The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Hippo signaling: growth control and beyond
Open accessAbstract
The Hippo pathway has emerged as a conserved signaling pathway that is essential for the proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms of signal transduction of the core kinases Hippo/Mst and Warts/Lats are relatively well understood, less is known about the upstream inputs of the pathway and about the downstream cellular and developmental outputs. Here, we review recently discovered mechanisms that contribute to the dynamic regulation of Hippo signaling during Drosophila and vertebrate development. We also discuss the expanding diversity of Hippo signaling functions during development, discoveries that shed light on a complex regulatory system and provide exciting new insights into the elusive mechanisms that regulate organ growth and regeneration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092
Self-citationA coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF β-TRCP
Zhao, B., Li, L., Tumaneng, K., Wang, C.-Y., & Guan, K.-L. (2010) · Genes & Development · doi:10.1101/gad.1843810 · Cited by 1,418
YAP1 increases organ size and expands undifferentiated progenitor cells
Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252
Justice, R. W., Zilian, O., Woods, D. F., Noll, M., & Bryant, P. J. (1995) · Genes & Development · doi:10.1101/gad.9.5.534 · Cited by 977
Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.015 · Cited by 804
Vassilev, A., Kaneko, K. J., Shu, H., Zhao, Y., & DePamphilis, M. L. (2001) · Genes & Development · doi:10.1101/gad.888601 · Cited by 719
Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways
Alarcón, C., Zaromytidou, A.-I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.035 · Cited by 719
Wu, S., Liu, Y., Zheng, Y., Dong, J., & Pan, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.007 · Cited by 640 · cited 2×
“At the center of the Hippo pathway are two kinases, the Ste20-like kinase Hpo and the nuclear Dbf2-related (NDR) family kinase Wts, that form a kinase cascade (Harvey et al., 2003; Jia et al., 2003; Justice et al., 1995; Pantalacci et al., 2003; Udan et al., 2003; Wu et al., 2003; Xu et al., 1995).”
BackgroundThe TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
Zhang, L., Ren, F., Zhang, Q., Chen, Y., Wang, B., & Jiang, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.006 · Cited by 630
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
Chan, E. H. Y., Nousiainen, M., Chalamalasetty, R. B., Schäfer, A., Nigg, E. A., & Silljé, H. H. W. (2005) · Oncogene · doi:10.1038/sj.onc.1208445 · Cited by 584
Cited by
Mechanisms of hepatic stellate cell activation
Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909
Hippo pathway in organ size control, tissue homeostasis, and cancer
Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell · doi:10.1016/j.cell.2015.10.044 · Cited by 2,206
Liu-Chittenden, Y., Huang, B., Shim, J. S., Chen, Q., Lee, S.-J., Anders, R. A., Liu, J. O., & Pan, D. (2012) · Genes & Development · doi:10.1101/gad.192856.112 · Cited by 1,452
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
Zanconato, F., Forcato, M., Battilana, G., Azzolin, L., Quaranta, E., Bodega, B., Rosato, A., Bicciato, S., Cordenonsi, M., & Piccolo, S. (2015) · Nature Cell Biology · doi:10.1038/ncb3216 · Cited by 1,219
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
Zhao, B., Tumaneng, K., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2303 · Cited by 1,205
Liver regeneration: biological and pathological mechanisms and implications
Michalopoulos, G. K., & Bhushan, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0342-4 · Cited by 998
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Bouhaddou, M., Memon, D., Meyer, B., White, K. M., Rezelj, V. V., Correa Marrero, M., Polacco, B. J., Melnyk, J. E., Ulferts, S., Kaake, R. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.034 · Cited by 1,020
Transduction of mechanical and cytoskeletal cues by YAP and TAZ
Halder, G., Dupont, S., & Piccolo, S. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3416 · Cited by 985
