Recent progress on peripheral neural interface technology towards bioelectronic medicine
Open accessAbstract
Modulation of the peripheral nervous system (PNS) has a great potential for therapeutic intervention as well as restore bodily functions. Recent interest has focused on autonomic nerves, as they regulate extensive functions implicated in organ physiology, chronic disease state and appear tractable to targeted modulation of discrete nerve units. Therapeutic interventions based on specific bioelectronic neuromodulation depend on reliable neural interface to stimulate and record autonomic nerves. Furthermore, the function of stimulation and recording requires energy which should be delivered to the interface. Due to the physiological and anatomical challenges of autonomic nerves, various forms of this active neural interface need to be developed to achieve next generation of neural interface for bioelectronic medicine. In this article, we present an overview of the state-of-the-art for peripheral neural interface technology in relation to autonomic nerves. Also, we reveal the current status of wireless neural interface for peripheral nerve applications. Recent studies of a novel concept of self-sustainable neural interface without battery and electronic components are presented. Finally, the recent results of non-invasive stimulation such as ultrasound and magnetic stimulation are covered and the perspective of the future research direction is provided.
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It is not easy to accurately acquire and interpret nerve signals due to their weak strength and high noise.
“However, it is not easy to accurately acquire and interpret the nerve signals, due to their features of weak strength and high noise (Cho et al. 2020; Xiang et al. 2016a).”
From Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform (2023) · cites this paper as Cho et al. 2020
Monitoring neural electrical signals or neurotransmitters provides insights into physiological and pathological processes, informing the prevention and treatment of neurological disorders.
“Monitoring neural electrical signals or neurotransmitters provides insights into physiological and pathological processes, informing the prevention and treatment of neurological disorders (Cho et al. 2020; Lee, S. et al. 2017; Lee et al. 2022).”
From Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform (2023) · cites this paper as Cho et al. 2020
Implantable neural interfaces have made significant progress in recent years, enabling new opportunities for understanding and interfacing with the nervous system.
“In summary, implantable neural interfaces have made significant progress in recent years, enabling new opportunities for understanding and interfacing with the nervous system (Cho et al. 2020; Lee, Sanghoon et al. 2017; Xiang et al. 2016a).”
From Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform (2023) · cites this paper as Cho et al. 2020
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- Authors
- Cho, Y., Park, J., Lee, C., & Lee, S.
- Affiliations
- Daegu Gyeongbuk Institute of Science and Technology (KR)
- National University of Singapore (SG)
- Corresponding author
- Lee, Chengkuo
- Lee, Sanghoon
- Venue
- Bioelectronic Medicine
- Published
- 2020-11-30
- Volume
- 6
- Issue
- 1
- Pages
- 23-23
- ISSN
- 2332-8886 (ISSN-L)
- PMC
- PMC7706233
- OpenAlex
- W3110418699
- Cited by
- 55
- References
- 63
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 10 · 2023: 11 · 2022: 10 · 2021: 15
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Bioelectronic Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation: Competitive Research Project (NRF-CRP10-2012-01)
- The Agency for Science, Technology and Research (A*STAR), Singapore and Narodowe Centrum Badań i Rozwoju (NCBR), Poland Joint Grant (R-263-000-C91-305)
- DGIST R&D Program of the Ministry of Science and ICT (2020010043)
- National Research Foundation of Korea (NRF) grant funded by the Korea government (NRF-2019R1C1C1008344)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Physical Sciences › Engineering › Biomedical Engineering › Wireless Body Area Networks
- Keywords
- autonomic nerves, neuromodulation, peripheral nerve stimulation, peripheral nerve recording, wireless neural interface, non-invasive stimulation, ultrasound stimulation, magnetic stimulation
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