European COMPARative Effectiveness research on blended Depression treatment versus treatment-as-usual (E-COMPARED): study protocol for a randomized controlled, non-inferiority trial in eight European countries
Open accessAbstract
BACKGROUND: Effective, accessible, and affordable depression treatment is of high importance considering the large personal and economic burden of depression. Internet-based treatment is considered a promising clinical and cost-effective alternative to current routine depression treatment strategies such as face-to-face psychotherapy. However, it is not clear whether research findings translate to routine clinical practice such as primary or specialized mental health care. The E-COMPARED project aims to gain knowledge on the clinical and cost-effectiveness of blended depression treatment compared to treatment-as-usual in routine care. METHODS/DESIGN: E-COMPARED will employ a pragmatic, multinational, randomized controlled, non-inferiority trial in eight European countries. Adults diagnosed with major depressive disorder (MDD) will be recruited in primary care (Germany, Poland, Spain, Sweden, and the United Kingdom) or specialized mental health care (France, The Netherlands, and Switzerland). Regular care for depression is compared to "blended" service delivery combining mobile and Internet technologies with face-to-face treatment in one treatment protocol. Participants will be followed up at 3, 6, and 12 months after baseline to determine clinical improvements in symptoms of depression (primary outcome: Patient Health Questionnaire-9), remission of depression, and cost-effectiveness. Main analyses will be conducted on the pooled data from the eight countries (n = 1200 in total, 150 participants in each country). DISCUSSION: The E-COMPARED project will provide mental health care stakeholders with evidence-based information and recommendations on the clinical and cost-effectiveness of blended depression treatment. TRIAL REGISTRATION: France: ClinicalTrials.gov NCT02542891 . Registered on 4 September 2015; Germany: German Clinical Trials Register DRKS00006866 . Registered on 2 December 2014; The Netherlands: Netherlands Trials Register NTR4962 . Registered on 5 January 2015; Poland: ClinicalTrials.Gov NCT02389660 . Registered on 18 February 2015; Spain: ClinicalTrials.gov NCT02361684 . Registered on 8 January 2015; Sweden: ClinicalTrials.gov NCT02449447 . Registered on 30 March 2015; Switzerland: ClinicalTrials.gov NCT02410616 . Registered on 2 April 2015; United Kingdom: ISRCTN registry, ISRCTN12388725 . Registered on 20 March 2015.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Innovative healthcare delivery models including self-management internet-delivered interventions may prove crucial in overcoming organizational and financial barriers of traditional healthcare delivery, especially in countries where non-pharmacologic support is virtually absent in primary care, as in Portugal.
“Innovative healthcare delivery models, where self-management internet-delivered interventions are included, may prove crucial in overcoming organizational and financial barriers frequently associated to the traditional healthcare delivery model in the future, especially in countries where non-pharmacologic support is virtually absent in primary care, as is the case of Portugal (Kleiboer et al., 20”
From A guided internet-delivered individually-tailored ACT-influenced cognitive behavioural intervention to improve psychosocial outcomes in breast cancer survivors (iNNOVBC): Study protocol (2019) · cites this paper as Kleiboer et al., 2016
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredBlended psychotherapy is a rather new field of research.
“Blended psychotherapy, i.e., the combination of online intervention elements with standard psychotherapeutic care, is a rather new field of research (19–22).”
The System Usability Scale (SUS) has increasingly been applied to measure usability of internet-based cognitive behavioural therapy (iCBT) in feasibility and evaluation studies in mental healthcare.
“In feasibility and evaluation studies on iCBT in mental healthcare, the System Usability Scale (SUS) has increasingly been applied to measure usability [7–9]”
From Dimensionality of the system usability scale among professionals using internet-based interventions for depression: a confirmatory factor analysis (2020) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
EuroQol: a new facility for the measurement of health-related quality of life
(1990) · Health Policy · doi:10.1016/0168-8510(90)90421-9 · Cited by 15,736 · see citing works
CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
the CONSORT Group, Schulz, K. F., Altman, D. G., & Moher, D. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-18 · Cited by 13,371 · see citing works
Cook, R. J., Dickens, B. M., & Fathalla, M. F. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199241323.003.0025 · Cited by 10,813 · see citing works
(1998) · PubMed · Cited by 10,216 · see citing works
CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
Schulz, K. F., Altman, D. G., Moher, D., & for the CONSORT Group (2010) · BMJ · doi:10.1136/bmj.c332 · Cited by 9,329 · see citing works
SUS: A 'Quick and Dirty' Usability Scale
(1996) · Usability Evaluation In Industry · doi:10.1201/9781498710411-35 · Cited by 8,989 · see citing works
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials
Chan, A.-W., Tetzlaff, J. M., Gotzsche, P. C., Altman, D. G., Mann, H., Berlin, J. A., Dickersin, K., Hrobjartsson, A., Schulz, K. F., Parulekar, W. R., et al. (2013) · BMJ · doi:10.1136/bmj.e7586 · Cited by 6,251 · see citing works
An Empirical Evaluation of the System Usability Scale
Bangor, A., Kortum, P. T., & Miller, J. T. (2008) · International Journal of Human–Computer Interaction · doi:10.1080/10447310802205776 · Cited by 5,181 · see citing works
Rush, A. J., Trivedi, M. H., Ibrahim, H. M., Carmody, T. J., Arnow, B., Klein, D. N., Markowitz, J. C., Ninan, P. T., Kornstein, S., Manber, R., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01866-8 · Cited by 3,829 · see citing works
(2001) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2001.tb01222.x · Cited by 3,515 · see citing works
Lecrubier, Y., Sheehan, D., Weiller, E., Amorim, P., Bonora, I., Sheehan, K. H., Janavs, J., & Dunbar, G. (1997) · European Psychiatry · doi:10.1016/s0924-9338(97)83296-8 · Cited by 3,513 · see citing works
Psychometric properties of the credibility/expectancy questionnaire
Devilly, G. J., & Borkovec, T. D. (2000) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/s0005-7916(00)00012-4 · Cited by 2,295 · cited 3× · see citing works
“Patients’ expectancy of treatment will be assessed with the credibility and expectancy questionnaire (CEQ) of Devilly and Borkovec [41] at baseline.”