Self-citationHippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
Moya, I. M., & Halder, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0086-y · Cited by 981
Self-citationHippo pathway effector Yap promotes cardiac regeneration
Xin, M., Kim, Y., Sutherland, L. B., Murakami, M., Qi, X., McAnally, J., Porrello, E. R., Mahmoud, A. I., Tan, W., Shelton, J. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313192110 · Cited by 895
E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
Kim, N.-G., Koh, E., Chen, X., & Gumbiner, B. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103345108 · Cited by 698
von Gise, A., Lin, Z., Schlegelmilch, K., Honor, L. B., Pan, G. M., Buck, J. N., Ma, Q., Ishiwata, T., Zhou, B., Camargo, F. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116136109 · Cited by 573
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway
Mo, J.-S., Meng, Z., Kim, Y. C., Park, H. W., Hansen, C. G., Kim, S., Lim, D.-S., & Guan, K.-L. (2015) · Nature Cell Biology · doi:10.1038/ncb3111 · Cited by 557
AMPK modulates Hippo pathway activity to regulate energy homeostasis
Wang, W., Xiao, Z.-D., Li, X., Aziz, K. E., Gan, B., Johnson, R. L., & Chen, J. (2015) · Nature Cell Biology · doi:10.1038/ncb3113 · Cited by 549
Self-citationDecoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state
Verfaillie, A., Imrichova, H., Atak, Z. K., Dewaele, M., Rambow, F., Hulselmans, G., Christiaens, V., Svetlichnyy, D., Luciani, F., Van den Mooter, L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7683 · Cited by 489
Self-citationRole of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction
Dupont, S. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.034 · Cited by 449
Hepatostat: Liver regeneration and normal liver tissue maintenance
Michalopoulos, G. K. (2017) · Hepatology · doi:10.1002/hep.28988 · Cited by 444
Aerobic glycolysis tunes YAP/TAZ transcriptional activity
Enzo, E., Santinon, G., Pocaterra, A., Aragona, M., Bresolin, S., Forcato, M., Grifoni, D., Pession, A., Zanconato, F., Guzzo, G., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201490379 · Cited by 414
The Hippo pathway effector YAP controls mouse hepatic stellate cell activation
Mannaerts, I., Leite, S. B., Verhulst, S., Claerhout, S., Eysackers, N., Thoen, L. F. R., Hoorens, A., Reynaert, H., Halder, G., & van Grunsven, L. A. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.04.011 · Cited by 410
Self-citationRecurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation
Morris, L. G. T., Kaufman, A. M., Gong, Y., Ramaswami, D., Walsh, L. A., Turcan, Ş., Eng, S., Kannan, K., Zou, Y., Peng, L., et al. (2013) · Nature Genetics · doi:10.1038/ng.2538 · Cited by 366
The Hippo-YAP signaling pathway and contact inhibition of growth
Gumbiner, B. M., & Kim, N.-G. (2014) · Journal of Cell Science · doi:10.1242/jcs.140103 · Cited by 339
Tepass, U. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154033 · Cited by 334
YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo
Monroe, T. O., Hill, M. C., Morikawa, Y., Leach, J. P., Heallen, T., Cao, S., Krijger, P. H. L., de Laat, W., Wehrens, X. H. T., Rodney, G. G., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.01.017 · Cited by 289
Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
Ma, B., Chen, Y., Chen, L., Cheng, H., Mu, C., Li, J., Gao, R., Zhou, C., Cao, L., Liu, J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3073 · Cited by 266
Del Re, D. P., Yang, Y., Nakano, N., Cho, J., Zhai, P., Yamamoto, T., Zhang, N., Yabuta, N., Nojima, H., Pan, D., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.436311 · Cited by 249
SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage
Seo, E., Basu-Roy, U., Gunaratne, P. H., Coarfa, C., Lim, D.-S., Basilico, C., & Mansukhani, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.029 · Cited by 216
“Yes-associated protein 1 (YAP1) is a key downstream effector of the Hippo signaling pathway that controls cell proliferation and organ size (Halder and Johnson, 2011; Pan, 2010; Sudol, 1994; Zhao et al., 2010).”
BackgroundRegulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex
Liang, N., Zhang, C., Dill, P., Panasyuk, G., Pion, D., Koka, V., Gallazzini, M., Olson, E. N., Lam, H., Henske, E. P., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20140341 · Cited by 205
Self-citationTumor suppression by cell competition through regulation of the Hippo pathway
Chen, C.-L., Schroeder, M. C., Kango-Singh, M., Tao, C., & Halder, G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113882109 · Cited by 187
Self-citationHippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration
Lu, L., Finegold, M. J., & Johnson, R. L. (2018) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.205 · Cited by 190
Self-citationSTAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis
Shen, Y., Wang, X., Liu, Y., Singhal, M., Gürkaşlar, C., Valls, A. F., Lei, Y., Hu, W., Schermann, G., Adler, H., et al. (2021) · Science Signaling · doi:10.1126/scisignal.abj8393 · Cited by 121
The Angiomotins – From discovery to function
Moleirinho, S., Guerrant, W., & Kissil, J. L. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.02.006 · Cited by 112
Atkins, M., Potier, D., Romanelli, L., Jacobs, J., Mach, J., Hamaratoglu, F., Aerts, S., & Halder, G. (2016) · Current Biology · doi:10.1016/j.cub.2016.06.035 · Cited by 88
Self-citationJNK signaling is converted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activity
Enomoto, M., Kizawa, D., Ohsawa, S., & Igaki, T. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.05.001 · Cited by 74
A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth
Vissers, J. H. A., Manning, S. A., Kulkarni, A., & Harvey, K. F. (2016) · Nature Communications · doi:10.1038/ncomms10368 · Cited by 70
Pham, T. H., Hagenbeek, T. J., Lee, H.-J., Li, J., Rose, C. M., Lin, E., Yu, M., Martin, S. E., Piskol, R., Lacap, J. A., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0706 · Cited by 64
Lin, A. Y. T., & Pearson, B. J. (2014) · Development · doi:10.1242/dev.101915 · Cited by 57
Scribble Acts in the Drosophila Fat-Hippo Pathway to Regulate Warts Activity
Verghese, S., Waghmare, I., Kwon, H., Hanes, K., & Kango-Singh, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047173 · Cited by 55
Kong, B., Sun, R., Huang, M., Chow, M. D., Zhong, X., Xie, W., Lee, Y., & Guo, G. L. (2018) · Hepatology · doi:10.1002/hep.30041 · Cited by 52
Hippo signaling controls cell cycle and restricts cell plasticity in planarians
de Sousa, N., Rodríguez-Esteban, G., Rojo-Laguna, J. I., Saló, E., & Adell, T. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2002399 · Cited by 41
Wittkorn, E., Sarkar, A., Garcia, K., Kango-Singh, M., & Singh, A. (2015) · Development · doi:10.1242/dev.117358 · Cited by 39
Yorkie is required to restrict the injury responses in planarians
Lin, A. Y. T., & Pearson, B. J. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006874 · Cited by 38
Role of YAP activation in nuclear receptor CAR-mediated proliferation of mouse hepatocytes
Abe, T., Amaike, Y., Shizu, R., Takahashi, M., Kano, M., Hosaka, T., Sasaki, T., Kodama, S., Matsuzawa, A., & Yoshinari, K. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy149 · Cited by 36
Chromatin dynamics during liver regeneration
Arechederra, M., Berasain, C., Avila, M. A., & Fernández-Barrena, M. G. (2020) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2019.03.004 · Cited by 28
Yang, S., Xu, W., Liu, C., Jin, J., Li, X., Jiang, Y., Zhang, L., Meng, X., Zhan, J., & Zhang, H. (2022) · Science China Life Sciences · doi:10.1007/s11427-020-1914-3 · Cited by 24
YAP transcriptionally regulates ErbB2 to promote liver cell proliferation
Wang, E. Y., Cheng, J.-C., Thakur, A., Yi, Y., Tsai, S.-H., & Hoodless, P. A. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2018.07.004 · Cited by 24
Metadata
- Authors
- Halder, G., & Johnson, R. L.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2011-01-01
- Volume
- 138
- Issue
- 1
- Pages
- 9-22
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2050712486
- Cited by
- 1,060
- References
- 15
- FWCI
- 24.56
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
