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Cited by 354Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Screening for Abnormal Glucose Tolerance in Adolescents with Polycystic Ovary Syndrome

Palmert, Mark R., Gordon, Catherine M., Kartashov, Alex I., Legro, Richard S., Emans, S. Jean, Dunaif, Andrea·2002·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.87.3.8305
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Abstract

Insulin resistance is common in adults with polycystic ovary syndrome (PCOS). Although recent data demonstrate that insulin resistance is present in the early stages of PCOS, the prevalence of insulin resistance in adolescents with PCOS has not been determined. Likewise, the prevalence of impaired glucose tolerance (IGT) or type 2 diabetes mellitus (DM) in adolescent cohorts has not been established. In this study we sought to obtain preliminary data regarding the prevalence of IGT and DM in adolescents with PCOS and to assess the ability of screening tests to predict these abnormalities within this population. Twenty-seven adolescents with PCOS underwent oral glucose tolerance tests. Plasma glucose and insulin levels were obtained at baseline, and glucose was measured 2 h after a 75-g glucose challenge. The 2-h plasma glucose level was used to categorize subjects as having IGT or the provisional diagnosis of DM. Eight of our 27 subjects had IGT, and 1 had previously undiagnosed DM. These abnormalities were seen among lean and obese subjects. Fasting plasma glucose levels and simple measures of insulin resistance were suboptimal predictors of IGT and DM within our cohort. As in adults, our results indicate that adolescents with PCOS are at increased risk for IGT and DM and that the 2-h plasma glucose level after an oral glucose challenge appears to be the most reliable screening test for these abnormalities. Our results need to be corroborated by future studies that determine the prevalence of abnormalities in glucose tolerance among large populations of adolescents, both with and without PCOS. However, as DM may be preventable by lifestyle modifications, we would recommend that adolescents with PCOS undergo periodic screening for abnormal glucose tolerance using 2-h postchallenge plasma glucose levels.

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Crossref · 10.1210/jcem.87.3.8305

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Metadata

Authors
Palmert, M. R., Gordon, C. M., Kartashov, A. I., Legro, R. S., Emans, S. J., & Dunaif, A.
Affiliations
  • Boston Children's Hospital (US)
  • Harvard University (US)
  • Pennsylvania State University (US)
  • Brigham and Women's Hospital (US)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2002-03
Volume
87
Issue
3
Pages
1017-1023
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.87.3.8305
OpenAlex
W2141862257
Cited by
354
References
41
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 10 · 2020: 6 · 2019: 12 · 2018: 8 · 2017: 7 · 2016: 14 · 2015: 21 · 2014: 19 · 2013: 20 · 2012: 34
FWCI
20.68
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Centers for Disease Control and Prevention
  • U.S. Public Health Service (T71-MC00009-09-S1-RO)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK040605)
  • National Center for Research Resources (M01RR010732, M01RR002172, K23RR015544, M01-RR-0265)
  • NIH Clinical Center
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD034449, K24HD001476)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
polycystic ovary syndrome, adolescents, impaired glucose tolerance, type 2 diabetes, insulin resistance, oral glucose tolerance test, fasting blood glucose
MeSH terms
Adolescent, Diabetes Mellitus, Type 1, Female, Glucose Tolerance Test, Humans, Mass Screening, Polycystic Ovary Syndrome, Prevalence, Glucose Intolerance

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