The human microbiome in evolution
Open accessAbstract
The trillions of microbes living in the gut-the gut microbiota-play an important role in human biology and disease. While much has been done to explore its diversity, a full understanding of our microbiomes demands an evolutionary perspective. In this review, we compare microbiomes from human populations, placing them in the context of microbes from humanity's near and distant animal relatives. We discuss potential mechanisms to generate host-specific microbiome configurations and the consequences of disrupting those configurations. Finally, we propose that this broader phylogenetic perspective is useful for understanding the mechanisms underlying human-microbiome interactions.
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A review of non-human primate and human gut microbiome datasets revealed a changing microbiome in response to host habitat, season and diet, although there appear to be common species-specific symbiotic communities.
“A review of non-human primate and human gut microbiome datasets, revealed a changing microbiome in response to host habitat, season and diet, although there appear to be common species-specific symbiotic communities [118].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [118]
Host-microbe interactions are frequently viewed from an evolutionary perspective.
“Host-microbe interactions are frequently viewed from an evolutionary perspective (Davenport et al., 2017).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Davenport et al., 2017
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The microbiome and human cancer
Sepich-Poore, G. D., Zitvogel, L., Straussman, R., Hasty, J., Wargo, J. A., & Knight, R. (2021) · Science · doi:10.1126/science.abc4552 · Cited by 1,332 · see citing works
Self-citationGut reactions: Breaking down xenobiotic–microbiome interactions
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One health, fermented foods and gut microbiota
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Losasso, C., Eckert, E. M., Mastrorilli, E., Villiger, J., Mancin, M., Patuzzi, I., Di Cesare, A., Cibin, V., Barrucci, F., Pernthaler, J., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00317 · Cited by 125 · see citing works
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
parker, J., O'Brien, C., Hawrelak, J., & Gersh, F. (2021) · doi:10.20944/preprints202112.0088.v1 · Cited by 113 · see citing works
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
Parker, J., O’Brien, C., Hawrelak, J., & Gersh, F. L. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031336 · Cited by 114 · see citing works
“A review of non-human primate and human gut microbiome datasets, revealed a changing microbiome in response to host habitat, season and diet, although there appear to be common species-specific symbiotic communities (118).”
BackgroundInfluentialGut microbiome strain-sharing within isolated village social networks
Beghini, F., Pullman, J., Alexander, M., Shridhar, S. V., Prinster, D., Singh, A., Matute Juárez, R., Airoldi, E. M., Brito, I. L., & Christakis, N. A. (2025) · Nature · doi:10.1038/s41586-024-08222-1 · Cited by 51 · see citing works
Teixeira, A. L., Martins, L. B., Berk, M., & Bauer, M. E. (2022) · Clinical Science · doi:10.1042/cs20211106 · Cited by 22 · see citing works
- Authors
- Davenport, E. R., Sanders, J. G., Song, S. J., Amato, K. R., Clark, A. G., & Knight, R.
- Affiliations
- Cornell University (US)
- University of California San Diego (US)
- Northwestern University (US)
- Corresponding author
- Knight, Rob
- Venue
- BMC Biology
- Published
- 2017-12
- Volume
- 15
- Issue
- 1
- Pages
- 127-127
- ISSN
- 1741-7007 (ISSN-L)
- PMC
- PMC5744394
- OpenAlex
- W2776194694
- Cited by
- 393
- References
- 138
- Citations by year
- 2026: 28 · 2025: 37 · 2024: 58 · 2023: 59 · 2022: 52 · 2021: 57 · 2020: 49 · 2019: 35 · 2018: 18
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- W. M. Keck Foundation
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (F32DK109595)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- human microbiome, gut microbiota, host-microbe interactions, dysbiosis, human population variation
- MeSH terms
- Gastrointestinal Microbiome, Animals, Biological Evolution, Humans, Phylogeny, Host Specificity, Microbiota
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