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Cited by 204Transcranial Magnetic Stimulation StudiesNeuroscience and Neuropharmacology ResearchNeurological disorders and treatments

Transcranial magnetic stimulation, synaptic plasticity and network oscillations

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Huerta, Patricio T, Volpe, Bruce T·2009·Journal of NeuroEngineering and Rehabilitation
DOI 10.1186/1743-0003-6-7PMC PMC2653496
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Abstract

Transcranial magnetic stimulation (TMS) has quickly progressed from a technical curiosity to a bona-fide tool for neurological research. The impetus has been due to the promising results obtained when using TMS to uncover neural processes in normal human subjects, as well as in the treatment of intractable neurological conditions, such as stroke, chronic depression and epilepsy. The basic principle of TMS is that most neuronal axons that fall within the volume of magnetic stimulation become electrically excited, trigger action potentials and release neurotransmitter into the postsynaptic neurons. What happens afterwards remains elusive, especially in the case of repeated stimulation. Here we discuss the likelihood that certain TMS protocols produce long-term changes in cortical synapses akin to long-term potentiation and long-term depression of synaptic transmission. Beyond the synaptic effects, TMS might have consequences on other neuronal processes, such as genetic and protein regulation, and circuit-level patterns, such as network oscillations. Furthermore, TMS might have non-neuronal effects, such as changes in blood flow, which are still poorly understood.

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Cited by

Sorted by citations

Authors
Huerta, P. T., & Volpe, B. T.
Affiliations
Cornell University (US)
Corresponding author
Huerta, Patricio T
ORCID
Venue
Journal of NeuroEngineering and Rehabilitation
Publisher
Springer Science and Business Media LLC
Published
2009-03-02
Volume
6
Issue
1
Pages
7-7
ISSN
1743-0003 (ISSN-L)
DOI
10.1186/1743-0003-6-7
PMC
PMC2653496
OpenAlex
W2076208297
Cited by
204
References
8
Citations by year
2026: 12 · 2025: 15 · 2024: 25 · 2023: 17 · 2022: 17 · 2021: 10 · 2020: 5 · 2019: 17 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 13 · 2014: 12 · 2013: 10 · 2012: 10
FWCI
0.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of NeuroEngineering and Rehabilitation (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Burke Foundation
  • Lupus Research Alliance
  • National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
transcranial magnetic stimulation, synaptic plasticity, long-term potentiation, long-term depression, network oscillations, repetitive stimulation, cortical synapses, gene expression regulation, protein regulation, blood flow changes, stroke, chronic depression, epilepsy
MeSH terms
Brain, Humans, Neural Inhibition, Synaptic Transmission, Neuronal Plasticity, Synapses, Transcranial Magnetic Stimulation

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