MethodInfluentialCost of disorders of the brain in Europe 2010
Gustavsson, A., Svensson, M., Jacobi, F., Allgulander, C., Alonso, J., Beghi, E., Dodel, R., Ekman, M., Faravelli, C., Fratiglioni, L., et al. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.08.008 · Cited by 1,723 · see citing works
The economic cost of brain disorders in Europe
Olesen, J., Gustavsson, A., Svensson, M., Wittchen, H., & Jönsson, B. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2011.03590.x · Cited by 1,560 · see citing works
Computer-based psychological treatments for depression: A systematic review and meta-analysis
Richards, D., & Richardson, T. (2012) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.02.004 · Cited by 1,442 · see citing works
Development and validation of a revised short version of the working alliance inventory
Hatcher, R. L., & Gillaspy, J. A. (2006) · Psychotherapy Research · doi:10.1080/10503300500352500 · Cited by 1,355 · see citing works
Monitoring Depression Treatment Outcomes With the Patient Health Questionnaire-9
L??we, B., Un??tzer, J., Callahan, C. M., Perkins, A. J., & Kroenke, K. (2004) · Medical Care · doi:10.1097/00005650-200412000-00006 · Cited by 1,354 · see citing works
Gilbody, S., Richards, D., Brealey, S., & Hewitt, C. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-007-0333-y · Cited by 1,290 · see citing works
Rebooting psychotherapy research and practice to reduce the burden of mental illness
Kazdin, A. E., & Blase, S. L. (2011) · Perspectives on Psychological Science · doi:10.1177/1745691610393527 · Cited by 1,254 · see citing works
Cuijpers, P., Berking, M., Andersson, G., Quigley, L., Kleiboer, A., & Dobson, K. S. (2013) · The Canadian Journal of Psychiatry · doi:10.1177/070674371305800702 · Cited by 1,066 · see citing works
Self-citationCost‐effectiveness acceptability curves – facts, fallacies and frequently asked questions
Fenwick, E. A. L., OʼBrien, B. J., & Briggs, A. H. (2004) · Health Economics · doi:10.1002/hec.903 · Cited by 946 · see citing works
Assessment of patient satisfaction: Development and refinement of a Service Evaluation Questionnaire
Nguyen, T. D., Attkisson, C. C., & Stegner, B. L. (1983) · Evaluation and Program Planning · doi:10.1016/0149-7189(83)90010-1 · Cited by 736 · see citing works
Cuijpers, P., Vogelzangs, N., Twisk, J., Kleiboer, A., Li, J., & Penninx, B. W. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13030325 · Cited by 677 · see citing works
Self-citationPrevalence and clinical course of depression: a review
Richards, D. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2011.07.004 · Cited by 623 · see citing works
Black, W. C. (1990) · Medical Decision Making · doi:10.1177/0272989x9001000308 · Cited by 578 · see citing works
Sobocki, P., Jönsson, B., Angst, J., & Rehnberg, C. (2006) · PubMed · Cited by 533 · see citing works
Diagnostic accuracy of the mood module of the patient health questionnaire: a systematic review
Wittkampf, K. A., Naeije, L., Schene, A. H., Huyser, J., & van Weert, H. C. (2007) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.06.004 · Cited by 493 · see citing works
Through the looking glass: understanding non-inferiority
Schumi, J., & Wittes, J. T. (2011) · Trials · doi:10.1186/1745-6215-12-106 · Cited by 446 · see citing works
Shortfall in mental health service utilisation
Andrews, G., Issakidis, C., & Carter, G. (2001) · British Journal of Psychiatry · doi:10.1192/bjp.179.5.417 · Cited by 420 · see citing works
(2006) · PubMed · Cited by 387 · see citing works
Self-citationMixing Online and Face-to-Face Therapy: How to Benefit From Blended Care in Mental Health Care
Wentzel, J., van der Vaart, R., Bohlmeijer, E. T., & van Gemert-Pijnen, J. E. W. C. (2016) · JMIR Mental Health · doi:10.2196/mental.4534 · Cited by 371 · see citing works
Willan, A. R., Briggs, A. H., & Hoch, J. S. (2004) · Health Economics · doi:10.1002/hec.843 · Cited by 364 · see citing works
Test-retest reliability of health state valuations collected with the EuroQol questionnaire
van Agt, H. M. E., Essink‐Bot, M., Krabbe, P. F. M., & Bonsel, G. J. (1994) · Social Science & Medicine · doi:10.1016/0277-9536(94)90005-1 · Cited by 343 · see citing works
Psychotherapy for chronic major depression and dysthymia: A meta-analysis
Cuijpers, P., van Straten, A., Schuurmans, J., van Oppen, P., Hollon, S. D., & Andersson, G. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.09.003 · Cited by 320 · see citing works
