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A role for cryptochromesin sleep regulation
Open accessAbstract
BACKGROUND: The cryptochrome 1 and 2 genes (cry1 and cry2) are necessary for the generation of circadian rhythms, as mice lacking both of these genes (cry1,2-/-) lack circadian rhythms. We studied sleep in cry1,2-/- mice under baseline conditions as well as under conditions of constant darkness and enforced wakefulness to determine whether cryptochromes influence sleep regulatory processes. RESULTS: Under all three conditions, cry1,2-/- mice exhibit the hallmarks of high non-REM sleep (NREMS) drive (i.e., increases in NREMS time, NREMS consolidation, and EEG delta power during NREMS). This unexpected phenotype was associated with elevated brain mRNA levels of period 1 and 2 (per1,2), and albumin d-binding protein (dbp), which are known to be transcriptionally inhibited by CRY1,2. To further examine the relationship between circadian genes and sleep homeostasis, we examined wild type mice and rats following sleep deprivation and found increased levels of per1,2 mRNA and decreased levels of dbp mRNA specifically in the cerebral cortex; these changes subsided with recovery sleep. The expression of per3, cry1,2, clock, npas2, bmal1, and casein-kinase-1epsilon did not change with sleep deprivation. CONCLUSIONS: These results indicate that mice lacking cryptochromes are not simply a genetic model of circadian arrhythmicity in rodents and functionally implicate cryptochromes in the homeostatic regulation of sleep.
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Cites
Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior
Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1994) · Science · doi:10.1126/science.8171325 · Cited by 1,632
Interacting molecular loops in the mammalian circadian clock
Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367
Dijk, D., & Czeisler, C. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03526.1995 · Cited by 1,356
Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.
Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00380-4 · Cited by 900
A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light
Albrecht, U., Sun, Z. S., Eichele, G., & Lee, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80495-x · Cited by 879
Circadian rhythms in isolated brain regions
Abe, M., Herzog, E. D., Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00350.2002 · Cited by 681
NPAS2: an analog of clock operative in the mammalian forebrain
Reick, M., Garcia, J. A., Dudley, C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060699 · Cited by 572
Wakamatsu, H., Yoshinobu, Y., Aida, R., Moriya, T., Akiyama, M., & Shibata, S. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01483.x · Cited by 308
Selby, C. P., Thompson, C., Schmitz, T. M., Van Gelder, R. N., & Sancar, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.260498597 · Cited by 184
Self-citation
Cited by
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
Saper, C. B., Fuller, P. M., Pedersen, N. P., Lu, J., & Scammell, T. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.032 · Cited by 1,404
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function
Piwecka, M., Glažar, P., Hernandez-Miranda, L. R., Memczak, S., Wolf, S. A., Rybak-Wolf, A., Filipchyk, A., Klironomos, F., Cerda Jara, C. A., Fenske, P., et al. (2017) · Science · doi:10.1126/science.aam8526 · Cited by 1,210
Extensive and divergent effects of sleep and wakefulness on brain gene expression
Cirelli, C., Gutierrez, C. M., & Tononi, G. (2004) · Neuron · doi:10.1016/s0896-6273(03)00814-6 · Cited by 627
PER3 polymorphism predicts sleep structure and waking performance
Viola, A. U., Archer, S. N., James, L. M., Groeger, J. A., Lo, J. C. Y., Skene, D. J., von Schantz, M., & Dijk, D.-J. (2007) · Current Biology · doi:10.1016/j.cub.2007.01.073 · Cited by 520
A clock shock: mouse CLOCK is not required for circadian oscillator function
DeBruyne, J. P., Noton, E., Lambert, C. M., Maywood, E. S., Weaver, D. R., & Reppert, S. M. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.041 · Cited by 430
Identification of SLEEPLESS, a sleep-promoting factor
Koh, K., Joiner, W. J., Wu, M. N., Yue, Z., Smith, C. J., & Sehgal, A. (2008) · Science · doi:10.1126/science.1155942 · Cited by 347
Sex differences in circadian timing systems: implications for disease
Bailey, M., & Silver, R. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.003 · Cited by 348
