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Cited by 182

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

Cole, John J., Robertson, Neil A., Rather, Mohammed Iqbal, Thomson, John P., McBryan, Tony, Sproul, Duncan, Wang, Tina, Brock, Claire, Clark, William, Ideker, Trey, Meehan, Richard R., Miller, Richard A., Brown-Borg, Holly M., Adams, Peter D.·2017·Genome Biology
DOI 10.1186/s13059-017-1185-3PMC PMC5370462
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  • Multiple interventions, acting at different levels, can delay or even reverse the aging process.

    “In contrast to the view of aging as an irreversible and unidirectional process akin to an increase in cell entropy, recent studies have demonstrated that multiple interventions, acting at different levels, can delay or even reverse this process [10][11][12][13][14][15][16][17] .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [10]

    The Background (page unavailable) says genetic, dietary, and drug interventions can extend longevity and healthspan, supporting the claim that interventions at different levels can delay aging. The paper reports suppression of age-associated epigenetic changes, but does not demonstrate reversal of the aging process. (LLM, conf=0.86)

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Research works printed but not linked: 44

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  9. Teschendorff AE, et al. Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res. 2010;20(4):440–6. · DOI · Paper page
  10. Day K, et al. Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. Genome Biol. 2013;14(9):R102. · DOI
  11. Raddatz G, et al. Aging is associated with highly defined epigenetic changes in the human epidermis. Epigenetics Chromatin. 2013;6(1):36. · DOI
  12. Hannum G, et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell. 2013;49(2):359–67. · DOI · Paper page
  13. Weidner CI, et al. Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol. 2014;15(2):R24. · DOI · Paper page
  14. Marioni RE, et al. DNA methylation age of blood predicts all-cause mortality in later life. Genome Biol. 2015;16(1):25. · DOI · Paper page
  15. Gross AM, et al. Methylome-wide analysis of chronic HIV infection reveals five-year increase in biological age and epigenetic targeting of HLA. Mol Cell. 2016;62(2):157–68. · DOI
  16. Maures TJ, et al. The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner. Aging Cell. 2011;10(6):980–90. · DOI · Paper page
  17. Dang W, et al. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell Metab. 2014;19(6):952–66. · DOI · Paper page
  18. Marzluff WF, et al. Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail. Nat Rev Genet. 2008;9(11):843–54. · DOI
  19. Sun D, et al. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell. 2014;14(5):673–88. · DOI · Paper page
  20. Beerman I, et al. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell. 2013;12(4):413–25. · DOI · Paper page
  21. Dhawan S, Tschen SI, Bhushan A. Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. Genes Dev. 2009;23(8):906–11. · DOI · Paper page
  22. Morgan MA, Shilatifard A. Chromatin signatures of cancer. Genes Dev. 2015;29(3):238–49. · DOI
  23. Maegawa S, et al. Age-related epigenetic drift in the pathogenesis of MDS and AML. Genome Res. 2014;24(4):580–91. · DOI
  24. Brown-Borg HM, et al. Growth hormone signaling is necessary for lifespan extension by dietary methionine. Aging Cell. 2014;13(6):1019–27. · DOI
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Metadata

Authors
Cole, J. J., Robertson, N. A., Rather, M. I., Thomson, J. P., McBryan, T., Sproul, D., Wang, T., Brock, C., Clark, W., Ideker, T., Meehan, R. R., Miller, R. A., Brown-Borg, H. M., & Adams, P. D.
Venue
Genome Biology
Publisher
Springer Science and Business Media LLC
Published
2017-03-28
Volume
18
Issue
1
ISSN
1474-760X
DOI
10.1186/s13059-017-1185-3
PMC
PMC5370462
Cited by
182
References
21
Language
en
Licence
Funders
  • National Institute on Aging (P01 AG031862, AG034206, AG034206-04S1, AG038509, AG022303, AG019899)
  • Cancer Research UK (C47648/A20837)
  • Medical Research Council (MC_PC_U127574433)

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