Self-citationCuijpers, P., van Straten, A., Warmerdam, L., & Andersson, G. (2009) · Depression and Anxiety · doi:10.1002/da.20519 · Cited by 281 · see citing works
Self-citationvan der Vaart, R., Witting, M., Riper, H., Kooistra, L., Bohlmeijer, E. T., & van Gemert-Pijnen, L. J. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0355-z · Cited by 273 · see citing works
Self-citationCuijpers, P., Turner, E. H., Koole, S. L., van Dijke, A., & Smit, F. (2014) · Depression and Anxiety · doi:10.1002/da.22249 · Cited by 242 · see citing works
Self-citationCuijpers, P., van Straten, A., van Oppen, P., & Andersson, G. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n1102 · Cited by 219 · see citing works
Self-citationMental health research priorities for Europe
Wykes, T., Haro, J. M., Belli, S. R., Obradors-Tarragó, C., Arango, C., Ayuso-Mateos, J. L., Bitter, I., Brunn, M., Chevreul, K., Demotes-Mainard, J., et al. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00332-6 · Cited by 218 · see citing works
Self-citationBeattie, A., Shaw, A., Kaur, S., & Kessler, D. (2009) · Health Expectations · doi:10.1111/j.1369-7625.2008.00531.x · Cited by 170 · cited 1× · see citing works
“Patients often present with complex clinical problems and may need more intensive guidance than Internet-based treatments alone are able to offer [24].”
BackgroundInternet-supported versus face-to-face cognitive behavior therapy for depression
Andersson, G., Topooco, N., Havik, O., & Nordgreen, T. (2016) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1125783 · Cited by 117 · see citing works
Self-citationKooistra, L. C., Wiersma, J. E., Ruwaard, J., van Oppen, P., Smit, F., Lokkerbol, J., Cuijpers, P., & Riper, H. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0290-z · Cited by 82 · see citing works
Self-citationSpijker, J., Bijl, R. V., de Graaf, R., & Nolen, W. A. (2001) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2001.00363.x · Cited by 82 · see citing works
Evans-Lacko, S. E., & Knapp, M. R. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091053 · Cited by 51 · see citing works
Krieger, T., Meyer, B., Sude, K., Urech, A., Maercker, A. R. A., & Berger, T. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0285-9 · Cited by 33 · see citing works
Self-citationMontero-Marín, J., Carrasco, J. M., Roca, M., Serrano-Blanco, A., Gili, M., Mayoral, F., Luciano, J. V., Lopez-del-Hoyo, Y., Olivan, B., Collazo, F., et al. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-64 · Cited by 26 · see citing works
Self-citationdel Hoyo, Y. L., Oliván‐Blázquez, B., Luciano, J. V., Mayoral, F., Roca, M., Gili, M., Andres, E. M., Serrano‐Blanco, A., Collazo, F., Araya, R., et al. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-21 · Cited by 22 · see citing works
Self-citationPsychotherapy for mental illness in Europe: An exploration on the evidence base and the status quo
Woelbert, E. (2015) · Joint Research Centre (European Commission) · doi:10.2788/25206 · Cited by 6 · see citing works
Flagged first, then by citations
2 of the 53 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [49]Food Drug Administration (FDA) International conference on harmonization, good clinical practice: consolidated guidelines Fed Regist 1997 62 25692 709
Cited by
Sorted by citations
Karyotaki, E., Efthimiou, O., Miguel, C., Maas genannt Bermpohl, F., Furukawa, T. A., Cuijpers, P., Individual Patient Data Meta-Analyses for Depression (IPDMA-DE) Collaboration, Riper, H., Patel, V., Mira, A., et al. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.4364 · Cited by 866 · see citing works
Self-citationErbe, D., Eichert, H.-C., Riper, H., & Ebert, D. D. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.6588 · Cited by 532 · see citing works
Self-citationEbert, D. D., Van Daele, T., Nordgreen, T., Karekla, M., Compare, A., Zarbo, C., Brugnera, A., Øverland, S., Trebbi, G., Jensen, K. L., et al. (2018) · European Psychologist · doi:10.1027/1016-9040/a000318 · Cited by 437 · see citing works
Self-citationJosephine, K., Josefine, L., Philipp, D., David, E., & Harald, B. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.021 · Cited by 341 · see citing works
Internet interventions: Past, present and future
Andersson, G. (2018) · Internet Interventions · doi:10.1016/j.invent.2018.03.008 · Cited by 315 · see citing works
“With regard to format, we have over the years done trials on smartphone-administration (Ly et al., 2014) and blended treatments (Ly et al., 2015b), and also been involved in EU-projects in this field (Kleiboer et al., 2016).”
