Cited by 393Gut microbiota and healthEvolution and Genetic DynamicsMicrobial Community Ecology and Physiology

The human microbiome in evolution

Open access
Davenport, Emily R., Sanders, Jon G., Song, Se Jin, Amato, Katherine R., Clark, Andrew G., Knight, Rob·2017·BMC Biology

Abstract

The trillions of microbes living in the gut-the gut microbiota-play an important role in human biology and disease. While much has been done to explore its diversity, a full understanding of our microbiomes demands an evolutionary perspective. In this review, we compare microbiomes from human populations, placing them in the context of microbes from humanity's near and distant animal relatives. We discuss potential mechanisms to generate host-specific microbiome configurations and the consequences of disrupting those configurations. Finally, we propose that this broader phylogenetic perspective is useful for understanding the mechanisms underlying human-microbiome interactions.

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  • A review of non-human primate and human gut microbiome datasets revealed a changing microbiome in response to host habitat, season and diet, although there appear to be common species-specific symbiotic communities.

    “A review of non-human primate and human gut microbiome datasets, revealed a changing microbiome in response to host habitat, season and diet, although there appear to be common species-specific symbiotic communities [118].”
  • Host-microbe interactions are frequently viewed from an evolutionary perspective.

    “Host-microbe interactions are frequently viewed from an evolutionary perspective (Davenport et al., 2017).”

    From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Davenport et al., 2017

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Authors
Davenport, E. R., Sanders, J. G., Song, S. J., Amato, K. R., Clark, A. G., & Knight, R.
Affiliations
  • Cornell University (US)
  • University of California San Diego (US)
  • Northwestern University (US)
Corresponding author
Knight, Rob
Venue
BMC Biology
Published
2017-12
Volume
15
Issue
1
Pages
127-127
ISSN
1741-7007 (ISSN-L)
OpenAlex
W2776194694
Cited by
393
References
138
Citations by year
2026: 28 · 2025: 37 · 2024: 58 · 2023: 59 · 2022: 52 · 2021: 57 · 2020: 49 · 2019: 35 · 2018: 18
FWCI
2.61
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • BMC Biology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • Howard Hughes Medical Institute
  • W. M. Keck Foundation
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (F32DK109595)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Keywords
human microbiome, gut microbiota, host-microbe interactions, dysbiosis, human population variation
MeSH terms
Gastrointestinal Microbiome, Animals, Biological Evolution, Humans, Phylogeny, Host Specificity, Microbiota

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