Cited by 204Muscle Physiology and DisordersNutrition and Health in AgingMuscle metabolism and nutrition

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Muscle metabolism and atrophy: let’s talk about sex

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Rosa-Caldwell, Megan E., Greene, Nicholas P.·2019·Biology of Sex Differences

DOI 10.1186/s13293-019-0257-3PMC PMC6714453

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Abstract

Skeletal muscle health is a strong predictor of overall health and longevity. Pathologies affecting skeletal muscle such as cancer cachexia, intensive care unit treatment, muscular dystrophies, and others are associated with decreased quality of life and increased mortality. Recent research has begun to determine that these muscular pathologies appear to present and develop differently between males and females. However, to our knowledge, there has yet to be a comprehensive review on musculoskeletal differences between males and females and how these differences may contribute to sex differences in muscle pathologies. Herein, we present a review of the current literature on muscle phenotype and physiology between males and females and how these differences may contribute to differential responses to atrophic stimuli. In general, females appear to be more susceptible to disuse induced muscle wasting, yet protected from inflammation induced (such as cancer cachexia) muscle wasting compared to males. These differences may be due in part to differences in muscle protein turnover, satellite cell content and proliferation, hormonal interactions, and mitochondrial differences between males and females. However, more works specifically examining muscle pathologies in females are necessary to more fully understand the inherent sex-based differences in muscle pathologies between the sexes and how they may correspond to different clinical treatments.

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Fig. 1 Summary of current literature of sex differences and similarities of muscle phenotype in males and femalesCC BY · PubMed Central

Fig. 2 Summary of the current literature of classical sex hormones and their influence on muscle size.CC BY · PubMed Central

Fig. 3 Summary of current data on mitochondrial differences between males and females as well as mitochondrial interventions for disuse atrophyCC BY · PubMed Central

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A randomized trial of adjunct testosterone for cancer‐related muscle loss in men and women
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Testosterone Treatment Results in Quiescent Satellite Cells Being Activated and Recruited into Cell Cycle in Rat Levator Ani Muscle
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Authors: Rosa-Caldwell, M. E., & Greene, N. P.
Affiliations: University of Arkansas at Fayetteville (US)
Corresponding author: Greene, Nicholas P.
ORCID: Greene, Nicholas P.
Venue: Biology of Sex Differences
Publisher: Springer Science and Business Media LLC
Published: 2019-08-28
Volume: 10
Issue: 1
Pages: 43-43
ISSN: 2042-6410 (ISSN-L)
DOI: 10.1186/s13293-019-0257-3
PMC: PMC6714453
OpenAlex: W2971287565
Cited by: 202
References: 199
Citations by year: 2026: 18 · 2025: 26 · 2024: 23 · 2023: 49 · 2022: 32 · 2021: 32 · 2020: 18 · 2019: 2
FWCI: 1.85
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biology of Sex Differences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (R15 AR069913/AR/NIAMS)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: sex differences, skeletal muscle metabolism, muscle atrophy, cancer cachexia, muscle protein turnover, satellite cells, hormonal differences
MeSH terms: Energy Metabolism, Female, Humans, Male, Muscular Atrophy, Risk Factors, Sex Characteristics, Muscle, Skeletal

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Muscle metabolism and atrophy: let’s talk about sex

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