MethodSelf-citationAttitudes towards digital treatment for depression: A European stakeholder survey
Topooco, N., Riper, H., Araya, R., Berking, M., Brunn, M., Chevreul, K., Cieslak, R., Ebert, D. D., Etchmendy, E., Herrero, R., et al. (2017) · Internet Interventions · doi:10.1016/j.invent.2017.01.001 · Cited by 262 · see citing works
Self-citationVis, C., Mol, M., Kleiboer, A., Bührmann, L., Finch, T., Smit, J., & Riper, H. (2018) · JMIR Mental Health · doi:10.2196/mental.9769 · Cited by 183 · see citing works
Self-citationTitzler, I., Saruhanjan, K., Berking, M., Riper, H., & Ebert, D. D. (2018) · Internet Interventions · doi:10.1016/j.invent.2018.01.002 · Cited by 176 · see citing works
Self-citationE-Health Practices and Technologies: A Systematic Review from 2014 to 2019
da Fonseca, M. H., Kovaleski, F., Picinin, C. T., Pedroso, B., & Rubbo, P. (2021) · Healthcare · doi:10.3390/healthcare9091192 · Cited by 176 · see citing works
Berger, T., Krieger, T., Sude, K., Meyer, B., & Maercker, A. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.021 · Cited by 153 · see citing works
Self-citationPaganini, S., Teigelkötter, W., Buntrock, C., & Baumeister, H. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.018 · Cited by 144 · see citing works
Schuster, R., Pokorny, R., Berger, T., Topooco, N., & Laireiter, A.-R. (2018) · Journal of Medical Internet Research · doi:10.2196/11007 · Cited by 121 · see citing works
Self-citationFrom Research to Practice: Ten Lessons in Delivering Digital Mental Health Services
Titov, N., Hadjistavropoulos, H. D., Nielssen, O. B., Mohr, D. C., Andersson, G., & Dear, B. F. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081239 · Cited by 117 · see citing works
Self-citationCuijpers, P., Kleiboer, A., Karyotaki, E., & Riper, H. (2017) · Depression and Anxiety · doi:10.1002/da.22641 · Cited by 112 · see citing works
Self-citationMol, M., van Schaik, A., Dozeman, E., Ruwaard, J., Vis, C., Ebert, D. D., Etzelmueller, A., Mathiasen, K., Moles, B., Mora, T., et al. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02627-8 · Cited by 92 · see citing works
Self-citationKooistra, L. C., Wiersma, J. E., Ruwaard, J., Neijenhuijs, K., Lokkerbol, J., van Oppen, P., Smit, F., & Riper, H. (2019) · Journal of Medical Internet Research · doi:10.2196/14261 · Cited by 84 · see citing works
Self-citationTopooco, N., Berg, M., Johansson, S., Liljethörn, L., Radvogin, E., Vlaescu, G., Nordgren, L. B., Zetterqvist, M., & Andersson, G. (2018) · BJPsych Open · doi:10.1192/bjo.2018.18 · Cited by 90 · see citing works
Self-citationTopooco, N., Byléhn, S., Nysäter, E. D., Holmlund, J., Lindegaard, J., Johansson, S., Åberg, L., Nordgren, L. B., Zetterqvist, M., & Andersson, G. (2019) · Journal of Medical Internet Research · doi:10.2196/13393 · Cited by 93 · see citing works
Self-citationHerrero, R., Vara, M. D., Miragall, M., Botella, C., García-Palacios, A., Riper, H., Kleiboer, A., & Baños, R. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17176169 · Cited by 81 · see citing works
Self-citationAchilles, M. R., Anderson, M., Li, S., Subotic-Kerry, M., Parker, B., & O’Dea, B. (2020) · Digital Health · doi:10.1177/2055207620926064 · Cited by 77 · see citing works
Milgrom, J., Danaher, B., Seeley, J., Holt, C. J., Holt, C., Ericksen, J., Tyler, M. S., Gau, J. M., & Gemmill, A. W. (2020) · Journal of Medical Internet Research · doi:10.2196/17185 · Cited by 69 · see citing works
Dorow, M., Löbner, M., Pabst, A., Stein, J., & Riedel-Heller, S. G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00181 · Cited by 80 · see citing works
Bennion, M. R., Hardy, G. E., Moore, R. K., Kellett, S., & Millings, A. (2020) · Journal of Medical Internet Research · doi:10.2196/16794 · Cited by 68 · see citing works
“Therefore, despite partially considering aspects of acceptability, usability, and satisfaction, it is rare for e-therapy studies to use the full array of international standards and associated validated instruments of usability, but there are some examples of good practice [17,18].”
