giaroni, C. (2015) · Autonomic Neuroscience · doi:10.1016/j.autneu.2015.04.009 · Cited by 22

Effects of a dietary excess of leucine and of the addition of leucine and 2-oxo-isocaproate on the metabolism of tryptophan and niacin in isolated rat liver cells

Bender, D. A. (1989) · British Journal Of Nutrition · doi:10.1079/bjn19890150 · Cited by 17

Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation (Gut (2007) 56, (1522-1528))

Gareau, M. G., Jury, J. A., & MacQUEEN, G. M. (2008) · Gut · doi:10.1136/gut.2006.117176corr1 · Cited by 17

Homeoprotein OTX1 and OTX2 involvement in rat myenteric neuron adaptation after DNBS-induced colitis

Bistoletti, M., Micheloni, G., Baranzini, N., Bosi, A., Conti, A., Filpa, V., Pirrone, C., Millefanti, G., Moro, E., Grimaldi, A., et al. (2020) · PeerJ · doi:10.7717/peerj.8442 · Cited by 15

Effects of nitric oxide in 5-hydroxytryptamine-, cholera toxin-, enterotoxigenic Escherichia coli- and Salmonella Typhimurium-induced secretion in the porcine small intestine

Grøndahl, M. L., Unmack, M. A., Ragnarsdóttir, H. B., Hansen, M. B., Olsen, J. E., & Skadhauge, E. (2005) · Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology · doi:10.1016/j.cbpb.2005.07.001 · Cited by 11

Irritable bowel syndrome

Laskaratos, F., Goodkin, O., Thoua, N. M., & Murray, C. D. (2015) · Medicine · doi:10.1016/j.mpmed.2015.02.010 · Cited by 8

Activity of Picolinic Acid in Combination with the Antiprotozoal Drug Quinacrine against Mycobacterium avium Complex

Shimizu, T., & Tomioka, H. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01510-05 · Cited by 7

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Scapinello, L., Maspero, A., Tollari, S., Palmisano, G., Nicholas, K. M., & Penoni, A. (2020) · Journal of Visualized Experiments · doi:10.3791/60201 · Cited by 7

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415

Dual Role of Indoles Derived From Intestinal Microbiota on Human Health

Ye, X., Li, H., Anjum, K., Zhong, X., Miao, S., Zheng, G., Liu, W., & Li, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.903526 · Cited by 288

The role of probiotics and prebiotics in modulating of the gut-brain axis

Ansari, F., Neshat, M., Pourjafar, H., Jafari, S. M., Samakkhah, S. A., & Mirzakhani, E. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1173660 · Cited by 230

Nutritional Support of Neurodevelopment and Cognitive Function in Infants and Young Children—An Update and Novel Insights

Kadosh, K. C., Muhardi, L., Parikh, P., Basso, M., Mohamed, H. J. J., Prawitasari, T., Samuel, F. O., Ma, G., & Geurts, J. M. W. (2021) · Nutrients · doi:10.3390/nu13010199 · Cited by 206

Impact of Microbial Metabolites on Microbiota–Gut–Brain Axis in Inflammatory Bowel Disease

Banfi, D., Moro, E., Bosi, A., Bistoletti, M., Cerantola, S., Crema, F., Maggi, F., Giron, M. C., Giaroni, C., & Baj, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041623 · Cited by 160

Molecular mechanisms and therapeutic potential of tryptophan metabolism in gut-brain signaling transduction: a narrative review

Zhang, J., Zhou, Y., Mei, X., Yan, S., Mao, J. Y., Li, Y., Bian, Z., Li, L., Ji, D., Lu, T., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03763-w · Cited by 16

Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain

Gao, K., Mu, C.-L., Farzi, A., & Zhu, W.-Y. (2020) · Advances in Nutrition · doi:10.1093/advances/nmz127 · Cited by 1,029

Tryptophan Metabolism and the Microbiome-Gut-Brain Axis

Clarke, G. A., Villalobos-Manríquez, F., & Marin, D. C. (2021) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.13 · Cited by 7

The Microbiota-Gut-Brain Axis: Tryptophan Metabolism and Potential Therapeutic Strategies

Mora-Navarro, M. A., Mora-Martínez, J. M., Patiño-Laguna, A. D. J., Barragán-Álvarez, C. P., Gonzalez-Mora, M. E., & Mora-Navarro, C. E. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.113888

Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis

Gheorghe, C. E., Martin, J. A., Manriquez, F. V., Dinan, T. G., Cryan, J. F., & Clarke, G. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.08.004 · Cited by 212