Circadian regulation of sleep in mammals: Role of the suprachiasmatic nucleus
Mistlberger, R. E. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.01.005 · Cited by 318
Hippocampal-dependent learning requires a functional circadian system
Ruby, N. F., Hwang, C. E., Wessells, C., Fernandez, F., Zhang, P., Sapolsky, R., & Heller, H. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808259105 · Cited by 234
The Neurobiology of Sleep and Wakefulness
Schwartz, M. D., & Kilduff, T. S. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.07.002 · Cited by 207
Self-citationLe‐Niculescu, H., Patel, S. D., Bhat, M., Kuczenski, R., Faraone, S. V., Tsuang, M. T., McMahon, F. J., Schork, N. J., Nurnberger, J. I., & Niculescu, A. B. (2009) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30887 · Cited by 201
Vadnie, C. A., & McClung, C. A. (2017) · Neural Plasticity · doi:10.1155/2017/1504507 · Cited by 199
Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson’s disease
Cai, Y., Liu, S., Sothern, R. B., Xu, S., & Chan, P. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02848.x · Cited by 184
Bunney, B. G., & Bunney, W. E. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.020 · Cited by 181
Circadian gene variants in cancer
Kettner, N. M., Katchy, C. A., & Fu, L. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.914808 · Cited by 147
Sleep and circadian rhythmicity as entangled processes serving homeostasis
Franken, P., & Dijk, D.-J. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00764-z · Cited by 147
Self-citationEvidence for Neuroinflammatory and Microglial Changes in the Cerebral Response to Sleep Loss
Wisor, J. P., Schmidt, M. A., & Clegern, W. C. (2011) · Sleep · doi:10.1093/sleep/34.3.261 · Cited by 141
Self-citationA role for clock genes in sleep homeostasis
Franken, P. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.05.002 · Cited by 125
Orozco-Solis, R., Montellier, E., Aguilar-Arnal, L., Sato, S., Vawter, M. P., Bunney, B. G., Bunney, W. E., & Sassone-Corsi, P. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.1176 · Cited by 119
Altered circadian clock gene expression in patients with schizophrenia
Johansson, A.-S., Owe-Larsson, B., Hetta, J., & Lundkvist, G. B. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.04.029 · Cited by 120
Mongrain, V., La Spada, F., Curie, T., & Franken, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026622 · Cited by 118
Self-citationEffect of sleep deprivation on rhythms of clock gene expression and melatonin in humans
Ackermann, K., Plomp, R., Lao, O., Middleton, B., Revell, V. L., Skene, D. J., & Kayser, M. (2013) · Chronobiology International · doi:10.3109/07420528.2013.784773 · Cited by 116
Homeostatic and circadian contribution to EEG and molecular state variables of sleep regulation
Curie, T., Mongrain, V., Dorsaz, S., Mang, G. M., Emmenegger, Y., & Franken, P. (2013) · SLEEP · doi:10.5665/sleep.2440 · Cited by 94
Self-citationBenedetti, F., Dallaspezia, S., Fulgosi, M. C., Barbini, B., Colombo, C., & Smeraldi, E. (2007) · Chronobiology International · doi:10.1080/07420520701649455 · Cited by 97
Wimmer, R. D., Astori, S., Bond, C. T., Rovó, Z., Chatton, J.-Y., Adelman, J. P., Franken, P., & Lüthi, A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2313-12.2012 · Cited by 90
“However, because over the course of an NREMS episode attempts to transition into REMS increase (Benington et al., 1994; Franken, 2002), even a small reduction in the success rate of these attempts could underlie the substantial shift toward longer NREMS bout durations in SK2-OE mice.”
Self-citationPhenotypic effects of genetic variability in human clock genes on circadian and sleep parameters
Von Schantz, M. (2008) · Journal of Genetics · doi:10.1007/s12041-008-0074-7 · Cited by 85
Nievergelt, C. M., Kripke, D. F., Remick, R. A., Sadovnick, A. D., McElroy, S. L., Keck, P. E., & Kelsoe, J. R. (2005) · Psychiatric Genetics · doi:10.1097/00041444-200503000-00008 · Cited by 38
Metadata
- Authors
- Wisor, J. P., O'Hara, B. F., Terao, A., Selby, C. P., Kilduff, T. S., Sancar, A., Edgar, D. M., & Franken, P.
- Venue
- BMC Neuroscience
- Published
- 2002-12-20
- Volume
- 3
- Issue
- 1
- Pages
- 20-20
- ISSN
- 1471-2202 (ISSN-L)
- OpenAlex
- W1808876722
- Cited by
- 291
- References
- 9
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- gold
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