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Systems Medicine: Physiological Circuits and the Dynamics of Disease

Alon, Uri·2023
DOI 10.1201/9781003356929
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  • The SR model was applied to invertebrates to explain rapid shifts in hazard curves in Drosophila and scaling of survival curves in C. elegans.

    “It was applied to invertebrates to explain rapid shifts in hazard curves in Drosophila and scaling of survival curves in Caenorhabditis elegans2,19.”

    From A damage accumulation model identifies distinct aging regimes across species (2026) · cites this paper as [2]

  • Experiments indicate that damage accelerates with age.

    “Mathematically, if damage did not saturate, that is, if removal was −βx, the steady-state damage would rise linearly with age, whereas experiments indicate that damage accelerates with age2,19,20.”

    From A damage accumulation model identifies distinct aging regimes across species (2026) · cites this paper as [2]

  • The SR model explains many quantitative patterns of aging including Gompertz and Weibull hazard curves, distributions of human frailty index, disease incidence curves and heritability of lifespan.

    “The SR model explains many quantitative patterns of aging including Gompertz and Weibull hazard curves19, distributions of human frailty index2, disease incidence curves31 and heritability of lifespan32.”

    From A damage accumulation model identifies distinct aging regimes across species (2026) · cites this paper as [2]

  • In the quasi-steady-state regime, the hazard curve resembles a Gompertz exponential rise over several decades that slows down at very old ages beyond the median lifespan (Fig. 2k).

    “The hazard curve resembles Gompertz exponential rise over several decades which slows down at very old ages beyond the median lifespan (Fig. 2k)2,19,29.”

    From A damage accumulation model identifies distinct aging regimes across species (2026) · cites this paper as [2]

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Authors
Alon, U.
Publisher
Chapman and Hall/CRC
Published
2023-10-11
DOI
10.1201/9781003356929
Cited by
27
References
6
Language
en

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