BackgroundSchuster, R., Topooco, N., Keller, A., Radvogin, E., & Laireiter, A.-R. (2020) · Internet Interventions · doi:10.1016/j.invent.2020.100326 · Cited by 77 · see citing works
Self-citationEbert, D. D., Harrer, M., Apolinário-Hagen, J., & Baumeister, H. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-32-9721-0_29 · Cited by 76 · see citing works
Self-citationEtzelmueller, A., Radkovsky, A., Hannig, W., Berking, M., & Ebert, D. D. (2018) · Internet Interventions · doi:10.1016/j.invent.2018.01.003 · Cited by 75 · see citing works
Self-citationRamos, G., Hernandez-Ramos, R., Taylor, M. E., & Schueller, S. M. (2024) · Behavior Therapy · doi:10.1016/j.beth.2024.04.004 · Cited by 64 · see citing works
Mol, M., van Genugten, C., Dozeman, E., van Schaik, D. J. F., Draisma, S., Riper, H., & Smit, J. H. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010091 · Cited by 61 · see citing works
Self-citationWorking alliance as a predictor of change in depression during blended cognitive behaviour therapy
Vernmark, K., Hesser, H., Topooco, N., Berger, T., Riper, H., Luuk, L., Backlund, L., Carlbring, P., & Andersson, G. (2019) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2018.1533577 · Cited by 59 · see citing works
Self-citationProbst, G. H., Berger, T., & Flückiger, C. (2022) · Verhaltenstherapie · doi:10.1159/000503432 · Cited by 54 · see citing works
Self-citationThe 9-year clinical course of depressive and anxiety disorders: New NESDA findings
Solis, E. C., van Hemert, A. M., Carlier, I. V. E., Wardenaar, K. J., Schoevers, R. A., Beekman, A. T. F., Penninx, B. W. J. H., & Giltay, E. J. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.08.108 · Cited by 50 · see citing works
Kemmeren, L., van Schaik, A., Riper, H. M., Kleiboer, A. M., Bosmans, J. E., & Smit, J. H. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0818-5 · Cited by 49 · see citing works
Self-citationUrech, A., Krieger, T., Möseneder, L., Biaggi, A., Vincent, A., Poppe, C., Meyer, B., Riper, H., & Berger, T. (2019) · Psychotherapy Research · doi:10.1080/10503307.2018.1430910 · Cited by 43 · see citing works
Self-citationSchuster, R., Leitner, I., Carlbring, P., & Laireiter, A.-R. (2017) · Internet Interventions · doi:10.1016/j.invent.2017.04.001 · Cited by 42 · see citing works
Blended CBT versus face-to-face CBT: a randomised non-inferiority trial
Mathiasen, K., Andersen, T. E., Riper, H. M., Kleiboer, A. M., & Roessler, K. K. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-1140-y · Cited by 42 · see citing works
Self-citationZwerenz, R., Baumgarten, C., Becker, J., Tibubos, A. N., Siepmann, M., Knickenberg, R. J., & Beutel, M. E. (2019) · Journal of Medical Internet Research · doi:10.2196/13655 · Cited by 42 · see citing works
Bremer, V., Becker, D., Kolovos, S., Funk, B., van Breda, W., Hoogendoorn, M., & Riper, H. M. (2018) · Journal of Medical Internet Research · doi:10.2196/10275 · Cited by 41 · see citing works
Self-citationBorjalilu, S., Mazaheri, M. A., & Talebpour, A. (2019) · Iranian Journal of Psychiatry and Behavioral Sciences · doi:10.5812/ijpbs.84726 · Cited by 40 · see citing works
Kemmeren, L. L., van Schaik, A., Smit, J. H., Ruwaard, J., Rocha, A., Henriques, M., Ebert, D. D., Titzler, I., Hazo, J.-B., Dorsey, M., et al. (2019) · JMIR Mental Health · doi:10.2196/12707 · Cited by 36 · see citing works
Self-citationMathiasen, K., Andersen, T. E., Lichtenstein, M. B., Ehlers, L. H., Riper, H., Kleiboer, A., & Roessler, K. K. (2022) · Journal of Medical Internet Research · doi:10.2196/36577 · Cited by 34 · see citing works
Self-citationSchuster, R., Sigl, S., Berger, T., & Laireiter, A.-R. (2018) · JMIR Mental Health · doi:10.2196/mental.9613 · Cited by 28 · see citing works
Self-citationMikus, A., Hoogendoorn, M., Rocha, A., Gama, J., Ruwaard, J., & Riper, H. (2018) · Internet Interventions · doi:10.1016/j.invent.2017.10.001 · Cited by 31 · see citing works
Baumeister, H., Bauereiss, N., Zarski, A.-C., Braun, L., Buntrock, C., Hoherz, C., Idrees, A. R., Kraft, R., Meyer, P., Nguyen, T. B. D., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.660534 · Cited by 30 · see citing works
Self-citationvan Ballegooijen, W., Ruwaard, J., Karyotaki, E., Ebert, D. D., Smit, J. H., & Riper, H. M. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-1065-5 · Cited by 32 · see citing works
Self-citationKooistra, L., Ruwaard, J., Wiersma, J., van Oppen, P., & Riper, H. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020347 · Cited by 30 · see citing works
Self-citationCerga-Pashoja, A., Doukani, A., Gega, L., Walke, J., & Araya, R. (2020) · Psychotherapy Research · doi:10.1080/10503307.2020.1720932 · Cited by 30 · see citing works
Self-citationMendes-Santos, C., Weiderpass, E., Santana, R., & Andersson, G. (2019) · Internet Interventions · doi:10.1016/j.invent.2019.01.004 · Cited by 24 · see citing works
Self-citationSchuster, R., Kalthoff, I., Walther, A., Köhldorfer, L., Partinger, E., Berger, T., & Laireiter, A.-R. (2019) · Journal of Medical Internet Research · doi:10.2196/11860 · Cited by 25 · see citing works
Self-citationULTEMAT: A mobile framework for smart ecological momentary assessments and interventions
van de Ven, P., O’Brien, H., Henriques, R., Klein, M., Msetfi, R., Nelson, J., Rocha, A., Ruwaard, J., O’Sullivan, D., & Riper, H. (2017) · Internet Interventions · doi:10.1016/j.invent.2017.07.001 · Cited by 26 · see citing works
Self-citationTitzler, I., Berking, M., Schlicker, S., Riper, H., & Ebert, D. D. (2020) · JMIR Mental Health · doi:10.2196/18642 · Cited by 25 · see citing works
Self-citationEnriching Mental Health Mobile Assessment and Intervention with Situation Awareness
Teles, A. S., Rocha, A., Silva, F., Lopes, J. C., O’Sullivan, D., van de Ven, P. W. J., & Endler, M. (2017) · Sensors · doi:10.3390/s17010127 · Cited by 26 · see citing works
(2024) · doi:10.2196/47515 · Cited by 24 · see citing works
Self-citationSchuster, R., Laireiter, A., Berger, T., Moritz, S., Meyer, B., Hohagen, F., & Klein, J. P. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.05.122 · Cited by 22 · see citing works
Self-citationSchuster, R., Fichtenbauer, I., Sparr, V. M., Berger, T., & Laireiter, A.-R. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-018412 · Cited by 23 · see citing works
Self-citationKemmeren, L. L., van Schaik, A., Draisma, S., Kleiboer, A., Riper, H., & Smit, J. H. (2023) · Cognitive Therapy and Research · doi:10.1007/s10608-023-10363-y · Cited by 22 · see citing works
Self-citationAskjer, S., & Mathiasen, K. (2021) · Internet Interventions · doi:10.1016/j.invent.2021.100404 · Cited by 18 · see citing works
Mohr, D. C., Silverman, A. L., Youn, S. J., Areán, P. A., Bertagnolli, A., Carl, J. R., Carlton, T., Chaudhary, N., Cooper, D. E., DeVito, S., et al. (2025) · Frontiers in Digital Health · doi:10.3389/fdgth.2025.1509387 · Cited by 20 · see citing works
E-mental health implementation in inpatient care: Exploring its potential and future challenges
Assche, E. V., Bonroy, B., Mertens, M., den Broeck, L. V., Desie, K., Bolinski, F., Amarti, K., Kleiboer, A. M., Riper, H. M., & Daele, T. V. (2022) · Frontiers in Digital Health · doi:10.3389/fdgth.2022.1027864 · Cited by 20 · see citing works
Self-citationProvoost, S., Kleiboer, A. M., Ornelas, J., Bosse, T., Ruwaard, J., Rocha, A., Cuijpers, P. J., & Riper, H. M. (2020) · Trials · doi:10.1186/s13063-020-04777-2 · Cited by 19 · see citing works
Self-citationSiemer, L., Allouch, S. B., Pieterse, M. E., Brusse-Keizer, M. G. J., Sanderman, R., & Postel, M. G. (2020) · JMIR Formative Research · doi:10.2196/14550 · Cited by 19 · see citing works
Friedl, N., Krieger, T., Chevreul, K., Hazo, J., Holtzmann, J., Hoogendoorn, M., Kleiboer, A. M., Mathiasen, K., Urech, A., Riper, H. M., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020490 · Cited by 19 · see citing works
Self-citation(2020) · Routledge eBooks · doi:10.4324/9780429020537 · Cited by 18 · see citing works
van Genugten, C., Schuurmans, J., Hoogendoorn, A. W., Araya, R., Andersson, G., Baños, R., Berger, T., Botella, C., Pashoja, A. C., Cieślak, R., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.755809 · Cited by 18 · see citing works
Self-citationProbst, G. H., Berger, T., & Flückiger, C. (2019) · Verhaltenstherapie · doi:10.1159/000501565 · Cited by 18 · see citing works
Self-citationKeller, F. M., Dahmen, A., Derksen, C., Kötting, L., & Lippke, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18178936 · Cited by 19 · see citing works
Vernmark, K., Buhrman, M., Carlbring, P., Hedman‐Lagerlöf, E., Kaldo, V., & Andersson, G. (2024) · Digital Health · doi:10.1177/20552076241287059 · Cited by 19 · see citing works
Self-citationYrondi, A., Bennabi, D., Haffen, É., Garnier, M., Bellivier, F., Bourgerol, T., Camus, V., d’Amato, T., Doumy, O., Haesebaert, F., et al. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00244 · Cited by 17 · see citing works
Kerber, A., Schaeuffele, C., Krieger, T., Urech, A., Riper, H. M., Berger, T., Boettcher, J., & Knaevelsrud, C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.648367 · Cited by 16 · see citing works
Self-citationPérez, J. C., Fernández, O., Cáceres, C., Carrasco, A. S., Moessner, M., Bauer, S., Espinosa-Duque, D., Gloger, S., & Krause, M. (2021) · JMIR Mental Health · doi:10.2196/26814 · Cited by 20 · see citing works
Doukani, A., Free, C., Michelson, D., Araya, R., Montero‐Marín, J., Smith, S. C., Pashoja, A. C., & Kakuma, R. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-036299 · Cited by 17 · see citing works
Self-citationDoukani, A., Free, C., Araya, R., Michelson, D., Cerga-Pashoja, A., & Kakuma, R. (2022) · BJPsych Open · doi:10.1192/bjo.2022.546 · Cited by 15 · see citing works
Self-citationMacLean, S. E., Corsi, D. J., Litchfield, S., Kucharski, J., Genise, K., Selaman, Z., Testa, V., & Hatcher, S. (2019) · Journal of Medical Internet Research · doi:10.2196/15001 · Cited by 15 · see citing works
Topooco, N. (2018) · doi:10.3384/diss.diva-148016 · Cited by 15 · see citing works
Self-citationBlended Smoking Cessation Treatment: Exploring Measurement, Levels, and Predictors of Adherence
Siemer, L., Brusse-Keizer, M. G. J., Postel, M. G., Allouch, S. B., Bougioukas, A. P., Sanderman, R., & Pieterse, M. E. (2018) · Journal of Medical Internet Research · doi:10.2196/jmir.9969 · Cited by 14 · see citing works
Bielinski, L. L., & Berger, T. (2020) · Counseling Psychology and Psychotherapy · doi:10.17759/cpp.2020280305 · Cited by 14 · see citing works
Self-citationvan Genugten, C., Schuurmans, J., van Ballegooijen, W., Hoogendoorn, A. W., Smit, J. H., & Riper, H. M. (2021) · Internet Interventions · doi:10.1016/j.invent.2021.100437 · Cited by 14 · see citing works
Self-citationShams, F., Tai, A. M. Y., Kim, J., Boyd, M., Meyer, M., Kazemi, A., & Krausz, R. M. (2023) · Digital Health · doi:10.1177/20552076231203876 · Cited by 14 · see citing works
Siemer, L., Brusse-Keizer, M. G. J., Postel, M. G., Allouch, S. B., Sanderman, R., & Pieterse, M. E. (2020) · Journal of Medical Internet Research · doi:10.2196/17207 · Cited by 13 · see citing works
E-Health in Diagnostik und Therapie psychischer Störungen
Lüttke, S., Hautzinger, M., & Fuhr, K. (2018) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-017-2684-9 · Cited by 13 · see citing works
MacLean, S. E., & Hatcher, S. (2019) · Frontiers in Communication · doi:10.3389/fcomm.2019.00052 · Cited by 25 · see citing works
Internetbasierte Therapie in der Versorgung von Patienten mit depressiven Störungen: Ein Überblick
Backenstrass, M., & Wolf, M. (2018) · Zeitschrift für Psychiatrie Psychologie und Psychotherapie · doi:10.1024/1661-4747/a000339 · Cited by 8 · see citing works
Internet-Interventionen: Ein Überblick
Berger, T., & Krieger, T. (2018) · PiD - Psychotherapie im Dialog · doi:10.1055/a-0592-0282 · Cited by 12 · see citing works
Self-citationLungu, A., Wickham, R. E., Chen, S.-Y., Jun, J. J., Leykin, Y., & Chen, C. E.-J. (2022) · Internet Interventions · doi:10.1016/j.invent.2022.100536 · Cited by 11 · see citing works
van Genugten, C. V., Schuurmans, J., Hoogendoorn, A., Araya, R., Andersson, G., Baños, R., Botella, C., Cerga-Pashoja, A., Cieślak, R., Ebert, D., et al. (2021) · JMIR Mental Health · doi:10.2196/32007 · Cited by 13 · see citing works
Self-citationDepression in Central and Eastern Europe: How Much It Costs? Cost of Depression in Romania
Iordache, M. M., Sorici, C. O., Aivaz, K.-A., Lupu, C. E., Dumitru, A., Tocia, C., & Dumitru, E. (2023) · Healthcare · doi:10.3390/healthcare11060921 · Cited by 11 · see citing works
Computer und Psychotherapie – geht das zusammen?
Schuster, R., Berger, T., & Laireiter, A. (2017) · Psychotherapeut · doi:10.1007/s00278-017-0214-8 · Cited by 10 · see citing works
Self-citationKann die Online-Therapie die Psychotherapie sinnvoll ergänzen? Pro
Hautzinger, M., & Fuhr, K. (2017) · Der Nervenarzt · doi:10.1007/s00115-017-0379-y · Cited by 10 · see citing works
Titzler, I., Egle, V., Berking, M., Gumbmann, C., & Ebert, D. D. (2019) · Verhaltenstherapie · doi:10.1159/000503408 · Cited by 9 · see citing works
Self-citationHatcher, S., Heisel, M. J., Ayonrinde, O., Campbell, J. K., Colman, I., Corsi, D. J., Edgar, N. E., Gillett, L., Kennedy, S. H., Hunt, S. L., et al. (2020) · Trials · doi:10.1186/s13063-020-04424-w · Cited by 6 · see citing works
Blended transdiagnostic group CBT for emotional disorders: A feasibility trial protocol
Díaz‐García, A., González‐Robles, A., García‐Palacios, A., Fernández‐Felipe, I., Tur, C., Castilla, D., & Botella, C. (2021) · Internet Interventions · doi:10.1016/j.invent.2021.100363 · Cited by 8 · see citing works
Self-citationMellentin, A. I., Behrendt, S., Bilberg, R., Blankers, M., Folker, M. P., Tarp, K., Uffelmann, J., & Nielsen, A. S. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03122-4 · Cited by 8 · see citing works
A systematic quality rating of available mobile health apps for borderline personality disorder
Steubl, L., Reimann, J., Simon, L., Terhorst, Y., Stach, M., Baumeister, H., Sander, L., & Meßner, E.-M. (2022) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-022-00186-w · Cited by 7 · see citing works
Rocha, A., Camacho, R., Ruwaard, J., & Riper, H. (2018) · Internet Interventions · doi:10.1016/j.invent.2018.03.003 · Cited by 7 · see citing works
Oudshoorn, C. E. M., Frielink, N., Riper, H. M., & Embregts, P. J. C. M. (2022) · Journal of Intellectual Disability Research · doi:10.1111/jir.12986 · Cited by 7 · see citing works
Self-citationTechnological Interventions for Emotion Regulation
Fernández‐Álvarez, J., Díaz‐García, A., Colombo, D., Botella, C., Cipresso, P., & Riva, G. (2020) · Comprehensive Clinical Psychology · doi:10.1016/b978-0-12-818697-8.00033-9 · Cited by 8 · see citing works
Self-citationBoumparis, N., Schulte, M. H. J., Kleiboer, A. M., Huizink, A. C., & Riper, H. M. (2021) · JMIR Research Protocols · doi:10.2196/29750 · Cited by 6 · see citing works
Self-citationSteubl, L., & Baumeister, H. (2023) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-022-03644-6 · Cited by 6 · see citing works
Does it blend? Exploring therapist fidelity in blended CBT for anxiety disorders
Romijn, G., Provoost, S., Batelaan, N. M., Koning, J., van Balkom, A. J. L. M., & Riper, H. M. (2021) · Internet Interventions · doi:10.1016/j.invent.2021.100418 · Cited by 5 · see citing works
Self-citationBremer, V., Funk, B., & Riper, H. M. (2019) · Depression Research and Treatment · doi:10.1155/2019/3481624 · Cited by 7 · see citing works
Self-citation
- Authors
- Kleiboer, A., Smit, J., Bosmans, J., Ruwaard, J., Andersson, G., Topooco, N., Berger, T., Krieger, T., Botella, C., Baños, R., Chevreul, K., Araya, R., Cerga-Pashoja, A., Cieślak, R., Rogala, A., Vis, C., Draisma, S., van Schaik, A., Kemmeren, L., Ebert, D., Berking, M., Funk, B., Cuijpers, P., & Riper, H.
- Affiliations
- Amsterdam Public Health (NL)
- Linköping University (SE)
- University of Bern (CH)
- Universitat Jaume I (ES)
- Assistance Publique – Hôpitaux de Paris (FR)
- London School of Hygiene & Tropical Medicine (GB)
- Uniwersytet SWPS (PL)
- Philipps University of Marburg (DE)
- Leuphana University of Lüneburg (DE)
- Corresponding author
- Kleiboer, Annet
- ORCID
- Kleiboer, Annet
- Bosmans, Judith
- Ruwaard, Jeroen
- Andersson, Gerhard
- Topooco, Naira
- Berger, Thomas
- Krieger, Tobias
- Botella, Cristina
- Baños, Rosa
- Chevreul, Karine
- Araya, Ricardo
- Cieślak, Roman
- Rogala, Anna
- Vis, Christiaan
- Draisma, Stasja
- Kemmeren, Lise
- Ebert, David
- Berking, Matthias
- Funk, Burkhardt
- Cuijpers, Pim
- Riper, Heleen
- Venue
- Trials
- Published
- 2016-08-03
- Volume
- 17
- Issue
- 1
- Pages
- 387-387
- ISSN
- 1745-6215 (ISSN-L)
- PMC
- PMC4972947
- OpenAlex
- W2500628273
- Cited by
- 133
- References
- 53
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 13 · 2021: 18 · 2020: 25 · 2019: 17 · 2018: 20 · 2017: 20 · 2016: 3
- FWCI
- 30.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Trials (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Multilingual Matters (Channel View Publications) (publishedVersion, cc-by)
- VU Research Portal (publishedVersion, other-oa)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Repositori UJI (Universitat Jaume I) (submittedVersion, other-oa)
- DiVA (Linkoping University) (submittedVersion, other-oa)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-sa)
- Research Portal (King's College London) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Seventh Framework Programme (603098)
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Telemedicine and Telehealth Implementation
- Keywords
- major depressive disorder, online therapy, mobile health, face-to-face psychotherapy, usual care, primary care, specialized mental health care, cost-effectiveness, non-inferiority, depression remission, PHQ-9, pragmatic trials, digital mental health interventions
- MeSH terms
- Equivalence Trials as Topic, Clinical Protocols, Cost-Benefit Analysis, Major Depressive Disorder, Europe, Humans, Primary Health Care, Surveys and Questionnaires, Remission Induction, Research Design, Therapy, Computer-Assisted, Time Factors, Cognitive Behavioral Therapy, Treatment Outcome, Health Care Costs, Internet, Comparative Effectiveness Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
